Fundamental Research Division
The DRF at the CEA assemble approximately 6,000 scientists since January 2016.
Press release | News | Highlight | Health ＆ life sciences | Diseases | Virus | DNA | Diagnosis and innovative treatment | Nanomedicine | Vaccine
Scientists from the French Alternative Energies & Atomic Energy Commission [CA1] (CEA), the University of Grenoble-Alpes (UGA), and the French National Centre for Scientific Research (CNRS) have combined forces with the European Synchrotron Radiation Facility (ESRF) to become the first to describe a key interaction between two SARS-CoV-2 proteins. This may lead to a new therapeutic strategy to treat Covid-19. The results of their study were published in Science Advances on 19 January 2022.
* from the Interdisciplinary Research Institute of Grenoble (IRIG)
** Intrinsically disordered proteins lack a fixed 3D structure and function in a disordered state. Their high flexibility allows them to easily bind to the surface of their partners or to replicate during interactions. Though this level of flexibility is key to their biochemical action, it also led to the mutation responsible for the heightened severity of the Delta variant.
The intrinsically disordered SARS-CoV-2 nucleoprotein in a dynamic complex with its viral partner nsp3a, Science Advances, 19 January 2022
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.