The Knowledge Factory - Sur le même thème https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/Structural-biology-better-understanding-of-microbial-rhodopsins.aspx DRF english version en-US https://www.cea.fr/_layouts/15/images/i2i/icon-144x144-1033.png The Knowledge Factory - Sur le même thème https://www.cea.fr/drf/english SARS-CoV-2: an essential interaction between two proteins could inspire a new therapeutic strategy https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/sars-cov-an-essential-interaction-between-two-proteins-could-inspire-a-new-therapeutic-strategy.aspx Researchers from the CEA-Irig (IBS), Grenoble Alpes University, the CNRS and the ESRF have described for the first time an essential interaction between two SARS-CoV-2 proteins that could inspire a new therapeutic strategy against COVID-19. Virus ; Structural biology ; Diagnosis and innovative treatment general public ; Journalists ; Researchers IRIG Découvertes et avancées ; Scientific result Thu, 20 Jan 2022 11:00:00 GMT The incredible resistance of tardigrades to different environmental stresses, explained by a gel https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/the-incredible-resistance-of-tardigrades-to-different-environmental-stresses-explained-by-a-gel.aspx Researchers at the CEA-Irig have partly lifted the veil on the extraordinary resistance of a small animal, the tardigrade. At play is a disordered protein capable of transforming itself into a protective gel for other biomolecules during drought or extreme cold. Structural biology ; Characterisation general public ; Journalists ; Researchers IRIG Découvertes et avancées ; Scientific result Mon, 20 Dec 2021 11:00:00 GMT A hybrid anticancer drug derived from a peptide and an artificial polymer https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/a-hybrid-anticancer-drug-derived-from-a-peptide-and-an-artificial-polymer.aspx In collaboration with the IECB in Bordeaux, a team from the CEA-Joliot has developed a molecule consisting of a hybrid of a peptide and an artificial polymer. This molecule is capable of inhibiting the action of a protein involved in cancers. Structural biology ; Cancer ; Epigenetics ; Molecular mechanisms general public ; Journalists ; Researchers Joliot Découvertes et avancées ; Scientific result Wed, 05 May 2021 10:00:00 GMT Parkinson’s disease: reduced immune support is involved https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/parkinsons-disease-reduced-immune-support-is-involved.aspx As part of a European collaboration, researchers at the CEA-Jacob have demonstrated that exposure to aggregates of α-synuclein proteins could reduce the support capacity of the brain’s immune cells, the astrocytes. Parkinson's disease ; Structural biology ; Proteomics general public ; Journalists ; Researchers Jacob Découvertes et avancées ; Scientific result Mon, 03 May 2021 10:00:00 GMT How plants handle stress through their stomata https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/how-plants-handle-stress-through-their-stomata.aspx Researchers at the Biam have unveiled one of the mechanisms involved in the responses of plants to variations in their environment. This work could help improve their capacity to adapt to climate change. Proteomics ; Structural biology ; Cellular mechanisms general public ; Journalists ; Researchers BIAM Découvertes et avancées ; Scientific result Mon, 26 Apr 2021 10:00:00 GMT Structural biology: better understanding of microbial rhodopsins https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/Structural-biology-better-understanding-of-microbial-rhodopsins.aspx Microbial rhodopsins are among the proteins responsible for capturing solar energy on the Earth, especially in the seas. Researchers from CEA-Irig (IBS) have characterized the structure and function of several unique rescently disoived rhodopsins. Structural biology Companies ; general public ; Institutions ; Journalists ; Researchers IRIG News ; Scientific result Thu, 26 Nov 2020 11:00:00 GMT What if our intestinal microbiota reveals a new antibiotic? https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/What-if-our-intestinal-microbiota-reveals-a-new-antibiotic.aspx A bacterium present in our intestinal macrobiota produces a particularly interesting antibiotic: Ruminococcin C1. Explanations from CEA-Irig. Structural biology ; Antibiotics ; Bacteria Companies ; general public ; Researchers ; Institutions IRIG Scientific result Fri, 21 Aug 2020 10:00:00 GMT Structural biology: at the heart of the core of bacterial metalloproteins https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/Structural-biology-at-the-heart-of-the-core-of-bacterial-metalloproteins.aspx To be or not to be expressed? Researchers at the CEA-Irig (IBS) are showing with precision how a bacterial metalloprotein controls the expression of certain genes. And all it takes is an electron and a proton! Structural biology ; Bacteria Companies ; general public ; Journalists ; Researchers IRIG Scientific result Wed, 13 May 2020 10:00:00 GMT Bacteria that converse with each other https://www.cea.fr/drf/english/Pages/News/Scientific-results/2018/Bacteria-that-converse-with-each-other.aspx Researchers from the IBS have shown how bacteria converse within floating biofilms. The proteins involved in this interaction could be new targets in the fight against antibiotic resistance and nosocomial infections. Structural biology ; Antibiotics general public ; Journalists ; Researchers IBS Scientific result Thu, 08 Mar 2018 11:00:00 GMT News about vaccinia, a close relative of the smallpox virus https://www.cea.fr/drf/english/Pages/News/Scientific-results/2018/News about vaccinia, a close relative of the smallpox virus.aspx The hypothesis of a smallpox re-emergence cannot be ruled out. Researchers from the IBS are working on its cousin, vaccinia. Infectious diseases ; Structural biology general public ; Journalists ; Researchers IBS Scientific result Fri, 19 Jan 2018 11:00:00 GMT Antibiotics are putting up a resistance https://www.cea.fr/drf/english/Pages/News/Scientific-results/2018/Antibiotics-are putting-up-a-resistance.aspx A team from the IBS has shown how some antibiotics become insensitive to the principal mechanisms of bacterial resistance. Antibiotics ; Structural biology Researchers ; general public ; Journalists IBS Scientific result Wed, 17 Jan 2018 11:00:00 GMT New developments in antibiotic strategy https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/new-developments-in-antibiotic-strategy.aspx Scientists from the IBS have characterized a potential target for new antibiotics. Structural biology ; Bacteria Researchers ; general public ; Journalists IBS Scientific result Fri, 22 Dec 2017 11:00:00 GMT From protein packing to protein dynamics https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/from-protein-packing-to-protein-dynamics.aspx Researchers from the IBS are working on crystallography techniques in order to see proteins in motion. Structural biology general public ; Journalists ; Researchers IBS Scientific result Tue, 19 Dec 2017 11:00:00 GMT Collagen: a very stable protein https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/Collagen-a-very-stable-protein.aspx To better understand the effects of therapeutic irradiation on cartilage, the structure of its main constituent, collagen, has been studied by a collaboration involving Iramis. Their analysis suggests that the stability of collagen owes nothing to its aqueous environment, but all to its remarkable triple helix structure that can exist in the absence of any solvent. Structural biology Researchers ; general public ; Journalists Iramis Scientific result Tue, 28 Nov 2017 11:00:00 GMT Amyloids in bacteria https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/amyloids-in-bacteria.aspx A collaboration involving Iramis and the Institut Joliot has revealed the spontaneous aggregation into amyloid fibers of a bacterial protein called Hfq and non-coding RNA strands. Furthermore, the collaborators demonstrated the ability of these fibers to penetrate a lipid membrane. This study paves the way for a better understanding of bacterial communication in addition to new approaches in antibiotic development. Structural biology Researchers ; general public ; Journalists Joliot Scientific result Tue, 21 Nov 2017 11:00:00 GMT Filming the Auto-assembly of an Uncommon Structure https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/filming-the-auto-assembly-of-an-uncommon-structure.aspx Biologic nanomachines are complex protein assemblies that are difficult to analyze. Researchers at IBS were able to film the auto-assembly of one of them in real time. Structural biology Researchers ; general public ; Journalists IBS Scientific result Tue, 12 Sep 2017 10:00:00 GMT A Closer Look at Protein Topless https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/a-closer-look-at-protein-topless.aspx Researchers from BIG and their partners have finely analyzed the structure and function of protein 'Topless', involved in plant development. Their work has potential applications in agronomy. Vegetal physiology ; Structural biology Researchers ; general public ; Journalists BIG Fri, 08 Sep 2017 10:00:00 GMT From Venoms to innovative Drugs with VENOMICS https://www.cea.fr/drf/english/Pages/News/Institutional-news/2017/From-Venoms-to-innovative-Drugs-with-VENOMICS.aspx Based on the study of two hundred poisonous animals, the European project VENOMICS managed to reproduce a bank of 3,616 “natural” toxins compatible with high throughput screening. VENOMICS demonstrated that animal toxins are hundred times more effective in identifying drug candidates than the usual banks of artificial molecules. Health & life sciences ; Diagnosis and innovative treatment ; Pharmacology ; Structural biology ; High-throughput screening Journalists ; general public ; Researchers Joliot News ; Newsletter ; CEA Research News ; European & international partnerships vaccine;Animal;bioeconomy and health;venoms; Mon, 19 Jun 2017 08:00:00 GMT Stopping Pathogenic Fungi https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/stopping-pathogenic-fungi.aspx The work by an international collaboration involving IBS and CEA-BIG has led to the discovery of a protein necessary for the survival of pathogenic fungi. Their work could lead to the development of a new antifungal therapeutic strategy. Infectious diseases ; DNA ; Structural biology Researchers ; general public ; Journalists BIG Scientific result Fri, 16 Jun 2017 14:00:00 GMT Biomimetic Welding https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/biomimetic-welding.aspx Researchers from IBS have patented a method of biological welding based on their study of pneumococcal pili. Technologies ; Structural biology Researchers ; general public ; Journalists IBS Scientific result Tue, 30 May 2017 10:00:00 GMT The Two Steps of a Protein's Life https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/the-two-steps-of-a-protein-s-life.aspx By combining two NMR techniques, researchers from IBS track certain furtive, yet essential states of a protein's functioning. A first application has already been found in joint and bone pathology. Structural biology ; Health & life sciences general public ; Journalists ; Researchers IBS Scientific result Thu, 27 Apr 2017 10:00:00 GMT Using the Spin to Visualize Proteins in their Natural Environment https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/using-the-spin-to-visualize-proteins-in-their-natural-environment.aspx A team of scientists from the Frédéric-Joliot Institute has demonstrated that the technique of PELDOR electron paramagnetic resonance makes it possible to detect the interaction between electronic spins in order to solve the structure of proteins in vivo. Structural biology ; Cellular mechanisms general public ; Journalists ; Researchers Joliot Scientific result Wed, 08 Mar 2017 11:00:00 GMT For a Better Grasp of Muscular Contraction https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/for-a-better-grasp-of-muscular-contraction.aspx A team of researchers from CEA-BIG has identified protein CLIMP-63 as the missing link between triadin and microtubules, two molecular actors in muscular contraction. This discovery paves the way toward a better understanding of certain severe cardiac pathologies and certain myopathies. Structural biology ; Health & life sciences general public ; Researchers ; Journalists IBS Scientific result Tue, 17 Jan 2017 11:00:00 GMT A “molecular switch” for use in optogenetics https://www.cea.fr/drf/english/Pages/News/Scientific-results/2015/molecular-switch-for-use-optogenetics.aspx Following the discovery of a protein structure that makes sodium transport across bacterial membranes possible, a team of Russian, German and French (IBS) scientists has developed a potential new tool for optogenetics. The latter is a field of research at the crossroads of optics and genetics. Structural biology ; Biotechnology ; Brain Grenoble Scientific result Wed, 06 May 2015 10:00:00 GMT Live observation of a “waking” protein https://www.cea.fr/drf/english/Pages/News/Scientific-results/2015/Live-observation-waking-protein.aspx What are the dynamics with which a protein becomes functional? Researchers from the IBS (CEA, CNRS, UJF), in collaboration with the EPFL and ENS of Lyon, have designed an NMR device capable of observing a protein progressively “wake up” from an inert to functional state. This is a first in analyzing these complex, perpetually mobile biological molecules. Structural biology Grenoble Scientific result Fri, 01 May 2015 10:00:00 GMT Alzheimer’s disease: could water be used as an early diagnostic? https://www.cea.fr/drf/english/Pages/News/Scientific-results/2015/Alzheimers-disease-could-water-be-used-early-diagnostic.aspx The movement of water in the brain, particularly within neurons, could serve as an early marker of Alzheimer’s disease. Structural biology ; Alzheimer's disease Grenoble Scientific result Tue, 28 Apr 2015 10:00:00 GMT The dance of water https://www.cea.fr/drf/english/Pages/News/Scientific-results/2015/dance-of-water.aspx An international team involving the IBS has just demonstrated the role that water has on the activity of proteins at the molecular level. The researchers discovered how the movement of water molecules is involved on the surface of proteins in order to make them dynamic and therefore functional. Structural biology ; Molecular mechanisms Grenoble Scientific result ; European & international partnerships Mon, 16 Mar 2015 11:00:00 GMT Formate dehydrogenase: a delicate mechanism has been elucidated https://www.cea.fr/drf/english/Pages/News/Scientific-results/2015/Formate-dehydrogenase.aspx Formate dehydrogenases are bacterial enzymes that represent a hope in giving value to CO2 as a renewable energy vector. A team from the CEA-IBEB has elucidated a key step in their maturation. Structural biology ; Bioenergy ; Biohydrogen LBC Scientific result Wed, 04 Feb 2015 11:00:00 GMT Disordered proteins: a “filmed” interaction https://www.cea.fr/drf/english/Pages/News/Scientific-results/2015/Disordered-proteins.aspx ​Although they are involved in many biological mechanisms, disordered proteins have escaped the methods of structural biology. A team from the IBS has now succeeded in characterizing the interaction of two of them. Structural biology Grenoble Scientific result Thu, 29 Jan 2015 11:00:00 GMT A molecular model of the bacterial cell wall https://www.cea.fr/drf/english/Pages/News/Scientific-results/2014/A-molecular-model-of-the-bacterial-cell-wall.aspx A team from the IBS has used solid-state NMR spectroscopy to obtain the structure of a key enzyme in the formation of the bacterial cell wall, revealing how it interacts with its substrate. Structural biology ; Bacteria Grenoble Scientific result Wed, 24 Dec 2014 11:00:00 GMT Serotonin receptor: the structure is revealed https://www.cea.fr/drf/english/Pages/News/Scientific-results/2014/Serotonin-receptor-the-structure-is-revealed.aspx A team from the IBS (CEA-CNRS-Université Joseph Fourrier) has published in Nature the full three-dimensional structure of a serotonin receptor. This is a first for mammals. Structural biology Grenoble Scientific result Tue, 05 Aug 2014 10:00:00 GMT The tempo of ribosomes https://www.cea.fr/drf/english/Pages/News/Scientific-results/2013/the-tempo-of-ribosomes.aspx A collaboration between the IBS, the EMBL and the ILL reveals the story of the ribosome, one of the essential components for cell survival. The researchers write the chemical scenario of the folding and assembly of this actor who has a complex structure. Structural biology ; Cellular mechanisms IBS Scientific result Mon, 14 Oct 2013 10:00:00 GMT Living fuel cells https://www.cea.fr/drf/english/Pages/News/Scientific-results/2013/Living-fuel-cells.aspx Bacteria contain astonishing enzymes that could inspire scientists in the fabrication of fuel cells. Such is the case for researchers from the IBS, who have just determined the crystallographic structure and mechanism of action for an enzyme from Escherichia coli. Structural biology ; Bio-inspired catalysis IBS Scientific result Thu, 28 Feb 2013 11:00:00 GMT Lynch Syndrome: structural biology in the service of diagnostic support https://www.cea.fr/drf/english/Pages/News/Scientific-results/2013/Lynch-Syndrome-structural-biology-in-the-service-of-diagnostic-support.aspx Researchers at the CEA, CNRS and Université Paris-Sud have presented the first model of the architecture of the MLH1 protein associated with Lynch syndrome, a genetic predisposition to colorectal cancer. This atomic level “image” of MLH1 will lead to better understanding of the genetic processes that cause the disease. Structural biology ; Cancer IBITECS Scientific result Mon, 25 Feb 2013 11:00:00 GMT Creation of the “Integrated Structural Biology, Grenoble (ISBG)” mixed research institute https://www.cea.fr/drf/english/Pages/News/Scientific-results/2013/Creation-of-the-Integrated-Structural-Biology-Grenoble-mixed-research-institute.aspx The Unité Mixte de Service (mixed research institute) UMS 3518 (CNRS-CEA-UJF-EMBL) was created on January 1st 2013, in Grenoble. This new unit brings together facilities from the IBS and UVHCI, and represents an impressive collection of state-of-the-art equipment for integrated structural biology. Structural biology IBS Scientific result Mon, 21 Jan 2013 11:00:00 GMT