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Valorisation of carbon dioxide for the labeling of pharmaceutical compounds


​In studies published in ChemPhotoChem, I2BC@Saclay, SCBM and ICMMO researchers have developed a gentle method for photo-CO2 reduction by molecular catalysts, followed by a carbonylation reaction that immediately reuse the CO produced. This device can be used for the introduction of radioactive carbon atoms into molecules of therapeutic interest.

Published on 6 September 2018

​Abstract

A convenient and safe approach in valorizing carbon monoxide (CO) produced from the photocatalytic reduction of carbon dioxide (CO2) has been investigated. Visible light was used to drive an optimized photocatalytic reduction using a ruthenium trisbipyridine complex as a sensitizer and a rhenium bipyridyl carbonyl complex as a catalyst to perform an efficient reduction of CO2 to CO, which was then simultaneously utilized in a palladium‐catalyzed aminocarbonylation reaction at room temperature. This approach provides safe handling of the produced CO which also opens the way for a more efficient application of 13C‐isotope and 14C‐radioisotope‐labeled CO2 in pharmaceutically relevant drug labeling.

Read the French version.

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