Fundamental Research Division
The DRF at the CEA assemble approximately 6,000 scientists since January 2016.
Scientific result | Structural biology | Bacteria
Researchers from the IBS have taken an interest in MreC, a bacterial cytoskeleton protein that serves as an "anchor" for other members of the elongation complex. The researchers have characterized, for the first time, the complex between a PBP and MreC. The PBP2:MreC complex thus represents the structural 'core' of the elongation. Any interference with its formation, for example by the introduction of mutations, prevents proper wall formation during elongation of the daughter cells, generating cells with an aberrant diameter that eventually die. The interaction surface between the two proteins represents a potential target for the development of specific inhibitors. Thus, this work paves the way for a new type of antibiotic, which does not block PBP activity like β-lactams do, but which prevents the formation of the PBP2:MreC complex.
Molecular architecture of the PBP2-MreC core bacterial cell wall synthesis complex | Nature communications
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