François Jacob Institute of biology - On the same theme https://jacob.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/Launch-of-CARE-program-IDMIT-steps-up-to-the-plate.aspx Website of the François Jacob Institute of Biology en-US https://jacob.cea.fr/drf/ifrancoisjacob/SiteAssets/logo-cea-JACOB.png François Jacob Institute of biology - On the same theme https://jacob.cea.fr/drf/ifrancoisjacob/english A passive immunization approach prevents SHIV infection https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/passive-immunization-shiv-infection.aspx In a study published in Nature Communications, IDMIT researchers demonstrated the efficacy of a neutralizing antibody against cell-associated infection by simian-human immunodeficiency virus. AIDS ; Infectious diseases ; Vaccine Researchers ; Journalists DRF Scientific result ; Highlight immunization;SHIV;HIV;preclinical studies;Antibody;bNAb;AIDS; Wed, 01 Nov 2023 11:00:00 GMT COVID-19: targeting the nuclear ACE2 pathway in SARS-CoV-2 infection https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/covid-receptor-ace-infection.aspx In a new study published in Nature Communications, researchers from IDMIT and the QIMR Berghofer Institute have shown that a peptide able to inhibit the nuclear ACE2 receptor provides protection against SARS-CoV-2 infection. Infectious diseases Researchers ; Journalists DRF Highlight ; Scientific result Inflammation;infection;COVID-19;SARS-CoV-2;nace2i;ace2;preclinical studies;infectious diseases; Wed, 19 Jul 2023 10:00:00 GMT Sotrovimab remains efficacious against the BQ.1.1 omicron subvariant of SARS-CoV-2 https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/Sotrovimab-efficacious-omicron-subvariant-sars-cov-2.aspx In a study published in Heliyon, researchers from IDMIT (CEA-Jacob) used a well-characterized non-human primate model to show that sotrovimab is efficacious against the BQ.1.1 subvariant of SARS-CoV-2. Their results lend support for the continued use of sotrovimab in patients ineligible for nirmatrelvir/ritonavir. Infectious diseases ; Virus Researchers ; general public ; Journalists IDMIT Highlight ; Scientific result COVID-19;Monoclonal antibodies;subvariants;omicron;SARS-CoV-2; Wed, 05 Jul 2023 10:00:00 GMT LMN/MIRCen team wins "Équipe FRM 2023" accreditation https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2023/lmn-mircen-frm-team.aspx Carole Escartin's Reactive Astrocytes team (UMR9199, Neurodegenerative Diseases Laboratory, MIRCen) has received the Équipe FRM 2023 label for its project on the role of astrocytes in the control of neuronal activity. Institutional ; Fundamental Research ; Brain ; Diagnosis and innovative treatment ; Gene and cell therapy ; Alzheimer's disease Researchers ; Journalists ; general public DRF Live in the center ; Highlight astrocytes;Alzheimer's Disease; Wed, 29 Mar 2023 10:00:00 GMT MXD4/MAD4 : a target of interest for ex vivo stem cell preservation https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/MXD4-MAD4-stel-cell-preservation.aspx In a study published in the Journal of Investigative Dermatology, researchers from LGRK (iRCM) identified the transcription factor MXD4/MAD4 as an element of the pathway regulating the stemness of keratinocyte precursors and their skin regeneration capacities. Diagnosis and innovative treatment ; Stem cells Researchers ; Journalists ; general public DRF Scientific result ; Highlight MXD4/MAD4;bioengineering;skin;skin repair;graft;stemness;cutaneous; Fri, 03 Feb 2023 11:00:00 GMT On the path toward a chikungunya vaccine https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/chikungunya-vaccine.aspx In a study published in JCI Insight, researchers from IDMIT have demonstrated the vaccinal effectiveness of serum transfers from volunteers vaccinated against the chikungunya virus to an animal model. This work is an important step toward vaccine marketing approval, as the nature of chikungunya epidemics hampers the deployment of conventional efficacy trials. Health & life sciences ; Vaccine ; Infectious diseases ; Chikungunya Researchers ; Journalists DRF Scientific result ; Highlight vaccine;chikungunya;idmit; Fri, 16 Dec 2022 11:00:00 GMT An in vitro model to study infertility https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/in-vitro-model-study-infertility.aspx In a work published in Scientific Reports, researchers from IRCM, the Sup'Biotech/SEPIA partnership lab and Imagine Institute teamed to develop an in vitro, model of infertility wherein induced pluripotent stem cells generated from the erythroblasts of infertile men presenting genetic abnormalities were used to successfully generate primordial germ-like cells. Diagnosis and innovative treatment ; Stem cells Researchers ; Journalists ; general public IRCM Highlight ; Scientific result stem cells;infertility;azoospermia; Mon, 28 Nov 2022 11:00:00 GMT IDMIT Director Roger Le Grand joins the new Committee For Health Risk Monitoring and Anticipation (COVARS) https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2022/Roger-Le-Grand-member-COVARS.aspx IDMIT (CEA-Jacob) Director Roger Le Grand has joined COVARS, a consultative body to guide decisions made by public entities on the anticipation, prevention and human consequences of health crises. Science & society ; Infectious diseases ; Institutional Researchers ; Journalists ; general public DRF Live in the center ; Highlight zoonotic disease;human infectious diseases;scientific committee;COVARS; Fri, 14 Oct 2022 10:00:00 GMT Does the menstrual cycle affect the risk of STIs? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/menstrual-cycle-risk-STI.aspx Researchers from IDMIT describe the course of immune & inflammatory markers and the vaginal microbiome during the menstrual cycle. Infectious diseases ; Cellular mechanisms ; Immune system Researchers ; Journalists ; general public IDMIT Scientific result ; Highlight bacteria;HIV;HIV-AIDS;Infectious Disease;immune response;cellular immune responses;viruses;therapy; Fri, 20 May 2022 10:00:00 GMT ComFC, a key protein in the transmission of antibiotic resistance among bacteria https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/ComFC-transmission-antibiotic-resistance-bacteria.aspx A team of researchers from IRCM (CEA-Jacob) and I2BC have shed light on the role of ComFC, a bacterial protein involved in natural transformation, itself a driving mechanism for the propagation of antibiotic resistance genes and virulence factors. Cellular mechanisms ; Molecular mechanisms ; Antibiotics Researchers ; general public ; Journalists SCSR Highlight ; Scientific result bacteria;Antibiotic;Antibiotic Resistance;Molecular mechanisms; Tue, 19 Apr 2022 10:00:00 GMT The beneficial role of reactive astrocytes in Huntington's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/huntington-disease-reactive-astrocytes.aspx In a new study published in Brain, researchers MIRCen used mouse models of Huntington's disease to show that stimulating reactive astrocyte formation favors the elimination of mutant huntingtin protein, reducing both the quantity and size of the aggregates. Neurodegenerative diseases ; Diagnosis and innovative treatment Researchers ; Journalists ; general public MIRcen Scientific result ; Highlight huntington;neuron;reactive astrocytes;astrocytes;JAK2-STAT3;huntingtin;preclinical research; Mon, 28 Mar 2022 10:00:00 GMT A protein-based candidate vaccine prevents SARS-CoV-2 transmission in preclinical trials https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/protein-candidate-vaccine-prevents-SARS-CoV-2.aspx Preclinical trials carried out as part of a CEA-Irig–CEA-Jacob partnership have shown that a spike-protein-based candidate vaccine provides complete protection against SARS-CoV-2 infection. Infectious diseases Researchers ; Journalists ; general public IDMIT Scientific result ; Highlight COVID-19;Spike;SARS-CoV-2;vaccine;preclinical research;Lipids; Mon, 21 Feb 2022 11:00:00 GMT Inflammation and COVID-19: the HLA-G immune checkpoint under surveillance https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/inflammation-Covid-19-HLA-G-checkpoint-immune-surveillance.aspx In a study published in Viruses, a team of researchers from SRHI and the University of Ferrara (Italy) showed that the soluble form of HLA-G may contribute significant anti-inflammatory properties via its role in controlling the adhesion of neutrophils to endothelial cells and thus improve disease outcome in patients with COVID-19. Infectious diseases ; Cellular mechanisms Researchers ; Journalists ; general public SRHI Scientific result ; Highlight HLA-G;COVID-19;endothelial cells;Angiogenesis;neutrophil; Tue, 11 Jan 2022 11:00:00 GMT CEA contributing to the European AI-powered personalized medicine project KATY https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2021/CEA-contributing-European-AI-powered-personalized-medicine-project-KATY.aspx The institutes IRIG and Jacob of the CEA's Fundamental Research Division and CEA-List joined forces to participate in KATY, a European Horizon 2020 project aimed at creating an artificial-intelligence-powered personalized medicine program. Diagnosis and innovative treatment ; Methodologies for life sciences Researchers ; general public ; Journalists Live in the center Mon, 14 Jun 2021 10:00:00 GMT Beta thalassemia: toward a more effective therapeutic strategy https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/beta-thalassemia-more-effective-therapeutic-strategy.aspx In a study published in Molecular Therapy, LCSAT (IDMIT, CEA-Jacob) researchers present a novel, optimized, lentiviral gene therapy for β-thalassemia. Gene and cell therapy Researchers ; general public ; Journalists STI Scientific result ; Highlight lentiglobin;lentiviral gene therapy;beta-thalassemia;he; Thu, 20 May 2021 10:00:00 GMT A potential therapeutic role for PPAR-γ in myelofibrosis https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/potential-therapeutic-role-PPAR-gamma-myelofibrosis.aspx In a study published in the Journal of Clinical Investigation, researchers from IDMIT's LCSAT lab (CEA-Jacob) evaluated PPAR-γ ligands in the development of myelofibrosis. Diagnosis and innovative treatment ; Cancer Researchers ; Journalists ; general public IDMIT Scientific result ; Highlight therapy;Inflammation;myeloid cells;PPAR-γ;Hematopoietic stem cells;fibrosis; Tue, 18 May 2021 10:00:00 GMT COVID-19 durably affects the intestinal microbiota https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/COVID-19-affects-intestinal-microbiota.aspx The microbial composition and metabolome of the intestinal microbiota of an animal model for COVID-19 were altered over the disease course and remained so after the resolution of lung infection. Those results, which will contribute were brought to light by the Institut Pasteur in Lille in partnership with IDMIT (CEA-Jacob). Infectious diseases ; Metagenomics Researchers ; Journalists ; general public DRF News ; Scientific result dysbiosis;intestinal microbiota;COVID 19;SARS-CoV2; Wed, 05 May 2021 10:00:00 GMT Mapping DNA methylation in simian immunodeficiency virus infection https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/mapping-dna-methylation-simian-immunodeficiency-infection.aspx In a partnership with IDMIT (CEA-Jacob) and Institut Pasteur, the Epigenetic and Environment Laboratory (LEE; CNRGH/CEA-Jacob) carried out two studies to evaluate DNA methylation in non-human primate models of immunodeficiency virus infections. Virus ; Epigenetics Researchers ; Journalists ; general public DRF Scientific result ; Highlight HIV;epigenetic;SIV;methylation; Mon, 05 Apr 2021 10:00:00 GMT Preclinical study sheds light on a new vaccine candidate for Covid-19 https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/preclinical-study-sheds-light-new-vaccine-candidate-Covid-19.aspx A new international study, published in Cell, co-leaded by IDMIT (CEA-Jacob) and the Department of Medical Microbiology of the University of Amsterdam, presents the results of preclinical trials of a new protein vaccine candidate against Covid-19. Infectious diseases ; Virus ; Vaccine Researchers ; Journalists ; general public DRF Highlight ; Scientific result COVID 19;SARS-CoV-2;vaccine;Nanoparticles;Preclinical; Mon, 08 Mar 2021 11:00:00 GMT Determining antibiotic resistance with artificial intelligence https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/determining-antibiotic-resistance-artificial-intelligence.aspx Under the coordination of the MSF Foundation, researchers and engineers from the University of Évry, the CEA, the CNRS, Médecins Sans Frontières and the Bacteriology/Virology Department of the Henri-Mondor hospital (AP-HP) teamed to develop a mobile application to ease the determination of antibiotic resistance.This application aimed at addressing a major public health issue will be freely available to medical personnel worldwide once clinically validated and CE certified. The demonstration of the technical feasibility of their approach was published on 19 February 2021 in Nature Communications. Antibiotics ; Artificial intelligence Researchers ; Journalists ; general public DRF Scientific result ; Highlight ; News Antibiotic Resistance;artificial intelligence;machine learning; Tue, 23 Feb 2021 11:00:00 GMT A virus at home in parasitic wasps https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/virus-at-home-in-parasitic-wasps.aspx Genoscope was part of an international team that assembled the genome of Cotesia wasps and identified therein chromosomal colonization by a virus that settled into the wasp genome a hundred-million years ago. Their results suggest that the evolutionary course of a virus integrated within the genome of a eukaryote changes completely when the former is beneficial to the latter. Genomics ; Bioremediation ; Virus Scientific result virus;genomics;wasps;cotesia; Sun, 14 Feb 2021 11:00:00 GMT POSCOVD : a new project from Genoscope for the diagnosis of COVID-19 https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2021/POSCOVD-project-diagnosis-Covid-19-Genoscope.aspx ​At the most-recent DIM ELICIT colloquium, Marco Mendoza, team leader at SysFate (UMR8030/Genoscope/CEA-Jacob), presented his project POSCOVD, financed by the special Fight-SARS-Cov2 call for projects. POSCOVD seeks to develop a large-scale COVID-19 screening methodology, building particularly upon high throughput sequencing technologies (Oxford Nanopore Sequencing). Genomics ; Diagnosis ; Virus Researchers ; general public ; Journalists DRF Live in the center sequencing;nanopore;DIM ELICIT;Covid19;COVID 19;SARS-CoV-2;diagnosis; Sat, 06 Feb 2021 11:00:00 GMT Immune response: not all are equal in interferon β production https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Immune-response-not-all-equal-interferon-beta-production.aspx Researchers from IRCM (CEA-Jacob) have identified a DNA sequence polymorphism that leads to reduced production of interferon β by myeloid cells. The substitution, which is present in about 30% of the population, could affect immune response to infections and tumors. Molecular mechanisms ; Cancer ; Infectious diseases ; Immune system Researchers ; general public ; Journalists IRCM Scientific result ; Highlight radiation-induced tumor;myeloid cells;infection;immunity;regulation of gene expression;virus;polymorphism; Wed, 18 Nov 2020 11:00:00 GMT A breakthrough in the understanding of natural HIV infection control mechanisms https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/breakthrough-understanding-natural-HIV-infection-control-mechanisms.aspx Researchers from IDMIT (CEA-Jacob) and the Institut Pasteur teamed for a study in which they showed that the antiviral activity of CD8+ T lymphocytes remained limited in the first two weeks of infection but grew progressively and durably thereafter in macaques able to control simian immunodeficiency virus infection (the equivalent of HIV infection in non-human primates). Their results suggest that the early development of highly effective memory CD8+ T-cells is essential for achieving viral control. Diagnosis and innovative treatment ; Vaccine ; Infectious diseases ; AIDS ; Virus Researchers ; general public ; Journalists IDMIT Highlight ; Scientific result HIV-AIDS;HIV;vaccine;human infectious diseases;SIV;lymphocytes;Immune system; Thu, 08 Oct 2020 10:00:00 GMT Experimental models and Covid-19 https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/experimental-models-Covid-19.aspx The COVID-19 pandemic has underlined how important intense preclinical research is to the development and validation of therapeutics. In this context, a WHO-mandated group of experts, including Roger le Grand and Pauline Maisonnasse from IDMIT (CEA-Jacob), have published an article in Nature that presents existing COVID-19 animal models and explores their pertinence for studying the pathology and identifying paths toward novel treatments for it. Infectious diseases ; Virus general public ; Researchers ; Journalists DRF Scientific result coronavirus;viral infectious;animal models;COVID 19;experimental models;preclinical studies; Fri, 02 Oct 2020 10:00:00 GMT Hydroxychloroquine and preclinical studies: a world tour in five experimental models https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Hydroxychloroquine-preclinical-studies-world-tour-five-experimental-models.aspx An international study involving IDMIT's (CEA-Jacob) Roger Le Grand and other researchers from more than 80 countries concluded that chloroquine and hydroxychloroquine likely provide no clinical benefits in the treatment of COVID-19. Infectious diseases ; Virus Researchers ; Journalists ; general public DRF Scientific result ; Highlight preclinical studies;pathology modeling;COVID-19;chloroquine;hydroxychloroquine;human infectious diseases; Fri, 28 Aug 2020 10:00:00 GMT Launch of Corona Accelerated R&D in Europe: IDMIT steps up to the plate https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/Launch-of-CARE-program-IDMIT-steps-up-to-the-plate.aspx IDMIT (CEA-Jacob) is participating in CARE, a public-private consortium of 37 organizations brought together to speed the development of treatments for COVID-19 and future coronavirus epidemics. Infectious diseases ; Virus ; Diagnosis and innovative treatment Journalists ; Researchers ; general public IDMIT News ; Headlines research;european project;Europe;funding;COVID 19;vaccine;consortium;infectious diseases; Thu, 27 Aug 2020 10:00:00 GMT Anti-HIV antibodies: predicting in vivo efficacy in vitro https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Anti-HIV-antibodies-predicting-in-vivo-efficacy-in-vitro.aspx A study performed by an IDMIT team (CEA-Jacob) has resulted in an in vitro approach for predicting the in vivo efficacy of antibodies used for the prevention of HIV-1 transmission. The work identified antibodies capable of efficaciously blocking intercellular viral transmission in infected semen. Vaccine ; AIDS ; Infectious diseases ; Diagnosis and innovative treatment ; Biotechnology ; Virus Researchers ; general public ; Journalists IDMIT Scientific result ; Highlight intercellular transmission;sperm;vaccine;Antibody;HIV;AIDS; Fri, 07 Aug 2020 10:00:00 GMT Questioning COVID-19 and hydroxychloroquine: a new preclinical study https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/questioning-COVID-19-hydroxychloroquine-new-preclinical-study.aspx A new preclinical study piloted by IDMIT and employing experimental infection models for SARS-CoV-2 found no therapeutic antiviral efficacy for hydroxychloroquine. The team behind the study tested the compound both alone and in combination with azithromycin, and as a prophylactic and in early and late infection. Their results have been published on Nature. Virus ; Infectious diseases Journalists ; Researchers ; general public DRF Scientific result ; Highlight COVID 19;SARS-CoV-2;virus;virology;idmit;translational approaches;preclinical research;azythromycine; Wed, 22 Jul 2020 10:00:00 GMT HIV transmission: a role for genital tract inflammation and immunity https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/HIV-transmission-inflammation-immunity.aspx In a study on the HIV-specific immune response in semen, published in Frontiers in Immunology, researchers from IDMIT (CEA-Jacob) have shed light on a complex interaction between immunity and inflammation in modulating semen infectivity and the risk of HIV transmission. Infectious diseases ; AIDS Researchers ; general public ; Journalists Jacob Scientific result ; Highlight Inflammation;immunity;HIV-AIDS;infectious diseases;HIV;AIDS;human infectious diseases; Tue, 07 Jul 2020 10:00:00 GMT COVID-19: two projects retained for the Paris-Saclay University exceptional research program https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/COVID-19-two-projects-retained-Paris-Saclay-University-exceptional-research-program.aspx Paris-Saclay University as well as its component institutions and member-associated universities , their partner national research organisms, and the LERMIT, CHARMMMAT, LASIPS and NanoSaclay laboratories of excellence (LabExs) collectively decided to release funds for research projects targeting the COVID-19 pandemic. Among the laureates are the CNRGH and IRCM, with their respective projects COVIDOGEN and BIOTHETARCOVI. Infectious diseases Researchers ; Journalists ; general public DRF Highlight Inflammation;COVID 19;LRTS;CNRGH;idmit;iRCM; Sun, 21 Jun 2020 10:00:00 GMT Flash ANR Covid-19: IDMIT engaged in a project selected by the ANR https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/Flash-ANR-Covid-19-IDMIT-engaged-in-a-project-selected-by-the-ANR.aspx As a part of the Covid-19 Flash call launched on March 6, 2020, the ANR selected 86 research projects for immediate funding, covering a large number of issues related to the Covid-19 epidemic. Among the selected projects, one project coordinated by Roger Le Grand (IDMIT) focuses on the study of the pathogenesis of the SARS-Cov-2 infection in a pre-clinical study model. Infectious diseases ; Virus Researchers ; Journalists DRF Highlight coronavirus;COVID 19; Sun, 12 Apr 2020 10:00:00 GMT Innate immune memory and vaccination: a controlled schedule for improved benefit https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Innate-immune-memory-and-vaccination-a-controlled-schedule-for-improved-benefit.aspx A study led by IMVA-HB/IDMIT researchers, published in NPJ Vaccines, has shown the influence of the delay between vaccinations (primary and booster) on the specific humoral immune response. This work also suggests the establishment of a trained immune memory. Vaccine ; Infectious diseases ; Immune system Researchers ; Journalists DRF Highlight ; News ; Scientific result immunization;immune response;vaccine;Immune memory;Immune system;Vaccination Immunogenicity; Thu, 19 Mar 2020 11:00:00 GMT IDMIT on point against COVID-19 https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/IDMIT-on-point-against-COVID-19.aspx With the support of the Ministry of Solidarity and Health and the Ministry of Higher Education, Research and Innovation, 20 scientific initiatives were selected by REACTing's scientific board and presented at a press conference on 11 March. Among them, IDMIT is piloting a fundamental research project on the evolution of Covid-19 in a specific pre-clinical study model. Infectious diseases Researchers ; Journalists DRF Highlight ; News virus;Infectious Disease;idmit; Fri, 13 Mar 2020 11:00:00 GMT European research gets organised against tuberculosis https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/European-research-gets-organised-against-tuberculosis.aspx To develop new treatments for tuberculosis, the world's leading cause of death from infectious diseases, the European Union and the European Federation of Pharmaceutical Industries and Associations are launching the ERA4TB (European Regimen Accelerator for Tuberculosis) consortium combining academic and private research, of which the IDMIT department is a partner Infectious diseases Researchers ; Journalists DRF Highlight ; News tuberculosis;Tuberculosis Bacterium;Infectious Disease; Mon, 17 Feb 2020 11:00:00 GMT Rapid genome analysis provides invaluable aid for hospitalized newborns https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/Rapid-genome-analysis-provides-invaluable-aid-for-hospitalized-newborns.aspx In their work entitled Fastgenomics, the Dijon Bourgogne University Hospital, Inserm and the CEA's National Center of Human Genomics Research (CNRGH) studied a rapid high-throughput genome sequencing process in 30 hospitalized newborns. The team was able to reduce the time needed for this process from an average of 18 months to only a month and a half at most (38 to 49 days), thus enabling rapid diagnoses for two-thirds of the patients. Genetic diseases ; Diagnosis Researchers ; Journalists DRF Highlight ; News ; Scientific result Genetic diseases;Gene Sequence; Wed, 18 Dec 2019 11:00:00 GMT Helicobacter pylori: please don't share… https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/Helicobacter-pylori-please-do-not-share.aspx ...or how finding the unique link may be a path toward curing gastric infections. In a study published in Nature Communications, researchers from LRIG (IRCM) identified a protein that is essential for an antibiotic resistance propagation pathway in the bacterium Helicobacter pylori. Infectious diseases ; Bacteria Researchers ; Journalists Highlight ; News ; Scientific result recombination;DNA repair;bacteria;infectious diseases;Helicobacter pylori; Thu, 28 Nov 2019 11:00:00 GMT On track to eradicating stomach infections in half the world's population https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2019/On-track-to-eradicating-stomach-infections-in-half-the-world's-population.aspx Health & life sciences ; Diseases ; Bacteria ; Infectious diseases News ; Press release ; Focus Wed, 27 Nov 2019 11:00:00 GMT New knowledge for cell therapies in neurodegenerative diseases https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/New-knowledge-for-cell-therapies-in-neurodegenerative-diseases.aspx MIRCen contributed to a study that showed that the use of histocompatible neuronal grafts did not eliminate the need for immunosuppressive drugs in a primate model. Those results provide important knowledge for the clinical use of certain cell therapies under development for the treatment of neurodegenerative diseases. Brain ; Neurodegenerative diseases ; Gene and cell therapy Scientific result Wed, 09 Oct 2019 10:00:00 GMT A new generation of lentivirus for gene therapy https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/A-new-generation-of-lentivirus-for-gene-therapy.aspx Researchers from STI have developed a new generation of lentivirus, paving the way for the use of Mauritian cynomolgus macaque as a pre-clinical study model for the development of new gene therapy products. Health & life sciences ; Gene and cell therapy Researchers ; Journalists STI Highlight ; Scientific result DNA;Gene and cell therapy;pre-clinical; Mon, 22 Jul 2019 10:00:00 GMT Alzheimer's disease: blocking reactive astrocytes to help neurons https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/Alzheimer-disease-blocking-reactive-astrocytes-help-neurons.aspx Researchers from MIRCen have shown that inhibiting reactive astrocytes is beneficial for certain characteristics of Alzheimer's disease. Their results could lead to novel therapies that act upon astrocytes to improve neuron function. Brain ; Gene and cell therapy ; Alzheimer's disease ; Cellular mechanisms Paris-Saclay Scientific result Alzheimer;astrocytes;neuron; Mon, 29 Oct 2018 11:00:00 GMT Revealing molecular mechanisms that prevent measles virus replication https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2018/Revealing-molecular-mechanisms-that-prevent-measles-virus-replication.aspx Researchers discovered a novel interaction between two proteins from the measles virus. This ultra-weak interaction, involving only four amino acids situated in a very flexible and dynamic protein region, is essential for measles virus replication. This newly discovered interaction constitutes a new target to treat measles infection, but also infection by other viruses from the same family, that comprises highly dangerous human pathogens. Health & life sciences ; Virus ; Proteomics ; Diagnosis and innovative treatment ; Diseases ; Molecular mechanisms ; DNA ; Immune system general public ; Journalists ; Researchers Grenoble News ; Scientific publications ; Scientific result Measles; Wed, 22 Aug 2018 18:00:00 GMT Darwinian selection happens in test tubes too https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/Darwinian-selection-in-test-tubes.aspx Bringing successive mutations to DNA and RNA in test tubes has been possible for several decades now. A MIRCen team has shown that high throughput sequencing can, with unequaled precision, reconstitute the evolutionary path taken by these macromolecules during their in vitro selection process, and furthermore that this path respects Darwinian theory. Methodologies for life sciences ; Diagnosis and innovative treatment ; Neurodegenerative diseases ; Evolution Fontenay-aux-Roses Scientific result in vitro selection;aptamers; Tue, 17 Jul 2018 10:00:00 GMT Idmit: inauguration of a new biology and health research infrastructure devoted to human infectious diseases and immunology https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2018/Idmit-inauguration-of-a-new-biology-and-health-research-infrastructure-devoted-to-human-infectious-diseases-and-immunology.aspx Institutional ; Diagnosis and innovative treatment ; Diseases ; Methodologies for life sciences Press release ; Inauguration ; Focus Fri, 22 Jun 2018 10:00:00 GMT A new success in gene therapy for beta thalassemia https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/New-success-in-gene-therapy-for-beta-thalassemia.aspx ​The efficacy of a gene therapy developed at the François Jacob Institute of Biology and Harvard University has been demonstrated in phase I/II clinical trials. Gene and cell therapy ; Genetic diseases Scientific result ; Press release Thu, 19 Apr 2018 10:00:00 GMT Theranexus signs partnership with the Collège de France https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2018/Theranexus-partnership-College-de-France.aspx Theranexus, a CEA-born biopharmaceutical company, signs a three-year research partnership agreement with the Collège de France. Pharmacology ; Brain Researchers ; general public ; Journalists Jacob Academic partnerships glial cells;narcolepsy;psychotropic medications; Thu, 15 Mar 2018 11:00:00 GMT Getting medicines to the brain with ultrasound https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/getting-medicines-brain-ultrasound.aspx Researchers from NeuroSpin (Frédéric-Joliot Institute/CEA) and MIRCen (François Jacob Institute of Biology/CEA) recently developed an MRI-guided focused ultrasound system that increases, temporarily and locally, cerebral vascular permeability in non-human primates. The system could improve the delivery of medicines to the brain. Diagnosis and innovative treatment ; MRI Fontenay-aux-Roses Scientific result MRI-guided focused ultrasound system;blood-brain barrier; Mon, 19 Feb 2018 11:00:00 GMT NeurATRIS : Call for collaborative projects on neurodegenerative diseases https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2018/Neuratris-call.aspx ​NeurATRIS lance un appel à projets pour initier des projets collaboratifs entre les membres de NeurATRIS, les laboratoires académiques et les sociétés de biotechnologies. A la clé, un financement à hauteur de 50K€. Diagnosis and innovative treatment ; Gene and cell therapy ; Neurodegenerative diseases News ; Academic partnerships ; Industrial partnerships Thu, 18 Jan 2018 11:00:00 GMT Hemoglobinopathies: a gene therapy modifies 100% of targeted cells https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/Hemoglobinopathies-amelioration-therapie-genique.aspx ​The researchers at the François Jacob Institute's Department of Innovative Therapies are pursuing the development of their gene therapy for hereditary blood diseases. They are looking to increase the performance of their strategy so that it can bring benefits to the greatest number of patients possible. Genetic diseases ; Gene and cell therapy STI Scientific result Thu, 21 Dec 2017 11:00:00 GMT HIV "elite controllers" starting to share their secrets https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/HIV-Elite-controllers.aspx What are the mechanisms preventing viral progression in HIV "elite controllers"? Researchers at the François Jacob Institute of Biology and their partners have shed light on some particularities of CD8+ T cells. AIDS Researchers ; general public ; Journalists Jacob Scientific result Fri, 28 Jul 2017 10:00:00 GMT Promising Tests of a Vaccine against Chikungunya virus https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/promising-tests-of-a-vaccine-against-chikungunya-virus.aspx A team from the CEA François-Jacob Institute has demonstrated the preclinical efficacy of three vaccine candidates against chikungunya. Health & life sciences ; Virus ; Chikungunya general public ; Journalists ; Researchers Jacob Scientific result Tue, 25 Apr 2017 10:00:00 GMT Chikungunya: Pain Caused by the Immune System https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/chikungunya-pain-caused-by-the-immune-system.aspx Joint damage in people infected with chikungunya remains poorly understood. Scientists from the CEA François-Jacob Institute and their partners have identified an actor of the antiviral immune response whose inhibition paradoxically reduces the severity of the symptoms. Infectious diseases ; Chikungunya ; Diagnosis and innovative treatment general public ; Journalists ; Researchers Jacob Scientific result Mon, 13 Mar 2017 11:00:00 GMT Sickle Cell Disease: Remission in the First Patient Treated by Gene Therapy https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/sickle-cell-disease-remission-first-patient-treated-by-gene-therapy.aspx A patient with severe sickle cell disease has undergone gene therapy developed at the CEA François-Jacob Institute. Two years after treatment, the remission of clinical signs was complete. Health & life sciences ; Genetic diseases ; Diagnosis and innovative treatment general public ; Journalists ; Researchers Jacob Scientific result Thu, 02 Mar 2017 11:00:00 GMT Sickle cell disease: remission of the signs of the disease in the first patient in the world treated with gene therapy https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2017/Sickle-cell-disease-remission-signs-disease-first-patient-treated-gene-therapy.aspx A patient aged of 13 years with severe sickle cell disease has been treated succesfully by a gene therapy. This innovative treatment allowed complete remission of clinical signs of disease and correction of biological signs. Gene and cell therapy ; Genetic diseases ; Diagnosis and innovative treatment ; Health & life sciences general public ; Journalists ; Researchers Paris-Saclay Press release ; Scientific publications sickle cell anemia;Diagnosis and innovative treatment;Genetic diseases;Gene and cell therapy;Health & life sciences; Thu, 02 Mar 2017 00:00:00 GMT Chronic Myeloid Leukemia: a New Therapy Proves Successful https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/Chronic-Myeloid-Leukemia-a-New-Therapy-Proves-Successful.aspx In a phase 2 clinical trial, scientists showed the efficiency of targeting cancer stem cells—an approach imagined and developed at the CEA François-Jacob Institute for the treatment of leukemia, chronic myeloid leukemia in particular. Cancer ; Gene and cell therapy general public ; Journalists ; Researchers Jacob Scientific result Tue, 28 Feb 2017 11:00:00 GMT Discovery of a gene associated with radiosensitivity and post-radiotherapy complications https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2016/Discovery-of-a-gene-associated-with-radiosensitivity-and-post-radiotherapy-complications.aspx ​Scientists at the CEA’s Institute of Cellular and Molecular Radiation Biology, in collaboration with INSERM, Université Paris-Sud, and international partners, have demonstrated a connection between the expression of the TRAIL gene, which plays a role in cell death, and the radiosensitivity of certain human T lymphocytes. Health & life sciences ; Diagnosis and innovative treatment ; Cellular mechanisms Researchers ; general public DRF Press release ; Scientific result Mon, 21 Mar 2016 11:00:00 GMT Modulating cerebral cholesterol: a new avenue of research to treat Alzheimer’s disease? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2015/Modulating-cerebral-cholesterol-new-avenue-research-treat-Alzheimer.aspx Two French research teams have recently shown in a rodent model that overexpression of an enzyme capable of eliminating excess cholesterol in the brain can act in a beneficial way on the tau component of the disease to completely correct it. Alzheimer's disease ; Gene and cell therapy ; Biotechnology MIRcen Scientific result Mon, 14 Sep 2015 10:00:00 GMT New giant virus discovered in Siberia's permafrost https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2015/new-giant-virus-discovered-in-siberia's-permafrost.aspx ​Scientists have recently discovered a new type of giant virus in the same sample of 30,000-year old Siberian permafrost from which Pithovirus had already been isolated Virus ; Genomics ; Proteomics Journalists ; Researchers Fontenay-aux-Roses Press release ; Scientific result IRTSV;Evry;microscope;IG;Fontenay;géant;virus; Wed, 09 Sep 2015 10:00:00 GMT