Vous êtes ici : Accueil > Projet INFORMED

Europe | Nouvelles technologies | Santé & sciences du vivant


INFORMED

The InForMed project is ensuring development of a new generation of medical instruments, including laparoscopic instruments, catheters and guide-wires, which will be used in Hospital and Heuristic Care, Home Care and Well-being.



Publié le 23 avril 2021



An integrated pilot line for micro-fabricated medical devices


The InForMed project is ensuring development of a new generation of medical instruments, including laparoscopic instruments, catheters and guide-wires, which will be used in Hospital and Heuristic Care, Home Care and Well-being.



 

Starting date : Jun. 2015 > Sep. 2018

Lifetime: 39 months

Program in support : Ecsel-2014-2 Innovation Actions (IA)

 

Status project : complete

CEA-Leti's contact :

Jean-Charles Souriau

 

Project Coordinator: Philips (NL)

Partners:  

  • ICSciences, (BE)
  • Imec, (BE)
  • Rsscan, (BE)
  • Comelec, (CH)
  • Brio Alphasip, (DE)
  • Cytocentrics, (DE)
  • Bioscience, (DE)
  • Fraunhofer, (DE)
  • JVI, (DE)
  • Lust Hybrid, (DE)
  • Multi Channel, (DE)
  • Osypka, (DE)
  • SPTS, (DE)
  • CEA-Leti, (FR)
  • ESIEE, (FR)
  • Ipdia, (FR)
  • Packaging SIP, (FR)
  • SAS Bodycap, (FR)
  • Smith Connectors, (FR)
  • Toppan, (FR)
  • Fleming Medical, (IE)
  • Tyndall, (IE)
  • BESI, (NL)
  • Boschman Technology, (NL)
  • Cytocentrics BV, (NL)
  • IMDS Service, (NL)
  • Iszgro Diodes BV, (NL)
  • Medtronic, (NL)
  • Micronit, (NL)
  • Philips, (NL)
  • Philips Healthcare, (NL)
  • Pluriomics, (NL)
  • TNO Holst Center, (NL)
  • TU Delft, (NL)
  • Silex, (SE)
  • Univ Zaragoza, (SP)



Publications:

  • «Development of micro-system encapsulation for silicon devices which are in contact with human cells», J.-C. Souriau et al; IEEE CPMT Symposium Japan (ICSJ) 2017.
  • «Evaluation of thin biocompatible barriers properties on A none-Biocompatible silicon test vehicle», J.-C. Souriau, C. Quiniou, L. Castagné, G. Simon; 4th ATW on Microelectronics, Systems and Packaging for Medical Applications December 7-8, 2016 Lyon, France
  • .«PEDOT and Iridium Oxide (SIROF) Ageing for Neural Stimulation», G. Grenot et al; 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC’16), 2016.


Investment:  € 48.1 m.

EC Contribution€ 11.4 m.


Website

Stakes

  • CEA-Leti has contributed to the InForMed project through its expertise in 3D packaging of microsystems and deposition of material for stimulation electrodes.

  • Study of thin layer biocompatible encapsulation has highlighted the following candidates: TiO2, HfO2, Al2O3-TiO2, Pt and Ti-TiN deposited by ALD. Most of these thin layers are very stable in PBS at 90°C. It has also been shown that the ALD layer comprising Al2O3-TiO2 on SiO2 offers a good barrier to PBS infiltration. No degradation of AlSi lines were observed after 90 days in PBS at 90°C. Finally, it has also been demonstrated that 500nn of Pt was a good candidate for encapsulating AlSi.

  • The PEDOT electropolymerization method has been confirmed in the Steering deep brain stimulation demonstrator: the CV method ensures the best PEDOT film properties (Charge Storage Capacities (CSC) and impedances). Moreover, a method has been optimized for grafting a molecule to improve the PEDOT electrodeposition and adhesion to the platinum surface. Electropolymerization has been performed on Medtronic test vehicles with different electrode shapes and sizes on a
    flexible Parylene substrate. Electrodeposition has given excellent results.


OBJECTIVES


The goal of the InForMed project is to set up an integrated micro-fabrication pilot line for medical devices, covering the complete innovation chain from technology concept to system qualification. 

The critical stages of technology transfer from university to industrial development (TRL 4/5) and subsequent qualification for manufacturing (TRL7/8) are specifically addressed. A number of innovative micro-fabricated medical devices serve as pilot products to identify and resolve all possible transfer issues along the value chain. This allows validation of the complete integrated pilot line infrastructure from novel idea to real product. The InForMed project targets innovation in three important classes of medical equipment and instruments:

  • Traditional diagnostic equipment: micro-fabricated devices are rapidly replacing traditional sensors and actuators in diagnostic equipment
  • Next generation medical instruments: more and more medical procedures are performed using minimally invasive techniques involving laparoscopic instruments, catheters or guide-wires
  • Organs-on-Chip and other emerging devices, micro-fluidics and polymer micro-fabrication combined with breakthroughs in cell-biology, in particular recently developed induced Pluripotent Stem Cell technology (iPSC), which leads to co-integration of living cells and tissue with micro-fabricated devices to form accurate models of human organs. CEA-Leti has contributed to the InForMed project through its expertise in 3D packaging of microsystems and deposition of material for stimulation electrodes.




    IMPACT

    • Material bio-compatibility and bio-stability in medical devices is a real challenge, especially when materials are deposited in thin layers.

    • CEA-Leti’s work on the InForMed project has been decisive for developing implantable devices and neurological stimulation. The results obtained are very positive and are universally recognized by the scientific community.