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Phosphorylation of tubulin beta by Cdk1 during mitosis


​Microtubules are made of tubulin α and ß. They form filamentous networks responsible for the organization of the cytoplasm of eukaryotic cells. When cells enter division (mitosis), these networks are reshaped to form the mitotic spindle, which plays a central role in the correct distribution of genetic material between two daughter cells. Defects in the formation and function of the mitotic spindle lead to genomic instability problems that promote tumor progression.

Published on 1 March 2006

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