The Knowledge Factory - Sur le même thème https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/prenatal-exposure-to-phthalates-what-are-the-effects.aspx DRF english version en-US https://www.cea.fr/_layouts/15/images/i2i/icon-144x144-1033.png The Knowledge Factory - Sur le même thème https://www.cea.fr/drf/english Prenatal exposure to phthalates: what are the effects? https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/prenatal-exposure-to-phthalates-what-are-the-effects.aspx Researchers from the CEA-Jacob (CNRGH) and their partners have described for the first time changes in placental DNA methylation associated with phthalate exposure during pregnancy. Their analysis used samples from the French mother-child cohort EDEN. Toxicology ; Impacts on living (organisms) general public ; Journalists ; Researchers Jacob Découvertes et avancées ; Scientific result Mon, 28 Mar 2022 10:00:00 GMT Protein crown around nanoparticles: Size matters! https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/protein-crown-around-nanoparticles---size-matters.aspx When immersed in biological media, nanoparticles are immediately "wrapped" in proteins. A study conducted by researchers from the Iramis and Joliot (I2BC) institutes clarifies the importance of protein size on the formation of this envelope and recommends better consideration of this parameter in proteomic and nanotoxicological studies. Micro-nanotechnologies ; Nanomedicine ; Proteomics ; Nanotoxicology general public ; Journalists ; Researchers Iramis Scientific result Wed, 03 Mar 2021 11:00:00 GMT Cancer: improved identification of radiosensitive patients https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/cancer-improved-identification-of-radiosensitive-patients.aspx Researchers from the CEA-Jacob and Claude Bernard University have identified a new radiosensitivity signature in patients with severe side effects following radiotherapy. Cancer ; Radiotherapy ; Radiosensitivity general public ; Researchers ; Journalists Jacob Découvertes et avancées ; Scientific result Fri, 12 Feb 2021 11:00:00 GMT FLASH radiotherapy for the treatment of acute lymphoblastic leukemia https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/FLASH-radiotherapy-for-the-treatment-of-acute-lymphoblastic-leukemia.aspx The CEA-Jacob and his partners teamed to compare FLASH radiotherapy to conventional radiotherapy in the setting of acute lymphoblastic leukemia. Diagnosis and innovative treatment ; Radiotherapy ; Cancer Companies ; general public ; Institutions ; Journalists ; Researchers Jacob Scientific result ; News Mon, 04 Jan 2021 11:00:00 GMT Amazing discovery: Variovorax, a bacterium that lives in the heart of a working nuclear reactor! https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/Variovorax-bacteria-living-heart-working-nuclear-reactor.aspx Researchers from I2BC and SPI (DMTS, Marcoule), in collaboration with CEA Grenoble and the Belgian nuclear research center, discovered, by using two meta-omic approaches, living bacteria in the core pool of the CEA Paris-Saclay research reactor, Osiris, in operation, thus opening up perspectives for the discovery of new radioresistant species. Bacteria ; Nuclear Toxicology Scientific result Thu, 17 Dec 2020 11:00:00 GMT Study of the possible toxicity of tungsten particles emitted by Iter https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/Study-of-the-possible-toxicity-of-tungsten-particles-emitted-by-Iter.aspx CEA researchers and their partners have synthesized and characterized tungsten particles similar to those to be produced by the Iter fusion reactor and have identified their cyto-genotoxic properties in lung models. Iter ; Toxicology Companies ; general public ; Institutions ; Researchers Joliot News ; Scientific result Wed, 29 Jan 2020 11:00:00 GMT The discovery of a new mechanism of DNA damage by low-energy UV radiation https://www.cea.fr/drf/english/Pages/News/Scientific-results/2018/The-discovery-of-a-new-mechanism-of-DNA-damage-by-low-energy-UV-radiation.aspx When exposed to low-energy ultraviolet radiation, the extremities of chromosomes (or telomeres) can produce radicals that cause oxidative damage. A detailed study using time-resolved spectroscopy conducted at the Iramis reveals the mechanisms associated with these processes. Radiobiology Researchers ; general public ; Journalists Inac Scientific result Wed, 14 Feb 2018 11:00:00 GMT Mimicking Proteins to Better Understand the Toxicity of Uranium https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/mimicking-proteins-to-better-understand-the-toxicity-of-uranium.aspx Researchers from INAC have used a biomimetic approach to analyze the interactions of uranium with the biological molecules involved in the toxicity of this element. Phosphoproteins appear to be priority targets. Nuclear Toxicology Researchers ; general public ; Journalists Inac Scientific result Tue, 10 Oct 2017 10:00:00 GMT The Yin and Yang of Low-dose Irradiation on Hematopoiesis https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/the-yin-and-yang-of-low-dose-irradiation-on-hematopoiesis.aspx Researchers at the François-Jacob Institute and their partners have shown that exposure to low doses of irradiation leads to function loss in hematopoietic stem cells. Radiobiology ; Low doses Researchers ; Journalists ; general public Fontenay-aux-Roses Scientific result Fri, 29 Sep 2017 10:00:00 GMT Cytosine in All Its Forms https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/cytosine-in-all-its-forms.aspx As a building block in DNA and RNA, cytosine possesses numerous isomers with the same molecular formula, but different structural formulas or distinct space configurations. An international consortium, of which IRAMIS is a member, was able to identify five of these forms by combining computer simulations of quantum chemistry and UV photonization imaging carried out at the SOLEIL synchrotron facility. Radiobiology general public ; Journalists ; Researchers Iramis Scientific result Tue, 21 Mar 2017 11:00:00 GMT Unveiling the Effects of Exposure to Titanium Dioxide Nanoparticles https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/unveiling-the-effects-of-exposure-to-titanium-dioxide-nanoparticles.aspx Researchers from INRA, CEA-INAC, and their partners have studied the effects of oral exposure to titanium dioxide, an additive in common foodstuffs (E171), including sweets. They provide the first evidence in animals that E171 penetrates the intestinal wall, thus entering the organism, and can create immune system disorders and induce pre-cancerous lesions in the colon. Toxicology ; Health & life sciences general public ; Journalists ; Researchers Inac Scientific result Fri, 20 Jan 2017 11:00:00 GMT Bisphenol A: dubious substitutes https://www.cea.fr/drf/english/Pages/News/Scientific-results/2015/Bisphenol-A-dubious-substitutes.aspx Bisphenol A, now prohibited in food containers, is sometimes replaced by bisphenol S and bisphenol F. A team from the CEA-IRCM has now demonstrated that the latter are also potentially dangerous. Toxicology Fontenay-aux-Roses Scientific result Thu, 15 Jan 2015 11:00:00 GMT Carbon nanotubes: distribution within the body https://www.cea.fr/drf/english/Pages/News/Scientific-results/2014/Carbon-nanotubes-distribution-within-the-body.aspx ​The rapid industrial success of carbon nanotubes raises questions about their impact on health and the environment. Researchers from the CEA and CNRS have developed a method to monitor these particles in the body, followed by observing their distribution after lung contamination. This study was published in ACS Nano. Toxicology ; Methodologies for life sciences Saclay Scientific result Thu, 03 Jul 2014 10:00:00 GMT Producing new neurons under all circumstances: just a mouse away… https://www.cea.fr/drf/english/Pages/News/Scientific-results/2013/Producing-new-neurons-under-all-circumstances-just-a-mouse-away.aspx Improving neuron production in elderly persons presenting with a decline in cognition is a major challenge facing an ageing society and the emergence of neuro-degenerative conditions such as Alzheimer’s disease. INSERM and CEA researchers recently showed that the pharmacological blocking of the TGFβ molecule improves the production of new neurons in the mouse model. Stem cells ; Pharmacology ; Radiotherapy IRCM Scientific result Tue, 02 Apr 2013 10:00:00 GMT Experimental proof for the harmful effects of bisphenol A https://www.cea.fr/drf/english/Pages/News/Scientific-results/2013/Experimental-proof-for-the-harmful-effects-of-bisphenol-A.aspx A team from the CEA-iRCM has just experimentally demonstrated for the first time that low concentrations of bisphenol A are sufficient to have a negative impact on human testes. Toxicology IRCM Scientific result Fri, 18 Jan 2013 11:00:00 GMT