Highlight | Molecular mechanisms
Researchers at the Chemistry and Biology of Metals laboratory recently obtained data on the functional and structural properties of the global bacterial transcriptional metalloregulator Fur (Ferric Uptake Regulation) which is involved in the control in iron homeostasis and the response to various stress (nitrosative, oxidant, acid ...).
D'Autreaux B, Pecqueur L, Peredo AG, Diederix RE, Caux-Thang C, Tabet L, Bersch B, Forest E and Michaud-Soret I
Reversible redox- and zinc-dependent dimerization of the Escherichia coli Fur protein.
Pecqueur L, D'Autreaux B, Dupuy J, Nicolet Y, Jacquamet L, Brutscher B, Michaud-Soret I and Bersch B
Structural changes of Escherichia coli ferric uptake regulator during metal-dependent dimerization and activation explored by NMR and X-ray crystallography.
Journal of Biological Chemistry, 2006
Tiss A, Barre O, Michaud-Soret I and Forest E
Characterization of the DNA-binding site in the ferric uptake regulator protein from Escherichia coli by UV crosslinking and mass spectrometry.
FEBS Letters, 2005
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