Bioscience and Biotechnology Institute of Aix-Marseille
We investigate bacterial adaptive response to rapid changing environments and also under non-natural stress conditions derived from human activities in nanotechnology (nanoparticles) fields. How bacteria adapt their physiology to withstand environmental fluctuations is investigated with an emphasis on the role of small non-coding RNAs (ncRNAs). These studies are conducted using interdisciplinary approaches.
Our research is focused on the molecular dialogue that occurs between plant and bacteria, and the evolution of these interactions in response to potential pollutants such as nanoparticles.
The light-dependent cell cycle of R. tataouinensis is probably the key strategy adopted by this bacterium to survive desiccation.
These research topics are based on genetic approaches, biochemical, molecular, -omics and benefit from the development of bioinformatics tools that contribute to a better understanding of the ecology of these bacteria by analysing their genomes and their genomic responses.
We are attempting to generate deeper knowledge about the functional properties of soil microbial communities and the ways in which different plant species impact bacterial diversity and bacterial activities: we are investigating how microbial communities are tailored by plant root exudates and how the genomes of phytobeneficial bacteria (PGPR) have evolved to better explore the resources in the rhizosphere. We are also seeking to dissect the signalling exchange between plants and phytobeneficial bacteria to determine how the expression of these phytobeneficial traits is regulated in the rhizosphere.
Research in LEMiRE addresses questions about the adaptive responses of bacteria to environmental fluctuations. Based on an integrative approach and functional genomics tools, these studies build our knowledge of the functioning of environmental bacteria and of how bacteria acclimate to environmental stress.
We have created a database of predicted prokaryotic transcription factors (P2TF), and a database of prokaryotic two-component systems (P2CS). Both databases represent important progress in the bioinformatics field, responding to the need for user-friendly, rigorous and consistent databases that enable scientists to overcome the inherent variability in annotation between genome sequences.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.