Frédéric Joliot Institute for Life Sciences - Sur le même thème https://joliot.cea.fr/drf/joliot/en/Pages/news/Science/2019/A-ferredoxin-to-fuel-metabolic-pathways.aspx Website of the Frédéric-Joliot Institute of Life Sciences which includes 4 departments: I2BC, DMTS, NeuroSpin and Service hospitalier Frédéric Joliot (SHFJ). The teams are mainly located at the CEA Paris-Saclay center and at the Orsay hospital. en-US https://www.cea.frhttps://www-cea-fr.admsite.extra.cea.fr/Style%20Library/Themes/drf/instituts/images/logo-cea-joliot.png Frédéric Joliot Institute for Life Sciences - Sur le même thème https://joliot.cea.fr/drf/joliot/en Functionalization of the B subunit of Shiga toxin as a vaccine tool https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Functionalization-B-subunit-Shigatoxin-vaccine-tool.aspx Researchers at SIMoS (DMTS) describe the synthesis, engineering and evaluation of the properties of the B subunit of bacterial Shiga toxin (STxB), administered mucosally, as a vaccine tool. Their results confirm the value of using a synthetic STxB in an anti-tumor and anti-infectious vaccination strategy. Biotechnology ; Vaccine SIMOPRO Scientific result préclinique; Fri, 26 Jan 2024 11:00:00 GMT Identification of a mechanism potentially involved in drought resistance in plants https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Potential-drought-resistance-mechanism-plants.aspx I2BC researchers identify drought-resistant mutants of the model plant A. thaliana. These mutants are no longer able to carry out the state transition, a process that enables plants to adjust the absorption of light by their two photosystems in an optimal way. They could constitute a way of improving crop resistance to drought. Photosynthesis SB2SM Scientific result Thu, 07 Dec 2023 11:00:00 GMT Photocatalytic carbon dioxide reduction for radiolabeled drug synthesis https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Photocatalytic-CO2-reduction-for-radiolabeled-drug-synthesis.aspx Researchers from SCBM (DMTS) and SB2SM (I2BC) describe a novel and optimized approach to the total photoreduction of 13C-labelled CO2 to carbon monoxide (CO), and the immediate reuse of the latter for the synthesis of high value-added compounds. A step towards a radiochemistry of carbon isotopes potentially useful in human health. Bio-inspired catalysis ; Chemistry ; Green Chemistry ; Carbon cycle SHFJ Scientific result Wed, 22 Nov 2023 11:00:00 GMT Click-Chemistry: optimized drug delivery from nanomicelles into tumor cells https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Click-Chemistry-optimized-drug-delivery-nanomicelles.aspx Researchers at SCBM have used a click-and-release chemistry approach to mass-release an anti-cancer drug into cells from cleavable nanomicelles, thanks to a bioorthogonal activation process. A step towards the development of new nanomedicines Chemistry ; Biotechnology SCBM Scientific result Fri, 10 Nov 2023 11:00:00 GMT Manganese homeostasis is essential for the proper functioning of photosynthesis in Marchantia polymorpha https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Manganese-homeostasis-functioning-photosynthesis.aspx A team from I2BC shows, by using super-resolution fluorescence microscopy and transmission electron microscopy approaches, that both excess and deficiency of Mn affect the organization of thylakoid membranes and photosynthetic electron transport in the plant Marchantia polymorpha Photosynthesis SB2SM Scientific result ; Article Thu, 20 Apr 2023 10:00:00 GMT Microalgae: the FAP enzyme on the road to biofuels https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/microalgae-FAP-road-biofuels.aspx ​In 2017, researchers from the CEA-BIAM and the CEA-Joliot discovered an enzyme with a rare property: when activated by light, it enables microalgae to convert their fatty acids directly into hydrocarbons. Today, together with the Institut Polytechnique de Paris, they have succeeded in understanding and demonstrating that this "FAP" enzyme can enable the production of fuel-like hydrocarbons thanks to an autocatalytic effect. Energies ; Biofuel ; Microalgae Researchers ; Teachers ; general public ; Journalists BIAM Scientific result électrochimie;catalyse; Fri, 31 Mar 2023 10:00:00 GMT Oxygen photoactivation for bio-inspired hydrocarbon catalysis https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/O2-photoactivation-bio-inspired-hydrocarbon-catalysis.aspx The oxidative functionalization of alkenes, hydrocarbons widely used in the chemical industry, remains a challenge. A team from I2BC used an Oxygen Atom Transfer reaction to an alkene and succeeded in capturing the intermediate species of a bio-inspired photocatalyst produced during the reaction. Bio-inspired catalysis ; Green Chemistry SB2SM Scientific result Wed, 22 Feb 2023 11:00:00 GMT Exploring the potential of a model cyanobacterium for the photosynthetic production of high-value terpenes https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Model-cyanobacterium-production-high-value-terpenes.aspx Through two publications, an I2BC team demonstrates the high biotechnological potential of the model cyanobacterium Synechocystis PCC 6803 for the photosynthetic production of high value-added organic compounds, the terpenes. Photosynthesis ; Microalgae ; Biotechnology SB2SM Scientific result Fri, 10 Feb 2023 11:00:00 GMT Discovery of a natural peptide from black mamba venom, with anticholinergic properties https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Discovery-natural-peptide-black-mamba-venom.aspx ​A team from SIMoS (DMTS) identifies and characterizes a toxin isolated from black mamba venom, whose specific anticholinergic properties at the type 2 acetylcholine receptor, a regulator of arterial tone, position it as a potential drug candidate for the treatment of cardiovascular diseases. Health & life sciences ; Biotechnology SIMOPRO Scientific result ; Article Mon, 21 Nov 2022 11:00:00 GMT Molecular engineering of antibodies to accommodate antigenic drift of SARS-CoV-1 and 2 https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Engineering-antibodies-accommodate-antigenic-drift-SARS-CoV-1-2.aspx Researchers from SIMoS and SPI (DMTS) demonstrate that molecular engineering of llama antibodies, capable of neutralizing SARS-CoV-1, allows to obtain optimized antibodies with very high affinities for SARS-CoV-2 and its variants, the culprits of the Covid-19 epidemic. Biotechnology ; Virus SPI Scientific result Thu, 22 Sep 2022 10:00:00 GMT How to make biodrugs less immunogenic? Answer with a monoclonal antibody with anti-inflammatory properties https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/How-to-make-biodrugs-less-immunogenic.aspx SIMoS team, in collaboration with Bicêtre Hospital, shows that certolizumab pegol, a pegylated monoclonal antibody fragment for anti-inflammatory use, is less likely to trigger an adverse immune response than the non-pegylated form. Health & life sciences ; Biotechnology SIMOPRO Scientific result Mon, 20 Jun 2022 10:00:00 GMT New perspectives for CO2 photoreduction by iron porphyrins https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Photoreduction-of-CO2-by-iron-porphyrins.aspx ​Researchers from ICMMO* and ISMO**, in collaboration with a team from I2BC, show that the urea-decorated iron porphyrin catalysts they developed previously for the electro-catalysis of CO2, can be successfully employed in a photo-catalytic approach. Chemistry ; Bio-inspired catalysis ; Photosynthesis SB2SM Scientific result Thu, 16 Jun 2022 10:00:00 GMT Exploring the reaction mechanism of DNA photorepair by electronic spectroscopy https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Electron-spectroscopy-DNA-photorepair.aspx A team from the I2BC has just demonstrated, using transient absorption spectroscopy, that the repair of UV-induced damage in DNA by a repair enzyme (6-4) photolyase occurs in two successive photoreactions. Photosynthesis SB2SM News ; Article Wed, 23 Mar 2022 11:00:00 GMT Optimization of a nanotube electrode containing a bio-inspired catalyst https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Optimization-bio-inspired-catalyst-anode.aspx Researchers from the SCBM have participated in the optimization of a bio-inspired catalyst anode developed by teams from IRIG (CEA, Grenoble). In particular, they have contributed to the fine control of the catalyst surface concentration. Bio-inspired catalysis Researchers IRIG Article ; Scientific result Fri, 04 Mar 2022 11:00:00 GMT Deeptope: accelerating the development of therapeutic antibodies via high-throughput functional tests https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2021/Deeptope-start-up-Simos.aspx Deeptope, founded in February 2021 from a technology developed at the DMTS Laboratory of Cellular Immunology and Biotechnology (LICB), is a company of therapeutic antibody engineering that provides antibody optimization and characterization services to biotech or pharmaceutical firms with the goal of increasing the quality of antibodies in a very short timeframe. Biotechnology ; Pharmacology News ; Article Mon, 29 Nov 2021 11:00:00 GMT Quantum physics in flowers: role of carotenoids https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Singlet-Fission-Plants-Carotenoids.aspx Researchers from I2BC (CEA-Joliot/CNRS/UPSay, in collaboration with the JP Bourgin Institute and the University of Vilnius, decipher for the first time the energy dissipation process called "singlet fission" in two natural flower carotenoids, a fundamental mechanism for the design of new and more efficient multi-electron photocatalysts. Solar energy ; Photosynthesis ; Quantum Physics Scientific result Mon, 30 Aug 2021 10:00:00 GMT Plants - Dissipating excess absorbed light energy as heat to protect themselves: light on molecular mechanisms https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Plants-dissipation-exces-energy.aspx In a study published in JBC, a team from I2BC/CEA-Joliot, in collaboration with the Beijing Botanical Institute (China), describes for the first time an intermediate state of the light-harvesting antenna of higher plants that provides a better understanding of the changes that take place at the molecular level during the activation of a plant's photoprotection mechanism. Photosynthesis ; Molecular mechanisms Researchers SB2SM Scientific result Raman analyzer; Mon, 05 Jul 2021 10:00:00 GMT A small RNA regulates photoprotection in cyanobacteria https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Small-RNA-regulates-photoprotection-cyanobacteria.aspx A team of the I2BC (LMB/SB2SM), in collaboration with the Institute of Biology (Freiburg University), discovered a posttranscriptional regulatory mechanism linking the expression of the cyanobacterial Orange Carotenoid Protein, related to photoprotection, directly and in an inverse fashion, to the synthesis of the light collector complexes (phycobilisomes), via a 3’ end-derived small RNA. Photosynthesis ; Microalgae ; Molecular mechanisms Scientific result Wed, 23 Jun 2021 10:00:00 GMT Green chemistry and biofuel: the functioning of a key photoenzyme deciphered https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Functioning-FAP-photoenzyme-deciphered.aspx An international consortium of scientists, including an I2BC team, has just deciphered the functioning of FAP (Fatty Acid Photodecarboxylase), a key photoenzyme for the production of biofuels and other high value added molecules. This work, published in Science, was the object of a CEA press release. Green Chemistry ; Microalgae ; Biofuel Scientific result Mon, 12 Apr 2021 10:00:00 GMT Valorization of CO2 by bio-inspired catalysts: essential role of through-space electrostatic interactions https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/CO2-valorization-ChemSusChem.aspx By studying the structure-reactivity relationships of bio-inspired catalysts for CO2 reduction, researchers from I2BC (SB2SM) and ICMMO have shown that the effects of through-space electrostatic interactions surpass the through-bonds electronic effects. A further step towards obtaining a durable catalyst to reduce the atmospheric accumulation of CO2, responsible for global warming. Green Chemistry ; Bio-inspired catalysis ; Carbon cycle Scientific result Wed, 24 Mar 2021 11:00:00 GMT Bruno Robert (head of SB2SM/I2BC) is awarded Honoris causa Professor at the University of Vilnius https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2020/Bruno-Robert-awarded-Honoris-causa-Professor-Vilnius.aspx This appointment comes after more than 15 years of close scientific collaboration between Bruno Robert's team in CEA Paris-Saclay and the Physics Department of the University of Vilnius. Quantum Physics ; Photosynthesis News ; Article Thu, 19 Nov 2020 11:00:00 GMT Cyanothece PCC 7425, a new model cyanobacterium for the sustainable production of molecules of interest https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Cyanothece-PCC7425-new-model-cyanobacterium-limonene.aspx I2BC and SCBM teams have identified and reprogrammed a new model of cyanobacterium, Cyanothece PCC 7425, for the photosynthetic production of a high value-added monoterpene, limonene, used in many industrial applications. Photosynthesis ; Microalgae Scientific result Tue, 17 Nov 2020 11:00:00 GMT CO2 valorization : optimization of a bio-inspired catalyst https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/CO2-valorization-optimization-bio-inspired-catalyst.aspx A team from I2BC (SB2SM), in collaboration with ICMMO, optimized a bio-inspired CO2 reduction catalyst, designed and developed in the laboratory, and showed that its efficiency relies on a subtle balance between CO2 fixation at the catalytic site and access to protons, which is essential for breaking the C=O bond. Bio-inspired catalysis Scientific result Tue, 10 Nov 2020 11:00:00 GMT Synthetic biology: new tools to increase the diversity of the 2,5-diketopiperazines produced in E.coli https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Synthetic-biology-increase-diversity-diketopiperazines.aspx Researchers from I2BC (SBIGeM), in collaboration with teams from Sorbonne University, have characterized cyclodipeptide oxidases in vivo and shown that they are valuable tools for producing dehydrogenated 2,5-diketopiperazines, precursors of bioactive molecules of pharmaceutical interest, in Escherichia coli using synthetic biology approaches. Fundamental Research ; Health & life sciences ; Biotechnology Scientific result Fri, 25 Sep 2020 10:00:00 GMT Methylglyoxal detoxification revisited in cyanobacteria https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Methylglyoxal-detoxification-in-cyanobacteria.aspx A team from I2BC (SB2SM) used a combination of in vitro and in vivo approaches in the model cyanobacterium Synechocystis to establish a logical, but as yet never described, link between the detoxification of methylglyoxal, a toxic metabolite, and glutathione S-transferase, an enzyme of the xenobiotic metabolism, conserved during evolution. Photosynthesis ; Toxicology ; Microalgae News Fri, 04 Sep 2020 10:00:00 GMT Artificial photosynthesis, a first: a nano-polymer capable of mimicking photosystem II https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Artificial-photosynthesis-nano-polymer-mimicking-PSII.aspx Researchers from the I2BC (SB2SM), in collaboration with CNRS (LCP, ICMMO) have designed an original artificial photosynthesis approach, based on the use of semiconductor nanopolymers composed of PolyDiPhenylButadiyne, capable of reproducing the full photo-redox reaction of plant Photosystem II, that is the production of O2 by photo-oxidation of water and the reduction of a quinone. Photosynthesis ; Bio-inspired catalysis Scientific result Tue, 07 Jul 2020 10:00:00 GMT Dynamic association of PTOX with thylakoids https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Dynamics-PTOX-thylakoides.aspx A collaboration led by I2BC researchers presents, in the Journal of Experimental Botany, a body of evidence for a dynamic association of the PTOX protein with thylakoid membranes, dependent on proton motive force. Bioenergy ; Molecular mechanisms SB2SM Scientific result photosystem;ATP; Sat, 02 May 2020 10:00:00 GMT From bacteria to Humans: characterization of a new player in tolerance to thermal and oxidative stress https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Characterization-new-player-tolerance-thermal-oxidative-stress.aspx Researchers from SB2SM (I2BC@Saclay) have shown for the first time in vivo in the model cyanobacterium Synechocystis that a cellular detoxification enzyme, the membrane glutathione-S-transferase (GST), maintained in part by evolution, plays a major role in resistance to thermal and oxidative stress, making this cellular model a valuable tool for the study of GSTs conserved from bacteria to plants, down to Humans. Photosynthesis ; Stress response Scientific result Tue, 18 Feb 2020 11:00:00 GMT Magnetic sensors for ultra-sensitive biochips https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Magnetic-sensors-ultra-sensitive-biochips.aspx Researchers from IRAMIS collaborated with a team from SPI (LERI) for the development of a microfluidic biochip ("lab-on-chip") based on ultra-sensitive magnetic sensors with giant magnetoresistance (GMR sensors), capable of individually and effectively detect magnetically-labeled biological targets. Biotechnology ; Biodetection ; Physics Scientific result Wed, 08 Jan 2020 11:00:00 GMT A clean and efficient photocatalysis for the production of compounds of interest https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/A-clean-efficient-photocatalysis-production-compounds-interest.aspx A team from I2BC@Saclay, in collaboration with the CNRS (ICMMO, UPSud and ISM2, Aix-Marseille University) has shown that the use of a reversible electron acceptor, able to accept and transfer an electron, in place of a sacrificial electron donor optimizes efficient and clean photocatalysis reactions for the production of organic compounds of interest. Photosynthesis ; Bio-inspired catalysis Scientific result Fri, 18 Oct 2019 10:00:00 GMT A ferredoxin to fuel metabolic pathways of biotechnological interest https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/A-ferredoxin-to-fuel-metabolic-pathways.aspx Researchers at BIAM and I2BC@Saclay, in collaboration with Japanese colleagues from Okayama University and Ehime, have characterized in a cyanobacterium a minor protein that diverts part of the energy from photosynthesis to secondary metabolic pathways. This discovery is promising to exploit these metabolic pathways in a biotechnological process of bioenergy production. Biotechnology ; Bioenergy ; Photosynthesis Scientific result Mon, 14 Oct 2019 10:00:00 GMT The molecular evolution of the Orange Carotenoid Protein finally elucidated! https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Molecular-evolution-Orange-Carotenoid-Protein-elucidated.aspx A new phylogenetic analysis of the Orange Carotenoid Proteins (OCPs) family, responsible for photoprotection in cyanobacteria, coupled with a functional study, was conducted by a team from I2BC@Saclay. This is the first functional study of the ancestral OCPX which, when compared to OCP1 and OCP2, revealed the molecular determinants that govern the photocycle of these proteins and in particular the fundamental role of the linker connecting the two domains of OCPs. Photosynthesis Scientific result Fri, 04 Oct 2019 10:00:00 GMT Elucidation of the activation mechanism of an extraordinary photoreceptor https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Elucidation-activation-mechanism-new-photoreceptor.aspx In collaboration with teams from ENS (Paris) and the University of Marburg, researchers from I2BC@Saclay have elucidated, by optical time-resolved spectroscopy, the complete phooactivation mechanism of a new cryptochrome of the green alga Chlamydomonas reinhardtii, CraCRY. Photosynthesis Scientific result Thu, 19 Sep 2019 10:00:00 GMT New light on photosynthesis regulation in the ancient cyanobacteria https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/New-light-on-photosynthesis-regulation-in-the-ancient-cyanobacteria-.aspx Plants, algae, cyanobacteria regulate their photosynthesis so that it is as effective as possible and not deleterious. A sutdy led by a SB2SM team unveils one of the mechanisms of regulation in cyanobacteria and show that it is very different from that equivalent in plants and algae. Photosynthesis SB2SM Scientific result plastoquinone;cytochrome b6f;photosystem;cyanobacteria; Wed, 20 Mar 2019 11:00:00 GMT Valorisation of carbon dioxide by a bio-inspired approach https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Valorisation-carbon-dioxide-bio-inspired-approach.aspx A team of SB2SM (I2BC@Saclay), in collaboration with the universities of South-Paris and Rennes1, has developed a new, particularly effective catalyst for the reduction of carbon dioxide (CO2), directly inspired by nature. Results are published in Angewandte Chemie. Bioenergy ; Bio-inspired catalysis Scientific result Mon, 25 Feb 2019 11:00:00 GMT Recycle carbone dioxide more efficiently and cleanly? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/Recycle-carbone-dioxide-efficiently-cleanly.aspx A collaboration involving the SB2SM (I2BC@Saclay) works on bio-inspired processes to recycle carbon dioxide (CO2), a major environmental problem. Researchers have formulated a new catalyzer very efficient for reducing CO2 in water. The study has been published in Chemical Communications. Recovery of CO2 ; Photosynthesis SB2SM Scientific result Tue, 27 Nov 2018 11:00:00 GMT Valorisation of carbon dioxide for the labeling of pharmaceutical compounds https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/valorisation-carbon-dioxide.aspx ​In studies published in ChemPhotoChem, I2BC@Saclay, SCBM and ICMMO researchers have developed a gentle method for photo-CO2 reduction by molecular catalysts, followed by a carbonylation reaction that immediately reuse the CO produced. This device can be used for the introduction of radioactive carbon atoms into molecules of therapeutic interest. Green Chemistry ; Photosynthesis Scientific result Thu, 06 Sep 2018 10:00:00 GMT An original biotechnological approach to create new bioactive molecules https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/biotechnological-approach-new-bioactive-molecules.aspx ​Muriel Gondry's Research Team (I2BC@Saclay / SBIGeM), in collaboration with SIMOPRO and Biomolecules Laboratory of the Sorbonne University's one, produced 200 cyclodipeptides containing non-natural amino acids by luring and diverting the cellular machinery for the synthesis of proteins. This unprecedented approach significantly increases the diversity of these bioactive molecules. Biotechnology ; Structural biology Scientific result Mon, 05 Mar 2018 11:00:00 GMT Artificial photosynthesis: the second electron finally accessible https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/artificial-photosynthesis-second-electron.aspx A Research Team from I2BC@Saclay (SB2SM), in collaboration with ISMO and ICMMO teams (CNRS / Univ.Paris-Sud, Univ.Paris-Saclay) measured accumulation kinetics of electrical charges within a molecular system designed for studies on artificial photosynthesis. These works, published in Angewandte Chemie, show for the first time the second electron of this fundamental process about the conversion of light energy into fuel. Health & life sciences ; Photosynthesis Scientific result Wed, 21 Feb 2018 11:00:00 GMT A plant strategy for a better energy technology https://www.cea.fr/drf/joliot/en/Pages/news/Science/2017/A-plant-strategy-for-betterenergy_technology.aspx Researchers from SB2SM and four other Research Teams (Yale University, Arizona State University, Argonne National Lab and Institute for High Performance Computing, Singapore) have identified a photosynthesis mechanism that protects plants from excess light energy . These results could contribute to the development of more efficient energy systems in new solar technologies. Photosynthesis ; Solar energy Scientific result Fri, 07 Jul 2017 10:00:00 GMT Phytoplankton needs allies https://www.cea.fr/drf/joliot/en/Pages/news/Science/2017/Phytoplankton_needs_allies.aspx As part of an international collaboration, researchers from LI2D (SPI / Marcoule) and University of Warwick have highlighted the long-term benefits of the association between different marine microorganisms. The study published in Nature Microbiology shows that, contrary to what was admitted up to now, these microorganisms are in equilibrium and not in competition for micronutrients, because they form a complementary ecosystem. Microalgae ; Environment ; Health & life sciences Scientific result Fri, 30 Jun 2017 10:00:00 GMT MOMENTOM project at the SB2SM https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2017/MOMENTOM_project_at_the_SB2SM.aspx Winfried Leibl (SB2SM) is a member of the steering committee of the MOMENTOM project (MOlecules and Materials for the ENergy of TOMorrow, IRS PARIS-SACLAY, 2017-2020) This project, funded within the framework of the Strategic Research Initiatives (IRS) of Paris-Saclay University, concerns molecules and materials for the energy of tomorrow. Institutional ; Photosynthesis ; Bioenergy News Mon, 26 Jun 2017 10:00:00 GMT High light-induced hydrogen peroxide production in Chlamydomonas reinhardtii is increased by high CO2 availability. https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2015/High-light-induced-hydrogen-peroxide-production-.aspx The rate of oxygen reduction by photosynthetic electron transport is significant in the presence of high concentrations of CO2 and not under CO2 limitation. Photosynthesis News Wed, 12 Apr 2017 13:22:22 GMT Bicarbonate, a new redox regulator for Photosystem II https://www.cea.fr/drf/joliot/en/Pages/news/Science/2017/Bicarbonate_new_redox_regulator_for_Photosystem_II.aspx ​This work, stemming from a collaboration between researchers from Imperial College London and an SB2SM Research Team, resolved a long-standing ambiguity about the redox potential (Em) value of the primary quinone, QA, of the Photosystem II (PSII). In addition, the authors discovered a new and very important phenomenon for the PSII: a reversible control effect of the redox potential of QA induced by binding of bicarbonate. Photosynthesis Scientific result Tue, 31 Jan 2017 11:00:00 GMT Modulating cerebral cholesterol: a new avenue of research to treat Alzheimer’s disease? https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/I2BM_anglais/News/Scientific_news/Articles/2015/Modulating-cerebral-cholesterol-new-avenue-research-treat-Alzheimer.aspx Two French research teams have recently shown in a rodent model that overexpression of an enzyme capable of eliminating excess cholesterol in the brain can act in a beneficial way on the tau component of the disease to completely correct it. Alzheimer's disease ; Gene and cell therapy ; Biotechnology MIRcen Scientific result Mon, 14 Sep 2015 10:00:00 GMT Protection from too much light. https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2015/Protection_from_too_much_light.aspx Photosynthetic organisms protect themselves from too much light using pigment photoswitches that absorb excess energy. American scientists (Berkeley, Michigan State University) and French researchers (SB2SM team) analyzed the structure of an active, energy-dissipating form of the orange carotenoid protein (OCP) from a cyanobacterium. Photosynthesis News Fri, 26 Jun 2015 10:00:00 GMT Bio-magnet for targeted medical imaging https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/I2BM_anglais/News/Scientific_news/Articles/2015/Bio-magnet-for-targeted-medical-imaging.aspx The CEA-IBEB has partnered with the CEA-I2BM to develop original MRI contrast agents. Nano-magnets produced by bacteria may reveal targets at the molecular level. Biotechnology ; Cell and molecular imaging ; MRI ; Diagnosis ; Nanomedicine LBC Scientific result Fri, 20 Feb 2015 11:00:00 GMT