François Jacob Institute of biology - On the same theme https://jacob.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/Revising-dogma-primate-brain-evolution.aspx Website of the François Jacob Institute of Biology en-US https://jacob.cea.fr/drf/ifrancoisjacob/SiteAssets/logo-cea-JACOB.png François Jacob Institute of biology - On the same theme https://jacob.cea.fr/drf/ifrancoisjacob/english A passive immunization approach prevents SHIV infection https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/passive-immunization-shiv-infection.aspx In a study published in Nature Communications, IDMIT researchers demonstrated the efficacy of a neutralizing antibody against cell-associated infection by simian-human immunodeficiency virus. AIDS ; Infectious diseases ; Vaccine Researchers ; Journalists DRF Scientific result ; Highlight immunization;SHIV;HIV;preclinical studies;Antibody;bNAb;AIDS; Wed, 01 Nov 2023 11:00:00 GMT Rad51-mediated homologous recombination: insights into aging and tumorigenesis https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/rad-medited-homologous-recombination-aging-tumorigenesis.aspx Using a murine preclinical model wherein Rad51 was selectively inhibited, researchers from the Laboratory of Development of the Gonads (iRCM:CEA-Jacob) and the Institut Cochin showed that in vivo alteration of Rad51-mediated homologous recombination does not favor the development of cancers, it reduces it. The team's work was published in The Embo Journal. Cellular mechanisms ; Stress response ; DNA Researchers ; Journalists IRCM Scientific result ; Highlight DNA;homologous recombination;premature aging; Wed, 18 Oct 2023 10:00:00 GMT The nuclear pore: a safe place for gene expression https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/nuclear-pore-safe-place-gene-expression.aspx In an article published in Nature Communications, researchers from Institut Jacques-Monod and iRCM (CEA-Jacob) merged imaging and biochemistry approaches to show that the genes involved in expression are conducted to nuclear pores in order to protect the genome. DNA ; Cellular mechanisms ; Molecular mechanisms Researchers ; Journalists IRCM Highlight ; Scientific result R-loop;RNA;gene;nuclear; Tue, 03 Oct 2023 10:00:00 GMT COVID-19: targeting the nuclear ACE2 pathway in SARS-CoV-2 infection https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/covid-receptor-ace-infection.aspx In a new study published in Nature Communications, researchers from IDMIT and the QIMR Berghofer Institute have shown that a peptide able to inhibit the nuclear ACE2 receptor provides protection against SARS-CoV-2 infection. Infectious diseases Researchers ; Journalists DRF Highlight ; Scientific result Inflammation;infection;COVID-19;SARS-CoV-2;nace2i;ace2;preclinical studies;infectious diseases; Wed, 19 Jul 2023 10:00:00 GMT Sotrovimab remains efficacious against the BQ.1.1 omicron subvariant of SARS-CoV-2 https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/Sotrovimab-efficacious-omicron-subvariant-sars-cov-2.aspx In a study published in Heliyon, researchers from IDMIT (CEA-Jacob) used a well-characterized non-human primate model to show that sotrovimab is efficacious against the BQ.1.1 subvariant of SARS-CoV-2. Their results lend support for the continued use of sotrovimab in patients ineligible for nirmatrelvir/ritonavir. Infectious diseases ; Virus Researchers ; general public ; Journalists IDMIT Highlight ; Scientific result COVID-19;Monoclonal antibodies;subvariants;omicron;SARS-CoV-2; Wed, 05 Jul 2023 10:00:00 GMT When a sporadic event changes the course of Alzheimer's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/sporadic-event-changes-course-Alzheimer-disease.aspx In a new study performed in a mouse model and published in Acta Neuropathologica Communications, researchers from the LMN (MIRCen/CEA-Jacob) have shown that the experimental transmission of abnormal amyloid-β proteins accelerates, over time, the development of cerebral lesions and memory disorders. Brain ; Neurodegenerative diseases Researchers ; Journalists DRF Scientific result ; Highlight Brain;preclinical studies;Alzheimer's Disease;amyloid deposits; Mon, 03 Jul 2023 10:00:00 GMT An Alzheimer's model to study the propagation of the pathological forms of tau https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/Alzheimer-propagation-forms-pathological-Tau-.aspx In an article published in Neurobiology of Disease, researchers from MIRCen's Neurodegenerative Diseases Laboratory present a novel model of Alzheimer's disease that enables the study of tauopathy inter-neuronal propagation mechanisms, the identification of new therapeutic targets and the exploration of new treatments. Neurodegenerative diseases ; Alzheimer's disease ; Cellular mechanisms Researchers ; general public ; Journalists MIRcen Highlight ; Scientific result Alzheimer Disease;Cellular biology;tau protein;AAV; Fri, 16 Jun 2023 10:00:00 GMT XLF/Cernunnos: premature neurogenesis and delayed brain development https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/xlf-cernunnos-premature-neurogenesis-brain-development.aspx In a work published in Cell Reports, researchers from the SGCSR mixed research unit (IRCM) have shown that the loss of XLF (a.k.a. Cernunnos), a component of the non-homologous end-joining complex, severely alters brain development and function in mice. Cellular mechanisms ; Stem cells ; Stress response ; Brain ; Cell division Researchers ; general public ; Journalists IRCM Highlight ; Scientific result neural progenitor cells;DNA repair;genome stability;mitosis;NHEJ;neurogenesis;microcephaly;brain development; Fri, 21 Apr 2023 10:00:00 GMT Mirusvirus : at the crossroads of evolution https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/mirusvirus-crossroads-evolution.aspx Using samples collected during the Tara Oceans expeditions and sequencing "big data" generated by Genoscope, an international research team has discovered an important group of DNA viruses living among ocean surface plankton. Published in Nature, this discovery brings novel opportunities for the field of ecology and the elucidation of DNA virus evolution pathways, in the seas and beyond. Genomics ; Metagenomics ; Bioinformatic ; Oceanography ; Biodiversity ; Environment Researchers ; general public ; Journalists GENOSCOPE Highlight ; Scientific result Tara Oceans;viruses;metagenome;DNA;ocean;Evolution;biodiversity;plankton; Thu, 20 Apr 2023 10:00:00 GMT LMN/MIRCen team wins "Équipe FRM 2023" accreditation https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2023/lmn-mircen-frm-team.aspx Carole Escartin's Reactive Astrocytes team (UMR9199, Neurodegenerative Diseases Laboratory, MIRCen) has received the Équipe FRM 2023 label for its project on the role of astrocytes in the control of neuronal activity. Institutional ; Fundamental Research ; Brain ; Diagnosis and innovative treatment ; Gene and cell therapy ; Alzheimer's disease Researchers ; Journalists ; general public DRF Live in the center ; Highlight astrocytes;Alzheimer's Disease; Wed, 29 Mar 2023 10:00:00 GMT A key complex for the repair of single-strand DNA gaps at replication forks https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/complex-repair-single-strand-DNA-replication-forks.aspx Researchers from iRCM identified new key proteins involved in the repair of single-strand DNA gaps, which occur when base lesions hamper DNA replication mechanisms. Molecular mechanisms ; DNA ; Fundamental Research Researchers ; general public ; Journalists SCSR Highlight ; Scientific result Yeast;replication;mutagenesis;Molecular mechanisms;DNA repair; Fri, 24 Mar 2023 11:00:00 GMT A model to better understand oogenesis and female infertility https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/model-oogenesis-femaile-infertility.aspx In a work published in Cells, researchers from LDG (IRCM) used human induced pluripotent stem cells to develop an in vitro model capable of reproducing the early stages of oogenesis. Cellular mechanisms ; Stem cells ; Cell division Researchers ; Journalists ; general public SCSR Highlight ; Scientific result induced pluripotent stem cells;oogenesis;infertility;primordial germ cells;podoplanin;model; Thu, 16 Mar 2023 11:00:00 GMT The role of epigenetics in tree-fungus symbiosis https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/epigenetics-tree-fungus-symbiosis.aspx Working with a model poplar line, researchers from the University of Orléans, Inrae, the University of Lorraine and CEA-Jacob's CNRGH have shown that the tree's epigenetics controls the development of ectomycorrhizas, i.e., the symbiotic relationship between the roots of certain trees and soil fungi. Environment ; Agronomy ; Molecular mechanisms ; Epigenetics Researchers ; Journalists DRF Highlight ; Scientific result dna methylation;Tree;Fungus;mycorrhization;epigenetics; Mon, 06 Mar 2023 11:00:00 GMT Marine microbiome : Genoscope contributes to the European project BlueRemediomics https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2023/microbiome-marin-genoscope-blueremediomics.aspx Launched in December 2022, the European project BlueRemediomics aims to valorize currently unexploited marine microbial resources. The four-year project brings together an international consortium of experts, including the Genomics Metabolics mixed research unit (Genoscope/CEA-Jacob), and enables the development of novel tools and approaches to explore marine microbiome data. Biodiversity ; Oceanography ; Genomics ; Environment Researchers ; Journalists DRF Live in the center ; Highlight biodiversity;marine microorganisms;marine microbiome;blueremediomics;genome;metagenome;ecosystem; Fri, 17 Feb 2023 11:00:00 GMT A duo of monoclonal antibodies for Sjögren syndrome https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/duo-monoclonal-antibodies-Sjogren-syndrome.aspx In a clinical trial, the IMVA-HB/IDMIT autoimmune team (UMR-S 1184 CEA/Inserm/UPSaclay/Kremlin Bicêtre Hospital) headed by Xavier Mariette has demonstrated the therapeutic benefits of the association of rituximab and belimumab for the treatment of Sjögren syndrome. Immune system Researchers ; Journalists DRF Highlight ; Scientific result autoimmune disease;b lymphocytes;Sjögren syndrome;Monoclonal antibodies; Mon, 06 Feb 2023 11:00:00 GMT MXD4/MAD4 : a target of interest for ex vivo stem cell preservation https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/MXD4-MAD4-stel-cell-preservation.aspx In a study published in the Journal of Investigative Dermatology, researchers from LGRK (iRCM) identified the transcription factor MXD4/MAD4 as an element of the pathway regulating the stemness of keratinocyte precursors and their skin regeneration capacities. Diagnosis and innovative treatment ; Stem cells Researchers ; Journalists ; general public DRF Scientific result ; Highlight MXD4/MAD4;bioengineering;skin;skin repair;graft;stemness;cutaneous; Fri, 03 Feb 2023 11:00:00 GMT In utero germ-cell exposure to bisphenols: a role for oxidative damage in oocyte aneuploidy https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/in-utero-germ-cell-exposure-bisphenols-oocyte-aneuploidy.aspx In a work published in Environmental Pollution, researchers from iRCM's LDG laboratory explored the effects of exposure to two bisphenol A substitutes, BADGE and BPAF, on murine germ cells, and more specifically on oocytes and their precursors. DNA ; Toxicology ; Impacts on living (organisms) Researchers ; Journalists IRCM Highlight ; Scientific result bisphenol;germ cells;oocyte;oogenesis;oxidative lesions;DNA;aneuploidy; Tue, 17 Jan 2023 11:00:00 GMT Retinoic acid receptors and neuronal differentiation: white-hat hijacking https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/retinoic-acid-receptors-neuronal-differentiation.aspx In a study published in Life Science Alliance, Genoscope researchers paired cell engineering and transcriptomics to explore gene regulatory programs driven by retinoic acid receptors and what role they play in neuronal differentiation. Brain ; Transcriptomics Researchers ; Journalists DRF Scientific result ; Highlight neuronal differentiation;retinoic acid receptor;gene regulatory programs;stemcelles;Brain; Tue, 20 Dec 2022 11:00:00 GMT On the path toward a chikungunya vaccine https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/chikungunya-vaccine.aspx In a study published in JCI Insight, researchers from IDMIT have demonstrated the vaccinal effectiveness of serum transfers from volunteers vaccinated against the chikungunya virus to an animal model. This work is an important step toward vaccine marketing approval, as the nature of chikungunya epidemics hampers the deployment of conventional efficacy trials. Health & life sciences ; Vaccine ; Infectious diseases ; Chikungunya Researchers ; Journalists DRF Scientific result ; Highlight vaccine;chikungunya;idmit; Fri, 16 Dec 2022 11:00:00 GMT Primary hyperaldosteronism and arterial hypertension : the genome under a microscope https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/primary-hyperaldosteronism-hypertension-genome.aspx For a study they published in Nature Communications, researchers from the CNRGH and PARCC joined forces to unprecedentedly identify genome loci associated with a risk of primary hyperaldosteronism (PHA), the most frequent cause of secondary arterial hypertension. Genomics Researchers ; Journalists ; general public DRF Scientific result ; Highlight genome loci;hypertension;aldosterone;primary hyperaldosteronism; Wed, 30 Nov 2022 11:00:00 GMT An in vitro model to study infertility https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/in-vitro-model-study-infertility.aspx In a work published in Scientific Reports, researchers from IRCM, the Sup'Biotech/SEPIA partnership lab and Imagine Institute teamed to develop an in vitro, model of infertility wherein induced pluripotent stem cells generated from the erythroblasts of infertile men presenting genetic abnormalities were used to successfully generate primordial germ-like cells. Diagnosis and innovative treatment ; Stem cells Researchers ; Journalists ; general public IRCM Highlight ; Scientific result stem cells;infertility;azoospermia; Mon, 28 Nov 2022 11:00:00 GMT Tauopathy in Alzheimer's disease: a new target https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/tauopathy-Alzheimer-disease-new-target.aspx In a new collaborative study published in Scientific Reports, researchers from the Gly-CRRET Laboratory (UPEC) and SEPIA (CEA-Jacob) deployed a novel cellular model to describe the induction of the autonomous abnormal aggregation of tau protein following the expression of HS3ST2. Neurodegenerative diseases Researchers ; Journalists ; general public DRF Scientific result ; Highlight Alzheimer;Alzheimer's Disease;tau protein;pebv;cellular and molecular imaging;Cellular biology; Fri, 04 Nov 2022 11:00:00 GMT IDMIT Director Roger Le Grand joins the new Committee For Health Risk Monitoring and Anticipation (COVARS) https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2022/Roger-Le-Grand-member-COVARS.aspx IDMIT (CEA-Jacob) Director Roger Le Grand has joined COVARS, a consultative body to guide decisions made by public entities on the anticipation, prevention and human consequences of health crises. Science & society ; Infectious diseases ; Institutional Researchers ; Journalists ; general public DRF Live in the center ; Highlight zoonotic disease;human infectious diseases;scientific committee;COVARS; Fri, 14 Oct 2022 10:00:00 GMT ATLASea selected for Priority Programs and Equipment for Research action https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2022/ATLASea-Priority -Programs -equipment-reesearch.aspx The ATLASea program, forwarded by Genoscope (CEA-Jacob/CNRS), has been chosen as a laureate of the Priority Programs and Equipment for Research action. The program's objective is to sequence and analyze the genomes of 5,000 marine species. Genomics ; Environment ; Biodiversity ; Large-scale biology Researchers ; Journalists ; general public DRF Live in the center ; Highlight genomics;marine species;ATLASea;PEPR;sequencing; Wed, 27 Jul 2022 10:00:00 GMT IDMIT partner of the European consortium INDENEO in the framework of the Rare Disease Research Challenge Call https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2022/IDMIT-consortium-INDENEO-rare-disease.aspx Following the Rare Disease Research Challenge Call launched by the European Joint Programme for Rare Disease and the Rare Disease Foundation, the European INDENEO consortium project has been selected to respond to the challenge targeting the development of a system for intranasal administration of biological drugs to newborns. Among the partners of this project, IDMIT brings its expertise in preclinical trials. Brain Researchers ; Journalists ; general public Jacob Live in the center ; Highlight Brain;preclinical research;neonatology; Wed, 13 Jul 2022 10:00:00 GMT The French Academy of Sciences recognizes work in climate genomics https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2022/french-academy-sciences-work-climate-genomics.aspx In June 2022, six young researchers were recognized for their major scientific contributions to biology at the French Academy of Sciences' "Great French Advances in Biology" event. Among them was Paul Frémont, PhD student at Genoscope (CEA-Jacob) and LSCE. Genomics ; Climate Researchers ; Journalists ; general public LSCE Prizes and awards ; Live in the center climate;genomics; Mon, 04 Jul 2022 10:00:00 GMT Genoscope takes part in the first D4GEN Hackathon https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2022/Genoscope-D4GEN-Hackathon.aspx Genopole held its first D4GEN Hackathon on 19–21 May 2022 with the goal of creating interdisciplinary, computational genomics communities aimed particularly at the sharing, preservation and (re)use of genomics Big Data. Jérôme Arnoux, PhD student at LABGeM (Genoscope), led the team that took home the third-place prize from that competition. Genomics Researchers ; Journalists ; general public DRF Live in the center ; Highlight hackathon;genomics; Wed, 08 Jun 2022 10:00:00 GMT Does the menstrual cycle affect the risk of STIs? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/menstrual-cycle-risk-STI.aspx Researchers from IDMIT describe the course of immune & inflammatory markers and the vaginal microbiome during the menstrual cycle. Infectious diseases ; Cellular mechanisms ; Immune system Researchers ; Journalists ; general public IDMIT Scientific result ; Highlight bacteria;HIV;HIV-AIDS;Infectious Disease;immune response;cellular immune responses;viruses;therapy; Fri, 20 May 2022 10:00:00 GMT CEA-Jacob involved in a new program dedicated to beetle genetics https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2022/CEA-Jacob-involved-program-beetle-genetics.aspx CEA-Jacob is collaborating with Ÿnsect in an industrial program, ŸNFABRE, devoted to the genetics of the Tenebrio Molitor beetle larva. This program has been awarded funding under the "Structuring Projects for Competitiveness" program of the French government's investment program for the future (PIA), operated by Bpifrance. It is in line with the actions carried out by Ÿnsect and the CEA, recently supported by Horizon H2020 and the ANR. Genomics Researchers ; Journalists ; general public DRF Highlight ; Live in the center tenebrio molitor;genetic selection;beetle;mealworm;sequencing; Thu, 19 May 2022 10:00:00 GMT Uncultured planktonic eukaryotes finally reveal their secrets https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/uncultured-planktonic-eukaryotes-secrets.aspx With massively parallel sequencing of DNA collected from the surfaces of the earth's oceans and seas (Tara Oceans expeditions) and more than ten years of analysis, an international team piloted by researchers from Genoscope (CEA-Jacob) and the CNRS has solved one of environmental biology's greatest puzzles. Environment ; DNA ; Oceanography Researchers ; Journalists ; general public GENOSCOPE Highlight ; Scientific result Tara Oceans;plankton;DNA;eukaryotic;Environmental impact;genomic;eukaryotes; Fri, 29 Apr 2022 10:00:00 GMT ComFC, a key protein in the transmission of antibiotic resistance among bacteria https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/ComFC-transmission-antibiotic-resistance-bacteria.aspx A team of researchers from IRCM (CEA-Jacob) and I2BC have shed light on the role of ComFC, a bacterial protein involved in natural transformation, itself a driving mechanism for the propagation of antibiotic resistance genes and virulence factors. Cellular mechanisms ; Molecular mechanisms ; Antibiotics Researchers ; general public ; Journalists SCSR Highlight ; Scientific result bacteria;Antibiotic;Antibiotic Resistance;Molecular mechanisms; Tue, 19 Apr 2022 10:00:00 GMT Do other primates daydream like we do? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/primates-daydream.aspx In an article published in Cell Reports, an international team including researchers from MIRCen showed that a cerebral network associated with highly elaborate cognitive capacities in humans differs from the comparable network in non-human primates. Brain ; Cognition Researchers ; Journalists ; general public DRF Scientific result ; Highlight Evolution;Brain;Primate;cognition;MRI;IRM;Imaging; Wed, 13 Apr 2022 10:00:00 GMT 'FRM 2022 team': an iRCM team awarded the label https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2022/team-iRCM-label-FRM-2022.aspx Stéphane Marcand's team (Telomeres and Chromosome Repair Laboratory / UMR SGCSR - iRCM) has just been labelled 'FRM 2022 Team' for its project on the regulation of DNA repair at telomeres and its consequences on genome stability. DNA ; Institutional ; Fundamental Research Researchers ; Journalists ; general public DRF Live in the center ; Highlight DNA repair;chromosome;telomere; Tue, 12 Apr 2022 10:00:00 GMT Preclinical multimodal imaging and Huntington's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/preclinical-multimodal-imaging-huntington-disease.aspx A preclinical multimodal imaging study conducted by the Neurodegenerative Diseases Laboratory (LMN/MIRCen) and published in Human Molecular Genetics has shed light on cerebral alterations in Huntington's disease. Neurodegenerative diseases ; MRI Researchers ; Journalists ; general public DRF Highlight ; Scientific result gluCEST;Imaging;huntington;Brain;brain imaging;cerebral; Tue, 12 Apr 2022 10:00:00 GMT 5,500 new RNA virus species identified in the world's oceans https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/RNA-virus-species-world-oceans.aspx Working from 35,000 worldwide water and plankton samples collected by the Tara Oceans Expeditions and sequenced by Genoscope,, an international team of researchers has identified 5,500 new RNA virus species and met the challenge of their phylogenetic classification. The team's work was published in Science. Genomics ; Metagenomics ; Bioinformatic ; Transcriptomics ; Oceanography ; Environment Researchers ; Journalists ; general public GENOSCOPE Scientific result ; Highlight Tara Oceans;plankton;RNA;ocean;biodiversity;viruses;ecosystem; Fri, 08 Apr 2022 10:00:00 GMT The beneficial role of reactive astrocytes in Huntington's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/huntington-disease-reactive-astrocytes.aspx In a new study published in Brain, researchers MIRCen used mouse models of Huntington's disease to show that stimulating reactive astrocyte formation favors the elimination of mutant huntingtin protein, reducing both the quantity and size of the aggregates. Neurodegenerative diseases ; Diagnosis and innovative treatment Researchers ; Journalists ; general public MIRcen Scientific result ; Highlight huntington;neuron;reactive astrocytes;astrocytes;JAK2-STAT3;huntingtin;preclinical research; Mon, 28 Mar 2022 10:00:00 GMT Phthalate exposition during pregnancy and DNA methylation https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/phthalate-exposition-pregnancy-DNA-methylation.aspx The Epigenetic and Environment Laboratory (CNRGH) was part of a study that characterized associations between placental DNA methylation and the concentrations of 11 phthalate-derived metabolites in urine samples from pregnant women. The samples used for the analysis, published in Environment International, were obtained from EDEN, a cohort of French mothers and children. Epigenetics ; DNA Researchers ; Journalists ; general public DRF Highlight ; Scientific result epigenetic;DNA;methylation;phtalate;pregnancy; Tue, 08 Mar 2022 11:00:00 GMT Gene editing to pull the plug on HLA-G: a novel antitumoral? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/gene-editing-HLAG-antitumoral.aspx As part of a international partnership, researchers from SRHI have shown that Crispr/Cas9 can be used to inactivate HLA-G expression in human cancer cell lines. Their unprecedented findings, published in Scientific Reports, suggest the possibility of novel treatment strategies to supplement current tumor immunotherapies. Cancer ; Immune system general public ; Journalists ; Researchers DRF Highlight ; Scientific result crispr-cas9;HLA-G;Cancer;immune checkpoint;Immune system;gene editing;Tumor; Tue, 22 Feb 2022 11:00:00 GMT A protein-based candidate vaccine prevents SARS-CoV-2 transmission in preclinical trials https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/protein-candidate-vaccine-prevents-SARS-CoV-2.aspx Preclinical trials carried out as part of a CEA-Irig–CEA-Jacob partnership have shown that a spike-protein-based candidate vaccine provides complete protection against SARS-CoV-2 infection. Infectious diseases Researchers ; Journalists ; general public IDMIT Scientific result ; Highlight COVID-19;Spike;SARS-CoV-2;vaccine;preclinical research;Lipids; Mon, 21 Feb 2022 11:00:00 GMT Homologous recombination or non-homologous end joining? Sir3 points the way https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/homologous-recombination-Sir3.aspx Researchers from IRCM furnish initial information on the mechanisms regulating DNA double-strand break repair in yeast heterochromatin. Sir3 plays an essential role in the choice of a repair pathway. Molecular mechanisms ; DNA Researchers ; general public ; Journalists IRCM Highlight ; Scientific result Molecular mechanisms;DNA repair;genome stability;heterochromatin; Wed, 09 Feb 2022 11:00:00 GMT Inflammation and COVID-19: the HLA-G immune checkpoint under surveillance https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/inflammation-Covid-19-HLA-G-checkpoint-immune-surveillance.aspx In a study published in Viruses, a team of researchers from SRHI and the University of Ferrara (Italy) showed that the soluble form of HLA-G may contribute significant anti-inflammatory properties via its role in controlling the adhesion of neutrophils to endothelial cells and thus improve disease outcome in patients with COVID-19. Infectious diseases ; Cellular mechanisms Researchers ; Journalists ; general public SRHI Scientific result ; Highlight HLA-G;COVID-19;endothelial cells;Angiogenesis;neutrophil; Tue, 11 Jan 2022 11:00:00 GMT HLA-G : a new therapeutic target in cancer https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/HLA-G-therapeutic-target-cancer.aspx In a study published in Cancer Letters, SRHI's researchers (CEA-Jacob) highlight the therapeutic value of targeting the HLA-G/IL2 immune checkpoint in clear cell renal cell carcinoma. Immune system ; Cancer Researchers ; Journalists ; general public DRF Scientific result ; Highlight therapeutic antibodies;HLA-G;immune checkpoint;Cancer; Tue, 24 Aug 2021 10:00:00 GMT A marine neurotoxin, seafood contaminant, is able to cross physiological barriers https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/Pinnatoxin-crosses-physiological-barriers.aspx In a study published in Science of the Total Environment, researchers from SIMoS (DMTS/CEA-Joliot), in collaboration with the Faculty of Pharmacy of Paris and MIRCen (CEA-Jacob) have shown for the first time in an animal model the capacity of Pinnatoxin-G, a marine neurotoxin, to cross physiological barriers to reach its molecular targets. Toxicology ; Impacts on living (organisms) Scientific result Thu, 05 Aug 2021 10:00:00 GMT The metabolic cooperation of astrocytes and neurons fashions brain activity https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/metabolic-cooperation-astrocytes-neurons-brain-activity.aspx In a review published in Cell Metabolism, Gilles Bonvento (LMN/MIRCen/CEA-Jacob) and Juan P. Bolaños (IBFG/University of Salamanca) present the latest findings on astrocyte-neuron metabolic cooperation and how it affects brain function. Brain Researchers ; Journalists ; general public DRF Scientific result ; Highlight Brain;metabolism;astrocyte;neurons; Tue, 03 Aug 2021 10:00:00 GMT Trees, drought tolerance and epigenetics https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/Trees-drought-tolerance-epigenetics.aspx A team of researchers from Inrae, Orleans University, the University of Oregon (USA), CEA-Jacob and IRD studied the role of epigenetics in drought tolerance in poplars. Their results, published in New Phytologist, suggest that epigenetic changes during droughts affect the genes involved in the tree's hormonal response to water deficits and may result in genetic mutations. Epigenetics ; Environment ; Climate Researchers ; Journalists ; general public DRF Scientific result ; Highlight Drought;Trees;epigenetic;climate change;poplars;hormonal response;DNA;methylation; Mon, 05 Jul 2021 10:00:00 GMT Diffusion MRI characterizes radiation-induced neurological impairments https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/diffusion-MRI-characterizes-radiation-induced-neurological-impairments.aspx A team comprising iRCM (CEA-Jacob) and NeuroSpin (CEA-Joliot) researchers analyzed the consequences of irradiation on brain development and neurogenesis in a preclinical model. That work, published in Radiation Research, lays a path for the use of diffusion imaging for the early detection of neurological abnormalities resulting from different types of stress. Brain ; Impacts on living (organisms) ; MRI ; Biomarkers ; Radiobiology Researchers ; Journalists ; general public DRF Scientific result ; Highlight ionizing radiations;Brain;neurodevelopmental disorder;neurogenesis;MRI;structural MRI;diffusion MRI; Thu, 24 Jun 2021 10:00:00 GMT MULTILAYER: a new tool to digitize biological tissues https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/Multilayer-tool-digitize-biological-tissues.aspx In a study published in Cell Systems, the SysFate laboratory (UMR8030/Genoscope/CEA-Jacob) presented MULTILAYER, an algorithm that provides digital functional maps of biological organs or tissues. Genomics ; Cell and molecular imaging Researchers ; Journalists ; general public DRF Highlight ; Scientific result digitize;multilayer;spatial transcriptomics; Tue, 15 Jun 2021 10:00:00 GMT CEA contributing to the European AI-powered personalized medicine project KATY https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2021/CEA-contributing-European-AI-powered-personalized-medicine-project-KATY.aspx The institutes IRIG and Jacob of the CEA's Fundamental Research Division and CEA-List joined forces to participate in KATY, a European Horizon 2020 project aimed at creating an artificial-intelligence-powered personalized medicine program. Diagnosis and innovative treatment ; Methodologies for life sciences Researchers ; general public ; Journalists Live in the center Mon, 14 Jun 2021 10:00:00 GMT The telomere mystery: a protection mechanism decrypted https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/telomere-mystery-protection-mechanism-decrypted.aspx The mechanisms that control the stability of telomeres, structures located at the ends of chromosomes, remain largely mysterious. One of them however has been decrypted by researchers from IRCM (CEA-Jacob) and I2BC (CEA-Joliot) in a work carried out in yeasts. Their results, published in Nature Communications, could help identify new therapeutic targets in human cancers. Molecular mechanisms ; DNA ; Cancer Researchers ; Journalists ; general public SCSR Highlight ; Scientific result telomere;Yeast;DNA repair;chromosome stability;modeling;genetic;Cancer;DNA; Thu, 27 May 2021 10:00:00 GMT Beta thalassemia: toward a more effective therapeutic strategy https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/beta-thalassemia-more-effective-therapeutic-strategy.aspx In a study published in Molecular Therapy, LCSAT (IDMIT, CEA-Jacob) researchers present a novel, optimized, lentiviral gene therapy for β-thalassemia. Gene and cell therapy Researchers ; general public ; Journalists STI Scientific result ; Highlight lentiglobin;lentiviral gene therapy;beta-thalassemia;he; Thu, 20 May 2021 10:00:00 GMT A potential therapeutic role for PPAR-γ in myelofibrosis https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/potential-therapeutic-role-PPAR-gamma-myelofibrosis.aspx In a study published in the Journal of Clinical Investigation, researchers from IDMIT's LCSAT lab (CEA-Jacob) evaluated PPAR-γ ligands in the development of myelofibrosis. Diagnosis and innovative treatment ; Cancer Researchers ; Journalists ; general public IDMIT Scientific result ; Highlight therapy;Inflammation;myeloid cells;PPAR-γ;Hematopoietic stem cells;fibrosis; Tue, 18 May 2021 10:00:00 GMT "Fingerprints" to differentiate pathogenic alpha-synuclein aggregates https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/fingerprints-pathogenic-alpha-synuclein-aggregates.aspx In a study published in JBC, researchers from MIRCen (CEA-Jacob) deployed a range of techniques to map the surfaces of various pathogenic alpha-synuclein aggregates, establishing thus "fingerprints" specific to each aggregate. Brain ; Parkinson's disease ; Neurodegenerative diseases Researchers ; Journalists ; general public DRF Scientific result ; Highlight therapeutic targets;diagnosis;Parkinson;Parkinson's disease;Fingerprint;alpha-synuclein;Lewy body dementia; Wed, 12 May 2021 10:00:00 GMT COVID-19 durably affects the intestinal microbiota https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/COVID-19-affects-intestinal-microbiota.aspx The microbial composition and metabolome of the intestinal microbiota of an animal model for COVID-19 were altered over the disease course and remained so after the resolution of lung infection. Those results, which will contribute were brought to light by the Institut Pasteur in Lille in partnership with IDMIT (CEA-Jacob). Infectious diseases ; Metagenomics Researchers ; Journalists ; general public DRF News ; Scientific result dysbiosis;intestinal microbiota;COVID 19;SARS-CoV2; Wed, 05 May 2021 10:00:00 GMT Role of salivary epithelial cells in the pathogenesis of primary Sjögren syndrome https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/salivary-epithelial-cells-pathogenesis-primary-Sjogren-syndrome.aspx The UMR1184S Autoimmune Diseases Team (IDMIT CEA-Jacobl) has published an article in Arthritis & Rheumatology confirming a direct pathogenic role for salivary epithelial cells in primary Sjögren syndrome. Immune system ; Autoimmune diseases Researchers ; Journalists ; general public DRF Scientific result primary Sjörgren syndrome;salivary epithelial cells;autoimmune disease;Interferon; Mon, 03 May 2021 10:00:00 GMT Cellular prion protein at the heart of radioresistance in solid tumors https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/cellular-prion-protein-radioresistance-solid-tumors.aspx In an article published in Oncogene, researchers from LRTS and LRIG (IRCM/CEA-Jacob) have shown that an increase in the expression of cellular prion protein driven by the ATM/TAK1/JUNK signaling pathway contributes to solid tumor radioresistance. Radiotherapy ; Radiosensitivity ; Cancer Researchers ; Journalists ; general public DRF Scientific result prion;DNA damage;DNA damage response;cellular prion protein;ionizing radiation;radioresistance; Wed, 28 Apr 2021 10:00:00 GMT Tau's wanderlust in neurodegenerative diseases https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/tau-neurodegenerative-diseases.aspx In an unprecedented work published in Brain, researchers from LMN (MIRCen/CEA-Jacob) showed that these abnormal tau proteins migrate from neurons to astrocytes, another type of cell within the brain, and remain toxic in the astrocytes as well. Neurodegenerative diseases ; Brain Researchers ; Journalists ; general public DRF Scientific result ; Highlight tau;astrocytes;Neurodegenerative disease;tauopathies;neuron; Mon, 12 Apr 2021 10:00:00 GMT Mapping DNA methylation in simian immunodeficiency virus infection https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/mapping-dna-methylation-simian-immunodeficiency-infection.aspx In a partnership with IDMIT (CEA-Jacob) and Institut Pasteur, the Epigenetic and Environment Laboratory (LEE; CNRGH/CEA-Jacob) carried out two studies to evaluate DNA methylation in non-human primate models of immunodeficiency virus infections. Virus ; Epigenetics Researchers ; Journalists ; general public DRF Scientific result ; Highlight HIV;epigenetic;SIV;methylation; Mon, 05 Apr 2021 10:00:00 GMT Targeting HIF1α or JMY in glioblastoma: if not one why not the other? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/HIF1-JMY-glioblastoma-targeting.aspx Glioblastomas are highly aggressive brain tumors with a very poor prognosis. Even with aggressive treatment, recurrence is nearly systematic. Researchers from IRCM (CEA-Jacob) have decrypted molecular mechanisms that enable treatment resistance and escape for a subpopulation of cells. Brain ; Cancer ; Stem cells Researchers ; Journalists ; general public SCSR Highlight ; Scientific result Brain;glioblastoma;Cancer;invasion;Tumor;ionizing radiations;HIF1α; Thu, 01 Apr 2021 10:00:00 GMT Astrocytes and α-synuclein in Parkinson's disease: when size matters https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/astrocytes-alpha-synuclein-Parkinson-size-matters.aspx Researchers from MIRCen (CEA-Jacob) have shown that exposure to alpha-synuclein aggregates may affect dopaminergic neuron survival in Parkinson's disease by reducing astrocyte support for them. Parkinson's disease ; Neurodegenerative diseases ; Brain Researchers ; Journalists ; general public Jacob Scientific result ; Highlight stem cells;Parkinson's disease;astrocytes;alpha-synuclein;aggregates;neuroinflammation; Mon, 29 Mar 2021 10:00:00 GMT Alpha-synuclein in Parkinson's disease : a versatile protein https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/alpha-synuclein-Parkinson-versatile-protein.aspx In an international collaboration, a team from MIRCen (CEA-Jacob) studied the properties of toxic alpha-synuclein aggregates in fixed brain samples from patients, depending on their tissue origin and the type of synucleinopathy developed. Brain ; Parkinson's disease ; Neurodegenerative diseases Researchers ; general public ; Journalists DRF Scientific result ; Highlight Parkinson's disease;proteolysis;enteric nervous system;Brain;alpha-synuclein;PMCA;transmission electron microscopy;protein misfolding; Thu, 18 Mar 2021 11:00:00 GMT Preclinical study sheds light on a new vaccine candidate for Covid-19 https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/preclinical-study-sheds-light-new-vaccine-candidate-Covid-19.aspx A new international study, published in Cell, co-leaded by IDMIT (CEA-Jacob) and the Department of Medical Microbiology of the University of Amsterdam, presents the results of preclinical trials of a new protein vaccine candidate against Covid-19. Infectious diseases ; Virus ; Vaccine Researchers ; Journalists ; general public DRF Highlight ; Scientific result COVID 19;SARS-CoV-2;vaccine;Nanoparticles;Preclinical; Mon, 08 Mar 2021 11:00:00 GMT Determining antibiotic resistance with artificial intelligence https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/determining-antibiotic-resistance-artificial-intelligence.aspx Under the coordination of the MSF Foundation, researchers and engineers from the University of Évry, the CEA, the CNRS, Médecins Sans Frontières and the Bacteriology/Virology Department of the Henri-Mondor hospital (AP-HP) teamed to develop a mobile application to ease the determination of antibiotic resistance.This application aimed at addressing a major public health issue will be freely available to medical personnel worldwide once clinically validated and CE certified. The demonstration of the technical feasibility of their approach was published on 19 February 2021 in Nature Communications. Antibiotics ; Artificial intelligence Researchers ; Journalists ; general public DRF Scientific result ; Highlight ; News Antibiotic Resistance;artificial intelligence;machine learning; Tue, 23 Feb 2021 11:00:00 GMT Lucile Ben Haïm wins support from Vaincre Alzheimer https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2021/Lucile-Ben-Haim-wins-support-from-Vaincre-Alzheimer.aspx Every year, the foundation Vaincre Alzheimer lends its support to promising projects in the battle against Alzheimer's disease. Among the six chosen this year is that of Lucile Ben Haïm of the Neurodegenerative Diseases Laboratory (MIRCen/CEA-Jacob). Her project involves targeting astrocytes to treat depression symptoms associated with this progressive neurological disorder. Alzheimer's disease Researchers ; Journalists ; general public Live in the center astrocyte;Alzheimer;Depression;reactive astrocytes; Wed, 17 Feb 2021 11:00:00 GMT Finally, a bit of agreement on reactive astrocytes ! https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/bit-of-agreement-reactive-astrocytes.aspx In an article entitled "Reactive astrocyte nomenclature, definitions, and future directions," published as a first consensus statement in the journal Nature Neuroscience, more than 80 international specialists, including Carole Escartin from LMN (MIRCen/CEA-Jacob) as first co-author, have established a nomenclature and definitions for reactive astrocytes. Brain ; Neurodegenerative diseases Researchers ; general public ; Journalists Highlight ; Scientific result neurons;Brain;neurodegenerative diseases;consensus;astrocytes;reactive astrocytes;Biomarkers; Mon, 15 Feb 2021 11:00:00 GMT The journal L'Édition of Université Paris-Saclay shines a light on stem cells https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2021/stem-cells-Edition-Universite-Paris-Saclay.aspx Read about the contributions of two François Jacob Institute of Biology laboratories in an article on human stem cells and their use in research published in the most recent edition of the journal L'Édition of Université Paris-Saclay. The article discusses the interest of stem cells for the development of novel disease models and potential therapies. Stem cells Researchers ; Journalists ; general public IRCM Live in the center stem cells; Sun, 14 Feb 2021 11:00:00 GMT A virus at home in parasitic wasps https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/virus-at-home-in-parasitic-wasps.aspx Genoscope was part of an international team that assembled the genome of Cotesia wasps and identified therein chromosomal colonization by a virus that settled into the wasp genome a hundred-million years ago. Their results suggest that the evolutionary course of a virus integrated within the genome of a eukaryote changes completely when the former is beneficial to the latter. Genomics ; Bioremediation ; Virus Scientific result virus;genomics;wasps;cotesia; Sun, 14 Feb 2021 11:00:00 GMT Big pangenomics to study microbial genomic diversity https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/big-pangenomics-study-microbial-genomic-diversity.aspx Researchers from LABGeM (CEA-Jacob), LaMME and the Pasteur Institute joined forces to develop a novel method for the analysis of prokaryote pangenomes, called PPanGGoLiN. As a complement to PPanGGoLiN, the team developed a second tool, panRGB, which brought unprecedented performance and speed to massive comparative genomics analyses. Genomics Researchers ; Journalists ; general public DRF Scientific result panRGP;PPanGGoLiN;pangenome;microbial genome;metagenome;procaryote;bioinformatics; Sun, 07 Feb 2021 11:00:00 GMT POSCOVD : a new project from Genoscope for the diagnosis of COVID-19 https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2021/POSCOVD-project-diagnosis-Covid-19-Genoscope.aspx ​At the most-recent DIM ELICIT colloquium, Marco Mendoza, team leader at SysFate (UMR8030/Genoscope/CEA-Jacob), presented his project POSCOVD, financed by the special Fight-SARS-Cov2 call for projects. POSCOVD seeks to develop a large-scale COVID-19 screening methodology, building particularly upon high throughput sequencing technologies (Oxford Nanopore Sequencing). Genomics ; Diagnosis ; Virus Researchers ; general public ; Journalists DRF Live in the center sequencing;nanopore;DIM ELICIT;Covid19;COVID 19;SARS-CoV-2;diagnosis; Sat, 06 Feb 2021 11:00:00 GMT A new molecular signature to better identify radiosensitive patients https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/new-molecular-signature-identify-radiosensitive-patients.aspx A study co-piloted by researchers from LGRK (IRCM/CEA-Jacob) and Claude Bernard Lyon 1 University and performed on cells from patients who experienced severe adverse effects after radiation therapy enabled the identification of a novel molecular signature of excessive radiosensitivity in healthy tissues. Radiotherapy ; Radiosensitivity Researchers ; general public ; Journalists DRF Scientific result ; Highlight radiosensitivity;Radiation Therapy;NFATC2;fibroblasts;skin;DNA repair;radioresistance; Wed, 03 Feb 2021 11:00:00 GMT The placenta knows you smoked https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/placenta-knows-you-smoked.aspx The CNRGH contributed to a work showing that tobacco exposure, even when stopped before becoming pregnant, leaves traces in the placenta in the form of epigenetic modifications to its DNA. Epigenetics Researchers ; Journalists ; general public Jacob Scientific result tobacco;epigenetic;placenta;methylation; Tue, 26 Jan 2021 11:00:00 GMT PET Imaging to visualize neuroinflammation in patients with Parkinson's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/PET-imaging-visualize-neuroinflammation-patients-Parkinson-disease.aspx Researchers from MIRCen (CEA-Jacob) teamed with the Frédéric Joliot Medical Imaging Center (SHFJ; CEA-Joliot) and the Henri-Mondor and Saint-Anne Hospitals to analyze neuroinflammatory response in a cohort of patients with Parkinson's disease and reported a correlation between it and disease progression. Their study, published in Parkinsonism & Related Disorders, sets a path toward the use of a radiotracer, [¹⁸F]-DPA714, for the evaluation of anti-inflammatories pertinent to the treatment of Parkinson's disease. Parkinson's disease ; Medical imaging ; MRI ; Positron Emission Tomography ; Brain Journalists ; Researchers ; general public DRF Scientific result TSPO;brain imaging;radiotracer;neuroinflammatory processes;neuroinflammation;dopamine;Neurodegenerative disease;PET imaging;Parkinson's disease; Fri, 18 Dec 2020 11:00:00 GMT Brain function in the world's smallest primate—in 3D https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Brain-function-world-smallest-primate-3D.aspx In an article published in NeuroImage, a CEA/CNRS/Paris-Saclay University team from MIRCen (CEA-Jacob) has described neuronal networks in the mouse lemur (Microcebus murinus), one of the smallest primates and one of the most genetically-distant from humans. Brain ; Cognition ; MRI ; Medical imaging Researchers ; Journalists MIRcen Scientific result ; Highlight high field MRI;in vivo imaging;3D imaging;Brain;functional MRI;MRI;brain imaging; Wed, 16 Dec 2020 11:00:00 GMT Discovering the ocean's microbiome: A new Tara expedition https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2021/Discovering-ocean-microbiome-new-Tara-expedition.aspx On 12 December 2020, the schooner Tara set sail from Lorient, France, for a new two-year scientific expedition. The voyage will cover 70,000 kilometers in the South Atlantic, along the African and South-American coasts and on to Antarctica. The expedition's objective is to explore the oceanic microbiome and determine its future in the current era of climate change.Conceived by the Tara Ocean Foundation, the CNRS, the CEA and the EMBL¹, the mission will involve close to 200 scientists across 42 research structures—including Genoscope (CEA-Jacob). Biodiversity ; Impact of climate change ; Oceanography ; Large-scale biology ; Metagenomics ; Metabolomics general public ; Journalists ; Researchers GENOSCOPE News Plastic;climate change;plankton;metagenome;microbiome;microorganism;schooner;Tara;ocean; Sun, 13 Dec 2020 11:00:00 GMT Stealthy agents in Alzheimer's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Stealthy-agents-Alzheimer-disease.aspx Researchers from MIRCen (CEA-Jacob) have shown that undetectable proteinaceous aggregates involved in Alzheimer's disease can be transmitted during brain surgeries in an experimental context. Brain ; Neurodegenerative diseases ; Alzheimer's disease Researchers ; general public ; Journalists MIRcen Scientific result ; Highlight amyloid deposits;Alzheimer Disease;transmission;neurodegenerative diseases; Wed, 09 Dec 2020 11:00:00 GMT Radioactive iodine and thyroid cancer: lessons from Chernobyl and Fukushima https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Radioactive-iodine-thyroid-cancer-Chernobyl-Fukushima.aspx The nuclear power plant accidents at Chernobyl and Fukushima released enormous amounts of radioactive iodine into the atmosphere. Researchers from IRCM (CEA-Jacob) propose an analysis of data on the health consequences of those accidents and particularly the effects they had on the thyroid. Radioactivity ; Radiobiology ; Radiotherapy ; Molecular mechanisms ; Cancer Researchers ; general public ; Journalists IRCM Scientific result ; Highlight molecular signature;prophylaxis;ionizing radiations;thyroid;nuclear accident;radioactive iodine;radiation-induced cancers;Cancer; Tue, 01 Dec 2020 11:00:00 GMT Chlordecone degradation: Citrobacter sp.86 genetics opens new perspectives for decontamination https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/chlordecone-degradation-Citrobacter-sp-86-genetics-decontamination.aspx In a recent work published in Frontiers in Microbiology, a team from Genoscope (CEA-Jacob) has shown a role for corrinoids in the degradation of chlorine compounds (such as chlordecone or lindane) by the bacterium Citrobacter sp86. Because their increased production in contaminated environments could accelerate decontamination processes, these corrinoids may lay paths to novel bioremediation applications. Bioremediation ; Environment ; Bacteria Researchers ; Journalists ; general public DRF Scientific result ; Highlight lindane;Kepone;chlordecone;bioremediation;bacteria;biotransformation;corrinoids;cobalamine;Citrobacter sp86; Thu, 26 Nov 2020 11:00:00 GMT FLASH radiotherapy for the treatment of acute lymphoblastic leukemia https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/FLASH-radiotherapy-treatment-acute-lymphoblastic-leukemia.aspx The LSHL (IRCM/CEA-Jacob) and the radiation oncology department of the Lausanne University Hospital teamed to compare FLASH radiotherapy to conventional radiotherapy in the setting of acute lymphoblastic leukemia. Their results, published in the International Journal of Radiation Oncology * Biology * Physics, open new paths to treat this type of leukemia while preserving normal hematopoiesis. Cancer ; Radiotherapy Researchers ; Journalists ; general public DRF Highlight ; News ; Scientific result FLASH-RT;FLASH radiotherapy;conventional radiotherapy;Radiotherapy;Leukemia;pediatric leukemia;acute lymphoblastic leukemia; Thu, 19 Nov 2020 11:00:00 GMT Immune response: not all are equal in interferon β production https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Immune-response-not-all-equal-interferon-beta-production.aspx Researchers from IRCM (CEA-Jacob) have identified a DNA sequence polymorphism that leads to reduced production of interferon β by myeloid cells. The substitution, which is present in about 30% of the population, could affect immune response to infections and tumors. Molecular mechanisms ; Cancer ; Infectious diseases ; Immune system Researchers ; general public ; Journalists IRCM Scientific result ; Highlight radiation-induced tumor;myeloid cells;infection;immunity;regulation of gene expression;virus;polymorphism; Wed, 18 Nov 2020 11:00:00 GMT New mode of propagation identified for variant Creutzfeldt-Jakob disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/new-mode-propagation-variant-Creutzfeldt-Jakob.aspx In an article published in Acta Neuropathologica, researchers from SEPIA (CEA-Jacob) reported the discovery of a new mode of prion propagation from a localized contamination. Neurodegenerative diseases ; Brain ; Prion diseases Researchers ; Journalists SEPIA News ; Highlight ; Scientific result Creutzfeldt-Jakob;prion diseases;Creutzfeldt-Jakob disease;Neurodegenerative disease;transmissible spongiform encephalopathy;prions;Prion protein; Mon, 16 Nov 2020 11:00:00 GMT Professor François Desgrandchamps wins FRM's 2020 Jean Bernard Prize https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/Professor-Desgrandchamps-wins-FRM-2020-Jean-Bernard-Prize.aspx The Jean Bernard Prize, named after the founder of the French Foundation for Medical Research (FRM), honors scientists whose research greatens public knowledge in health. This year, the FRM presented the Jean Bernard Prize to Prof. François Desgrandchamps of the Immuno-Hematology Research Unit (CEA-Jacob). Cancer ; Immune system general public ; Researchers ; Journalists DRF Live in the center ; News ; Highlight Tue, 03 Nov 2020 11:00:00 GMT A breakthrough in the understanding of natural HIV infection control mechanisms https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/breakthrough-understanding-natural-HIV-infection-control-mechanisms.aspx Researchers from IDMIT (CEA-Jacob) and the Institut Pasteur teamed for a study in which they showed that the antiviral activity of CD8+ T lymphocytes remained limited in the first two weeks of infection but grew progressively and durably thereafter in macaques able to control simian immunodeficiency virus infection (the equivalent of HIV infection in non-human primates). Their results suggest that the early development of highly effective memory CD8+ T-cells is essential for achieving viral control. Diagnosis and innovative treatment ; Vaccine ; Infectious diseases ; AIDS ; Virus Researchers ; general public ; Journalists IDMIT Highlight ; Scientific result HIV-AIDS;HIV;vaccine;human infectious diseases;SIV;lymphocytes;Immune system; Thu, 08 Oct 2020 10:00:00 GMT Skin and ionizing radiation: sensitivity under surveillance https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/skin-ionizing-radiation-sensitivity-under-surveillance.aspx In a study published in Cells, researchers from LGRK (IRCM/CEA-Jacob) showed that human skin stem cells are sensitive to low doses of genotoxic stress in the setting of active regeneration. Stem cells ; Radiobiology ; Radiosensitivity ; Radiotherapy Researchers ; Journalists DRF Scientific result ; Highlight epidermis;skin;organoids;ionizing radiation;keratinocyte stem cells;medical imaging;radiosensitivity; Wed, 07 Oct 2020 10:00:00 GMT Experimental models and Covid-19 https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/experimental-models-Covid-19.aspx The COVID-19 pandemic has underlined how important intense preclinical research is to the development and validation of therapeutics. In this context, a WHO-mandated group of experts, including Roger le Grand and Pauline Maisonnasse from IDMIT (CEA-Jacob), have published an article in Nature that presents existing COVID-19 animal models and explores their pertinence for studying the pathology and identifying paths toward novel treatments for it. Infectious diseases ; Virus general public ; Researchers ; Journalists DRF Scientific result coronavirus;viral infectious;animal models;COVID 19;experimental models;preclinical studies; Fri, 02 Oct 2020 10:00:00 GMT Genoscope researchers honored in Shanghai rankings https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/Genoscope-researchers-honored-Shanghai-rankings.aspx Paris-Saclay University earned the 14th spot among the top 1000 universities in the 2020 edition of the Shanghai Ranking, becoming thus the first French higher learning institute to break into the top-15 regardless of specialties. Of the 35 Paris-Saclay University researchers who were the most cited in their fields, 13 are affiliated with CEA centers and four of those with CEA-Jacob: Jean-Marc Aury, Karine Labadie, Julie Poulain and Patrick Wincker. Institutional ; Health & life sciences Researchers ; Institutions ; Journalists ; general public ; Teachers ; Partners GENOSCOPE News ; Live in the center research;ranking;Shanghai;Paris-Saclay University; Wed, 02 Sep 2020 11:00:00 GMT Hydroxychloroquine and preclinical studies: a world tour in five experimental models https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Hydroxychloroquine-preclinical-studies-world-tour-five-experimental-models.aspx An international study involving IDMIT's (CEA-Jacob) Roger Le Grand and other researchers from more than 80 countries concluded that chloroquine and hydroxychloroquine likely provide no clinical benefits in the treatment of COVID-19. Infectious diseases ; Virus Researchers ; Journalists ; general public DRF Scientific result ; Highlight preclinical studies;pathology modeling;COVID-19;chloroquine;hydroxychloroquine;human infectious diseases; Fri, 28 Aug 2020 10:00:00 GMT Launch of Corona Accelerated R&D in Europe: IDMIT steps up to the plate https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/Launch-of-CARE-program-IDMIT-steps-up-to-the-plate.aspx IDMIT (CEA-Jacob) is participating in CARE, a public-private consortium of 37 organizations brought together to speed the development of treatments for COVID-19 and future coronavirus epidemics. Infectious diseases ; Virus ; Diagnosis and innovative treatment Journalists ; Researchers ; general public IDMIT News ; Headlines research;european project;Europe;funding;COVID 19;vaccine;consortium;infectious diseases; Thu, 27 Aug 2020 10:00:00 GMT Chlordecone degradation and Desulfovibrio sp. 86: Dr Jekyll or Mr Hyde? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/chlordecone-degradation-Desulfovibrio-sp-86-Jekyll-Hyde.aspx In a study published in Scientific Reports, researchers from Genoscope (CEA-Jacob) showed that a same bacterium can degrade chlordecone differently according to the conditions in which it was cultured. Furthermore, one of the newly-identified transformation products was detected in chlordecone-contaminated mangroves in the French West Indies. Bacteria ; Bioremediation ; Environment Researchers ; general public ; Journalists DRF Highlight ; News ; Scientific result bactery;Microbiology;pesticide;Environment;anaerobic;chlordecone;organic pollutants;ecology;Desulfovibrio sp.86; Tue, 11 Aug 2020 10:00:00 GMT Anti-HIV antibodies: predicting in vivo efficacy in vitro https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Anti-HIV-antibodies-predicting-in-vivo-efficacy-in-vitro.aspx A study performed by an IDMIT team (CEA-Jacob) has resulted in an in vitro approach for predicting the in vivo efficacy of antibodies used for the prevention of HIV-1 transmission. The work identified antibodies capable of efficaciously blocking intercellular viral transmission in infected semen. Vaccine ; AIDS ; Infectious diseases ; Diagnosis and innovative treatment ; Biotechnology ; Virus Researchers ; general public ; Journalists IDMIT Scientific result ; Highlight intercellular transmission;sperm;vaccine;Antibody;HIV;AIDS; Fri, 07 Aug 2020 10:00:00 GMT Angiogenesis and immunity: a double target for kidney cancer treatment https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/angiogenesis-immunity-double-target-kidney-cancer-treatment.aspx Researchers from SRHI (CEA-Jacob) have demonstrated a correlation between VEGF expression and the HLA-G/IL4 immune checkpoint in the most common form of kidney cancer. Their study, published in BMC Cancer, opens new horizons for the deployment of novel therapeutic protocols. Cancer ; Immune system Researchers ; general public ; Journalists DRF News ; Scientific result Immune system;bevacizumab;therapeutic targets;HLA-G;immune checkpoint;VEGF;Angiogenesis;kidney cancer;therapeutic antibodies;Cancer; Wed, 05 Aug 2020 10:00:00 GMT Two technologies are better than one for understanding Huntington's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Two-technologies-for-understanding-Huntington-s-disease.aspx Researchers at MIRCen (CEA-Jacob) combined spectroscopy and metabolic imaging to identify novel biomarkers for Huntington's disease. Their approach enables the monitoring of disease course and may prove useful for exploring other neurodegenerative diseases or testing future treatments. Neurodegenerative diseases ; Genetic diseases ; MRI ; Cell and molecular imaging Researchers ; general public ; Journalists MIRcen Scientific result ; Highlight glutamate;gluCEST;huntington;NMR;neurodegenerative diseases; Fri, 31 Jul 2020 10:00:00 GMT Questioning COVID-19 and hydroxychloroquine: a new preclinical study https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/questioning-COVID-19-hydroxychloroquine-new-preclinical-study.aspx A new preclinical study piloted by IDMIT and employing experimental infection models for SARS-CoV-2 found no therapeutic antiviral efficacy for hydroxychloroquine. The team behind the study tested the compound both alone and in combination with azithromycin, and as a prophylactic and in early and late infection. Their results have been published on Nature. Virus ; Infectious diseases Journalists ; Researchers ; general public DRF Scientific result ; Highlight COVID 19;SARS-CoV-2;virus;virology;idmit;translational approaches;preclinical research;azythromycine; Wed, 22 Jul 2020 10:00:00 GMT A preclinical study shows that hydroxychloroquine has no antiviral effect on SARS-CoV-2 in vivo https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2020/A-preclinical-study-shows-that-hydroxychloroquine-has-no-antiviral-effect-on-SARS-CoV-2-in-vivo0612-4497.aspx Health & life sciences ; Technologies News Wed, 22 Jul 2020 09:00:00 GMT The brain: a careful balance between stability and genetic variability https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/The-brain-balance-stability-variability.aspx In a study published in DNA Repair, an IRCM (CEA-Jacob) team has elucidated mechanisms through which neural stem and progenitor cells maintain genome integrity more efficaciously than other cell types. The team's work contributes to a better understanding of the high-fidelity transmission of genetic information so crucial to brain development. Brain ; DNA ; Stem cells ; Stress response Researchers ; general public ; Journalists DRF Scientific result ; Highlight adaptive response;chromosome stability;genetic diversity;neural progenitor cells;Brain;DNA repair;development;radiation;genotoxic stress;non-homologous end-joining;Neural stem cells; Mon, 20 Jul 2020 10:00:00 GMT Molecular chaperones and tauopathies: a double-edged sword https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Molecular- chaperones-tauopathies-double-edged-sword.aspx As part of an international study published in The Journal of Biological Chemistry, a team from LMN (MIRCen/CEA-Jacob) discovered an unexpected mechanism involving chaperone proteins in Tau disassembly. Neurodegenerative diseases ; Alzheimer's disease general public ; Journalists ; Researchers MIRcen Scientific result ; Highlight molecular chaperones;Alzheimer;tauopathies;neurodegenerative diseases; Fri, 17 Jul 2020 10:00:00 GMT HIV transmission: a role for genital tract inflammation and immunity https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/HIV-transmission-inflammation-immunity.aspx In a study on the HIV-specific immune response in semen, published in Frontiers in Immunology, researchers from IDMIT (CEA-Jacob) have shed light on a complex interaction between immunity and inflammation in modulating semen infectivity and the risk of HIV transmission. Infectious diseases ; AIDS Researchers ; general public ; Journalists Jacob Scientific result ; Highlight Inflammation;immunity;HIV-AIDS;infectious diseases;HIV;AIDS;human infectious diseases; Tue, 07 Jul 2020 10:00:00 GMT Alzheimer's and Parkinson's diseases: infectious proteinopathies capture the attention of academicians https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/infectious-proteinopathies-capture-attention-of-academicians.aspx At a joint meeting of the French Academies of Medicine and Pharmacy held 19 November 2019, Ronald Melki of the Neurodegenerative Diseases Laboratory (MIRCen/CEA-Jacob) gave a descriptive review of experimental elements enabling a better understanding of infectious proteinopathy in Alzheimer's and Parkinson's diseases. Alzheimer's disease ; Parkinson's disease ; Neurodegenerative diseases Journalists ; general public ; Researchers DRF News Alzheimer Disease;aggregation;abnormal Tau protein aggregates;Alzheimer;neurodegenerative diseases;Parkinson;tauopathies;Parkinson's disease; Sun, 05 Jul 2020 10:00:00 GMT Tara Oceans: more news on plankton https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/tara-oceans-more-news-on-plankton.aspx A team from the Genomics Metabolics laboratory (Genoscope / CEA-Jacob) has developed a bioinformatics analysis method for environmental genomics data and applied it to those of plankton resulting from the Tara Oceans expeditions. The method reconstructs transcriptomes of eukaryotes from environmental sequencing data, thus enabling access to the genetic organization of these organisms, even those that have not yet been described, to study their functional potential. Also, with the method, interspecies associations can be identified across samples taken in different oceanic provinces. The novel approach is a door to the environmental context and biological functions of numerous species of ecological interest. The team's work was published in Genome Research. Biodiversity ; Metagenomics ; Transcriptomics ; Genomics Researchers ; general public ; Journalists DRF Highlight ; Scientific result Tara Oceans;Climat;cyanobacteria;Environment;ocean;plankton;genomics; Fri, 26 Jun 2020 10:00:00 GMT Federating research organisms to extend the reach of preclinical imaging research https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/federating-research-organisms-to-extend-the-reach-of-preclinical-imaging-research.aspx A study on preclinical imaging involving several national research organisms (Inserm, CNRS, CEA, Universities) has produced MRI relaxometry maps for healthy rat brains. The impetus for that work is to be found in the France Life Imaging (FLI) initiative and its continuing momentum manifests today as the Small Animal Imaging Network (SAIN), which unites about ten French imaging facilities. The study, published in Frontiers in Neuroinformatics, demonstrates the feasibility of large-scale, multicenter, MRI studies in the preclinical setting. Brain ; MRI Journalists ; Researchers ; general public DRF Scientific result preclinic;relaxometry;brain imaging;mapping;MRI;in vivo imaging;Brain;neurosciences; Mon, 22 Jun 2020 10:00:00 GMT COVID-19: two projects retained for the Paris-Saclay University exceptional research program https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/COVID-19-two-projects-retained-Paris-Saclay-University-exceptional-research-program.aspx Paris-Saclay University as well as its component institutions and member-associated universities , their partner national research organisms, and the LERMIT, CHARMMMAT, LASIPS and NanoSaclay laboratories of excellence (LabExs) collectively decided to release funds for research projects targeting the COVID-19 pandemic. Among the laureates are the CNRGH and IRCM, with their respective projects COVIDOGEN and BIOTHETARCOVI. Infectious diseases Researchers ; Journalists ; general public DRF Highlight Inflammation;COVID 19;LRTS;CNRGH;idmit;iRCM; Sun, 21 Jun 2020 10:00:00 GMT Multiple system atrophy: tracking down epigenetic markers https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/multiple-system-atrophy-tracking-down-epigenetic-markers.aspx In a study published in Acta Neuropathologica Communications, researchers from LEE (CNRGH/CEA-Jacob) and the LRSN (Bispebjerg-Frederiksberg University Hospital, Copenhagen) joined forces to characterize DNA methylation profiles in patients with multiple system atrophy (MSA). The team brought to light epigenetic aspects that suggest an active neuro-immune response in patients with MSA. Their work contributes to a better understanding of the diseases and opens new horizons for therapeutic strategies. Epigenetics Researchers ; general public ; Journalists Jacob Scientific result ; Highlight dna methylation;epigenetics;Neurodegenerative disease;SMA; Wed, 17 Jun 2020 10:00:00 GMT