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Electrochemical Micro-Sensors

Published on 20 April 2023

Direct Analysis of soil, water and biological fluids

  What is Electrochemical micro-sensors

Electrochemical micro-sensor devices offer real-time information on complex environments by coupling a chemically selective layer to an electrochemical transducer. Electrochemical sensors provide a direct conversion of a biological event to an electronic signal. There are four main types of electrochemical sensors: potentiometric or ion-selective electrodes (ISEs), amperometric, impedimetric and transistors (OECT—organic electrochemical transistor, ISFET, etc.)

Electrochemical micro-sensors provide an attractive means to perform rapid and sensitive analysis.This technology also offers a high performance-cost ratio and is user friendly. Devices are now being used with success in clinical chemistry, food industry, and in environmental studies.


Human and veterinarian healthcare for monitoring purposes:

  • wearable devices for noninvasive physiological monitoring,
  • point-of-care testing and diagnostics,
  • wearable artificial organs,
  • post-surgery infection.

Environment and industrial studies for monitoring purposes:
  • water and soil quality,
  • inline or in bioreactor process.

  What's new?

Electrochemical microfluidic-biosensors offers a wide range of improvements for both health practitioners and scientists:

  • Compact and low-cost devices
  • Real-time and continuous multi-parametric measurement
  • Biocompatible, flexible or pitch medium
  • Autonomous devices: wireless communication, low energy consumption
  • Formulation of sensitive and bio-sensitive layers for specific electrochemical detection
  • Form factor, level of robustness depending on the application

The range of parameters measured covers: pH, Sodium (Na+), Potassium (K+), Calcium (Ca2+), Ammonium (NH4+), Carbon dioxide (CO2), Nitrate/nitrite (NO3-/ NO2-), Nitrogen monoxide (NO), Glucose (H2O2), Lactic acide, Creatinine.

  What's next?

CEA-Leti’s team is currently developing:

  • Electrochemical sensors integrated into a microfluidic device—lab on a chip
  • Sensor networks for both cell culture and organ-on-chip
  • Resorbable sensors
  • Sensors on paper
  • Liquid gated field effect transistors (LGFET) based on graphene
  • Coupling OECT and LGFET for design Boolean electrochemical sensors

Additional parameters are coming soon: Magnesium (Mg2+), Fluorine (F-), Phosphate (PO4-), Urea, heavy metal (Lead, Cadmium, Mercury, etc.), Arsenic


 3 patents

  •       FLYER

    (180 ko)