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Research Topics

Database development


​We have created a database of predicted prokaryotic transcription factors (P2TF), and a database of prokaryotic two-component systems (P2CS). Both databases represent important progress in the bioinformatics field, responding to the need for user-friendly, rigorous and consistent databases that enable scientists to overcome the inherent variability in annotation between genome sequences.​

Published on 8 July 2015

​We have created a database of predicted prokaryotic transcription factors (P2TF), and a database of prokaryotic two-component systems (P2CS). Both databases represent important progress in the bioinformatics field, responding to the need for user-friendly, rigorous and consistent databases that enable scientists to overcome the inherent variability in annotation between genome sequences.

Because bacteria have evolved two-component systems to sense environmental changes and consequently adjust their physiology, P2CS has proved an invaluable resource for the TCS research community, helping scientists to improve their knowledge about signalling networks in bacterial organisms. It also provides researchers with the tools to identify and annotate TCS genes and their products, and includes intuitive navigation analysis techniques for users. Moreover, a recent feature added to the P2CS database includes provision for phylogenetic trees of TCS proteins, which give illuminating evolutionary insights into TCS biology. Users of the database are able to pinpoint TCS proteins of interest in a variety of different ways, including domain architecture searches and browsing through different genomes.​