The Knowledge Factory - Sur le même thème https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/bacteria-medley-swimming-champions.aspx DRF english version en-US https://www.cea.fr/_layouts/15/images/i2i/icon-144x144-1033.png The Knowledge Factory - Sur le même thème https://www.cea.fr/drf/english Modelling the influenza viral genome to an unprecedented scale https://www.cea.fr/drf/english/Pages/News/Scientific-results/2024/modelling-the-influenza-viral-genome-to-an-unprecedented-scale.aspx Scientists at IRIG have observed, to a resolution of 0.5 nanometres, the interactions between the influenza virus genome and its associated proteins. This opens the way to a better understanding of the mechanisms underlying the replication of this virus with high pandemic potential. Virus ; Molecular mechanisms ; Cell and molecular imaging general public ; Journalists ; Researchers IRIG Découvertes et avancées ; Scientific result Tue, 30 Jan 2024 11:00:00 GMT NRBC risks: the CEA coordinator for the COUNTERACT project https://www.cea.fr/drf/english/Pages/News/Institutional-news/2023/nrbc-risks-cea-coordinator-counteract-project.aspx The CEA coordinates the European project COUNTERACT which aims to reinforce the European Union’s preparedness for nuclear, radiological, biological and chemical (NRBC) threats. Health & life sciences ; Defence & security Institutions ; Journalists ; general public IDMIT News ; Press release radiological;biological and chemical (NRBC) threats.;nuclear;NRBC risks; Fri, 06 Jan 2023 11:00:00 GMT Evaluating the stress response of a bacterium using optical tweezers on a chip https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/evaluating-the-stress-response-of-a-bacterium-using-optical-tweezers-on-a-chip.aspx Physicists at the CEA-Irig and their partners in Grenoble (CEA-Leti, CNRS, UGA) have shown that it is possible to trap individual bacteria and measure their response to stress using silicon photonic crystals. This disruptive technique, which does not require cell culture, opens the way to rapid antibiotic resistance tests. Photonics ; Micro-nanotechnologies ; Bacteria ; Antibiotics ; Diagnosis and innovative treatment general public ; Journalists ; Researchers IRIG Découvertes et avancées ; Scientific result Wed, 19 Oct 2022 10:00:00 GMT Is it possible to control the polarity of an artificial cell? https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/is-it-possible-to-control-the-polarity-of-an-artificial-cell.aspx Researchers at the CEA-Irig have succeeded in combining the dynamics of microtubules and actin filaments in a cell-sized compartment, allowing them to position the “microtubule-organizing center”. Cytoskeleton ; Cellular mechanisms general public ; Journalists ; Researchers IRIG Découvertes et avancées ; Scientific result Mon, 17 Oct 2022 10:00:00 GMT The 11.7-tesla Iseult MRI has received its parallel transmit radiofrequency coil, and it’s a technological wonder! https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/Iseult-mri-has-received-its-parallel-transmit-radiofrequency-coil.aspx Nearly a year after its first images were obtained with a simple validation radiofrequency (RF) coil, NeuroSpin’s Iseult 11.7-tesla MRI is now equipped with an 8-transmit and 32-receive RF coil array integrated in a local magnetic shim array that will allow it to reach its full potential. Here we look back at this development, a technological feat achieved by CEA-Joliot and CEA-Irfu. MRI ; Tools & research instruments ; Brain general public ; Journalists ; Researchers Irfu Découvertes et avancées ; Scientific result Fri, 14 Oct 2022 10:00:00 GMT Molecular engineering of antibodies: from SARS-CoV-1 to SARS-CoV-2 and its variants https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/molecular-engineering-of-antibodies-from-sars-cov.aspx Researchers from the CEA-Joliot have shown that molecular engineering of llama antibodies directed against SARS-CoV-1 can be used to obtain optimized antibodies with very high affinities for SARS-CoV-2 and its variants. This is a step towards designing neutralizing molecules for new emerging pathogen strains! Diagnosis and innovative treatment ; Virus general public ; Journalists ; Researchers Joliot Découvertes et avancées ; Scientific result Thu, 13 Oct 2022 10:00:00 GMT The slowed down time of confinement https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/the-slowed-down-time-of-confinement.aspx Blursday, the first database dedicated to the alteration of the perception of time during the confinement imposed by the COVID-19 pandemic, has been made available to the scientific community by a consortium led by a researcher from the CEA-Joliot. This large-scale participatory study reveals that the feeling of isolation may have induced the perception of slowed time. Brain ; Cognition ; Science & society general public ; Journalists ; Researchers Joliot Découvertes et avancées ; Scientific result Mon, 10 Oct 2022 10:00:00 GMT Reading thoughts in the working mind https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/reading-thoughts-in-the-working-mind.aspx Researchers at the CEA-Joliot (NeuroSpin) have succeeded in systematically decoding the cognitive activity associated with various brain activation patterns as recorded by functional MRI. This feat was achieved using neural networks trained on the largest public brain imaging database. Cognition ; MRI general public ; Journalists ; Researchers Découvertes et avancées ; Scientific result Mon, 25 Jul 2022 10:00:00 GMT An in vitro structure that mimics a pancreatic cancer mini-tumor https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/an-in-vitro-structure-that-mimics-a-pancreatic-cancer-mini-tumor.aspx Using almost fully automated processes, researchers at Irig have designed a three-dimensional microenvironment in which cells form a tissue resembling a mini-tumor. Their work opens new perspectives for personalized medicine. Pharmacology ; Cellular mechanisms ; Diagnosis and innovative treatment ; Methodologies for life sciences general public ; Journalists ; Researchers IRIG Découvertes et avancées ; Scientific result Wed, 01 Jun 2022 10:00:00 GMT MRI: Using deep learning to study rare brain tumors https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/mri-using-deep-learning-to-study-rare-brain-tumors.aspx Researchers at the CEA-Joliot (NeuroSpin), in collaboration with the Gustave Roussy Institute, the Necker Hospital and the Curie Institute (Orsay), have proposed an original method for analyzing MRI images of rare brain tumors, by combining automatic object detection and deep learning segmentation for common tumors. Cancer ; Brain ; MRI general public ; Journalists ; Researchers Joliot Découvertes et avancées ; Scientific result Wed, 01 Jun 2022 10:00:00 GMT PET/MRI improves the detection of epileptogenic foci https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/petmri-improves-the-detection-of-epileptogenic-foci.aspx Studies carried out by the CEA-Joliot show that simultaneous PET/MR imaging noticeably improves the detection of lesions responsible for epilepsies, as well as the preparation of the surgical interventions used to treat them. Medical imaging ; MRI ; Positron Emission Tomography ; Methodologies for life sciences ; Brain general public ; Journalists ; Researchers Joliot Découvertes et avancées ; Scientific result Mon, 16 May 2022 10:00:00 GMT The photosynthetic “booster” of microalgae revealed https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/the-photosynthetic-booster-of-microalgae-revealed.aspx An international collaboration involving researchers from the CEA-BIAM and the Carnegie Institution at Stanford University (USA) has just deciphered the mechanisms that microalgae use to capture atmospheric CO2 in a highly efficient manner. Vegetal physiology ; Microalgae ; Photosynthesis general public ; Journalists ; Researchers BIAM Découvertes et avancées ; Scientific result Thu, 28 Apr 2022 10:00:00 GMT AI and Tech summit 2022 from Politico Live: participate to the roundtable with CEA’s expert https://www.cea.fr/drf/english/Pages/News/Institutional-news/2022/ai-and-tech-summit-2022-politico.aspx The CEA is a partner for the European event organised by the media Politico AI and Tech summit, which will take place in Brussels and online on 21 April 2022. Artificial intelligence ; Technologies ; Health & life sciences ; Science & society Institutions ; Researchers ; Companies DRF News ; Event ; Europe Politico; Wed, 13 Apr 2022 10:00:00 GMT 5,500 new RNA virus species identified in the global ocean https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/new-rna-virus-species-identified-in-the-global-ocean.aspx Using seawater samples collected during Tara Ocean expeditions and sequenced by the CEA-Jacob (Genoscope), an international team has identified 5,500 new species of RNA viruses, most of which belong to previously unknown phylogenetic branches. Metagenomics ; Oceanography ; Biodiversity general public ; Journalists ; Researchers Jacob Découvertes et avancées ; Scientific result Fri, 08 Apr 2022 10:00:00 GMT Restoring consciousness through deep brain stimulation https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/restoring-consciousness-through-deep-brain-stimulation.aspx A research team led by the CEA-Joliot has provided evidence that deep brain stimulation can restore consciousness when it is impaired. This result obtained in animals could lead to clinical trials in unconscious patients. Brain ; Diagnosis and innovative treatment general public ; Journalists ; Researchers Joliot Découvertes et avancées ; Scientific result Thu, 07 Apr 2022 10:00:00 GMT Using genomics to shed a light on climate https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/using-genomics-to-shed-a-light-on-climate.aspx Using metagenomic analysis, researchers from the CEA-Jacob/Genoscope and the LSCE (CEA-CNRS-UVSQ) have unveiled a “biogeography” of ocean plankton communities. Based on this work, they predict the evolution of their geographical distribution by 2100, with a reduction in the flux of organic carbon from surface waters to the depths. Climate ; Oceanography ; Carbon cycle ; Large-scale biology ; Metagenomics general public ; Journalists ; Researchers LSCE Découvertes et avancées ; Scientific result Tue, 05 Apr 2022 10:00:00 GMT High field MRI for the benefit of psychiatry https://www.cea.fr/drf/english/Pages/News/Institutional-news/2022/high-field-MRI.aspx Improving the quality of life for people with psychiatric problems thanks to more targeted treatment protocols, or even preventing the appearance of such pathologies, would be a major breakthrough for public health care. This is one of the objectives of researchers at NeuroSpin, the CEA centre for innovation in neuroimaging in Saclay, near Paris. Health & life sciences ; Brain ; Diagnosis and innovative treatment ; Diseases Journalists ; Institutions ; general public Neurospin News ; Highlight artificial intelligence;psychiatry;Mental Health;Neuroimaging;MRI;biomarker;Brain;NeuroSpin;psychiatric deseases; Mon, 04 Apr 2022 10:00:00 GMT Prenatal exposure to phthalates: what are the effects? https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/prenatal-exposure-to-phthalates-what-are-the-effects.aspx Researchers from the CEA-Jacob (CNRGH) and their partners have described for the first time changes in placental DNA methylation associated with phthalate exposure during pregnancy. Their analysis used samples from the French mother-child cohort EDEN. Toxicology ; Impacts on living (organisms) general public ; Journalists ; Researchers Jacob Découvertes et avancées ; Scientific result Mon, 28 Mar 2022 10:00:00 GMT Measuring insulin production in a single pancreatic islet with a microfluidic chip https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/measuring-insulin-production-in-a-single-pancreatic-islet-with-a-microfluidic-chip.aspx Researchers at the Irig, in collaboration with the CEA-Leti, have developed a microfluidic chip that can measure insulin secretion from a single pancreatic islet. The same technology can be adapted to other biological tissues and secretomes. Biochip ; Diagnosis and innovative treatment ; Cellular mechanisms general public ; Journalists ; Researchers Découvertes et avancées ; Scientific result Wed, 09 Mar 2022 11:00:00 GMT Brain development and mental health in adolescents and young adults https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/brain-development-and-mental-health-in-adolescents-and-young-adults.aspx Using data from the Healthy Brain Network cohort, a team from the CEA-Joliot (NeuroSpin) has discovered a correlation between certain symptoms, which may be precursors of mood disorders in adulthood, and structural changes in the developing brain in more than 650 young people. Brain ; Diseases general public ; Journalists ; Researchers Joliot Découvertes et avancées ; Scientific result Fri, 18 Feb 2022 11:00:00 GMT A promising gene therapy for the treatment of sickle cell disease and “transfusion-dependent” beta-thalassemia https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/a-promising-gene-therapy-for-the-treatment-of-sickle-cell-disease-and-transfusion-dependent-beta-thalassemia.aspx In order to fight sickle cell disease and beta-thalassemia, two common genetic diseases affecting red blood cells, the AP-HP, the University of Paris, Inserm (Imagine Institute), Paris-Est Créteil University and the CEA-Jacob have conducted a clinical study utilizing the transplantation of a patient’s own genetically modified stem cells. A phase I/II trial with bluebird bio as the sponsor has been completed. Gene and cell therapy ; Diagnosis and innovative treatment ; Genetic diseases general public ; Journalists ; Researchers Jacob Découvertes et avancées ; Scientific result Fri, 28 Jan 2022 11:00:00 GMT SARS-CoV-2: an essential interaction between two proteins could inspire a new therapeutic strategy https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/sars-cov-an-essential-interaction-between-two-proteins-could-inspire-a-new-therapeutic-strategy.aspx Researchers from the CEA-Irig (IBS), Grenoble Alpes University, the CNRS and the ESRF have described for the first time an essential interaction between two SARS-CoV-2 proteins that could inspire a new therapeutic strategy against COVID-19. Virus ; Structural biology ; Diagnosis and innovative treatment general public ; Journalists ; Researchers IRIG Découvertes et avancées ; Scientific result Thu, 20 Jan 2022 11:00:00 GMT Discovery of stage-specific biomarkers of liver cirrhosis https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/discovery-of-stage-specific-biomarkers-of-liver-cirrhosis.aspx By analyzing the blood lipidome of patients with cirrhosis, a European collaboration involving the CEA-Joliot has discovered specific biomarkers for the different stages of the disease. This is an important step towards achieving a personalized and more effective management of this illness. Biomarkers ; Diseases general public ; Journalists ; Researchers Joliot Découvertes et avancées ; Scientific result Fri, 07 Jan 2022 11:00:00 GMT The incredible resistance of tardigrades to different environmental stresses, explained by a gel https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/the-incredible-resistance-of-tardigrades-to-different-environmental-stresses-explained-by-a-gel.aspx Researchers at the CEA-Irig have partly lifted the veil on the extraordinary resistance of a small animal, the tardigrade. At play is a disordered protein capable of transforming itself into a protective gel for other biomolecules during drought or extreme cold. Structural biology ; Characterisation general public ; Journalists ; Researchers IRIG Découvertes et avancées ; Scientific result Mon, 20 Dec 2021 11:00:00 GMT 11.7-tesla MRI: the Iseult magnet is fully operational https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/mri-the-iseult-magnet-is-fully-operational.aspx At the CEA-Joliot’s NeuroSpin neuroimaging center, the Iseult project’s 11.7-tesla MRI produced its first images in September 2021, thanks to the extraordinary magnet developed by the CEA-Irfu. Read on for a look at the origins behind this world premiere. Tools & research instruments ; MRI ; Brain ; Cognition general public ; Journalists ; Researchers Joliot Découvertes et avancées ; Scientific result Wed, 10 Nov 2021 11:00:00 GMT Hematopoietic stem cells go out of their way to differentiate https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/hematopoietic-stem-cells-go-out-of-their-way-to-differentiate.aspx With the help of a “bone marrow on a chip”, researchers at Irig and their partners (Inserm, Hôpital St-Louis, Paris Diderot University) have observed the onset of differentiation in stem cells, before their transformation into blood cells. Upon contact with a bone cell, some of them completely reorganize. This unexpected discovery opens up entirely new paths for the study of a number of diseases such as leukemia. Stem cells ; Cellular mechanisms ; Cancer general public ; Journalists ; Researchers IRIG Découvertes et avancées ; Scientific result Tue, 02 Nov 2021 11:00:00 GMT The most powerful MRI scanner in the world delivers its first images! https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/premieres-images-irm-iseult-2021.aspx September 2021, the 11.7 Tesla MRI of the Iseult project, the most powerful in the world for human imaging, has just unveiled its first images. Health & life sciences ; Brain ; Physics Journalists ; general public ; Researchers ; Partners Neurospin News ; Press release ; Découvertes et avancées Brain;MRI;neuroanatomy;Iseult;supra; Thu, 07 Oct 2021 05:00:00 GMT HLA-G: a new anti-cancer therapeutic target https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/hla-g-a-new-anti-cancer-therapeutic-target.aspx Researchers at the CEA-Jacob (Immuno-Hematology Research Unit – SRHI) have designated a new target for the immunotherapy treatment of clear cell renal cell carcinoma, aimed at patients who cannot undergo conventional immunotherapy. Cancer ; Diagnosis and innovative treatment ; Molecular mechanisms general public ; Journalists ; Researchers Jacob Découvertes et avancées ; Scientific result Fri, 24 Sep 2021 10:00:00 GMT An enzymatic process for reducing CO2 https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/An-enzymatic-process-for-reducing-CO2.aspx Researchers from the CEA-Irig and their partners have developed a new enzymatic process for reducing CO2 and oxidizing CO. Efficient and able to operate under mild conditions, it could be used to purify gas from biomass pyrolysis in order to produce fuels or chemical precursors. Bioenergy ; Molecular mechanisms ; Chemistry general public ; Journalists ; Researchers IRIG Découvertes et avancées ; Scientific result Mon, 06 Sep 2021 10:00:00 GMT Quantum physics finds its way into the heart of flowers https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/quantum-physics-finds-its-way-into-the-heart-of-flowers.aspx Researchers from the CEA-Joliot (I2BC) and their partners have deciphered for the first time the quantum process of energy dissipation in aggregates of natural flower carotenoids. This fundamental biological mechanism could inspire the design of photovoltaic materials capable of supplying two electrons for every photon. Molecular mechanisms ; Vegetal physiology ; Quantum Physics ; Photovoltaic solar power general public ; Journalists ; Researchers Joliot Découvertes et avancées ; Scientific result Fri, 03 Sep 2021 10:00:00 GMT COVID-19: development of a new vaccine candidate that targets dendritic cells https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/covid-development-of-a-new-vaccine-candidate-that-targets-dendritic-cells.aspx Researchers at the CEA-Jacob, in collaboration with Inserm and the Université Paris-Est Créteil, have developed a new vaccine candidate against COVID-19 that targets key cells of the immune system, the dendritic cells. The study reports efficacy in preclinical models, with clinical trials planned for 2022. Vaccine ; Infectious diseases general public ; Journalists ; Researchers Jacob Découvertes et avancées ; Scientific result Wed, 01 Sep 2021 10:00:00 GMT DNA transcription can now be watched “live” in any cell of a plant https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/dna-transcription-can-now-be-watched-live-in-any-cell-of-a-plant.aspx For the first time, a team from Biam is showing the transcription of DNA into messenger RNA in the cells of young plants, in real time and with an unprecedented resolution. This exceptional live work reveals highly useful information on the biological mechanisms linked to the plant’s response to its environment. Cell and molecular imaging ; Molecular mechanisms ; Vegetal physiology ; DNA general public ; Journalists ; Researchers BIAM Découvertes et avancées ; Scientific result Mon, 09 Aug 2021 10:00:00 GMT WIKIBrainStem: a new anatomical atlas of the human brainstem using ultra-high field MRI (11.7 Tesla) https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/wikibrainstem-a-new-anatomical-atlas-of-the-human-brainstem-using-ultra-high-field-mri.aspx A team from the NeuroSpin (CEA-Joliot), in collaboration with Inserm (Tours), has published the first anatomical atlas of the human brain stem using mesoscopic resolution ultra-high field MRI. This atlas, freely accessible as a wiki, will be used in particular by neuroanatomists and neurosurgeons to help them in their procedures. Brain ; MRI general public ; Journalists ; Researchers Joliot Découvertes et avancées ; Scientific result Fri, 11 Jun 2021 10:00:00 GMT Humans possess a unique sense of geometry https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/humans-possess-a-unique-sense-of-geometry.aspx Researchers from the CEA-Joliot, the Collège de France, the CNRS and the University of Paris 8 have shown that humans possess a universal capacity to understand abstract geometric concepts. In contrast, this ability, which does not depend on age, culture or education, does not exist in any of the studied non-human primates. Brain ; Cognition general public ; Journalists ; Researchers Joliot Découvertes et avancées ; Scientific result Thu, 10 Jun 2021 10:00:00 GMT Phytoplankton: cellular architecture and energy metabolism https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/phytoplankton-cellular-architecture-and-energy-metabolism.aspx Drawing upon the 3D reconstruction of the cellular architecture of several phytoplankton families, researchers at the CEA-Irig have demonstrated that the physiological responses of these eukaryotes are associated with certain characteristics of their energy-producing organelles. This work thus provides new perspectives for the production of algal biomass, upstream of biotechnology applications. Cell and molecular imaging ; Microalgae ; Molecular mechanisms general public ; Journalists ; Researchers IRIG Scientific result ; Découvertes et avancées Thu, 03 Jun 2021 10:00:00 GMT Genetics and cerebral sulci: new findings based on the UK Biobank cohort https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/genetics-and-cerebral-sulci-new-findings-based-on-the-uk-biobank-cohort.aspx Using the UK Biobank cohort, researchers at the Joliot-NeuroSpin and the Jacob-CNRGH explored genome-wide associations between groups of linked genes (haplotypes) and the opening of brain sulci, an indicator of brain aging. Brain ; Medical imaging ; Genomics general public ; Journalists ; Researchers Joliot Découvertes et avancées ; Scientific result Tue, 01 Jun 2021 10:00:00 GMT Well Plate Maker: a user-friendly application for limiting bias in large-scale biomedical studies https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/well-plate-maker-a-user-friendly-application-for-limiting-bias-in-large-scale-biomedical-studies.aspx Researchers at the Irig have developed an application to help biologists prepare their large-scale experiments using randomly distributed well plates, without requiring any programming skills. Methodologies for life sciences ; Bioinformatic ; Large-scale biology general public ; Journalists ; Researchers Découvertes et avancées ; Scientific result Tue, 01 Jun 2021 10:00:00 GMT Beta-thalassemia: a new therapeutic strategy https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/beta-thalassemia-a-new-therapeutic-strategy.aspx Researchers at the CEA-Jacob have reported a new optimized strategy to treat β-thalassemia that uses a lentiviral gene therapy vector. Gene and cell therapy ; Diagnosis and innovative treatment ; Genetic diseases general public ; Journalists ; Researchers Découvertes et avancées ; Scientific result Fri, 28 May 2021 10:00:00 GMT Therapeutic potential of PPAR-γ in the treatment of myelofibrosis https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/therapeutic-potential-of-ppar-γ-in-the-treatment-of-myelofibrosis.aspx Researchers at the CEA-Jacob have shown that activation of the PPAR-γ receptor is a relevant therapeutic target for the management of myelofibrosis. This work signals that agonists of PPAR-γ could be introduced into clinical practice. Diagnosis and innovative treatment ; Genetic diseases general public ; Journalists ; Researchers Jacob Découvertes et avancées ; Scientific result Thu, 27 May 2021 10:00:00 GMT Lensless imaging gives a boost to phagotherapy! https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/lensless-imaging-gives-a-boost-to-phagotherapy.aspx Thanks to an innovative approach developed by researchers at the Irig, the CEA-Leti and their partners, the identification of phages effective against antibiotic-resistant bacteria has been accelerated and the number of false negatives reduced. This work opens up the possibility of using phage therapy in hospitals! Antibiotics ; Diagnosis and innovative treatment general public ; Journalists ; Researchers IRIG Découvertes et avancées ; Scientific result Tue, 25 May 2021 10:00:00 GMT SARS-CoV-2: a new mode of virus transmission involving immune cells https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/sars-cov--a-new-mode-of-virus-transmission-involving-immune-cells.aspx Scientists from the Institute of Structural Biology (Irig) and their partners have confirmed that the COVID-19 virus can use immune cells to increase its transmission to other cells. They also show that it is possible to inhibit this new mode of transmission of the virus through the use of glycomimetics, i.e. molecules that can mimic the surface “sugars” of the virus. Infectious diseases ; Virus general public ; Journalists ; Researchers IRIG Découvertes et avancées ; Scientific result Fri, 21 May 2021 10:00:00 GMT Organoids On a Chip (OOC) FOCUS incentive Program https://www.cea.fr/drf/english/Pages/News/Institutional-news/2021/organoids-on-a-chip-focus-incentive-program-.aspx Under the impetus of Patrick Landais, the High Commissioner, the FOCUS incentive program has selected the Organoids On a Chip (OOC) project to support interdisciplinary synergies between technological sciences and life sciences within the CEA. The objective is to promote the emergence of breakthrough ideas, concepts or technologies in the biomedical field. Health & life sciences Highlight Fri, 07 May 2021 10:00:00 GMT A 3-in-1 agent https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/An--agent.aspx BIAM researchers, together with international partners, have succeeded in developing a contrast agent that improves the accuracy of medical imaging, and that is also capable of treating tumors and delivering localized treatment. Micro-nanotechnologies ; Diagnosis and innovative treatment ; Medical imaging ; MRI ; Nanomedicine general public ; Journalists ; Researchers BIAM Découvertes et avancées ; Scientific result Fri, 07 May 2021 10:00:00 GMT A hybrid anticancer drug derived from a peptide and an artificial polymer https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/a-hybrid-anticancer-drug-derived-from-a-peptide-and-an-artificial-polymer.aspx In collaboration with the IECB in Bordeaux, a team from the CEA-Joliot has developed a molecule consisting of a hybrid of a peptide and an artificial polymer. This molecule is capable of inhibiting the action of a protein involved in cancers. Structural biology ; Cancer ; Epigenetics ; Molecular mechanisms general public ; Journalists ; Researchers Joliot Découvertes et avancées ; Scientific result Wed, 05 May 2021 10:00:00 GMT Guiding microswimmers by magnetic fields https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/guiding-microswimmers-by-magnetic-fields.aspx As part of an international collaboration, BIAM researchers have successfully produced 3D-printed microswimmers that can be guided by magnetic fields. Ultimately, these devices could be used within the human body for therapeutic purposes. Micro-nanotechnologies ; Medical imaging ; Nanomedicine general public ; Journalists ; Researchers BIAM Découvertes et avancées ; Scientific result Wed, 05 May 2021 10:00:00 GMT Parkinson’s disease: reduced immune support is involved https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/parkinsons-disease-reduced-immune-support-is-involved.aspx As part of a European collaboration, researchers at the CEA-Jacob have demonstrated that exposure to aggregates of α-synuclein proteins could reduce the support capacity of the brain’s immune cells, the astrocytes. Parkinson's disease ; Structural biology ; Proteomics general public ; Journalists ; Researchers Jacob Découvertes et avancées ; Scientific result Mon, 03 May 2021 10:00:00 GMT Bacteriophages: viruses that expand the genetic alphabet https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/bacteriophages-viruses-that-expand-the-genetic-alphabet.aspx A collaboration involving the CEA-Jacob is lifting the veil on a mystery surrounding certain bacterial viruses: the substitution in their DNA of adenine by another base, aminoadenine. DNA ; Virus general public ; Journalists ; Researchers Découvertes et avancées ; Scientific result Fri, 30 Apr 2021 10:00:00 GMT How plants handle stress through their stomata https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/how-plants-handle-stress-through-their-stomata.aspx Researchers at the Biam have unveiled one of the mechanisms involved in the responses of plants to variations in their environment. This work could help improve their capacity to adapt to climate change. Proteomics ; Structural biology ; Cellular mechanisms general public ; Journalists ; Researchers BIAM Découvertes et avancées ; Scientific result Mon, 26 Apr 2021 10:00:00 GMT COVID-19: using mass spectrometry to diagnose and assess viral load https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/covid-using-mass-spectrometry-to-diagnose-and-assess-viral-load.aspx A CEA-Joliot team is developing with the AP-HP a mass spectrometry diagnostic test for COVID-19 that would also make it possible to assess the patient’s viral load. Their aim is to make the method more sensitive and more compatible with hospital equipment. Diagnosis ; Proteomics general public ; Journalists ; Researchers Joliot Découvertes et avancées ; Scientific result Mon, 12 Apr 2021 10:00:00 GMT Green chemistry and biofuel: the mechanism of a key photoenzyme decrypted https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/Green-chemistry-and-biofuel-the-mechanism-of-a-key-photoenzyme-decrypted-.aspx Green Chemistry ; Chemistry ; 3rd generation biofuel ; Microalgae ; Synchrotron ; Laser ; Molecular mechanisms ; Bioenergy Press release Fri, 09 Apr 2021 10:00:00 GMT Glycemia and clinical outcome after a stroke: what is the link? https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/glycemia-and-clinical-outcome-after-a-stroke-what-is-the-link.aspx With the help of metabolomics, a study by the CEA-Joliot and its partners has improved the understanding of the complex relationship between blood glucose levels (glycemia) and the functional outcome of patients following a stroke. Brain ; Diseases general public ; Journalists ; Researchers Joliot Découvertes et avancées ; Scientific result Wed, 10 Mar 2021 11:00:00 GMT Protein crown around nanoparticles: Size matters! https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/protein-crown-around-nanoparticles---size-matters.aspx When immersed in biological media, nanoparticles are immediately "wrapped" in proteins. A study conducted by researchers from the Iramis and Joliot (I2BC) institutes clarifies the importance of protein size on the formation of this envelope and recommends better consideration of this parameter in proteomic and nanotoxicological studies. Micro-nanotechnologies ; Nanomedicine ; Proteomics ; Nanotoxicology general public ; Journalists ; Researchers Iramis Scientific result Wed, 03 Mar 2021 11:00:00 GMT Improved tracking of brain inflammation to better treat Parkinson’s disease https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/improved-tracking-of-brain-inflammation-to-better-treat-parkinsons-disease.aspx Researchers at the CEA’s Jacob and Joliot Institutes have improved the monitoring of brain inflammation in Parkinson’s disease patients with PET imaging, using a molecule called [18F]-DPA714. This radiotracer could be useful for evaluating anti-inflammatory drugs specific to this disease, and for monitoring the inflammatory process in other neurodegenerative pathologies. Brain ; Parkinson's disease ; Positron Emission Tomography general public ; Journalists ; Researchers Jacob Découvertes et avancées ; Scientific result Thu, 25 Feb 2021 11:00:00 GMT Testing for Antimicrobial Resistance using Artificial Intelligence https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/-Testing-for-Antimicrobial-Resistance-using-Artificial-Intelligence.aspx Health & life sciences ; Antibiotics ; Diagnosis News ; Press release ; Partnerships ; Scientific result Wed, 24 Feb 2021 11:00:00 GMT How an imbalance in gut microbiota can lead to depression https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/how-an-imbalance-in-gut-microbiota-can-lead-to-depression.aspx A study involving the CEA-Joliot has revealed the mechanism by which certain depressive states are linked to an imbalance in gut microbiota. The endocannabinoid system makes the connecting link. Diseases ; Brain ; Bacteria general public ; Journalists ; Researchers Joliot Découvertes et avancées ; Scientific result Thu, 18 Feb 2021 11:00:00 GMT Cancer: improved identification of radiosensitive patients https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/cancer-improved-identification-of-radiosensitive-patients.aspx Researchers from the CEA-Jacob and Claude Bernard University have identified a new radiosensitivity signature in patients with severe side effects following radiotherapy. Cancer ; Radiotherapy ; Radiosensitivity general public ; Researchers ; Journalists Jacob Découvertes et avancées ; Scientific result Fri, 12 Feb 2021 11:00:00 GMT Accelerating green chemistry using artificial enzymes https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/accelerating-green-chemistry-using-artificial-enzymes.aspx Researchers at the CEA-Irig have introduced a new catalysis tool for green chemistry, by creating crystalline artificial enzymes whose solid form increases stability and allows more reaction cycles under harsher conditions. Green Chemistry ; Bacteria general public ; Journalists ; Researchers IRIG Découvertes et avancées ; Scientific result Tue, 09 Feb 2021 11:00:00 GMT When artificial enzymes accelerate green chemistry https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/When-artificial-enzymes-accelerate-green-chemistry.aspx Researchers at CEA- Irig have offered a new catalysis tool to green chemistry by creating artificial crystalline enzymes whose solid form increases stability and allows more cycles of reactions under harder conditions of use. Green Chemistry ; Bacteria Companies ; general public ; Institutions ; Journalists ; Researchers IRIG News ; Scientific result Tue, 09 Feb 2021 11:00:00 GMT A statistical and dynamic approach to better understand the limits of COVID-19 epidemiological models https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/a-statistical-and-dynamic-approach-to-better-understand-the-limits-of-covid-epidemiological-models.aspx Noting the inconsistencies in health policies aimed at combating COVID-19, a mathematician from the LSCE (CEA-CNRS-UVSQ) and his co-authors are calling attention to the poor quality of available data, as well as the intrinsic sensitivity of epidemiological models to these data. According to them, it is impossible to make predictions about the number of infections without a thorough understanding of the non-linearities underlying the dynamics of a “complex system”, such as an epidemic. Mathematics ; Simulation & modelling ; Virus general public ; Journalists ; Researchers LSCE Scientific result Thu, 21 Jan 2021 11:00:00 GMT The brain function of the world's smallest primate in 3D https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/The-brain-function-of-the-world's-smallest-primate-in-3D.aspx How did Evolution shape the architecture of neural networks? A CEA-Jacob team describes these networks in one of the smallest and most genetically distant primates from humans. Brain ; MRI Companies ; general public ; Institutions ; Journalists ; Researchers Jacob News ; Scientific result Thu, 07 Jan 2021 11:00:00 GMT FLASH radiotherapy for the treatment of acute lymphoblastic leukemia https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/FLASH-radiotherapy-for-the-treatment-of-acute-lymphoblastic-leukemia.aspx The CEA-Jacob and his partners teamed to compare FLASH radiotherapy to conventional radiotherapy in the setting of acute lymphoblastic leukemia. Diagnosis and innovative treatment ; Radiotherapy ; Cancer Companies ; general public ; Institutions ; Journalists ; Researchers Jacob Scientific result ; News Mon, 04 Jan 2021 11:00:00 GMT Amazing discovery: Variovorax, a bacterium that lives in the heart of a working nuclear reactor! https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/Variovorax-bacteria-living-heart-working-nuclear-reactor.aspx Researchers from I2BC and SPI (DMTS, Marcoule), in collaboration with CEA Grenoble and the Belgian nuclear research center, discovered, by using two meta-omic approaches, living bacteria in the core pool of the CEA Paris-Saclay research reactor, Osiris, in operation, thus opening up perspectives for the discovery of new radioresistant species. Bacteria ; Nuclear Toxicology Scientific result Thu, 17 Dec 2020 11:00:00 GMT There is a specific signature of COVID-19 infections in the exhaled air of patients. https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/There-is-a-specific-signature-of-COVID-19-infections-in-the-exhaled-air-of-patients.aspx There is a specific signature of COVID infections in expired air in intubated and ventilated patients, referred to as "severe COVID patients". Explanations from CEA-Joliot and CEA-List. Diagnosis ; Virus Companies ; general public ; Institutions ; Journalists ; Researchers List News ; Scientific result Thu, 10 Dec 2020 11:00:00 GMT CEA carries for France the EBRAINS infrastructure inscription on the ESFRI roadmap https://www.cea.fr/drf/english/Pages/News/Institutional-news/2020/CEA-carries-EBRAINS-inscription-for-ESFRI.aspx EBRAINS (European Brain ReseArch INfrastructureS) is a european research infrastructure designed by the scientific community which, based on a set of state-of-the-art digital platforms, aims to answer the analysis and processing needs of large brain data sets. CEA carries for France EBRAINS inscription on the European Strategy Forum on Research Infrastructures roadmap, which was submitted in early September 2020. Brain ; Simulation & modelling News ; Article ; Europe Wed, 09 Dec 2020 11:00:00 GMT Mambaquaretin: therapeutic as well as diagnostic uses? https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/Mambaquaretin-therapeutic-as-well-as-diagnostic-uses.aspx New work by the CEA-Joliot on the venom of the green mamba confirms the therapeutic potential of the toxin and paves the way for its use as a diagnostic tool. Diagnosis and innovative treatment Companies ; general public ; Institutions ; Journalists ; Researchers Joliot News ; Scientific result Wed, 09 Dec 2020 11:00:00 GMT PAP8, a double agent involved in the greening of flowering plants https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/PAP8,-a-double-agent-involved-in-the-greening-of-flowering-plants.aspx The construction of the photosynthetic apparatus in the cells of leaves of flowering plants involves subtle mechanisms. The CEA-Irig is providing some explanations. Vegetal physiology Companies ; general public ; Journalists ; Institutions ; Researchers IRIG News ; Scientific result Mon, 07 Dec 2020 11:00:00 GMT Cell mechanics: definitely very surprising https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/Cell-mechanics-definitly-very-surprising.aspx Cells move, deform and divide. CEA-Irig researchers are gaining a better and better understanding of how. To do this, they have "cut" the contractile cables very precisely with a laser. Cytoskeleton ; Cellular mechanisms Companies ; general public ; Institutions ; Journalists ; Researchers IRIG News ; Scientific result Tue, 01 Dec 2020 11:00:00 GMT Structural biology: better understanding of microbial rhodopsins https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/Structural-biology-better-understanding-of-microbial-rhodopsins.aspx Microbial rhodopsins are among the proteins responsible for capturing solar energy on the Earth, especially in the seas. Researchers from CEA-Irig (IBS) have characterized the structure and function of several unique rescently disoived rhodopsins. Structural biology Companies ; general public ; Institutions ; Journalists ; Researchers IRIG News ; Scientific result Thu, 26 Nov 2020 11:00:00 GMT Discovery of a surprising mode of transmission for variant Creutzfeldt-Jakob disease https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/Discovery-of-a-surprising-mode-of-transmission-for-variant-Creutzfeldt-Jakob-disease.aspx Researchers at the CEA-Jacob have discovered a new mode of prion transmission after the localized contamination of a finger. Prion diseases Companies ; Institutions ; Journalists ; Researchers Jacob News ; Scientific result Fri, 20 Nov 2020 11:00:00 GMT A breakthrough in our understanding of the natural control mechanisms of HIV infection https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/A-breakthrough-in-our-understanding-of-the-natural-control-mechanisms-of-HIV-infection.aspx A new step has been made in understanding how HIV control mechanisms allow some individuals to manage the infection without any treatment. The CEA-Jacob provides some explanations. AIDS ; Virus Companies ; general public ; Institutions ; Journalists ; Researchers Jacob News ; Scientific result Mon, 12 Oct 2020 10:00:00 GMT SARS-CoV-2: discovery of a novel transmission mechanism https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/SARS-CoV-2-discovery-of-a-novel-transmission-mechanism.aspx Researchers at the IBS (CEA-Irig) have revealed a previously unknown mechanism for the proliferation of SARS-CoV-2, in which the virus uses immune cells to enhance its own capture and transmission! Vaccine ; Virus ; Immune system ; Diagnosis and innovative treatment Companies ; general public ; Institutions ; Journalists ; Researchers IRIG News ; Scientific result Wed, 30 Sep 2020 10:00:00 GMT Hydrogen isotopes in the race for new drugs https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/Hydrogen-isotopes-in-the-race-for-new-drugs.aspx Isotopic labeling remains essential for monitoring the in vivo fate of drug candidates. CEA-Joliot researchers have developed high-performance deuterium and tritium labelling techniques. Pharmacology ; Chemistry Companies ; general public ; Institutions ; Journalists ; Researchers Joliot Scientific result ; News Mon, 28 Sep 2020 10:00:00 GMT MRI: a new multiparametric acquisition method for mapping the brain https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/MRI-a-new-multiparametric-acquisition-method-for-mapping-the-brain.aspx A team from the CEA-Joliot has developed an MRI technique that makes it possible to acquire multiple parameters and to reconstruct quantitative maps of the brain with different contrasts, crucial for the diagnosis of brain pathologies. Brain ; MRI Companies ; general public ; Institutions ; Journalists ; Researchers Joliot News ; Scientific result Fri, 18 Sep 2020 10:00:00 GMT Nanovectors in radiotherapy: how to optimize the polymer crown of gold nanoparticles https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/nanovectors-in-radiotherapy-how-to-optimize-the-polymer-crown-of-gold-nanoparticles.aspx With the help of X-ray and neutron scattering measurements of model nanoparticles, a team from the Iramis is developing recommendations for the use of functionalized gold nanoparticles in anticancer therapy: the polymer crown must be made from hydrophobic, positively charged monomers. Micro-nanotechnologies ; Nanomedicine ; Diagnosis and innovative treatment ; Chemistry general public ; Journalists ; Researchers Iramis Scientific result Fri, 28 Aug 2020 10:00:00 GMT What if our intestinal microbiota reveals a new antibiotic? https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/What-if-our-intestinal-microbiota-reveals-a-new-antibiotic.aspx A bacterium present in our intestinal macrobiota produces a particularly interesting antibiotic: Ruminococcin C1. Explanations from CEA-Irig. Structural biology ; Antibiotics ; Bacteria Companies ; general public ; Researchers ; Institutions IRIG Scientific result Fri, 21 Aug 2020 10:00:00 GMT When listening to bubbles helps to heal the brain https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/When-listening-to-bubbles-helps-to-heal-the-brain.aspx A NeuroSpin team, in collaboration with researchers from SHFJ and MIRCen (CEA-Jacob), is identifying a predictive indicator of the potentially deleterious effect of devices using ultrasound to deliver drugs to the brain. Brain ; Pharmacology Companies ; general public ; Institutions ; Journalists ; Researchers Jacob News ; Scientific result Tue, 11 Aug 2020 10:00:00 GMT SARS-CoV-2 detection: mass spectrometry shows its potential for rapidity https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/SARS-CoV-2-detection-mass-spectrometry-shows-its-potential-for-rapidity.aspx A team from CEA-Joliot in Marcoule detected by mass spectrometry, in 3 minutes and without specific reagents, signature peptides of the SARS-CoV-2 virus in clinical samples (nasopharyngeal swabs). It thus provides a proof of concept of the use of this method as a possible alternative to PCR, currently the reference method. Infectious diseases ; Diagnosis Companies ; general public ; Institutions ; Journalists ; Researchers Joliot News ; Scientific result Fri, 07 Aug 2020 11:00:00 GMT Anisotropic functionalization of gold nanoparticles assisted by surface plasmons https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/Anisotropic-functionalization-of-gold-nanoparticles-assisted-by-surface-plasmons.aspx Researchers at the CEA-Iramis and their partners have locally grafted organic molecules onto gold nanoparticles, using two photopolymerization steps. This new flexible functionalization technique can be used for applications ranging from biosensing to photonics. Photonics ; Micro-nanotechnologies ; Chemistry ; Laser ; Diagnosis ; Innovation for industry general public ; Journalists ; Researchers Iramis Scientific result Wed, 05 Aug 2020 10:00:00 GMT Molecular insight into the transmission of avian influenza to enable human infection https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/molecular-insight-into-the-transmission-of-avian-influenza-to-enable-human-infection.aspx Researchers at CEA-IRIG have used NMR to reveal the molecular mechanisms that support the adaptation of avian influenza virus from birds to humans. By uncovering the secrets of the interactions between the mutated viral polymerase and a key transcription factor in host cells, this new insight will make it possible to study the mechanism of cross-species contagion of these viruses and thus open up potential new therapeutic avenues. Virus ; Infectious diseases ; Diseases general public ; Journalists ; Researchers IRIG Scientific result Wed, 29 Jul 2020 00:00:00 GMT A preclinical study shows that hydroxychloroquine has no antiviral effect on SARS-CoV-2 in vivo https://www.cea.fr/drf/english/Pages/News/Institutional-news/2020/A-preclinical-study-shows-that-hydroxychloroquine-has-no-antiviral-effect-on-SARS-CoV-2-in-vivo.aspx A study on the effects of hydroxychloroquine in macaques infected with the SARS-CoV-2 virus, used alone or in combination with azithromycin, have been published on Nature; the 22th oh july. Scientists from the CEA, CNRS, Inserm, Institut Pasteur, Université de Paris-Saclay, Université Claude Bernard Lyon 1 and Aix-Marseille Université have been involved in the study, which has been carried out under the aegis of the multidisciplinary consortium, REACTing. Pharmacology ; Infectious diseases Companies ; general public ; Institutions ; Journalists Jacob Scientific result Wed, 22 Jul 2020 10:00:00 GMT Ebola: towards a new vaccine? https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/Ebola-towards-a-new-vaccine.aspx CEA-Joliot researchers and their partners have used a large-scale approach to map and characterize the response of CD4 T cells from healthy donors to two proteins of the Ebola-Zaire virus. They suggest that one of these proteins could be a target in the design of new vaccines. Virus ; Vaccine Companies ; general public ; Institutions ; Journalists ; Researchers Joliot Scientific result Wed, 15 Jul 2020 10:00:00 GMT Breast cancer: new develoments for early cases https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/Breast-cancer-new-develoments-for-early-cases.aspx Researchers at the CEA-Joliot (I2BC) have used NMR to decipher a novel mechanism in breast cancers linked to the BRCA2 gene. Cancer Companies ; general public ; Institutions ; Journalists ; Researchers Joliot Scientific result Wed, 17 Jun 2020 10:00:00 GMT Structural biology: at the heart of the core of bacterial metalloproteins https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/Structural-biology-at-the-heart-of-the-core-of-bacterial-metalloproteins.aspx To be or not to be expressed? Researchers at the CEA-Irig (IBS) are showing with precision how a bacterial metalloprotein controls the expression of certain genes. And all it takes is an electron and a proton! Structural biology ; Bacteria Companies ; general public ; Journalists ; Researchers IRIG Scientific result Wed, 13 May 2020 10:00:00 GMT Reducing mosquito populations https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/Reducing-mosquito-populations.aspx Researchers at the CEA-Irig have elucidated the activation cascade of one of the four Bacillus thuringiensis toxins that specifically target mosquito larvae, in order to prevent them from becoming vectors of devastating diseases. Bacteria ; Environment ; Health & life sciences Companies ; general public ; Institutions ; Journalists ; Researchers IRIG Scientific result Tue, 07 Apr 2020 10:00:00 GMT Regeneration or fibrosis of injured tissue: macrophages lead the way https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/Regeneration-or-Fibrosis-of-injured-tissue-Macrophages-lead-the-way.aspx After an injury, many tissues often develop fibrosis[1], which can be disabling. An international team involving researchers from CEA-Jacob has now identified a key player in the fibrosis development: macrophages [2]. These observations pave the way for targeted treatments. Cellular mechanisms ; Gene and cell therapy Companies ; general public ; Institutions ; Journalists ; Researchers Jacob News ; Scientific result Thu, 02 Apr 2020 10:00:00 GMT Study of the possible toxicity of tungsten particles emitted by Iter https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/Study-of-the-possible-toxicity-of-tungsten-particles-emitted-by-Iter.aspx CEA researchers and their partners have synthesized and characterized tungsten particles similar to those to be produced by the Iter fusion reactor and have identified their cyto-genotoxic properties in lung models. Iter ; Toxicology Companies ; general public ; Institutions ; Researchers Joliot News ; Scientific result Wed, 29 Jan 2020 11:00:00 GMT Rapid genome analysis provides invaluable aid for hospitalized newborns https://www.cea.fr/drf/english/Pages/News/Scientific-results/2019/Rapid-genome-analysis-provides-invaluable-aid-for-hospitalized-newborns.aspx In their work entitled Fastgenomics, the Dijon Bourgogne University Hospital, Inserm and the CEA's National Center of Human Genomics Research (CNRGH) studied a rapid high-throughput genome sequencing process in 30 hospitalized newborns. The team was able to reduce the time needed for this process from an average of 18 months to only a month and a half at most (38 to 49 days), thus enabling rapid diagnoses for two-thirds of the patients. Genomics ; Diagnosis Companies ; general public ; Institutions ; Journalists ; Researchers Jacob News Wed, 18 Dec 2019 11:00:00 GMT Fast genome analysis helps with diagnosis for babies in neonatal intensive care https://www.cea.fr/drf/english/Pages/News/Scientific-results/2019/Fast-genome-analysis-helps-with-diagnosis-for-babies-in-neonatal-intensive-care.aspx Teams from CHU Dijon-Bourgogne, Inserm and the CEA have just produced genome analysis results for very sick newborn babies in neonatal intensive care, shortening the analysis time to 38 days compared to an average of 18 months at present. Diagnosis ; Genomics general public ; Journalists ; Researchers ; Companies Jacob Scientific result Wed, 11 Dec 2019 11:00:00 GMT On track to eradicating stomach infections in half the world's population https://www.cea.fr/drf/english/Pages/News/Scientific-results/2019/On-track-to-eradicating-stomach-infections-in-half-the-world-s-population.aspx A Franco-Indian collaboration has identified an important mechanism involved in the transmission of antibiotic resistance, which is the principal cause of the failure of therapies aiming to eradicate Helicobacter pylori, a bacterium that infects half the world’s population. Health & life sciences ; Diseases ; Bacteria ; Infectious diseases Companies ; general public ; Institutions ; Journalists ; Researchers Scientific result Wed, 27 Nov 2019 11:00:00 GMT The Tara Oceans mission reveals variations in plankton biodiversity and activity from the equator to the poles https://www.cea.fr/drf/english/Pages/News/Scientific-results/2019/The-Tara-Oceans-mission-reveals-variations-in-plankton-biodiversity-and-activity-from-the-equator-to-the-poles.aspx New results from the Tara Oceans expedition, led by a collaboration between the Tara Ocean Foundation and teams from the CNRS, EMBL, CEA, Sorbonne Université and Université Paris Science Lettres between 2009 and 2013 show that the diversity and functions of planktonic species in the global ocean change dramatically according to latitude. Biodiversity ; Genomics ; Environment ; Climate Companies ; general public ; Institutions ; Journalists ; Researchers Jacob Scientific result Mon, 18 Nov 2019 11:00:00 GMT Skin graft: a new molecular target for activating stem cells https://www.cea.fr/drf/english/Pages/News/Scientific-results/2019/Skin-graft-a-new-molecular-target-for-activating-stem-cells.aspx A CEA-Jacob team has just published a paper in which it demonstrates the central role of the transcription factor KLF4 in regulating the proliferation of epidermal stem cells and their ability to regenerate this tissue. This study opens perspectives for regenerative skin medicine. Fundamental Research ; Health & life sciences ; Cellular mechanisms ; Stem cells ; Genomics Companies ; general public ; Institutions ; Journalists ; Researchers Jacob Scientific result Wed, 23 Oct 2019 10:00:00 GMT The brain’s role in cancer development https://www.cea.fr/drf/english/Pages/News/Scientific-results/2019/The-brain-role-in-cancer-development.aspx New neurons appear inside the tumor microenvironment, contributing to the cancer’s development. These nerve cells stem from progenitors coming from the brain via the blood flow. This astounding discovery opens up a new research field regarding the role of the nervous system in cancer development, as well as the interactions between the vascular, immune and nervous systems with the tumorigenesis. Brain ; Diseases ; Cancer ; Cellular mechanisms ; Health & life sciences Journalists ; general public ; Researchers BIAM Scientific result Mon, 20 May 2019 10:00:00 GMT Submarine symbiosis: microorganisms that never get lost https://www.cea.fr/drf/english/Pages/News/Scientific-results/2019/Submarine-symbiosis-microorganisms-that-never-get-lost--.aspx A team of CEA-Biam has uncovered a symbiotic behavior between magnetism-using bacteria and eukaryotic microorganisms. Biodiversity ; Bacteria ; Genomics Researchers ; Journalists ; general public BIAM En direct ; Scientific result Tue, 14 May 2019 10:00:00 GMT The Arctic Ocean, cradle of viral biodiversity https://www.cea.fr/drf/english/Pages/News/Scientific-results/2019/The-Arctic-Ocean,-cradle-of-viral-biodiversity.aspx Fundamental Research ; Cellular mechanisms ; Impact of climate change ; Climate ; Oceanography Press release ; Scientific result ; Focus Mon, 29 Apr 2019 10:00:00 GMT Bacteria: more than one weapon at their disposal https://www.cea.fr/drf/english/Pages/News/Scientific-results/2018/Bacteria-more-than-one-weapon-at-their-disposal.aspx IBS researchers and their partners have discovered a new weapon in the Pseudomonas aeruginosa arsenal. Bacteria ; Antibiotics Researchers ; Journalists ; general public BIG Scientific result Mon, 26 Mar 2018 10:00:00 GMT The hippocampus as never seen before https://www.cea.fr/drf/english/Pages/News/Scientific-results/2018/The-hippocampus-as-never-seen-before.aspx Researchers at the Institut Frédéric-Joliot have provided the mapping of the hippocampus at an unequalled resolution using high field MRI. In addition to its substructures, this has revealed its internal connections and its cellular composition. Brain ; MRI Researchers ; general public ; Journalists Joliot Scientific result Wed, 21 Mar 2018 11:00:00 GMT Corolla or calyx? https://www.cea.fr/drf/english/Pages/News/Scientific-results/2018/Corolla-or-calyx.aspx Researchers at the CEA’s BIG Institute have shown how floral stem cells differentiate to form a flower, through an epigenetic regulation that could upset the canonical models. Vegetal physiology Researchers ; Journalists ; general public BIG Scientific result Mon, 19 Mar 2018 11:00:00 GMT How the brain learns to read https://www.cea.fr/drf/english/Pages/News/Scientific-results/2018/How-the-brain-learns-to-read.aspx Researchers at the Institut Frédéric-Joliot have demonstrated how the brain region specific to word recognition develops when learning to read. Learning ; MRI Researchers ; general public ; Journalists Joliot Scientific result Wed, 14 Mar 2018 11:00:00 GMT Alzheimer’s disease: a look back at some assumptions https://www.cea.fr/drf/english/Pages/News/Scientific-results/2018/Alzheimer’s-disease-a-look-back-at-some-assumptions.aspx Tau protein aggregates observed in the neurons of people with Alzheimer’s disease are considered to be partially responsible for the disease. Researchers at the Institut François-Jacob now suggest, on the contrary, that they have a protective role. Alzheimer's disease general public ; Researchers ; Journalists Jacob Scientific result Wed, 14 Mar 2018 11:00:00 GMT Cultivated plants: moving towards sustainable resistance https://www.cea.fr/drf/english/Pages/News/Scientific-results/2018/Cultivated-plants-moving-towards-sustainable-resistance.aspx Researchers from the Biam and Inra have shown how the modification of a protein in a plant leads to an effective resistance against potyviruses. Agronomy ; Vegetal physiology Researchers ; Journalists ; general public BIAM Scientific result Tue, 13 Mar 2018 11:00:00 GMT