The Knowledge Factory - Sur le même thème https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/sars-cov--a-new-mode-of-virus-transmission-involving-immune-cells.aspx DRF english version en-US https://www.cea.fr/_layouts/15/images/i2i/icon-144x144-1033.png The Knowledge Factory - Sur le même thème https://www.cea.fr/drf/english Modelling the influenza viral genome to an unprecedented scale https://www.cea.fr/drf/english/Pages/News/Scientific-results/2024/modelling-the-influenza-viral-genome-to-an-unprecedented-scale.aspx Scientists at IRIG have observed, to a resolution of 0.5 nanometres, the interactions between the influenza virus genome and its associated proteins. This opens the way to a better understanding of the mechanisms underlying the replication of this virus with high pandemic potential. Virus ; Molecular mechanisms ; Cell and molecular imaging general public ; Journalists ; Researchers IRIG Découvertes et avancées ; Scientific result Tue, 30 Jan 2024 11:00:00 GMT Molecular engineering of antibodies: from SARS-CoV-1 to SARS-CoV-2 and its variants https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/molecular-engineering-of-antibodies-from-sars-cov.aspx Researchers from the CEA-Joliot have shown that molecular engineering of llama antibodies directed against SARS-CoV-1 can be used to obtain optimized antibodies with very high affinities for SARS-CoV-2 and its variants. This is a step towards designing neutralizing molecules for new emerging pathogen strains! Diagnosis and innovative treatment ; Virus general public ; Journalists ; Researchers Joliot Découvertes et avancées ; Scientific result Thu, 13 Oct 2022 10:00:00 GMT SARS-CoV-2: an essential interaction between two proteins could inspire a new therapeutic strategy https://www.cea.fr/drf/english/Pages/News/Scientific-results/2022/sars-cov-an-essential-interaction-between-two-proteins-could-inspire-a-new-therapeutic-strategy.aspx Researchers from the CEA-Irig (IBS), Grenoble Alpes University, the CNRS and the ESRF have described for the first time an essential interaction between two SARS-CoV-2 proteins that could inspire a new therapeutic strategy against COVID-19. Virus ; Structural biology ; Diagnosis and innovative treatment general public ; Journalists ; Researchers IRIG Découvertes et avancées ; Scientific result Thu, 20 Jan 2022 11:00:00 GMT COVID-19: development of a new vaccine candidate that targets dendritic cells https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/covid-development-of-a-new-vaccine-candidate-that-targets-dendritic-cells.aspx Researchers at the CEA-Jacob, in collaboration with Inserm and the Université Paris-Est Créteil, have developed a new vaccine candidate against COVID-19 that targets key cells of the immune system, the dendritic cells. The study reports efficacy in preclinical models, with clinical trials planned for 2022. Vaccine ; Infectious diseases general public ; Journalists ; Researchers Jacob Découvertes et avancées ; Scientific result Wed, 01 Sep 2021 10:00:00 GMT SARS-CoV-2: a new mode of virus transmission involving immune cells https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/sars-cov--a-new-mode-of-virus-transmission-involving-immune-cells.aspx Scientists from the Institute of Structural Biology (Irig) and their partners have confirmed that the COVID-19 virus can use immune cells to increase its transmission to other cells. They also show that it is possible to inhibit this new mode of transmission of the virus through the use of glycomimetics, i.e. molecules that can mimic the surface “sugars” of the virus. Infectious diseases ; Virus general public ; Journalists ; Researchers IRIG Découvertes et avancées ; Scientific result Fri, 21 May 2021 10:00:00 GMT Bacteriophages: viruses that expand the genetic alphabet https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/bacteriophages-viruses-that-expand-the-genetic-alphabet.aspx A collaboration involving the CEA-Jacob is lifting the veil on a mystery surrounding certain bacterial viruses: the substitution in their DNA of adenine by another base, aminoadenine. DNA ; Virus general public ; Journalists ; Researchers Découvertes et avancées ; Scientific result Fri, 30 Apr 2021 10:00:00 GMT A statistical and dynamic approach to better understand the limits of COVID-19 epidemiological models https://www.cea.fr/drf/english/Pages/News/Scientific-results/2021/a-statistical-and-dynamic-approach-to-better-understand-the-limits-of-covid-epidemiological-models.aspx Noting the inconsistencies in health policies aimed at combating COVID-19, a mathematician from the LSCE (CEA-CNRS-UVSQ) and his co-authors are calling attention to the poor quality of available data, as well as the intrinsic sensitivity of epidemiological models to these data. According to them, it is impossible to make predictions about the number of infections without a thorough understanding of the non-linearities underlying the dynamics of a “complex system”, such as an epidemic. Mathematics ; Simulation & modelling ; Virus general public ; Journalists ; Researchers LSCE Scientific result Thu, 21 Jan 2021 11:00:00 GMT There is a specific signature of COVID-19 infections in the exhaled air of patients. https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/There-is-a-specific-signature-of-COVID-19-infections-in-the-exhaled-air-of-patients.aspx There is a specific signature of COVID infections in expired air in intubated and ventilated patients, referred to as "severe COVID patients". Explanations from CEA-Joliot and CEA-List. Diagnosis ; Virus Companies ; general public ; Institutions ; Journalists ; Researchers List News ; Scientific result Thu, 10 Dec 2020 11:00:00 GMT A breakthrough in our understanding of the natural control mechanisms of HIV infection https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/A-breakthrough-in-our-understanding-of-the-natural-control-mechanisms-of-HIV-infection.aspx A new step has been made in understanding how HIV control mechanisms allow some individuals to manage the infection without any treatment. The CEA-Jacob provides some explanations. AIDS ; Virus Companies ; general public ; Institutions ; Journalists ; Researchers Jacob News ; Scientific result Mon, 12 Oct 2020 10:00:00 GMT SARS-CoV-2: discovery of a novel transmission mechanism https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/SARS-CoV-2-discovery-of-a-novel-transmission-mechanism.aspx Researchers at the IBS (CEA-Irig) have revealed a previously unknown mechanism for the proliferation of SARS-CoV-2, in which the virus uses immune cells to enhance its own capture and transmission! Vaccine ; Virus ; Immune system ; Diagnosis and innovative treatment Companies ; general public ; Institutions ; Journalists ; Researchers IRIG News ; Scientific result Wed, 30 Sep 2020 10:00:00 GMT SARS-CoV-2 detection: mass spectrometry shows its potential for rapidity https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/SARS-CoV-2-detection-mass-spectrometry-shows-its-potential-for-rapidity.aspx A team from CEA-Joliot in Marcoule detected by mass spectrometry, in 3 minutes and without specific reagents, signature peptides of the SARS-CoV-2 virus in clinical samples (nasopharyngeal swabs). It thus provides a proof of concept of the use of this method as a possible alternative to PCR, currently the reference method. Infectious diseases ; Diagnosis Companies ; general public ; Institutions ; Journalists ; Researchers Joliot News ; Scientific result Fri, 07 Aug 2020 11:00:00 GMT Molecular insight into the transmission of avian influenza to enable human infection https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/molecular-insight-into-the-transmission-of-avian-influenza-to-enable-human-infection.aspx Researchers at CEA-IRIG have used NMR to reveal the molecular mechanisms that support the adaptation of avian influenza virus from birds to humans. By uncovering the secrets of the interactions between the mutated viral polymerase and a key transcription factor in host cells, this new insight will make it possible to study the mechanism of cross-species contagion of these viruses and thus open up potential new therapeutic avenues. Virus ; Infectious diseases ; Diseases general public ; Journalists ; Researchers IRIG Scientific result Wed, 29 Jul 2020 00:00:00 GMT A preclinical study shows that hydroxychloroquine has no antiviral effect on SARS-CoV-2 in vivo https://www.cea.fr/drf/english/Pages/News/Institutional-news/2020/A-preclinical-study-shows-that-hydroxychloroquine-has-no-antiviral-effect-on-SARS-CoV-2-in-vivo.aspx A study on the effects of hydroxychloroquine in macaques infected with the SARS-CoV-2 virus, used alone or in combination with azithromycin, have been published on Nature; the 22th oh july. Scientists from the CEA, CNRS, Inserm, Institut Pasteur, Université de Paris-Saclay, Université Claude Bernard Lyon 1 and Aix-Marseille Université have been involved in the study, which has been carried out under the aegis of the multidisciplinary consortium, REACTing. Pharmacology ; Infectious diseases Companies ; general public ; Institutions ; Journalists Jacob Scientific result Wed, 22 Jul 2020 10:00:00 GMT Ebola: towards a new vaccine? https://www.cea.fr/drf/english/Pages/News/Scientific-results/2020/Ebola-towards-a-new-vaccine.aspx CEA-Joliot researchers and their partners have used a large-scale approach to map and characterize the response of CD4 T cells from healthy donors to two proteins of the Ebola-Zaire virus. They suggest that one of these proteins could be a target in the design of new vaccines. Virus ; Vaccine Companies ; general public ; Institutions ; Journalists ; Researchers Joliot Scientific result Wed, 15 Jul 2020 10:00:00 GMT On track to eradicating stomach infections in half the world's population https://www.cea.fr/drf/english/Pages/News/Scientific-results/2019/On-track-to-eradicating-stomach-infections-in-half-the-world-s-population.aspx A Franco-Indian collaboration has identified an important mechanism involved in the transmission of antibiotic resistance, which is the principal cause of the failure of therapies aiming to eradicate Helicobacter pylori, a bacterium that infects half the world’s population. Health & life sciences ; Diseases ; Bacteria ; Infectious diseases Companies ; general public ; Institutions ; Journalists ; Researchers Scientific result Wed, 27 Nov 2019 11:00:00 GMT A stop to ricin... and much more! https://www.cea.fr/drf/english/Pages/News/Scientific-results/2018/A-stop-to-ricin-and-much-more.aspx A molecule proves to reduce the sensitivity of cells to many particularly aggressive toxins and viruses. Scientists from the CEA’s Institut Frédéric-Joliot have deciphered this protection mechanism. CBRN-E threats ; Infectious diseases Researchers ; general public ; Journalists Joliot Scientific result Fri, 09 Feb 2018 11:00:00 GMT News about vaccinia, a close relative of the smallpox virus https://www.cea.fr/drf/english/Pages/News/Scientific-results/2018/News about vaccinia, a close relative of the smallpox virus.aspx The hypothesis of a smallpox re-emergence cannot be ruled out. Researchers from the IBS are working on its cousin, vaccinia. Infectious diseases ; Structural biology general public ; Journalists ; Researchers IBS Scientific result Fri, 19 Jan 2018 11:00:00 GMT A revelation about phages, the alternative to antibiotics https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/a-revelation-about-phages-the-alternative-to-antibiotics.aspx The phage is a formidable killer of bacteria. Researchers from the IBS have shown how its tail, which recognizes its target, and its capsid, which contains what it needs to destroy the bacterium, communicate. Virus ; Infectious diseases Researchers ; general public ; Journalists IBS Scientific result Fri, 15 Dec 2017 11:00:00 GMT HIV Controllers Are Starting to Unravel Their Secrets https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/HIV-controllers-are-starting-to-unravel-their-secrets.aspx What are the mechanisms of HIV control in individuals known as "controllers"? Researchers at the François-Jacob Institute and their partners have highlighted the peculiarities of CD8+ T cells. AIDS Researchers ; general public ; Journalists Jacob Scientific result Fri, 28 Jul 2017 10:00:00 GMT Stopping Pathogenic Fungi https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/stopping-pathogenic-fungi.aspx The work by an international collaboration involving IBS and CEA-BIG has led to the discovery of a protein necessary for the survival of pathogenic fungi. Their work could lead to the development of a new antifungal therapeutic strategy. Infectious diseases ; DNA ; Structural biology Researchers ; general public ; Journalists BIG Scientific result Fri, 16 Jun 2017 14:00:00 GMT Promising Tests of a Vaccine against Chikungunya virus https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/promising-tests-of-a-vaccine-against-chikungunya-virus.aspx A team from the CEA François-Jacob Institute has demonstrated the preclinical efficacy of three vaccine candidates against chikungunya. Health & life sciences ; Virus ; Chikungunya general public ; Journalists ; Researchers Jacob Scientific result Tue, 25 Apr 2017 10:00:00 GMT Chikungunya: Pain Caused by the Immune System https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/chikungunya-pain-caused-by-the-immune-system.aspx Joint damage in people infected with chikungunya remains poorly understood. Scientists from the CEA François-Jacob Institute and their partners have identified an actor of the antiviral immune response whose inhibition paradoxically reduces the severity of the symptoms. Infectious diseases ; Chikungunya ; Diagnosis and innovative treatment general public ; Journalists ; Researchers Jacob Scientific result Mon, 13 Mar 2017 11:00:00 GMT ZIKAlliance Kickoff https://www.cea.fr/drf/english/Pages/News/Institutional-news/2017/zikalliance-kickoff.aspx CEA-Joliot Institute is part of ZIKAlliance, a project of the European Union focused on studying infection by the Zika virus and preparing for possible epidemics. Health & life sciences ; Infectious diseases general public ; Journalists ; Researchers Joliot Highlight Thu, 16 Feb 2017 11:00:00 GMT A New Molecule for Blocking HIV Infection https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/new-molecule-for-blocking-hiv-infection.aspx A new strategy developed at IBS, in collaboration with Institut Pasteur, can block the entry of the Human Immunodeficiency Virus (HIV) into the cells with a microbicidal gel, stabilizing the viral load or even destroying the infected cells. The microbicidal gel was successfully tested on an animal model at CEA-Institute Jacob . Health & life sciences ; AIDS ; Infectious diseases general public ; Journalists ; Researchers IBS Scientific result Tue, 07 Feb 2017 11:00:00 GMT Reducing the Virulence of the Vaccinia Virus https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/Reducing-the-Virulence-of-the-Vaccinia-Virus.aspx Molecules developed at CEA-Institute Joliot can block the formation of the most virulent viral particles of vaccinia, a model of interest for the smallpox virus. Health & life sciences ; Infectious diseases general public ; Journalists ; Researchers IBS Scientific result Thu, 02 Feb 2017 11:00:00 GMT In search of a Zika vaccine https://www.cea.fr/drf/english/Pages/News/Institutional-news/2017/in-search-of-a-zika-vaccine.aspx A consortium composed of CEA, the European Vaccine Initiative, Institut Pasteur and Themis Bioscience is launching the Zikavax project, with the goal of developing a vaccine against infection by the Zika virus. Health & life sciences ; Vaccine ; Infectious diseases general public ; Journalists ; Researchers Jacob Highlight Tue, 10 Jan 2017 11:00:00 GMT Bacteria, Medley Swimming Champions https://www.cea.fr/drf/english/Pages/News/Scientific-results/2017/bacteria-medley-swimming-champions.aspx In a study at the interface of physics and biology, a team from CEA-BIG has characterized the swimming behavior of bacteria in the vicinity of cells. Their work contributes to an improved understanding of the infectious potential of bacteria, and possibly to the development of a new anti-infective strategy. Health & life sciences ; Infectious diseases general public ; Journalists ; Researchers BIG Scientific result Wed, 04 Jan 2017 11:00:00 GMT Ebola eZYSCREEN: a diagnostic “field” test https://www.cea.fr/drf/english/Pages/News/Scientific-results/2014/Ebola-eZYSCREEN-a-diagnostic-field-test.aspx A team from the CEA-IBEB has developed a rapid immunological test of the Ebola virus. Validated at the Laboratoire Jean Mérieux (Inserm), this test will be industrialized by VEDALAB. Infectious diseases ; Diagnosis and innovative treatment Marcoule Scientific result ; Industrial partnerships Wed, 22 Oct 2014 10:00:00 GMT Towards a vaccine to stop Chikungunya https://www.cea.fr/drf/english/Pages/News/Scientific-results/2014/Towards-a-vaccine-to-stop-Chikungunya.aspx A European consortium, of which the CEA-IMETI is a member, has developed a vaccine against the Chikungunya virus and tested it in a rodent model. Trials in humans could begin in 2015. ​ Vaccine ; Chikungunya IMETI Scientific result Wed, 12 Feb 2014 11:00:00 GMT 400 exomes sequenced https://www.cea.fr/drf/english/Pages/News/Scientific-results/2013/400-exomes-sequenced.aspx 400 exomes were sequenced by the CEA-IG-CNG through a partnership with the Fondation maladies rares. Genomics ; Autoimmune diseases ; Neurodegenerative diseases ; Infectious diseases Fontenay-aux-Roses Scientific result Fri, 13 Dec 2013 11:00:00 GMT