The François Jacob Institute of Biology brings together five departments and three services
The last two years in scientific news
Metagenomics of prokaryotes
The Laboratory for the Metagenomics of Prokaryotes (LMP) is currently focusing much of its activity on the study of recalcitrant xenobiotic degradation including that of chlordecone.
The LMP initiated the "Cloaca maxima" project designed to study the biodiversity of the microorganisms involved in waste water treatment. The LMP has set up environmental genomic and metagenomic methods for that purpose. The aim of the program was to inventory the microorganisms, genes and enzymes responsible for the principal stages in water treatment and use that metagenomic resource to characterize new enzymes and metabolic pathways of particular interest with respect to anaerobic metabolism.
The LMP is also addressing the diversity of eukaryotes present in sewage plants, in particular through the Pegasus project.
The LMP has contributed to national and international metagenomic projects: microorganisms essential in the nitrogen cycle, sediment contaminated by arsenic, human intestinal microbiome and soil microbiome.
The Laboratory has also contributed to sequencing key microorganisms in the nitrogen cycle. In most cases, the bacteria had never been isolated in pure cultures and had thus retained "Candidatus" status.
The work was implemented in cooperation with the teams of :
- Marc Strous and Mike Jetten
- Holger Daims and Michael Wagner
"Candidatus Kuenenia stuttgartiensis"
"Candidatus Methylomirabilis oxyfera"
"Candidatus Nitrospira defluvii"
"Candidatus Nitrosotenuis uzonensis"
The project was implemented in cooperation with Philippe Bertin, University of Strasbourg, and received financing from the National Research Agency (ANR).
The work was conducted in cooperation with Tim Vogel and Pascal Simonet, Ecole Centrale, Lyon, and received ANR financing.
MetaHit Human intestinal microbiome: MicroObes and MetaHit projects
The work was conducted in cooperation with Joël Doré and Dusko Ehrlich, INRA, Jouy-en-Josas.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.