Highlight | Molecular mechanisms
Researchers at the Cancer Biology and Infection laboratory are studying the repair mechanisms implemented at the level of injury they created in a monolayer of endothelial cells in culture. They observed that the cells located at the periphery of these lesions emitted filopodia on which motors proteins where traveling, carrying other proteins in order to interact with the cells located on the other side of the lesion. This study identifies that motor protein and sheds new light on the mechanisms underlying the remodeling, the tissue repair and the angiogenesis.
Almagro S, Durmort C, Chervin-Pétinot A, Heyraud S, Dubois M, Lambert O, Maillefaud C, Hewat E, Schaal JP, Huber P and Gulino-Debrac D
The motor protein Myosin-X transports VE-cadherin along filopodia to allow the formation of early endothelial cell-cell contacts.
Molecular and Cellular Biology, 2010
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.