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Design of artificial metalloenzymes – Synthesis and Catalysis


​Master in Chemistry - Master 2 Internship’s subject
Published on 12 September 2017




Laboratory: Chemistry and Biology of Metals laboratory
Head: Dr. Stéphane Ménage
Name of the team: Bioinorganic Chemistry and Environment (BioCE)
Head of the team: Dr. Stéphane Ménage
Name and quality of the internship’s head: Dr. Caroline Marchi-Delapierre, MCF, HDR
Address: Bâtiment K’, 17 avenue des martyrs, 38054 Grenoble cedex 9
Phone: 04 38 78 91 04
Master 2: Chemistry for Life Sciences (CLS) and SOIPA

Design of artificial metalloenzymes – Synthesis and Catalysis

Main goals:
The impact of this project is expected (i) to foster the field of heterogeneous biocatalysis, (ii) to control the dioxygen activation for selective reactions, (iii) to provide new strategies for enantioselective sulfoxidation, (iv) to open the field of oxidation for CLEC technology.

Educational interests and skills targeted:
Organic synthesis practice
Discovering of inorganic synthesis, catalysis and chemistry at the interface
New analytical techniques: ICP, GC, HPLC, EPR
How to deal with a whole project: from synthesis to application

Summary:
Catalytic processes are at the cutting-edge of the development of green chemistry. Our original strategy relies on the conception of a heterogeneous crystal/solution version of the already demonstrated artificial enzymes technology coupled to an infinite declension of catalyzed reactions.
The project is based on the setting up of oxidation reactions catalyzed «in cristallo», thanks to the gain in mechanical and chemical stability of protein crystals by Cross Linking methods (CLEC).
The applicant will be asked to synthesize new substrates (to develop a new tandem chemistry) or new ligands (to implement the already discovered reactions). The new molecules will be tested in oxidation catalysis with inorganic complexes, artificial metalloenzymes and crystals.




Keywords:

Organic and inorganic synthesis – Heterogeneous catalysis – Biochemistry – CLEC technology – Oxidation reactions.

Approaches & material used:
For all these purposes we will combine X-Ray crystallographic and spectroscopic studies (MS, ICP, IR, UV- vis, NMR and EPR) with classical methodologies of organic and inorganic synthesis (and biochemistry depending on the applicant will).

Technical skills needed:
Organic synthesis – Inorganic synthesis – spectroscopy – iron will for learning – (biochemistry)

Internship’s date:
January to june 2018
Be careful: CEA entrance needs 3 months’ formalities.

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