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Discovery of a new system of maturation of the iron-sulfur centers


​​​​​​A team from the Biological Chemistry Laboratory (currently Chemistry and Biology of Metals laboratory) identified in Escherichia coli, in collaboration with a bacterial microbiology team of Marseille (UPR-CNRS 9043), a third system enabling the maturation of iron-sulfur centers. This new system would play a specific role in the maturation of a protein involved in the biosynthesis of nicotinamide adenine dinucleotide, a cofactor involved in cellular respiration (glycolysis). This discovery could challenge the assumption of the central role played by the protein scaffold in the biosynthesis of iron-sulfur proteins and in the related molecular mechanisms.​

Published on 2 July 2005

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