François Jacob Institute of biology - On the same theme https://jacob.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/Professor-Desgrandchamps-wins-FRM-2020-Jean-Bernard-Prize.aspx Website of the François Jacob Institute of Biology en-US https://jacob.cea.fr/drf/ifrancoisjacob/SiteAssets/logo-cea-JACOB.png François Jacob Institute of biology - On the same theme https://jacob.cea.fr/drf/ifrancoisjacob/english A duo of monoclonal antibodies for Sjögren syndrome https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/duo-monoclonal-antibodies-Sjogren-syndrome.aspx In a clinical trial, the IMVA-HB/IDMIT autoimmune team (UMR-S 1184 CEA/Inserm/UPSaclay/Kremlin Bicêtre Hospital) headed by Xavier Mariette has demonstrated the therapeutic benefits of the association of rituximab and belimumab for the treatment of Sjögren syndrome. Immune system Researchers ; Journalists DRF Highlight ; Scientific result autoimmune disease;b lymphocytes;Sjögren syndrome;Monoclonal antibodies; Mon, 06 Feb 2023 11:00:00 GMT Does the menstrual cycle affect the risk of STIs? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/menstrual-cycle-risk-STI.aspx Researchers from IDMIT describe the course of immune & inflammatory markers and the vaginal microbiome during the menstrual cycle. Infectious diseases ; Cellular mechanisms ; Immune system Researchers ; Journalists ; general public IDMIT Scientific result ; Highlight bacteria;HIV;HIV-AIDS;Infectious Disease;immune response;cellular immune responses;viruses;therapy; Fri, 20 May 2022 10:00:00 GMT Gene editing to pull the plug on HLA-G: a novel antitumoral? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/gene-editing-HLAG-antitumoral.aspx As part of a international partnership, researchers from SRHI have shown that Crispr/Cas9 can be used to inactivate HLA-G expression in human cancer cell lines. Their unprecedented findings, published in Scientific Reports, suggest the possibility of novel treatment strategies to supplement current tumor immunotherapies. Cancer ; Immune system general public ; Journalists ; Researchers DRF Highlight ; Scientific result crispr-cas9;HLA-G;Cancer;immune checkpoint;Immune system;gene editing;Tumor; Tue, 22 Feb 2022 11:00:00 GMT HLA-G : a new therapeutic target in cancer https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/HLA-G-therapeutic-target-cancer.aspx In a study published in Cancer Letters, SRHI's researchers (CEA-Jacob) highlight the therapeutic value of targeting the HLA-G/IL2 immune checkpoint in clear cell renal cell carcinoma. Immune system ; Cancer Researchers ; Journalists ; general public DRF Scientific result ; Highlight therapeutic antibodies;HLA-G;immune checkpoint;Cancer; Tue, 24 Aug 2021 10:00:00 GMT The telomere mystery: a protection mechanism decrypted https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/telomere-mystery-protection-mechanism-decrypted.aspx The mechanisms that control the stability of telomeres, structures located at the ends of chromosomes, remain largely mysterious. One of them however has been decrypted by researchers from IRCM (CEA-Jacob) and I2BC (CEA-Joliot) in a work carried out in yeasts. Their results, published in Nature Communications, could help identify new therapeutic targets in human cancers. Molecular mechanisms ; DNA ; Cancer Researchers ; Journalists ; general public SCSR Highlight ; Scientific result telomere;Yeast;DNA repair;chromosome stability;modeling;genetic;Cancer;DNA; Thu, 27 May 2021 10:00:00 GMT A potential therapeutic role for PPAR-γ in myelofibrosis https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/potential-therapeutic-role-PPAR-gamma-myelofibrosis.aspx In a study published in the Journal of Clinical Investigation, researchers from IDMIT's LCSAT lab (CEA-Jacob) evaluated PPAR-γ ligands in the development of myelofibrosis. Diagnosis and innovative treatment ; Cancer Researchers ; Journalists ; general public IDMIT Scientific result ; Highlight therapy;Inflammation;myeloid cells;PPAR-γ;Hematopoietic stem cells;fibrosis; Tue, 18 May 2021 10:00:00 GMT Role of salivary epithelial cells in the pathogenesis of primary Sjögren syndrome https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/salivary-epithelial-cells-pathogenesis-primary-Sjogren-syndrome.aspx The UMR1184S Autoimmune Diseases Team (IDMIT CEA-Jacobl) has published an article in Arthritis & Rheumatology confirming a direct pathogenic role for salivary epithelial cells in primary Sjögren syndrome. Immune system ; Autoimmune diseases Researchers ; Journalists ; general public DRF Scientific result primary Sjörgren syndrome;salivary epithelial cells;autoimmune disease;Interferon; Mon, 03 May 2021 10:00:00 GMT Cellular prion protein at the heart of radioresistance in solid tumors https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/cellular-prion-protein-radioresistance-solid-tumors.aspx In an article published in Oncogene, researchers from LRTS and LRIG (IRCM/CEA-Jacob) have shown that an increase in the expression of cellular prion protein driven by the ATM/TAK1/JUNK signaling pathway contributes to solid tumor radioresistance. Radiotherapy ; Radiosensitivity ; Cancer Researchers ; Journalists ; general public DRF Scientific result prion;DNA damage;DNA damage response;cellular prion protein;ionizing radiation;radioresistance; Wed, 28 Apr 2021 10:00:00 GMT Targeting HIF1α or JMY in glioblastoma: if not one why not the other? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/HIF1-JMY-glioblastoma-targeting.aspx Glioblastomas are highly aggressive brain tumors with a very poor prognosis. Even with aggressive treatment, recurrence is nearly systematic. Researchers from IRCM (CEA-Jacob) have decrypted molecular mechanisms that enable treatment resistance and escape for a subpopulation of cells. Brain ; Cancer ; Stem cells Researchers ; Journalists ; general public SCSR Highlight ; Scientific result Brain;glioblastoma;Cancer;invasion;Tumor;ionizing radiations;HIF1α; Thu, 01 Apr 2021 10:00:00 GMT Radioactive iodine and thyroid cancer: lessons from Chernobyl and Fukushima https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Radioactive-iodine-thyroid-cancer-Chernobyl-Fukushima.aspx The nuclear power plant accidents at Chernobyl and Fukushima released enormous amounts of radioactive iodine into the atmosphere. Researchers from IRCM (CEA-Jacob) propose an analysis of data on the health consequences of those accidents and particularly the effects they had on the thyroid. Radioactivity ; Radiobiology ; Radiotherapy ; Molecular mechanisms ; Cancer Researchers ; general public ; Journalists IRCM Scientific result ; Highlight molecular signature;prophylaxis;ionizing radiations;thyroid;nuclear accident;radioactive iodine;radiation-induced cancers;Cancer; Tue, 01 Dec 2020 11:00:00 GMT FLASH radiotherapy for the treatment of acute lymphoblastic leukemia https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/FLASH-radiotherapy-treatment-acute-lymphoblastic-leukemia.aspx The LSHL (IRCM/CEA-Jacob) and the radiation oncology department of the Lausanne University Hospital teamed to compare FLASH radiotherapy to conventional radiotherapy in the setting of acute lymphoblastic leukemia. Their results, published in the International Journal of Radiation Oncology * Biology * Physics, open new paths to treat this type of leukemia while preserving normal hematopoiesis. Cancer ; Radiotherapy Researchers ; Journalists ; general public DRF Highlight ; News ; Scientific result FLASH-RT;FLASH radiotherapy;conventional radiotherapy;Radiotherapy;Leukemia;pediatric leukemia;acute lymphoblastic leukemia; Thu, 19 Nov 2020 11:00:00 GMT Immune response: not all are equal in interferon β production https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Immune-response-not-all-equal-interferon-beta-production.aspx Researchers from IRCM (CEA-Jacob) have identified a DNA sequence polymorphism that leads to reduced production of interferon β by myeloid cells. The substitution, which is present in about 30% of the population, could affect immune response to infections and tumors. Molecular mechanisms ; Cancer ; Infectious diseases ; Immune system Researchers ; general public ; Journalists IRCM Scientific result ; Highlight radiation-induced tumor;myeloid cells;infection;immunity;regulation of gene expression;virus;polymorphism; Wed, 18 Nov 2020 11:00:00 GMT Professor François Desgrandchamps wins FRM's 2020 Jean Bernard Prize https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/Professor-Desgrandchamps-wins-FRM-2020-Jean-Bernard-Prize.aspx The Jean Bernard Prize, named after the founder of the French Foundation for Medical Research (FRM), honors scientists whose research greatens public knowledge in health. This year, the FRM presented the Jean Bernard Prize to Prof. François Desgrandchamps of the Immuno-Hematology Research Unit (CEA-Jacob). Cancer ; Immune system general public ; Researchers ; Journalists DRF Live in the center ; News ; Highlight Tue, 03 Nov 2020 11:00:00 GMT Angiogenesis and immunity: a double target for kidney cancer treatment https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/angiogenesis-immunity-double-target-kidney-cancer-treatment.aspx Researchers from SRHI (CEA-Jacob) have demonstrated a correlation between VEGF expression and the HLA-G/IL4 immune checkpoint in the most common form of kidney cancer. Their study, published in BMC Cancer, opens new horizons for the deployment of novel therapeutic protocols. Cancer ; Immune system Researchers ; general public ; Journalists DRF News ; Scientific result Immune system;bevacizumab;therapeutic targets;HLA-G;immune checkpoint;VEGF;Angiogenesis;kidney cancer;therapeutic antibodies;Cancer; Wed, 05 Aug 2020 10:00:00 GMT Immune checkpoints: new targets in kidney cancer https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/immune-checkpoints-new-targets-kidney-cancer.aspx Researchers from SRHI in partnership with the MICS lab (CentraleSupélec, Paris-Saclay University) have identified new immune checkpoints as potential targets in clear cell renal cell carcinoma. The team's results, obtained by pairing statistics and biological analyses, have been published in Cancer Immunology, Immunotherapy. Cancer ; Immune system Researchers ; Journalists ; general public Jacob Scientific result immunotherapy;PD-L1;Cancer;clear cell renal cell carcinoma;HLA-G; Fri, 22 May 2020 10:00:00 GMT Tissue repair: when macrophages lead the way https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Tissue-repair-when-macrophages-lead-the-way.aspx Through an international collaboration, researchers from the LRTS laboratory (IRCM/CEA-Jacob) have characterized the cellular and molecular events regulating the balance between fibrotic repair and tissue regeneration and have identified a key player in this balance : macrophages. This study, published in Science Advances, opens up a new therapeutic perspective for the treatment of pathological tissue lesions. Immune system Researchers ; Journalists DRF Highlight ; Scientific result Inflammation;phagocytosis;tissue repair;Macrophages;fibrosis;skin;healing; Tue, 31 Mar 2020 10:00:00 GMT Innate immune memory and vaccination: a controlled schedule for improved benefit https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Innate-immune-memory-and-vaccination-a-controlled-schedule-for-improved-benefit.aspx A study led by IMVA-HB/IDMIT researchers, published in NPJ Vaccines, has shown the influence of the delay between vaccinations (primary and booster) on the specific humoral immune response. This work also suggests the establishment of a trained immune memory. Vaccine ; Infectious diseases ; Immune system Researchers ; Journalists DRF Highlight ; News ; Scientific result immunization;immune response;vaccine;Immune memory;Immune system;Vaccination Immunogenicity; Thu, 19 Mar 2020 11:00:00 GMT A bit of air please... https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/A-bit-of-air-please-.aspx ...or how small amounts of oxygen contribute to the preservation of lymphocyte progenitors in humans. In an article published in Cell Reports, researchers from LSHL (IRCM) shared new findings on the role of hypoxia in human lymphocyte differentiation. Stem cells ; Immune system Researchers ; Journalists Jacob News ; Highlight ; Scientific result hematopoietic differentiation;T lymphocytes;Hematopoietic stem cells;hypoxia;Immune system; Tue, 19 Nov 2019 11:00:00 GMT DNA breakage: a rescue pathway identified in Saccharomyces cerevisiae https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/DNA-breakage-a-rescue-pathway-identified-in-Saccharomyces-cerevisiae.aspx In a study recently published in the journal Molecular Cell, IRCM researchers describe the key elements of a pathway that protects chromosomes from certain radiation-induced rearrangements. Radiobiology ; Radiosensitivity ; Cancer ; DNA Researchers ; general public ; Journalists IRCM News ; Scientific publications ; Scientific result ; Highlight radiobiology;Cancer;DNA;radiosensitivity; Fri, 14 Jun 2019 10:00:00 GMT The brain: a key participant in the development of cancer? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/The-brain-a-key-participant-in-the-development-of-cancer.aspx A French team from IRCM (CEA/Inserm) recently published a study in the scientific journal Nature showing that neurons can develop within the tumoral microenvironment and thus contribute to the development of certain types of cancer. Brain ; Cancer ; Health & life sciences ; Cellular mechanisms Researchers ; Journalists ; general public Paris-Saclay Scientific publications ; Scientific result ; News health;Cancer;neural network;Brain;neuron;neurosciences; Fri, 17 May 2019 10:00:00 GMT 8th international Conference on HLA-G https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2019/8th-international-Conference-on-HLA-G.aspx The 8th International Conference on HLA-G will take place at the Ministry of Health and Solidarity (Ministère de la Santé et des Solidarités) in Paris on 8, 9 and 10 July 2019. Cancer ; Health & life sciences ; Immune system Researchers ; Journalists Agenda ; News ; Institute ; Highlight ; Conference ; Seminars Cancer;HLA-G;Immune system; Fri, 03 May 2019 10:00:00 GMT Revealing molecular mechanisms that prevent measles virus replication https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2018/Revealing-molecular-mechanisms-that-prevent-measles-virus-replication.aspx Researchers discovered a novel interaction between two proteins from the measles virus. This ultra-weak interaction, involving only four amino acids situated in a very flexible and dynamic protein region, is essential for measles virus replication. This newly discovered interaction constitutes a new target to treat measles infection, but also infection by other viruses from the same family, that comprises highly dangerous human pathogens. Health & life sciences ; Virus ; Proteomics ; Diagnosis and innovative treatment ; Diseases ; Molecular mechanisms ; DNA ; Immune system general public ; Journalists ; Researchers Grenoble News ; Scientific publications ; Scientific result Measles; Wed, 22 Aug 2018 18:00:00 GMT A blood test to predict bladder cancer recurrence https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/blood-test-bladder-cancer.aspx In a 100-patient cohort at the Saint-Louis Hospital in Paris, researchers from the CEA and Paris-Diderot University have shown that the rate of certain immune cells in the blood is predictive of bladder cancer recurrence or progression. They suggest using their patented blood test to predict recurrence in other types of cancers. Cancer ; Biomarkers Researchers ; general public ; Journalists Jacob Scientific result Tue, 18 Jul 2017 10:00:00 GMT Chronic Myeloid Leukemia: a New Therapy Proves Successful https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/Chronic-Myeloid-Leukemia-a-New-Therapy-Proves-Successful.aspx In a phase 2 clinical trial, scientists showed the efficiency of targeting cancer stem cells—an approach imagined and developed at the CEA François-Jacob Institute for the treatment of leukemia, chronic myeloid leukemia in particular. Cancer ; Gene and cell therapy general public ; Journalists ; Researchers Jacob Scientific result Tue, 28 Feb 2017 11:00:00 GMT