Many antibiotics and antiparasitic are based on an inhibition of the fotates biosynthesis pathway (vitamin B9). The regular appearance of resistance to these molecules leads to search for new molecules. In search of such inhibitors, researchers at the Cell & Plant Physiology laboratory have developed a method for assaying the activity of enzymes involved in the biosynthetic pathway of folate. This assay method, compatible with a high throughput screening robotic platform, allowed them to identify such a molecule.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.