Clefs CEA n°48 : Radiological and chemical toxicology
Editorial, by Bernard Bouquin (pdf 56 Ko - p. 1)

Institutions and official bodies: who does what? (pdf 56 Ko - p. 2)

I. FROM SOURCE TO MAN

The exposure routes
• Air, water and food,
by Xavier Machuron-Mandard, Patrick Armand and Éric Pili (pdf 1,1 Mo - p. 3-8)

Box A: Natural and artificial radioactivity (pdf 856 Ko)
• Soil-plant transfer, by Siobhán Staunton (pdf 1,1 Mo - p. 9-10)
• Transfer in animals, by Silvia Vincent-Naulleau (pdf 980 Ko - p. 11-13)
Box B: Human exposure routes (pdf 904 Ko)
Speciation in the environment and in biological media,
by Éric Ansoborlo, Remo Chiappini and Valérie Moulin (pdf 1,2 Mo - p. 14-18)
II. THE BIOLOGICAL BEHAVIOUR
OF NUCLEAR TOXICS
The fate of radionuclides in the body,
by Paul Fritsch and Béatrice Le Gall (pdf 1,8 Mo - p. 19-24)
Box C: Vital elements in the human body (pdf 1 Mo)
The mechanisms involved at the cell level
• Can vital biological exchanges also be life-threatening?
• Iodine, its isotopes and technetium,
by Gérard Leblanc, Thierry Pourcher and Barbara Perron (pdf 1,8 Mo - p. 25-28)
• Cadmium, a stress that builds up, by Florent Guillain (pdf 1 Mo - p. 29-30)
Cells that adapt to cadmium, by Jean Labarre
• Uranium, better known each day, by Éric Quéméneur (pdf 1,3 Mo - p. 31-34)
Box D: Radiological and chemical toxicity (pdf 856 Ko)
• The biological fate of plutonium, by Paul Fritsch (pdf 1 Mo - p. 35-36)
Human monitoring tools, by Xavier Millot, Didier Cavadore,
Christine Riasse and Jean-Michel Giraud
(pdf 952 Ko - p. 37 -38)
III. WHAT ARE THE EFFECTS ON HEALTH?
The effects of high exposures
Physiopathological consequences in cells and tissues
• Radon and lung cancer: Research into specific features of radio-induced genetic alterations,
by Sylvie Chevillard and Marie-Noëlle Guilly (pdf 1 Mo - p. 39-43)
• Radioactive iodine and the thyroid, by Martin Schlumberger (pdf 1 Mo - p. 44-47)
Box E: When radionuclides take the place of vital elements (pdf 776 Ko)
• The effects of ionising radiation on the kidneys,
by Christian de Rouffignac (pdf 1,1 Mo - p. 48-50)
• The skeleton, an important target, by Jean-Luc Poncy (pdf 972 Ko - p. 51-52)
• Effects of ionising radiation on human skin,
by Michèle Martin (pdf 1,1 Mo - p. 53-55)
The effects of radiation on reproductive functions
• Radionuclides and gonads: the example of plutonium,
by Anne Flüry-Hérard and Florence Ménétrier
• Effects of radiation on genetic material,
by Bernard Dutrillaux (pdf 1,3 Mo - p. 56-61)
Effects of high exposures to radionuclides: clinical and epidemiological findings,
by Florence Ménétrier, Anne Flüry-Hérard and Daniel Schoulz (pdf 1,3 Mo - p. 62-67)
Box F: From rays to dose (pdf 948 Ko)
Risk assessment at low exposure levels
Specific features of occupational medicine in nuclear research and industrial applications,
by Jean-Michel Giraud and Benoît Quesne (pdf 1 Mo - p. 68-69)
Transposing biologically based dose calculations to whole populations,
by Jean Piechowski (pdf 1,1 Mo - p. 70-72)
Box G: The regulatory dose limits (pdf 1 Mo)
How is the ICRP keeping pace with change?
by Jean-Marc Cosset (pdf 1,1 Mo - p. 73)
The role of occupational health services and biological medical laboratories
in committed dose assessments,
by Philippe Bérard, Nicolas Blanchin, Didier Cavadore,
Jean-Michel Giraud and Jean Piechowski
(pdf 952 Ko - p. 74-76)
Box H: How could the relative risk due to ionising radiation be estimated?
by Jean-Michel Giraud (pdf 956 Ko)
Limits of the comparison between radiological and chemical hazards,
by Rémy Maximilien
• Beryllium, an example of a non-radioactive nuclear toxic element,
by Bernadette Bounolleau (pdf 1,3 Mo - p. 77-82)
IV. HOW CAN THE EFFECTS OF TOXICS BE PREVENTED AND TREATED?
Biosensors to track down toxic metals,
by Claudio Vita (pdf 940 Ko - p. 83-85)
Biodepollution and bioremediation
• Plants to clean up soils and water,
by Alain Vavasseur, Jacques Bourguignon and Gilles Peltier
• Use of heavy metal resistant bacteria for restoration of polluted environments,
by David Pignol and Jacques Coves (pdf 544 Ko - p. 85-88)
How can toxics be cleared from the body?
by Jean-Michel Giraud and Jean Piechowski (pdf 960 Ko - p. 88-90)
CEA on the trail of new treatments,
by Jean-Robert Deverre, Béatrice Le Gall, Henri Benech and Frédéric Taran (pdf 1,3 Mo - p. 90-92)
V. STANDARDISATION ASPECTS
Standardising the measurement of radionuclides
in the environment, by Dominique Calmet (pdf 1,1 Mo - p. 93-99)
RESEARCH PERSPECTIVES
The effects on health of radiological and chemical toxicity.
• A concern shared by scientific research, medicine
and engineering, by Anne Flüry-Hérard (pdf 1,4 Mo - p. 100-106)
The cellular mechanism of oxidative stress surveillance unravelled,
by Michel Toledano

What is the purpose of a nuclear toxicology programme?
by Jean-Jacques Leguay (pdf 952 Ko - p. 107-108)
Physical and toxicological characteristics
of significant radionuclides (pdf 864 Ko - p. 109-110)
Glossary (pdf 416 Ko)

 


Clefs CEA n°48 - Radiological and chemical toxicology