François Jacob Institute of biology - Sur le même thème https://jacob.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/Parkinson-disease-journey-center-alpha-synuclein.aspx Website of the François Jacob Institute of Biology en-US https://jacob.cea.fr/drf/ifrancoisjacob/SiteAssets/logo-cea-JACOB.png François Jacob Institute of biology - Sur le même thème https://jacob.cea.fr/drf/ifrancoisjacob/english "Fingerprints" to differentiate pathogenic alpha-synuclein aggregates https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/fingerprints-pathogenic-alpha-synuclein-aggregates.aspx In a study published in JBC, researchers from MIRCen (CEA-Jacob) deployed a range of techniques to map the surfaces of various pathogenic alpha-synuclein aggregates, establishing thus "fingerprints" specific to each aggregate. Brain ; Parkinson's disease ; Neurodegenerative diseases Researchers ; Journalists ; general public DRF Scientific result ; Highlight therapeutic targets;diagnosis;Parkinson;Parkinson's disease;Fingerprint;alpha-synuclein;Lewy body dementia; Wed, 12 May 2021 10:00:00 GMT Astrocytes and α-synuclein in Parkinson's disease: when size matters https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/astrocytes-alpha-synuclein-Parkinson-size-matters.aspx Researchers from MIRCen (CEA-Jacob) have shown that exposure to alpha-synuclein aggregates may affect dopaminergic neuron survival in Parkinson's disease by reducing astrocyte support for them. Parkinson's disease ; Neurodegenerative diseases ; Brain Researchers ; Journalists ; general public Jacob Scientific result ; Highlight stem cells;Parkinson's disease;astrocytes;alpha-synuclein;aggregates;neuroinflammation; Mon, 29 Mar 2021 10:00:00 GMT Alpha-synuclein in Parkinson's disease : a versatile protein https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/alpha-synuclein-Parkinson-versatile-protein.aspx In an international collaboration, a team from MIRCen (CEA-Jacob) studied the properties of toxic alpha-synuclein aggregates in fixed brain samples from patients, depending on their tissue origin and the type of synucleinopathy developed. Brain ; Parkinson's disease ; Neurodegenerative diseases Researchers ; general public ; Journalists DRF Scientific result ; Highlight Parkinson's disease;proteolysis;enteric nervous system;Brain;alpha-synuclein;PMCA;transmission electron microscopy;protein misfolding; Thu, 18 Mar 2021 11:00:00 GMT PET Imaging to visualize neuroinflammation in patients with Parkinson's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/PET-imaging-visualize-neuroinflammation-patients-Parkinson-disease.aspx Researchers from MIRCen (CEA-Jacob) teamed with the Frédéric Joliot Medical Imaging Center (SHFJ; CEA-Joliot) and the Henri-Mondor and Saint-Anne Hospitals to analyze neuroinflammatory response in a cohort of patients with Parkinson's disease and reported a correlation between it and disease progression. Their study, published in Parkinsonism & Related Disorders, sets a path toward the use of a radiotracer, [¹⁸F]-DPA714, for the evaluation of anti-inflammatories pertinent to the treatment of Parkinson's disease. Parkinson's disease ; Medical imaging ; MRI ; Positron Emission Tomography ; Brain Journalists ; Researchers ; general public DRF Scientific result TSPO;brain imaging;radiotracer;neuroinflammatory processes;neuroinflammation;dopamine;Neurodegenerative disease;PET imaging;Parkinson's disease; Fri, 18 Dec 2020 11:00:00 GMT Alzheimer's and Parkinson's diseases: infectious proteinopathies capture the attention of academicians https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/infectious-proteinopathies-capture-attention-of-academicians.aspx At a joint meeting of the French Academies of Medicine and Pharmacy held 19 November 2019, Ronald Melki of the Neurodegenerative Diseases Laboratory (MIRCen/CEA-Jacob) gave a descriptive review of experimental elements enabling a better understanding of infectious proteinopathy in Alzheimer's and Parkinson's diseases. Alzheimer's disease ; Parkinson's disease ; Neurodegenerative diseases Journalists ; general public ; Researchers DRF News Alzheimer Disease;aggregation;abnormal Tau protein aggregates;Alzheimer;neurodegenerative diseases;Parkinson;tauopathies;Parkinson's disease; Sun, 05 Jul 2020 10:00:00 GMT Molecular "fingerprints" to better identify synucleinopathies https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/molecular-fingerprints-to-better-identify-synucleinopathies.aspx The term "synucleinopathy" covers a range of diseases, including Parkinson's disease, Lewy body dementia and multiple system atrophy, that involve pathological alpha-synuclein aggregations. An analysis of the properties of the different aggregate strains present in synucleinopathies has delineated the molecular bases of the diseases. The study, led by MIRCen (CEA-Jacob) researchers in partnership with the University of Louvain and Imperial College London, was published in Acta Neuropathologica Neurodegenerative diseases ; Parkinson's disease Researchers ; Journalists ; general public DRF Highlight ; Scientific result Neurodegenerative disease;dementia with Lewy bodies;multiple system atrophy;synuclein;synucleinopathies;Parkinson's disease; Thu, 30 Apr 2020 10:00:00 GMT Synucleinopathies: the shape of diseases https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Synucleinopathies-the-shape-of-diseases.aspx As part of an international partnership, a team from the Neurodegenerative Diseases Laboratory (MIRCen) has characterized the pathological effects of various alpha-synuclein aggregate strains in vivo. In their work, published in Acta Neuropathologica Communications, the researchers showed that the conformation of these aggregates plays a key role in their amplification and propagation in the brain. Neurodegenerative diseases ; Parkinson's disease Researchers ; Journalists DRF Highlight ; News ; Scientific result Brain;Parkinson's disease;Parkinson;synucleinopathies;neurodegenerative diseases; Mon, 03 Feb 2020 11:00:00 GMT Parkinson's disease: Journey to the Center of Alpha-Synuclein https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/Parkinson-disease-journey-center-alpha-synuclein.aspx A new structure for aggregated alpha-synuclein has been determined at the atomic level using cryo-electron microscopy. The work, lead by a team from MIRCen's Neurodegenerative Diseases Laboratory, was published in the journal eLife. The determination of this previously undescribed structure opens new doors for the development of ligands specifically targeting alpha-synuclein aggregates in Parkinson's disease. Parkinson's disease Researchers ; Journalists Fontenay-aux-Roses Highlight ; News ; Scientific result alpha-synuclein;Parkinson's disease;cryo microscopy;Biochemistry;NMR; Tue, 10 Dec 2019 11:00:00 GMT