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Tissue Biomimetism

Published on 28 September 2020



Objectives
Our goal is to engineer biomimetic surfaces to mimic some features of the natural extracellular matrices, notably their biochemical and physical properties. Using these well-controlled surfaces, we study in vitro the cellular processes guiding tissue formation, including cell signaling. Our team has an expertise in glycosaminoglycans (GAG, such as heparan sulfates, hyaluronic acid) and in bone morphogenetic proteins (BMPs), which are playing a role in a large number of physiological and pathological processes.
- The first research topic focuses on 2D platforms made of streptavidin to bind heparan sulfate, cell adhesive ligands and BMPs.
- The second research topic focuses on biomimetic films made by the layer-by-layer assembly.

Using several biophysical techniques (QCM, spectroscopic ellipsometry) that are surface-sensitive, we can precisely control the functionalization of the biomimetic surfaces and quantify molecular interactions.

Fundings
Team Fondation Recherche Medicale, ANR CODECIDE (PI Corinne ALBIGES-RIZO, IAB Grenoble), IDEX IRS (IDEX University Grenoble Alpes), SATT Bioactivecoatings, ANR PRCI GlyCON (PI E. Migliorini and A. Vortkamp)

Researchers and Technical Staff
Elisa Migliorini, CNRS Researcher - Biography
Catherine Picart, CEA Research Director - Biography
Paul Machillot, CNRS Assistant Engineer - Biography
Laura Clauzier, Research Engineer, CEA, CDD - Biography

Students
Adrià Sales (Post-doc)
Jean Le Pennec (PhD student)
Julius Sefkow-Werner (PhD student)
Valia Khodr (PhD student)

Alumni
Elaine Castro (M2 student, 2020)
João Carlos Lopes Cardoso Filho (M2 student, 2020)
Simon Peyras (M1 student, 2018)
Vincent Fitzpatrick (PhD student, 2014-2017)
Quentin Lubart (PhD student, 2013-2016)
Anne Valat (PhD student, 2013-2016)
Flora Gilde (PhD student, 2011-2014)

Selected Publications
Migliorini E, Horn P, Haraszti T, Wegner SV, Hiepen C, Knaus P, Richter RP and Cavalcanti-Adam EA
Enhanced biological activity of BMP-2 bound to surface-grafted heparan sulfate.
Advanced Biosystems, 2017, 1(4): 1600041

Thakar D, Dalonneau F, Migliorini E, Lortat-Jacob H, Boturyn D, Albiges-Rizo C, Coche-Guerente L, Picart C and Richter RP
Binding of the chemokine CXCL12a to its natural extracellular matrix ligand heparan sulfate enables myoblast adhesion and facilitates cell motility.
Biomaterials, 2017, 123: 24-38

Migliorini E, Valat A, Picart C and Cavalcanti-Adam EA
Tuning cellular responses to BMP-2 with material surfaces.
Cytokine Growth Factor Reviews, 2016, 27: 43-54