The Knowledge Factory - Sur le même thème https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/measuring-insulin-production-in-a-single-pancreatic-islet-with-a-microfluidic-chip.aspx DRF english version en-US https://www.cea.fr/_layouts/15/images/i2i/icon-144x144-1033.png The Knowledge Factory - Sur le même thème https://www.cea.fr/drf/english Evaluating the stress response of a bacterium using optical tweezers on a chip https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/evaluating-the-stress-response-of-a-bacterium-using-optical-tweezers-on-a-chip.aspx Physicists at the CEA-Irig and their partners in Grenoble (CEA-Leti, CNRS, UGA) have shown that it is possible to trap individual bacteria and measure their response to stress using silicon photonic crystals. This disruptive technique, which does not require cell culture, opens the way to rapid antibiotic resistance tests. Photonics ; Micro-nanotechnologies ; Bacteria ; Antibiotics ; Diagnosis and innovative treatment general public ; Journalists ; Researchers IRIG Découvertes et avancées ; Scientific result Wed, 19 Oct 2022 10:00:00 GMT Is it possible to control the polarity of an artificial cell? https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/is-it-possible-to-control-the-polarity-of-an-artificial-cell.aspx Researchers at the CEA-Irig have succeeded in combining the dynamics of microtubules and actin filaments in a cell-sized compartment, allowing them to position the “microtubule-organizing center”. Cytoskeleton ; Cellular mechanisms general public ; Journalists ; Researchers IRIG Découvertes et avancées ; Scientific result Mon, 17 Oct 2022 10:00:00 GMT Molecular engineering of antibodies: from SARS-CoV-1 to SARS-CoV-2 and its variants https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/molecular-engineering-of-antibodies-from-sars-cov.aspx Researchers from the CEA-Joliot have shown that molecular engineering of llama antibodies directed against SARS-CoV-1 can be used to obtain optimized antibodies with very high affinities for SARS-CoV-2 and its variants. This is a step towards designing neutralizing molecules for new emerging pathogen strains! Diagnosis and innovative treatment ; Virus general public ; Journalists ; Researchers Joliot Découvertes et avancées ; Scientific result Thu, 13 Oct 2022 10:00:00 GMT An in vitro structure that mimics a pancreatic cancer mini-tumor https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/an-in-vitro-structure-that-mimics-a-pancreatic-cancer-mini-tumor.aspx Using almost fully automated processes, researchers at Irig have designed a three-dimensional microenvironment in which cells form a tissue resembling a mini-tumor. Their work opens new perspectives for personalized medicine. Pharmacology ; Cellular mechanisms ; Diagnosis and innovative treatment ; Methodologies for life sciences general public ; Journalists ; Researchers IRIG Découvertes et avancées ; Scientific result Wed, 01 Jun 2022 10:00:00 GMT Restoring consciousness through deep brain stimulation https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/restoring-consciousness-through-deep-brain-stimulation.aspx A research team led by the CEA-Joliot has provided evidence that deep brain stimulation can restore consciousness when it is impaired. This result obtained in animals could lead to clinical trials in unconscious patients. Brain ; Diagnosis and innovative treatment general public ; Journalists ; Researchers Joliot Découvertes et avancées ; Scientific result Thu, 07 Apr 2022 10:00:00 GMT High field MRI for the benefit of psychiatry https://www.cea.fr/drf/english/Pages/News/Institutional-news/2022/high-field-MRI.aspx Improving the quality of life for people with psychiatric problems thanks to more targeted treatment protocols, or even preventing the appearance of such pathologies, would be a major breakthrough for public health care. This is one of the objectives of researchers at NeuroSpin, the CEA centre for innovation in neuroimaging in Saclay, near Paris. Health & life sciences ; Brain ; Diagnosis and innovative treatment ; Diseases Journalists ; Institutions ; general public Neurospin News ; Highlight artificial intelligence;psychiatry;Mental Health;Neuroimaging;MRI;biomarker;Brain;NeuroSpin;psychiatric deseases; Mon, 04 Apr 2022 10:00:00 GMT Measuring insulin production in a single pancreatic islet with a microfluidic chip https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/measuring-insulin-production-in-a-single-pancreatic-islet-with-a-microfluidic-chip.aspx Researchers at the Irig, in collaboration with the CEA-Leti, have developed a microfluidic chip that can measure insulin secretion from a single pancreatic islet. The same technology can be adapted to other biological tissues and secretomes. Biochip ; Diagnosis and innovative treatment ; Cellular mechanisms general public ; Journalists ; Researchers Découvertes et avancées ; Scientific result Wed, 09 Mar 2022 11:00:00 GMT A promising gene therapy for the treatment of sickle cell disease and “transfusion-dependent” beta-thalassemia https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/a-promising-gene-therapy-for-the-treatment-of-sickle-cell-disease-and-transfusion-dependent-beta-thalassemia.aspx In order to fight sickle cell disease and beta-thalassemia, two common genetic diseases affecting red blood cells, the AP-HP, the University of Paris, Inserm (Imagine Institute), Paris-Est Créteil University and the CEA-Jacob have conducted a clinical study utilizing the transplantation of a patient’s own genetically modified stem cells. A phase I/II trial with bluebird bio as the sponsor has been completed. Gene and cell therapy ; Diagnosis and innovative treatment ; Genetic diseases general public ; Journalists ; Researchers Jacob Découvertes et avancées ; Scientific result Fri, 28 Jan 2022 11:00:00 GMT SARS-CoV-2: an essential interaction between two proteins could inspire a new therapeutic strategy https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/sars-cov-an-essential-interaction-between-two-proteins-could-inspire-a-new-therapeutic-strategy.aspx Researchers from the CEA-Irig (IBS), Grenoble Alpes University, the CNRS and the ESRF have described for the first time an essential interaction between two SARS-CoV-2 proteins that could inspire a new therapeutic strategy against COVID-19. Virus ; Structural biology ; Diagnosis and innovative treatment general public ; Journalists ; Researchers IRIG Découvertes et avancées ; Scientific result Thu, 20 Jan 2022 11:00:00 GMT Hematopoietic stem cells go out of their way to differentiate https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/hematopoietic-stem-cells-go-out-of-their-way-to-differentiate.aspx With the help of a “bone marrow on a chip”, researchers at Irig and their partners (Inserm, Hôpital St-Louis, Paris Diderot University) have observed the onset of differentiation in stem cells, before their transformation into blood cells. Upon contact with a bone cell, some of them completely reorganize. This unexpected discovery opens up entirely new paths for the study of a number of diseases such as leukemia. Stem cells ; Cellular mechanisms ; Cancer general public ; Journalists ; Researchers IRIG Découvertes et avancées ; Scientific result Tue, 02 Nov 2021 11:00:00 GMT HLA-G: a new anti-cancer therapeutic target https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/hla-g-a-new-anti-cancer-therapeutic-target.aspx Researchers at the CEA-Jacob (Immuno-Hematology Research Unit – SRHI) have designated a new target for the immunotherapy treatment of clear cell renal cell carcinoma, aimed at patients who cannot undergo conventional immunotherapy. Cancer ; Diagnosis and innovative treatment ; Molecular mechanisms general public ; Journalists ; Researchers Jacob Découvertes et avancées ; Scientific result Fri, 24 Sep 2021 10:00:00 GMT COVID-19: development of a new vaccine candidate that targets dendritic cells https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/covid-development-of-a-new-vaccine-candidate-that-targets-dendritic-cells.aspx Researchers at the CEA-Jacob, in collaboration with Inserm and the Université Paris-Est Créteil, have developed a new vaccine candidate against COVID-19 that targets key cells of the immune system, the dendritic cells. The study reports efficacy in preclinical models, with clinical trials planned for 2022. Vaccine ; Infectious diseases general public ; Journalists ; Researchers Jacob Découvertes et avancées ; Scientific result Wed, 01 Sep 2021 10:00:00 GMT Beta-thalassemia: a new therapeutic strategy https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/beta-thalassemia-a-new-therapeutic-strategy.aspx Researchers at the CEA-Jacob have reported a new optimized strategy to treat β-thalassemia that uses a lentiviral gene therapy vector. Gene and cell therapy ; Diagnosis and innovative treatment ; Genetic diseases general public ; Journalists ; Researchers Découvertes et avancées ; Scientific result Fri, 28 May 2021 10:00:00 GMT Therapeutic potential of PPAR-γ in the treatment of myelofibrosis https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/therapeutic-potential-of-ppar-γ-in-the-treatment-of-myelofibrosis.aspx Researchers at the CEA-Jacob have shown that activation of the PPAR-γ receptor is a relevant therapeutic target for the management of myelofibrosis. This work signals that agonists of PPAR-γ could be introduced into clinical practice. Diagnosis and innovative treatment ; Genetic diseases general public ; Journalists ; Researchers Jacob Découvertes et avancées ; Scientific result Thu, 27 May 2021 10:00:00 GMT Lensless imaging gives a boost to phagotherapy! https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/lensless-imaging-gives-a-boost-to-phagotherapy.aspx Thanks to an innovative approach developed by researchers at the Irig, the CEA-Leti and their partners, the identification of phages effective against antibiotic-resistant bacteria has been accelerated and the number of false negatives reduced. This work opens up the possibility of using phage therapy in hospitals! Antibiotics ; Diagnosis and innovative treatment general public ; Journalists ; Researchers IRIG Découvertes et avancées ; Scientific result Tue, 25 May 2021 10:00:00 GMT A 3-in-1 agent https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/An--agent.aspx BIAM researchers, together with international partners, have succeeded in developing a contrast agent that improves the accuracy of medical imaging, and that is also capable of treating tumors and delivering localized treatment. Micro-nanotechnologies ; Diagnosis and innovative treatment ; Medical imaging ; MRI ; Nanomedicine general public ; Journalists ; Researchers BIAM Découvertes et avancées ; Scientific result Fri, 07 May 2021 10:00:00 GMT Guiding microswimmers by magnetic fields https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/guiding-microswimmers-by-magnetic-fields.aspx As part of an international collaboration, BIAM researchers have successfully produced 3D-printed microswimmers that can be guided by magnetic fields. Ultimately, these devices could be used within the human body for therapeutic purposes. Micro-nanotechnologies ; Medical imaging ; Nanomedicine general public ; Journalists ; Researchers BIAM Découvertes et avancées ; Scientific result Wed, 05 May 2021 10:00:00 GMT How plants handle stress through their stomata https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/how-plants-handle-stress-through-their-stomata.aspx Researchers at the Biam have unveiled one of the mechanisms involved in the responses of plants to variations in their environment. This work could help improve their capacity to adapt to climate change. Proteomics ; Structural biology ; Cellular mechanisms general public ; Journalists ; Researchers BIAM Découvertes et avancées ; Scientific result Mon, 26 Apr 2021 10:00:00 GMT COVID-19: using mass spectrometry to diagnose and assess viral load https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/covid-using-mass-spectrometry-to-diagnose-and-assess-viral-load.aspx A CEA-Joliot team is developing with the AP-HP a mass spectrometry diagnostic test for COVID-19 that would also make it possible to assess the patient’s viral load. Their aim is to make the method more sensitive and more compatible with hospital equipment. Diagnosis ; Proteomics general public ; Journalists ; Researchers Joliot Découvertes et avancées ; Scientific result Mon, 12 Apr 2021 10:00:00 GMT Protein crown around nanoparticles: Size matters! https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/protein-crown-around-nanoparticles---size-matters.aspx When immersed in biological media, nanoparticles are immediately "wrapped" in proteins. A study conducted by researchers from the Iramis and Joliot (I2BC) institutes clarifies the importance of protein size on the formation of this envelope and recommends better consideration of this parameter in proteomic and nanotoxicological studies. Micro-nanotechnologies ; Nanomedicine ; Proteomics ; Nanotoxicology general public ; Journalists ; Researchers Iramis Scientific result Wed, 03 Mar 2021 11:00:00 GMT Testing for Antimicrobial Resistance using Artificial Intelligence https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/-Testing-for-Antimicrobial-Resistance-using-Artificial-Intelligence.aspx Health & life sciences ; Antibiotics ; Diagnosis News ; Press release ; Partnerships ; Scientific result Wed, 24 Feb 2021 11:00:00 GMT FLASH radiotherapy for the treatment of acute lymphoblastic leukemia https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/FLASH-radiotherapy-for-the-treatment-of-acute-lymphoblastic-leukemia.aspx The CEA-Jacob and his partners teamed to compare FLASH radiotherapy to conventional radiotherapy in the setting of acute lymphoblastic leukemia. Diagnosis and innovative treatment ; Radiotherapy ; Cancer Companies ; general public ; Institutions ; Journalists ; Researchers Jacob Scientific result ; News Mon, 04 Jan 2021 11:00:00 GMT There is a specific signature of COVID-19 infections in the exhaled air of patients. https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/There-is-a-specific-signature-of-COVID-19-infections-in-the-exhaled-air-of-patients.aspx There is a specific signature of COVID infections in expired air in intubated and ventilated patients, referred to as "severe COVID patients". Explanations from CEA-Joliot and CEA-List. Diagnosis ; Virus Companies ; general public ; Institutions ; Journalists ; Researchers List News ; Scientific result Thu, 10 Dec 2020 11:00:00 GMT Mambaquaretin: therapeutic as well as diagnostic uses? https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/Mambaquaretin-therapeutic-as-well-as-diagnostic-uses.aspx New work by the CEA-Joliot on the venom of the green mamba confirms the therapeutic potential of the toxin and paves the way for its use as a diagnostic tool. Diagnosis and innovative treatment Companies ; general public ; Institutions ; Journalists ; Researchers Joliot News ; Scientific result Wed, 09 Dec 2020 11:00:00 GMT Cell mechanics: definitely very surprising https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/Cell-mechanics-definitly-very-surprising.aspx Cells move, deform and divide. CEA-Irig researchers are gaining a better and better understanding of how. To do this, they have "cut" the contractile cables very precisely with a laser. Cytoskeleton ; Cellular mechanisms Companies ; general public ; Institutions ; Journalists ; Researchers IRIG News ; Scientific result Tue, 01 Dec 2020 11:00:00 GMT SARS-CoV-2: discovery of a novel transmission mechanism https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/SARS-CoV-2-discovery-of-a-novel-transmission-mechanism.aspx Researchers at the IBS (CEA-Irig) have revealed a previously unknown mechanism for the proliferation of SARS-CoV-2, in which the virus uses immune cells to enhance its own capture and transmission! Vaccine ; Virus ; Immune system ; Diagnosis and innovative treatment Companies ; general public ; Institutions ; Journalists ; Researchers IRIG News ; Scientific result Wed, 30 Sep 2020 10:00:00 GMT Hydrogen isotopes in the race for new drugs https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/Hydrogen-isotopes-in-the-race-for-new-drugs.aspx Isotopic labeling remains essential for monitoring the in vivo fate of drug candidates. CEA-Joliot researchers have developed high-performance deuterium and tritium labelling techniques. Pharmacology ; Chemistry Companies ; general public ; Institutions ; Journalists ; Researchers Joliot Scientific result ; News Mon, 28 Sep 2020 10:00:00 GMT Nanovectors in radiotherapy: how to optimize the polymer crown of gold nanoparticles https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/nanovectors-in-radiotherapy-how-to-optimize-the-polymer-crown-of-gold-nanoparticles.aspx With the help of X-ray and neutron scattering measurements of model nanoparticles, a team from the Iramis is developing recommendations for the use of functionalized gold nanoparticles in anticancer therapy: the polymer crown must be made from hydrophobic, positively charged monomers. Micro-nanotechnologies ; Nanomedicine ; Diagnosis and innovative treatment ; Chemistry general public ; Journalists ; Researchers Iramis Scientific result Fri, 28 Aug 2020 10:00:00 GMT What if our intestinal microbiota reveals a new antibiotic? https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/What-if-our-intestinal-microbiota-reveals-a-new-antibiotic.aspx A bacterium present in our intestinal macrobiota produces a particularly interesting antibiotic: Ruminococcin C1. Explanations from CEA-Irig. Structural biology ; Antibiotics ; Bacteria Companies ; general public ; Researchers ; Institutions IRIG Scientific result Fri, 21 Aug 2020 10:00:00 GMT When listening to bubbles helps to heal the brain https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/When-listening-to-bubbles-helps-to-heal-the-brain.aspx A NeuroSpin team, in collaboration with researchers from SHFJ and MIRCen (CEA-Jacob), is identifying a predictive indicator of the potentially deleterious effect of devices using ultrasound to deliver drugs to the brain. Brain ; Pharmacology Companies ; general public ; Institutions ; Journalists ; Researchers Jacob News ; Scientific result Tue, 11 Aug 2020 10:00:00 GMT SARS-CoV-2 detection: mass spectrometry shows its potential for rapidity https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/SARS-CoV-2-detection-mass-spectrometry-shows-its-potential-for-rapidity.aspx A team from CEA-Joliot in Marcoule detected by mass spectrometry, in 3 minutes and without specific reagents, signature peptides of the SARS-CoV-2 virus in clinical samples (nasopharyngeal swabs). It thus provides a proof of concept of the use of this method as a possible alternative to PCR, currently the reference method. Infectious diseases ; Diagnosis Companies ; general public ; Institutions ; Journalists ; Researchers Joliot News ; Scientific result Fri, 07 Aug 2020 11:00:00 GMT Anisotropic functionalization of gold nanoparticles assisted by surface plasmons https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/Anisotropic-functionalization-of-gold-nanoparticles-assisted-by-surface-plasmons.aspx Researchers at the CEA-Iramis and their partners have locally grafted organic molecules onto gold nanoparticles, using two photopolymerization steps. This new flexible functionalization technique can be used for applications ranging from biosensing to photonics. Photonics ; Micro-nanotechnologies ; Chemistry ; Laser ; Diagnosis ; Innovation for industry general public ; Journalists ; Researchers Iramis Scientific result Wed, 05 Aug 2020 10:00:00 GMT A preclinical study shows that hydroxychloroquine has no antiviral effect on SARS-CoV-2 in vivo https://www.cea.fr/drf/english/Pages/News/Institutional-news/2020/A-preclinical-study-shows-that-hydroxychloroquine-has-no-antiviral-effect-on-SARS-CoV-2-in-vivo.aspx A study on the effects of hydroxychloroquine in macaques infected with the SARS-CoV-2 virus, used alone or in combination with azithromycin, have been published on Nature; the 22th oh july. Scientists from the CEA, CNRS, Inserm, Institut Pasteur, Université de Paris-Saclay, Université Claude Bernard Lyon 1 and Aix-Marseille Université have been involved in the study, which has been carried out under the aegis of the multidisciplinary consortium, REACTing. Pharmacology ; Infectious diseases Companies ; general public ; Institutions ; Journalists Jacob Scientific result Wed, 22 Jul 2020 10:00:00 GMT Ebola: towards a new vaccine? https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/Ebola-towards-a-new-vaccine.aspx CEA-Joliot researchers and their partners have used a large-scale approach to map and characterize the response of CD4 T cells from healthy donors to two proteins of the Ebola-Zaire virus. They suggest that one of these proteins could be a target in the design of new vaccines. Virus ; Vaccine Companies ; general public ; Institutions ; Journalists ; Researchers Joliot Scientific result Wed, 15 Jul 2020 10:00:00 GMT Regeneration or fibrosis of injured tissue: macrophages lead the way https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/Regeneration-or-Fibrosis-of-injured-tissue-Macrophages-lead-the-way.aspx After an injury, many tissues often develop fibrosis[1], which can be disabling. An international team involving researchers from CEA-Jacob has now identified a key player in the fibrosis development: macrophages [2]. These observations pave the way for targeted treatments. Cellular mechanisms ; Gene and cell therapy Companies ; general public ; Institutions ; Journalists ; Researchers Jacob News ; Scientific result Thu, 02 Apr 2020 10:00:00 GMT Rapid genome analysis provides invaluable aid for hospitalized newborns https://www.cea.fr/drf/english/Pages/News/Scientific-results/2019/Rapid-genome-analysis-provides-invaluable-aid-for-hospitalized-newborns.aspx In their work entitled Fastgenomics, the Dijon Bourgogne University Hospital, Inserm and the CEA's National Center of Human Genomics Research (CNRGH) studied a rapid high-throughput genome sequencing process in 30 hospitalized newborns. The team was able to reduce the time needed for this process from an average of 18 months to only a month and a half at most (38 to 49 days), thus enabling rapid diagnoses for two-thirds of the patients. Genomics ; Diagnosis Companies ; general public ; Institutions ; Journalists ; Researchers Jacob News Wed, 18 Dec 2019 11:00:00 GMT Fast genome analysis helps with diagnosis for babies in neonatal intensive care https://www.cea.fr/drf/english/Pages/News/Scientific-results/2019/Fast-genome-analysis-helps-with-diagnosis-for-babies-in-neonatal-intensive-care.aspx Teams from CHU Dijon-Bourgogne, Inserm and the CEA have just produced genome analysis results for very sick newborn babies in neonatal intensive care, shortening the analysis time to 38 days compared to an average of 18 months at present. Diagnosis ; Genomics general public ; Journalists ; Researchers ; Companies Jacob Scientific result Wed, 11 Dec 2019 11:00:00 GMT Skin graft: a new molecular target for activating stem cells https://www.cea.fr/drf/english/Pages/News/Scientific-results/2019/Skin-graft-a-new-molecular-target-for-activating-stem-cells.aspx A CEA-Jacob team has just published a paper in which it demonstrates the central role of the transcription factor KLF4 in regulating the proliferation of epidermal stem cells and their ability to regenerate this tissue. This study opens perspectives for regenerative skin medicine. Fundamental Research ; Health & life sciences ; Cellular mechanisms ; Stem cells ; Genomics Companies ; general public ; Institutions ; Journalists ; Researchers Jacob Scientific result Wed, 23 Oct 2019 10:00:00 GMT The brain’s role in cancer development https://www.cea.fr/drf/english/Pages/News/Scientific-results/2019/The-brain-role-in-cancer-development.aspx New neurons appear inside the tumor microenvironment, contributing to the cancer’s development. These nerve cells stem from progenitors coming from the brain via the blood flow. This astounding discovery opens up a new research field regarding the role of the nervous system in cancer development, as well as the interactions between the vascular, immune and nervous systems with the tumorigenesis. Brain ; Diseases ; Cancer ; Cellular mechanisms ; Health & life sciences Journalists ; general public ; Researchers BIAM Scientific result Mon, 20 May 2019 10:00:00 GMT The Arctic Ocean, cradle of viral biodiversity https://www.cea.fr/drf/english/Pages/News/Scientific-results/2019/The-Arctic-Ocean,-cradle-of-viral-biodiversity.aspx Fundamental Research ; Cellular mechanisms ; Impact of climate change ; Climate ; Oceanography Press release ; Scientific result ; Focus Mon, 29 Apr 2019 10:00:00 GMT Bacteria: more than one weapon at their disposal https://www.cea.fr/drf/english/Pages/News/Scientific-results/2018/Bacteria-more-than-one-weapon-at-their-disposal.aspx IBS researchers and their partners have discovered a new weapon in the Pseudomonas aeruginosa arsenal. Bacteria ; Antibiotics Researchers ; Journalists ; general public BIG Scientific result Mon, 26 Mar 2018 10:00:00 GMT Bacteria that converse with each other https://www.cea.fr/drf/english/Pages/News/Scientific-results/2018/Bacteria-that-converse-with-each-other.aspx Researchers from the IBS have shown how bacteria converse within floating biofilms. The proteins involved in this interaction could be new targets in the fight against antibiotic resistance and nosocomial infections. Structural biology ; Antibiotics general public ; Journalists ; Researchers IBS Scientific result Thu, 08 Mar 2018 11:00:00 GMT White fat and brown fat: preventing obesity https://www.cea.fr/drf/english/Pages/News/Scientific-results/2018/White-fat-and-brown-fat-preventing-obesity.aspx A team from the Institut François-Jacob has discovered a molecular mechanism that regulates the balance between the production of adipose tissue and thermogenesis in mice. Cell division Researchers ; Journalists ; general public Jacob Scientific result Tue, 27 Feb 2018 11:00:00 GMT Antibiotics are putting up a resistance https://www.cea.fr/drf/english/Pages/News/Scientific-results/2018/Antibiotics-are putting-up-a-resistance.aspx A team from the IBS has shown how some antibiotics become insensitive to the principal mechanisms of bacterial resistance. Antibiotics ; Structural biology Researchers ; general public ; Journalists IBS Scientific result Wed, 17 Jan 2018 11:00:00 GMT Hemoglobinopathies: 100% of target cells modified by gene therapy https://www.cea.fr/drf/english/Pages/News/Scientific-results/2018/Hemoglobinopathies-100-of-target-cells-modified-by-gene-therapy.aspx Researchers from the Institut François-Jacob are pursuing the development of their gene therapy to treat hereditary blood diseases. Their objective: to let a greater number of individuals benefit from it. Gene and cell therapy Researchers ; Journalists ; general public Jacob Scientific result Tue, 16 Jan 2018 11:00:00 GMT Biocompatible chemistry and the medicine of tomorrow https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/biocompatible-chemistry-and-the-medicine-of-tomorrow.aspx Two teams from the Institut Frédéric-Joliot and their partners have discovered a chemical reaction that allows the binding or breaking of molecules in biological environments. Chemistry ; Pharmacology ; Medical imaging Researchers ; general public ; Journalists Joliot Scientific result Thu, 21 Dec 2017 11:00:00 GMT A boost to neurological treatments with THN102 https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/A-boost-to-neurological-treatments-with-THN102.aspx Theranexus receives US patent protection for its drug candidate, THN102. In the line of sight: treating the symptoms of narcolepsy and Parkinson’s disease. Neurodegenerative diseases ; Pharmacology Researchers ; general public ; Journalists Jacob Scientific result Tue, 14 Nov 2017 11:00:00 GMT Multiplying the Sensitivity of Biological Analyses by Thirty Thanks to Microfluidics https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/multiplying-the-sensitivity-of-biological-analyses.aspx In collaboration with scientists from the Frédéric-Joliot Institute, a team from IRAMIS has developed a microfluidic device coupled with a mass spectrometry technique. The scientists were able to multiply the analysis sensitivity by thirty compared to the current state of the art, as shown by a spectrum obtained using this process on a deposit of a model peptide of a few femtomoles (10-15). Diagnosis Researchers ; general public ; Journalists Iramis Scientific result Tue, 07 Nov 2017 11:00:00 GMT From Venoms to innovative Drugs with VENOMICS https://www.cea.fr/drf/english/Pages/News/Institutional-news/2017/From-Venoms-to-innovative-Drugs-with-VENOMICS.aspx Based on the study of two hundred poisonous animals, the European project VENOMICS managed to reproduce a bank of 3,616 “natural” toxins compatible with high throughput screening. VENOMICS demonstrated that animal toxins are hundred times more effective in identifying drug candidates than the usual banks of artificial molecules. Health & life sciences ; Diagnosis and innovative treatment ; Pharmacology ; Structural biology ; High-throughput screening Journalists ; general public ; Researchers Joliot News ; Newsletter ; CEA Research News ; European & international partnerships vaccine;Animal;bioeconomy and health;venoms; Mon, 19 Jun 2017 08:00:00 GMT Magnetic Nanotweezers to Grab Bacteria or Cells https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/magnetic-nanotweezers-to-grab-bacteria-or-cells.aspx A team from INAC has developed “nanotweezers” operating through remote actuation by an external magnetic field. Inspired from microelectronics techniques, they may collect microscopic biological samples for analysis—biopsies in particular. Diagnosis Researchers ; general public ; Journalists Inac Scientific result nanotechnologie;biopsie;ADN;diagnostic;Microélectronique;silicium; Tue, 13 Jun 2017 10:00:00 GMT Using Diffusion MRI to Estimate Tissue Stiffness https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/unsing-diffusion-mri-to-estimate-tissue-stiffness.aspx A collaboration between Japanese researchers and a team from the Frédéric-Joliot Institute at CEA has shown that liver lesions can be characterized from their elastic properties as estimated virtually using diffusion MRI. MRI ; Diagnosis Researchers ; general public ; Journalists Joliot Scientific result Tue, 13 Jun 2017 10:00:00 GMT Within the Cell, How an Oak Becomes a Reed https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/within-the-cell.aspx Cells have a skeleton of microtubules that can either soften or stiffen, depending on the cell's needs. A team from CEA-BIG and its partners has revealed the relationship between the underlying biochemical and mechanical properties. Fundamental Research ; Cytoskeleton Researchers ; general public ; Journalists BIG Scientific result Tue, 09 May 2017 10:00:00 GMT Tracking Down an Aneurysm https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/tracking-down-an-aneurysm.aspx A team from the CEA Frédéric-Joliot Institute has developed new optical probes for non-invasive imaging. These chemical tools could lead to the development of diagnostic agents to better characterize the risk of aortic aneurysm. Diagnosis ; Medical imaging Journalists ; general public ; Researchers Joliot Scientific result Fri, 05 May 2017 10:00:00 GMT Chikungunya: Pain Caused by the Immune System https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/chikungunya-pain-caused-by-the-immune-system.aspx Joint damage in people infected with chikungunya remains poorly understood. Scientists from the CEA François-Jacob Institute and their partners have identified an actor of the antiviral immune response whose inhibition paradoxically reduces the severity of the symptoms. Infectious diseases ; Chikungunya ; Diagnosis and innovative treatment general public ; Journalists ; Researchers Jacob Scientific result Mon, 13 Mar 2017 11:00:00 GMT Using the Spin to Visualize Proteins in their Natural Environment https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/using-the-spin-to-visualize-proteins-in-their-natural-environment.aspx A team of scientists from the Frédéric-Joliot Institute has demonstrated that the technique of PELDOR electron paramagnetic resonance makes it possible to detect the interaction between electronic spins in order to solve the structure of proteins in vivo. Structural biology ; Cellular mechanisms general public ; Journalists ; Researchers Joliot Scientific result Wed, 08 Mar 2017 11:00:00 GMT Sickle Cell Disease: Remission in the First Patient Treated by Gene Therapy https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/sickle-cell-disease-remission-first-patient-treated-by-gene-therapy.aspx A patient with severe sickle cell disease has undergone gene therapy developed at the CEA François-Jacob Institute. Two years after treatment, the remission of clinical signs was complete. Health & life sciences ; Genetic diseases ; Diagnosis and innovative treatment general public ; Journalists ; Researchers Jacob Scientific result Thu, 02 Mar 2017 11:00:00 GMT Chronic Myeloid Leukemia: a New Therapy Proves Successful https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/Chronic-Myeloid-Leukemia-a-New-Therapy-Proves-Successful.aspx In a phase 2 clinical trial, scientists showed the efficiency of targeting cancer stem cells—an approach imagined and developed at the CEA François-Jacob Institute for the treatment of leukemia, chronic myeloid leukemia in particular. Cancer ; Gene and cell therapy general public ; Journalists ; Researchers Jacob Scientific result Tue, 28 Feb 2017 11:00:00 GMT A Slow-Motion Film of the Changes in a Membrane Protein https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/slow-motion-film-of-the-changes-in-a-membrane-protein.aspx Bacteriorhodopsin is a protein that transports protons through cell membranes—an essential function of biological systems. An international consortium involving IBS has "filmed" this transfer of protons. Health & life sciences ; Cellular mechanisms ; Large-scale biology general public ; Journalists ; Researchers IBS Scientific result Thu, 19 Jan 2017 11:00:00 GMT Parkinson's: for a Better Diagnosis of the Disease https://www.cea.fr/drf/english/Pages/News/Institutional-news/2017/parkinson-for-a-better-diagnosis-of-the-disease.aspx CEA and the Cyclopharma Laboratories, in partnership with company Orphachem and University Francois Rabelais in Tours, signed an exclusive license agreement for a new radiotracer for the early diagnosis of Parkinson's disease by PET scan. Phase I trials are underway. Health & life sciences ; Brain ; Diagnosis and innovative treatment general public ; Journalists ; Researchers Jacob Highlight Thu, 12 Jan 2017 11:00:00 GMT In search of a Zika vaccine https://www.cea.fr/drf/english/Pages/News/Institutional-news/2017/in-search-of-a-zika-vaccine.aspx A consortium composed of CEA, the European Vaccine Initiative, Institut Pasteur and Themis Bioscience is launching the Zikavax project, with the goal of developing a vaccine against infection by the Zika virus. Health & life sciences ; Vaccine ; Infectious diseases general public ; Journalists ; Researchers Jacob Highlight Tue, 10 Jan 2017 11:00:00 GMT Modulating cerebral cholesterol: a new avenue of research to treat Alzheimer’s disease? https://www.cea.fr/drf/english/Pages/News/Scientific-results/2015/Modulating-cerebral-cholesterol-new-avenue-research-treat-Alzheimer.aspx Two French research teams have recently shown in a rodent model that overexpression of an enzyme capable of eliminating excess cholesterol in the brain can act in a beneficial way on the tau component of the disease to completely correct it. Alzheimer's disease ; Gene and cell therapy ; Biotechnology MIRcen Scientific result Mon, 14 Sep 2015 10:00:00 GMT Flexibility and self-repair of the cytoskeleton https://www.cea.fr/drf/english/Pages/News/Scientific-results/2015/Flexibility-self-repair-cytoskeleton.aspx Key elements of the cytoskeleton, microtubules exhibit fascinating and unexpected mechanical properties, such as adapting to stresses as well as self-repair. Their repair dynamics could inspire materials engineering. Cytoskeleton Scientific result Tue, 08 Sep 2015 10:00:00 GMT A therapy to defeat chronic myeloid leukemia (CML) once and for all https://www.cea.fr/drf/english/Pages/News/Scientific-results/2015/therapy-defeat-chronic-myeloid-leukemia-once-for-all.aspx Development of a novel therapy that targets stem cells responsible for chronic myeloid leukemia (CML). The first treated patients no longer present a detectable disease more than 5 years after stopping this new treatment, which represents a solid hope for a lasting recovery. Cancer ; Pharmacology Fontenay-aux-Roses Scientific result Wed, 02 Sep 2015 10:00:00 GMT The mechanism that changes the color of cyanobacteria https://www.cea.fr/drf/english/Pages/News/Scientific-results/2015/mechanism-that-changes-color-of-cyanobacteria.aspx Cyanobacteria, which use light as a source of energy during photosynthesis, also need to know how to protect themselves from it. Researchers have uncovered a unique mechanism of photoprotection that opens new perspectives for synthetic biology and the production of biomolecules of industrial interest. Photosynthesis ; Stress response IBITECS Scientific result Fri, 26 Jun 2015 10:00:00 GMT Cerebral Connections: MAP6, a new unexpected actor https://www.cea.fr/drf/english/Pages/News/Scientific-results/2015/Cerebral-Connections-MAP6-new-unexpected-actor.aspx Proteins that are supposed to be the guardians of neuronal cytoskeletons turn out to play a role in the establishment of brain connections. This discovery from the CEA-IRTSV and INSERM, made in a rodent model, has potential applications in psychiatry. Cognition ; Cytoskeleton Grenoble Scientific result Mon, 08 Jun 2015 10:00:00 GMT How does a mobile DNA sequence find its target? https://www.cea.fr/drf/english/Pages/News/Scientific-results/2015/How-does-mobile-DNA-sequence-find-target.aspx Certain mobile DNA sequences shape genomes and are maintained over the course of generations. How is this explained? The interaction between two proteins, which is essential for their integration into a specific area of the yeast genome, has been identified. This finding has interesting implications for gene therapy. DNA ; Gene and cell therapy Saclay Scientific result Fri, 01 May 2015 10:00:00 GMT A nano-drug for protecting neurons https://www.cea.fr/drf/english/Pages/News/Scientific-results/2015/a-nano-drug-for-protecting-neurons.aspx A nano-drug has been developed for treating certain neurological diseases such as brain ischemia, as well as injuries to bone marrow. It is composed of a therapeutic molecule, adenosine, and the vector squalene, which allows it to circulate in the body and reach the areas to be treated. Brain ; Pharmacology IBITECS Scientific result Thu, 05 Mar 2015 11:00:00 GMT Bio-magnet for targeted medical imaging https://www.cea.fr/drf/english/Pages/News/Scientific-results/2015/Bio-magnet-for-targeted-medical-imaging.aspx The CEA-IBEB has partnered with the CEA-I2BM to develop original MRI contrast agents. Nano-magnets produced by bacteria may reveal targets at the molecular level. Biotechnology ; Cell and molecular imaging ; MRI ; Diagnosis ; Nanomedicine LBC Scientific result Fri, 20 Feb 2015 11:00:00 GMT The normal prion protein protects DNA https://www.cea.fr/drf/english/Pages/News/Scientific-results/2015/The-normal-prion-protein-protects-DNA.aspx Notorious in its abnormal form, the normal prion protein is present in all mammals, although its role is unknown. A team from the CEA-IRCM has just shed some light on this. Stress response ; DNA ; Neurodegenerative diseases Fontenay-aux-Roses Scientific result Fri, 23 Jan 2015 11:00:00 GMT Ebola eZYSCREEN: a diagnostic “field” test https://www.cea.fr/drf/english/Pages/News/Scientific-results/2014/Ebola-eZYSCREEN-a-diagnostic-field-test.aspx A team from the CEA-IBEB has developed a rapid immunological test of the Ebola virus. Validated at the Laboratoire Jean Mérieux (Inserm), this test will be industrialized by VEDALAB. Infectious diseases ; Diagnosis and innovative treatment Marcoule Scientific result ; Industrial partnerships Wed, 22 Oct 2014 10:00:00 GMT How to direct the fate of a stem cell https://www.cea.fr/drf/english/Pages/News/Scientific-results/2014/How-to-direct-the-fate-of-a-stem-cell.aspx ​Researchers at the Institut Pasteur, the CEA-IRTSV and the CNRS have shown that the direct environment of stem cells influences the fate of their offspring. According to the tension exerted on these cells types of in division, they can preferentially produce two new stem cells, or a stem cell and a specialized cell, or even two specialized cells. Stem cells ; Cell division Grenoble Scientific result Fri, 23 May 2014 10:00:00 GMT Towards a new generation of antiviruses https://www.cea.fr/drf/english/Pages/News/Scientific-results/2014/Towards-a-new-generation-of-antiviruses.aspx A team from the CEA-IBITECS participated in the identification of a novel role for an enzyme, the protease MMP-12, in the immune response to viral infection. The researchers developed an inhibitor of MMP-12, which enhances the immune response in a rodent model. This work, opens the way for the development of new antiviral therapies. Diagnosis and innovative treatment ; Immune system Saclay Scientific result Tue, 29 Apr 2014 10:00:00 GMT Non-coding DNA to the aid of red blood cell diseases https://www.cea.fr/drf/english/Pages/News/Scientific-results/2014/Non-coding-DNA-to-the-aid-of-red-blood-cell-diseases.aspx Non-coding regions of the genome appear to reduce the severity of two red blood cell diseases: beta thalassemias and sickle cell anemia. Researchers at the CEA-IRCM, in collaboration with English and Dutch laboratories, have elucidated mechanisms explaining how non-coding DNA sequences exert their action to improve symptoms of these two diseases. Genetic diseases ; Cellular mechanisms IRCM Scientific result Mon, 10 Mar 2014 11:00:00 GMT Towards a vaccine to stop Chikungunya https://www.cea.fr/drf/english/Pages/News/Scientific-results/2014/Towards-a-vaccine-to-stop-Chikungunya.aspx A European consortium, of which the CEA-IMETI is a member, has developed a vaccine against the Chikungunya virus and tested it in a rodent model. Trials in humans could begin in 2015. ​ Vaccine ; Chikungunya IMETI Scientific result Wed, 12 Feb 2014 11:00:00 GMT Parkinson’s disease: a major breakthrough thanks to gene therapy https://www.cea.fr/drf/english/Pages/News/Scientific-results/2014/Parkinsons-disease-a-major-breakthrough-thanks-to-gene-therapy.aspx An Anglo-French team (AP-HP, Inserm, CEA/Mircen, UPEC, Oxford Biomedica, Cambridge University) coordinated by Professor Stéphane Palfi (head of the neurosurgery department at the hôpital Henri-Mondor) conducted a gene therapy trial in 15 patients with an advanced form of Parkinson’s disease. Parkinson's disease ; Gene and cell therapy MIRcen Scientific result Fri, 10 Jan 2014 11:00:00 GMT Antibiotic resistance: a lock is released for Gram+ bacteria https://www.cea.fr/drf/english/Pages/News/Scientific-results/2013/Antibiotic-resistance-a-lock-is-released-for-Gram--bacteria.aspx How can new therapeutic strategies for antibiotic-resistant bacteria be found? A team from the IBS is developing a means for investigation through the in vitro fabrication of the Pneumococcus wall. This is a method with which to develop and test new antibiotics. Antibiotics IBS Scientific result Mon, 23 Dec 2013 11:00:00 GMT Inhibitory signalling to the Arp2/3 complex steers cell migration https://www.cea.fr/drf/english/Pages/News/Scientific-results/2013/Inhibitory-signalling-to-the-Arp-complex-steers-cell-migration.aspx Cytoskeleton ; Bioinformatic BIG Scientific result Thu, 17 Oct 2013 10:00:00 GMT The tempo of ribosomes https://www.cea.fr/drf/english/Pages/News/Scientific-results/2013/the-tempo-of-ribosomes.aspx A collaboration between the IBS, the EMBL and the ILL reveals the story of the ribosome, one of the essential components for cell survival. The researchers write the chemical scenario of the folding and assembly of this actor who has a complex structure. Structural biology ; Cellular mechanisms IBS Scientific result Mon, 14 Oct 2013 10:00:00 GMT Producing new neurons under all circumstances: just a mouse away… https://www.cea.fr/drf/english/Pages/News/Scientific-results/2013/Producing-new-neurons-under-all-circumstances-just-a-mouse-away.aspx Improving neuron production in elderly persons presenting with a decline in cognition is a major challenge facing an ageing society and the emergence of neuro-degenerative conditions such as Alzheimer’s disease. INSERM and CEA researchers recently showed that the pharmacological blocking of the TGFβ molecule improves the production of new neurons in the mouse model. Stem cells ; Pharmacology ; Radiotherapy IRCM Scientific result Tue, 02 Apr 2013 10:00:00 GMT Quantum dot: a promising new imaging agent https://www.cea.fr/drf/english/Pages/News/Scientific-results/2013/Quantum-dot-a-promising-new-imaging-agent.aspx The drawback to current optical imaging markers is their short life. Researchers are now developing fluorescent nanocrystals (quantum dots) to supplant these markers. A team from the CEA-iBiTec-S, in collaboration with the CEA-I2BM and ESPCI, has developed a new surface chemistry for these particularly effective nanoparticles. Cell and molecular imaging ; Nanomedicine ; Chemistry Fontenay-aux-Roses Scientific result Fri, 22 Mar 2013 11:00:00 GMT Using biological connections for microelectronics https://www.cea.fr/drf/english/Pages/News/Scientific-results/2013/Using-biological-connections-for-microelectronics.aspx The miniaturization of electronic components is now reaching its physical limitations. Even if space can be saved by using a three-dimensional assembly solution, manufacturing electrical connections for these new devices is still a technological challenge. A team of biologists and physicists has now devised a system of self-assembled connections, thanks to actin filaments . Cytoskeleton Scientific result Mon, 11 Feb 2013 11:00:00 GMT