Speeding innovation for industry
Success | Diagnosis and innovative treatment
Leti innovation stories
Illumina’s table-top lab on chip may be small, but it packs in an impressive range of
functions. The lab does all the things a “real” lab can do, from dispensing, mixing, and
rinsing substances to adding reagents. Testing samples requires only tiny 300-nanoliter
droplets of various reagents. That’s barely a hundredth of a drop of liquid. The
lab is currently used to prepare samples for DNA Next Generation Sequencing on
The lab-on-chip technology developed
by Leti and Illumina, which acquired Leti
R&D partner Advanced Liquid Logic, is
based on an innovative sampling method
that differentiates it from other LOCs. By
using electrowetting on dielectric to move
and mix liquids and reagents, it eliminates
the need for pumps and valves.
An electric field-applied by activating
an electrode under the droplet-moves
the liquid to the desired location at the
desired speed. This opens the door
to automation, while taking system
miniaturization to new dimensions.
Illumina and Leti have each filed many
patents for electrowetting technologies.
So, it was only natural for them to
continue collaborating to improve labon-
chip performance, reliability and cost.
Resources and skills
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.