Highlight | Bioinformatic | Proteomics | Large-scale biology
As part of its work in the field of new proteomic analysis methods, EDyP Laboratory uses a new automatic analysis approach of mass spectrometry data. This method consists of generating "labels" through a partial reading of fragmentation spectra (MS/MS) of proteolytic fragments (tryptic peptides), and to position them on raw genomic sequences.
In collaboration with the Helix group of Inria Rhône-Alpes and the Cogenics society, the Exploring the Dynamics of Proteomes laboratory has created the PepLine software that can transform the mass information contained in MS/MS spectra into a mixed sequence information of amino acids and mass. Then PepLine maps this information on the genomic DNA according to a vicinity method based on the distance. PepLine was designed to be able of detecting the exon-intron boundaries of a gene and is consequently suitable to syntactic annotation of eukaryotic genomes
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.