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Integrative Biology and Molecular Genetics Unit

Published on 24 April 2017
The research projects of the Integrative Biology and Molecular Genetics Unit (SBIGeM) aim at understanding the fundamental mechanisms used by eukaryotic and prokaryotic cells to adapt to their natural environment or to a variety of stresses.

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Photo_OL.jpgHead of Unit
+33 1 69 08 35 86
Jean-Yves THURET
+33 1 69 08 64 25
Catherine DOREAU
+33 1 69 08 80 26
Monique BIZEUL
+33 1 69 08 78 45
Lab Manager
Emmanuel GABETTE
+33 1 69 08 40 85

This unit is part of the Institute of Integrative Biology of the Cell (I2BC), established on 1 January 2015 (mixed research unit (UMR) 9198, CEA/CNRS/Paris Sud university).

The teams of the Unit try to unravel the mechanisms that control DNA damage and cellular proliferation, those that regulate gene expression, the implication of chromatin structure in epigenetic mechanisms, and the nature of the stress responses induced by oxidants, heavy metals, nanoparticules or ionizing radiations.

Various biological model systems chosen for their biological and experimental relevance are studied (bacteria, yeast Saccharomyces cerevisae, the mouse or mammalian cell cultures). The research teams use a large number of experimental approaches that are either targeted (biochemistry, genetics, molecular and cellular biology…) or global (transcriptomics, proteomics, metabolomics, bio-informatics, model building…) to understand the mechanisms under study in an integrated fashion at the molecular, cellular or tissular level.

The Unit is organized in four laboratories:

Mammalian Epigenomics Laboratory (Matthieu GERARD)
Peptidic Biosynthesis and Gene expression Laboratory (Muriel GONDRY)
Oxidative Stress and Cancer Laboratory (Michel TOLEDANO)
Transcription and Genomics Laboratory (Julie SOUTOURINA)