François Jacob Institute of biology - Sur le même thème https://jacob.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2019/QST-NIRS-seminar-CEA-and-IRSN-presented-their-research-activities.aspx Website of the François Jacob Institute of Biology en-US https://jacob.cea.fr/drf/ifrancoisjacob/SiteAssets/logo-cea-JACOB.png François Jacob Institute of biology - Sur le même thème https://jacob.cea.fr/drf/ifrancoisjacob/english Diffusion MRI characterizes radiation-induced neurological impairments https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/diffusion-MRI-characterizes-radiation-induced-neurological-impairments.aspx A team comprising iRCM (CEA-Jacob) and NeuroSpin (CEA-Joliot) researchers analyzed the consequences of irradiation on brain development and neurogenesis in a preclinical model. That work, published in Radiation Research, lays a path for the use of diffusion imaging for the early detection of neurological abnormalities resulting from different types of stress. Brain ; Impacts on living (organisms) ; MRI ; Biomarkers ; Radiobiology Researchers ; Journalists ; general public DRF Scientific result ; Highlight ionizing radiations;Brain;neurodevelopmental disorder;neurogenesis;MRI;structural MRI;diffusion MRI; Thu, 24 Jun 2021 10:00:00 GMT Cellular prion protein at the heart of radioresistance in solid tumors https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/cellular-prion-protein-radioresistance-solid-tumors.aspx In an article published in Oncogene, researchers from LRTS and LRIG (IRCM/CEA-Jacob) have shown that an increase in the expression of cellular prion protein driven by the ATM/TAK1/JUNK signaling pathway contributes to solid tumor radioresistance. Radiotherapy ; Radiosensitivity ; Cancer Researchers ; Journalists ; general public DRF Scientific result prion;DNA damage;DNA damage response;cellular prion protein;ionizing radiation;radioresistance; Wed, 28 Apr 2021 10:00:00 GMT A new molecular signature to better identify radiosensitive patients https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/new-molecular-signature-identify-radiosensitive-patients.aspx A study co-piloted by researchers from LGRK (IRCM/CEA-Jacob) and Claude Bernard Lyon 1 University and performed on cells from patients who experienced severe adverse effects after radiation therapy enabled the identification of a novel molecular signature of excessive radiosensitivity in healthy tissues. Radiotherapy ; Radiosensitivity Researchers ; general public ; Journalists DRF Scientific result ; Highlight radiosensitivity;Radiation Therapy;NFATC2;fibroblasts;skin;DNA repair;radioresistance; Wed, 03 Feb 2021 11:00:00 GMT Radioactive iodine and thyroid cancer: lessons from Chernobyl and Fukushima https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Radioactive-iodine-thyroid-cancer-Chernobyl-Fukushima.aspx The nuclear power plant accidents at Chernobyl and Fukushima released enormous amounts of radioactive iodine into the atmosphere. Researchers from IRCM (CEA-Jacob) propose an analysis of data on the health consequences of those accidents and particularly the effects they had on the thyroid. Radioactivity ; Radiobiology ; Radiotherapy ; Molecular mechanisms ; Cancer Researchers ; general public ; Journalists IRCM Scientific result ; Highlight molecular signature;prophylaxis;ionizing radiations;thyroid;nuclear accident;radioactive iodine;radiation-induced cancers;Cancer; Tue, 01 Dec 2020 11:00:00 GMT FLASH radiotherapy for the treatment of acute lymphoblastic leukemia https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/FLASH-radiotherapy-treatment-acute-lymphoblastic-leukemia.aspx The LSHL (IRCM/CEA-Jacob) and the radiation oncology department of the Lausanne University Hospital teamed to compare FLASH radiotherapy to conventional radiotherapy in the setting of acute lymphoblastic leukemia. Their results, published in the International Journal of Radiation Oncology * Biology * Physics, open new paths to treat this type of leukemia while preserving normal hematopoiesis. Cancer ; Radiotherapy Researchers ; Journalists ; general public DRF Highlight ; News ; Scientific result FLASH-RT;FLASH radiotherapy;conventional radiotherapy;Radiotherapy;Leukemia;pediatric leukemia;acute lymphoblastic leukemia; Thu, 19 Nov 2020 11:00:00 GMT Skin and ionizing radiation: sensitivity under surveillance https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/skin-ionizing-radiation-sensitivity-under-surveillance.aspx In a study published in Cells, researchers from LGRK (IRCM/CEA-Jacob) showed that human skin stem cells are sensitive to low doses of genotoxic stress in the setting of active regeneration. Stem cells ; Radiobiology ; Radiosensitivity ; Radiotherapy Researchers ; Journalists DRF Scientific result ; Highlight epidermis;skin;organoids;ionizing radiation;keratinocyte stem cells;medical imaging;radiosensitivity; Wed, 07 Oct 2020 10:00:00 GMT Radiation and oxidative stress: helping blood stem cells avoid a rough day https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Radiation-and-oxidative-stress-helping-blood-stem-cells-avoid-a-rough-day.aspx An IRCM team (CEA/Inserm) has shown that exposure to low-dose ionizing radiation causes functional losses in human hematopoietic stem cells. Their results, published in Haematologica, suggest the need for complementary care during radiation therapy regimens. Radiotherapy ; Radiosensitivity Researchers ; Journalists DRF Highlight ; News ; Scientific result Radiotherapy;oxydative stress;hematopoiesis;Hematopoietic stem cells; Fri, 24 Jan 2020 11:00:00 GMT QST-NIRS seminar: CEA and IRSN presented their research activities https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2019/QST-NIRS-seminar-CEA-and-IRSN-presented-their-research-activities.aspx CEA and IRSN presented their research activities in radiobiology, radiopathology, epidemiology and dosimetry in a tripartite seminar organized on 28-29 October 2019 by the QST-NIRS in Chiba, Japan. Radiobiology Researchers ; Journalists DRF News ; Colloquium radiobiology; Wed, 30 Oct 2019 09:14:59 GMT DNA breakage: a rescue pathway identified in Saccharomyces cerevisiae https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/DNA-breakage-a-rescue-pathway-identified-in-Saccharomyces-cerevisiae.aspx In a study recently published in the journal Molecular Cell, IRCM researchers describe the key elements of a pathway that protects chromosomes from certain radiation-induced rearrangements. Radiobiology ; Radiosensitivity ; Cancer ; DNA Researchers ; general public ; Journalists IRCM News ; Scientific publications ; Scientific result ; Highlight radiobiology;Cancer;DNA;radiosensitivity; Fri, 14 Jun 2019 10:00:00 GMT DNA repair: the importance of proximity https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/DNA-repair-importance-proximity.aspx Researchers at IRCM have shown that certain mechanisms involved in DNA repair are influenced by the intramolecular and intranuclear spatial organization of the macromolecule. Fundamental Research ; Radiobiology ; DNA Scientific result genotoxic stress; Wed, 11 Apr 2018 10:00:00 GMT The yin and yang of low-dose irradiation on hematopoiesis https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/Yin-Yang-low-dose-irradiation-hematopoiesis.aspx Researchers at the CEA's François Jacob Institute of Biology and their partners show that exposure to low-dose irradiation causes a loss of function in hematopoietic stem cells. Which is bad. And good. Radiobiology ; Low doses Researchers ; Journalists ; general public Fontenay-aux-Roses Scientific result Fri, 29 Sep 2017 10:00:00 GMT