François Jacob Institute of biology - On the same theme https://jacob.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Immune-response-not-all-equal-interferon-beta-production.aspx Website of the François Jacob Institute of Biology en-US https://jacob.cea.fr/drf/ifrancoisjacob/SiteAssets/logo-cea-JACOB.png François Jacob Institute of biology - On the same theme https://jacob.cea.fr/drf/ifrancoisjacob/english A passive immunization approach prevents SHIV infection https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/passive-immunization-shiv-infection.aspx In a study published in Nature Communications, IDMIT researchers demonstrated the efficacy of a neutralizing antibody against cell-associated infection by simian-human immunodeficiency virus. AIDS ; Infectious diseases ; Vaccine Researchers ; Journalists DRF Scientific result ; Highlight immunization;SHIV;HIV;preclinical studies;Antibody;bNAb;AIDS; Wed, 01 Nov 2023 11:00:00 GMT Rad51-mediated homologous recombination: insights into aging and tumorigenesis https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/rad-medited-homologous-recombination-aging-tumorigenesis.aspx Using a murine preclinical model wherein Rad51 was selectively inhibited, researchers from the Laboratory of Development of the Gonads (iRCM:CEA-Jacob) and the Institut Cochin showed that in vivo alteration of Rad51-mediated homologous recombination does not favor the development of cancers, it reduces it. The team's work was published in The Embo Journal. Cellular mechanisms ; Stress response ; DNA Researchers ; Journalists IRCM Scientific result ; Highlight DNA;homologous recombination;premature aging; Wed, 18 Oct 2023 10:00:00 GMT The nuclear pore: a safe place for gene expression https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/nuclear-pore-safe-place-gene-expression.aspx In an article published in Nature Communications, researchers from Institut Jacques-Monod and iRCM (CEA-Jacob) merged imaging and biochemistry approaches to show that the genes involved in expression are conducted to nuclear pores in order to protect the genome. DNA ; Cellular mechanisms ; Molecular mechanisms Researchers ; Journalists IRCM Highlight ; Scientific result R-loop;RNA;gene;nuclear; Tue, 03 Oct 2023 10:00:00 GMT COVID-19: targeting the nuclear ACE2 pathway in SARS-CoV-2 infection https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/covid-receptor-ace-infection.aspx In a new study published in Nature Communications, researchers from IDMIT and the QIMR Berghofer Institute have shown that a peptide able to inhibit the nuclear ACE2 receptor provides protection against SARS-CoV-2 infection. Infectious diseases Researchers ; Journalists DRF Highlight ; Scientific result Inflammation;infection;COVID-19;SARS-CoV-2;nace2i;ace2;preclinical studies;infectious diseases; Wed, 19 Jul 2023 10:00:00 GMT Sotrovimab remains efficacious against the BQ.1.1 omicron subvariant of SARS-CoV-2 https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/Sotrovimab-efficacious-omicron-subvariant-sars-cov-2.aspx In a study published in Heliyon, researchers from IDMIT (CEA-Jacob) used a well-characterized non-human primate model to show that sotrovimab is efficacious against the BQ.1.1 subvariant of SARS-CoV-2. Their results lend support for the continued use of sotrovimab in patients ineligible for nirmatrelvir/ritonavir. Infectious diseases ; Virus Researchers ; general public ; Journalists IDMIT Highlight ; Scientific result COVID-19;Monoclonal antibodies;subvariants;omicron;SARS-CoV-2; Wed, 05 Jul 2023 10:00:00 GMT A key complex for the repair of single-strand DNA gaps at replication forks https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/complex-repair-single-strand-DNA-replication-forks.aspx Researchers from iRCM identified new key proteins involved in the repair of single-strand DNA gaps, which occur when base lesions hamper DNA replication mechanisms. Molecular mechanisms ; DNA ; Fundamental Research Researchers ; general public ; Journalists SCSR Highlight ; Scientific result Yeast;replication;mutagenesis;Molecular mechanisms;DNA repair; Fri, 24 Mar 2023 11:00:00 GMT The role of epigenetics in tree-fungus symbiosis https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/epigenetics-tree-fungus-symbiosis.aspx Working with a model poplar line, researchers from the University of Orléans, Inrae, the University of Lorraine and CEA-Jacob's CNRGH have shown that the tree's epigenetics controls the development of ectomycorrhizas, i.e., the symbiotic relationship between the roots of certain trees and soil fungi. Environment ; Agronomy ; Molecular mechanisms ; Epigenetics Researchers ; Journalists DRF Highlight ; Scientific result dna methylation;Tree;Fungus;mycorrhization;epigenetics; Mon, 06 Mar 2023 11:00:00 GMT A duo of monoclonal antibodies for Sjögren syndrome https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/duo-monoclonal-antibodies-Sjogren-syndrome.aspx In a clinical trial, the IMVA-HB/IDMIT autoimmune team (UMR-S 1184 CEA/Inserm/UPSaclay/Kremlin Bicêtre Hospital) headed by Xavier Mariette has demonstrated the therapeutic benefits of the association of rituximab and belimumab for the treatment of Sjögren syndrome. Immune system Researchers ; Journalists DRF Highlight ; Scientific result autoimmune disease;b lymphocytes;Sjögren syndrome;Monoclonal antibodies; Mon, 06 Feb 2023 11:00:00 GMT In utero germ-cell exposure to bisphenols: a role for oxidative damage in oocyte aneuploidy https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/in-utero-germ-cell-exposure-bisphenols-oocyte-aneuploidy.aspx In a work published in Environmental Pollution, researchers from iRCM's LDG laboratory explored the effects of exposure to two bisphenol A substitutes, BADGE and BPAF, on murine germ cells, and more specifically on oocytes and their precursors. DNA ; Toxicology ; Impacts on living (organisms) Researchers ; Journalists IRCM Highlight ; Scientific result bisphenol;germ cells;oocyte;oogenesis;oxidative lesions;DNA;aneuploidy; Tue, 17 Jan 2023 11:00:00 GMT On the path toward a chikungunya vaccine https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/chikungunya-vaccine.aspx In a study published in JCI Insight, researchers from IDMIT have demonstrated the vaccinal effectiveness of serum transfers from volunteers vaccinated against the chikungunya virus to an animal model. This work is an important step toward vaccine marketing approval, as the nature of chikungunya epidemics hampers the deployment of conventional efficacy trials. Health & life sciences ; Vaccine ; Infectious diseases ; Chikungunya Researchers ; Journalists DRF Scientific result ; Highlight vaccine;chikungunya;idmit; Fri, 16 Dec 2022 11:00:00 GMT IDMIT Director Roger Le Grand joins the new Committee For Health Risk Monitoring and Anticipation (COVARS) https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2022/Roger-Le-Grand-member-COVARS.aspx IDMIT (CEA-Jacob) Director Roger Le Grand has joined COVARS, a consultative body to guide decisions made by public entities on the anticipation, prevention and human consequences of health crises. Science & society ; Infectious diseases ; Institutional Researchers ; Journalists ; general public DRF Live in the center ; Highlight zoonotic disease;human infectious diseases;scientific committee;COVARS; Fri, 14 Oct 2022 10:00:00 GMT Does the menstrual cycle affect the risk of STIs? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/menstrual-cycle-risk-STI.aspx Researchers from IDMIT describe the course of immune & inflammatory markers and the vaginal microbiome during the menstrual cycle. Infectious diseases ; Cellular mechanisms ; Immune system Researchers ; Journalists ; general public IDMIT Scientific result ; Highlight bacteria;HIV;HIV-AIDS;Infectious Disease;immune response;cellular immune responses;viruses;therapy; Fri, 20 May 2022 10:00:00 GMT Uncultured planktonic eukaryotes finally reveal their secrets https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/uncultured-planktonic-eukaryotes-secrets.aspx With massively parallel sequencing of DNA collected from the surfaces of the earth's oceans and seas (Tara Oceans expeditions) and more than ten years of analysis, an international team piloted by researchers from Genoscope (CEA-Jacob) and the CNRS has solved one of environmental biology's greatest puzzles. Environment ; DNA ; Oceanography Researchers ; Journalists ; general public GENOSCOPE Highlight ; Scientific result Tara Oceans;plankton;DNA;eukaryotic;Environmental impact;genomic;eukaryotes; Fri, 29 Apr 2022 10:00:00 GMT ComFC, a key protein in the transmission of antibiotic resistance among bacteria https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/ComFC-transmission-antibiotic-resistance-bacteria.aspx A team of researchers from IRCM (CEA-Jacob) and I2BC have shed light on the role of ComFC, a bacterial protein involved in natural transformation, itself a driving mechanism for the propagation of antibiotic resistance genes and virulence factors. Cellular mechanisms ; Molecular mechanisms ; Antibiotics Researchers ; general public ; Journalists SCSR Highlight ; Scientific result bacteria;Antibiotic;Antibiotic Resistance;Molecular mechanisms; Tue, 19 Apr 2022 10:00:00 GMT 'FRM 2022 team': an iRCM team awarded the label https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2022/team-iRCM-label-FRM-2022.aspx Stéphane Marcand's team (Telomeres and Chromosome Repair Laboratory / UMR SGCSR - iRCM) has just been labelled 'FRM 2022 Team' for its project on the regulation of DNA repair at telomeres and its consequences on genome stability. DNA ; Institutional ; Fundamental Research Researchers ; Journalists ; general public DRF Live in the center ; Highlight DNA repair;chromosome;telomere; Tue, 12 Apr 2022 10:00:00 GMT Phthalate exposition during pregnancy and DNA methylation https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/phthalate-exposition-pregnancy-DNA-methylation.aspx The Epigenetic and Environment Laboratory (CNRGH) was part of a study that characterized associations between placental DNA methylation and the concentrations of 11 phthalate-derived metabolites in urine samples from pregnant women. The samples used for the analysis, published in Environment International, were obtained from EDEN, a cohort of French mothers and children. Epigenetics ; DNA Researchers ; Journalists ; general public DRF Highlight ; Scientific result epigenetic;DNA;methylation;phtalate;pregnancy; Tue, 08 Mar 2022 11:00:00 GMT Gene editing to pull the plug on HLA-G: a novel antitumoral? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/gene-editing-HLAG-antitumoral.aspx As part of a international partnership, researchers from SRHI have shown that Crispr/Cas9 can be used to inactivate HLA-G expression in human cancer cell lines. Their unprecedented findings, published in Scientific Reports, suggest the possibility of novel treatment strategies to supplement current tumor immunotherapies. Cancer ; Immune system general public ; Journalists ; Researchers DRF Highlight ; Scientific result crispr-cas9;HLA-G;Cancer;immune checkpoint;Immune system;gene editing;Tumor; Tue, 22 Feb 2022 11:00:00 GMT A protein-based candidate vaccine prevents SARS-CoV-2 transmission in preclinical trials https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/protein-candidate-vaccine-prevents-SARS-CoV-2.aspx Preclinical trials carried out as part of a CEA-Irig–CEA-Jacob partnership have shown that a spike-protein-based candidate vaccine provides complete protection against SARS-CoV-2 infection. Infectious diseases Researchers ; Journalists ; general public IDMIT Scientific result ; Highlight COVID-19;Spike;SARS-CoV-2;vaccine;preclinical research;Lipids; Mon, 21 Feb 2022 11:00:00 GMT Homologous recombination or non-homologous end joining? Sir3 points the way https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/homologous-recombination-Sir3.aspx Researchers from IRCM furnish initial information on the mechanisms regulating DNA double-strand break repair in yeast heterochromatin. Sir3 plays an essential role in the choice of a repair pathway. Molecular mechanisms ; DNA Researchers ; general public ; Journalists IRCM Highlight ; Scientific result Molecular mechanisms;DNA repair;genome stability;heterochromatin; Wed, 09 Feb 2022 11:00:00 GMT Inflammation and COVID-19: the HLA-G immune checkpoint under surveillance https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/inflammation-Covid-19-HLA-G-checkpoint-immune-surveillance.aspx In a study published in Viruses, a team of researchers from SRHI and the University of Ferrara (Italy) showed that the soluble form of HLA-G may contribute significant anti-inflammatory properties via its role in controlling the adhesion of neutrophils to endothelial cells and thus improve disease outcome in patients with COVID-19. Infectious diseases ; Cellular mechanisms Researchers ; Journalists ; general public SRHI Scientific result ; Highlight HLA-G;COVID-19;endothelial cells;Angiogenesis;neutrophil; Tue, 11 Jan 2022 11:00:00 GMT HLA-G : a new therapeutic target in cancer https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/HLA-G-therapeutic-target-cancer.aspx In a study published in Cancer Letters, SRHI's researchers (CEA-Jacob) highlight the therapeutic value of targeting the HLA-G/IL2 immune checkpoint in clear cell renal cell carcinoma. Immune system ; Cancer Researchers ; Journalists ; general public DRF Scientific result ; Highlight therapeutic antibodies;HLA-G;immune checkpoint;Cancer; Tue, 24 Aug 2021 10:00:00 GMT Trees, drought tolerance and epigenetics https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/Trees-drought-tolerance-epigenetics.aspx A team of researchers from Inrae, Orleans University, the University of Oregon (USA), CEA-Jacob and IRD studied the role of epigenetics in drought tolerance in poplars. Their results, published in New Phytologist, suggest that epigenetic changes during droughts affect the genes involved in the tree's hormonal response to water deficits and may result in genetic mutations. Epigenetics ; Environment ; Climate Researchers ; Journalists ; general public DRF Scientific result ; Highlight Drought;Trees;epigenetic;climate change;poplars;hormonal response;DNA;methylation; Mon, 05 Jul 2021 10:00:00 GMT The telomere mystery: a protection mechanism decrypted https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/telomere-mystery-protection-mechanism-decrypted.aspx The mechanisms that control the stability of telomeres, structures located at the ends of chromosomes, remain largely mysterious. One of them however has been decrypted by researchers from IRCM (CEA-Jacob) and I2BC (CEA-Joliot) in a work carried out in yeasts. Their results, published in Nature Communications, could help identify new therapeutic targets in human cancers. Molecular mechanisms ; DNA ; Cancer Researchers ; Journalists ; general public SCSR Highlight ; Scientific result telomere;Yeast;DNA repair;chromosome stability;modeling;genetic;Cancer;DNA; Thu, 27 May 2021 10:00:00 GMT A potential therapeutic role for PPAR-γ in myelofibrosis https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/potential-therapeutic-role-PPAR-gamma-myelofibrosis.aspx In a study published in the Journal of Clinical Investigation, researchers from IDMIT's LCSAT lab (CEA-Jacob) evaluated PPAR-γ ligands in the development of myelofibrosis. Diagnosis and innovative treatment ; Cancer Researchers ; Journalists ; general public IDMIT Scientific result ; Highlight therapy;Inflammation;myeloid cells;PPAR-γ;Hematopoietic stem cells;fibrosis; Tue, 18 May 2021 10:00:00 GMT COVID-19 durably affects the intestinal microbiota https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/COVID-19-affects-intestinal-microbiota.aspx The microbial composition and metabolome of the intestinal microbiota of an animal model for COVID-19 were altered over the disease course and remained so after the resolution of lung infection. Those results, which will contribute were brought to light by the Institut Pasteur in Lille in partnership with IDMIT (CEA-Jacob). Infectious diseases ; Metagenomics Researchers ; Journalists ; general public DRF News ; Scientific result dysbiosis;intestinal microbiota;COVID 19;SARS-CoV2; Wed, 05 May 2021 10:00:00 GMT Role of salivary epithelial cells in the pathogenesis of primary Sjögren syndrome https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/salivary-epithelial-cells-pathogenesis-primary-Sjogren-syndrome.aspx The UMR1184S Autoimmune Diseases Team (IDMIT CEA-Jacobl) has published an article in Arthritis & Rheumatology confirming a direct pathogenic role for salivary epithelial cells in primary Sjögren syndrome. Immune system ; Autoimmune diseases Researchers ; Journalists ; general public DRF Scientific result primary Sjörgren syndrome;salivary epithelial cells;autoimmune disease;Interferon; Mon, 03 May 2021 10:00:00 GMT Cellular prion protein at the heart of radioresistance in solid tumors https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/cellular-prion-protein-radioresistance-solid-tumors.aspx In an article published in Oncogene, researchers from LRTS and LRIG (IRCM/CEA-Jacob) have shown that an increase in the expression of cellular prion protein driven by the ATM/TAK1/JUNK signaling pathway contributes to solid tumor radioresistance. Radiotherapy ; Radiosensitivity ; Cancer Researchers ; Journalists ; general public DRF Scientific result prion;DNA damage;DNA damage response;cellular prion protein;ionizing radiation;radioresistance; Wed, 28 Apr 2021 10:00:00 GMT Mapping DNA methylation in simian immunodeficiency virus infection https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/mapping-dna-methylation-simian-immunodeficiency-infection.aspx In a partnership with IDMIT (CEA-Jacob) and Institut Pasteur, the Epigenetic and Environment Laboratory (LEE; CNRGH/CEA-Jacob) carried out two studies to evaluate DNA methylation in non-human primate models of immunodeficiency virus infections. Virus ; Epigenetics Researchers ; Journalists ; general public DRF Scientific result ; Highlight HIV;epigenetic;SIV;methylation; Mon, 05 Apr 2021 10:00:00 GMT Targeting HIF1α or JMY in glioblastoma: if not one why not the other? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/HIF1-JMY-glioblastoma-targeting.aspx Glioblastomas are highly aggressive brain tumors with a very poor prognosis. Even with aggressive treatment, recurrence is nearly systematic. Researchers from IRCM (CEA-Jacob) have decrypted molecular mechanisms that enable treatment resistance and escape for a subpopulation of cells. Brain ; Cancer ; Stem cells Researchers ; Journalists ; general public SCSR Highlight ; Scientific result Brain;glioblastoma;Cancer;invasion;Tumor;ionizing radiations;HIF1α; Thu, 01 Apr 2021 10:00:00 GMT Preclinical study sheds light on a new vaccine candidate for Covid-19 https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/preclinical-study-sheds-light-new-vaccine-candidate-Covid-19.aspx A new international study, published in Cell, co-leaded by IDMIT (CEA-Jacob) and the Department of Medical Microbiology of the University of Amsterdam, presents the results of preclinical trials of a new protein vaccine candidate against Covid-19. Infectious diseases ; Virus ; Vaccine Researchers ; Journalists ; general public DRF Highlight ; Scientific result COVID 19;SARS-CoV-2;vaccine;Nanoparticles;Preclinical; Mon, 08 Mar 2021 11:00:00 GMT The placenta knows you smoked https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/placenta-knows-you-smoked.aspx The CNRGH contributed to a work showing that tobacco exposure, even when stopped before becoming pregnant, leaves traces in the placenta in the form of epigenetic modifications to its DNA. Epigenetics Researchers ; Journalists ; general public Jacob Scientific result tobacco;epigenetic;placenta;methylation; Tue, 26 Jan 2021 11:00:00 GMT Radioactive iodine and thyroid cancer: lessons from Chernobyl and Fukushima https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Radioactive-iodine-thyroid-cancer-Chernobyl-Fukushima.aspx The nuclear power plant accidents at Chernobyl and Fukushima released enormous amounts of radioactive iodine into the atmosphere. Researchers from IRCM (CEA-Jacob) propose an analysis of data on the health consequences of those accidents and particularly the effects they had on the thyroid. Radioactivity ; Radiobiology ; Radiotherapy ; Molecular mechanisms ; Cancer Researchers ; general public ; Journalists IRCM Scientific result ; Highlight molecular signature;prophylaxis;ionizing radiations;thyroid;nuclear accident;radioactive iodine;radiation-induced cancers;Cancer; Tue, 01 Dec 2020 11:00:00 GMT FLASH radiotherapy for the treatment of acute lymphoblastic leukemia https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/FLASH-radiotherapy-treatment-acute-lymphoblastic-leukemia.aspx The LSHL (IRCM/CEA-Jacob) and the radiation oncology department of the Lausanne University Hospital teamed to compare FLASH radiotherapy to conventional radiotherapy in the setting of acute lymphoblastic leukemia. Their results, published in the International Journal of Radiation Oncology * Biology * Physics, open new paths to treat this type of leukemia while preserving normal hematopoiesis. Cancer ; Radiotherapy Researchers ; Journalists ; general public DRF Highlight ; News ; Scientific result FLASH-RT;FLASH radiotherapy;conventional radiotherapy;Radiotherapy;Leukemia;pediatric leukemia;acute lymphoblastic leukemia; Thu, 19 Nov 2020 11:00:00 GMT Immune response: not all are equal in interferon β production https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Immune-response-not-all-equal-interferon-beta-production.aspx Researchers from IRCM (CEA-Jacob) have identified a DNA sequence polymorphism that leads to reduced production of interferon β by myeloid cells. The substitution, which is present in about 30% of the population, could affect immune response to infections and tumors. Molecular mechanisms ; Cancer ; Infectious diseases ; Immune system Researchers ; general public ; Journalists IRCM Scientific result ; Highlight radiation-induced tumor;myeloid cells;infection;immunity;regulation of gene expression;virus;polymorphism; Wed, 18 Nov 2020 11:00:00 GMT Professor François Desgrandchamps wins FRM's 2020 Jean Bernard Prize https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/Professor-Desgrandchamps-wins-FRM-2020-Jean-Bernard-Prize.aspx The Jean Bernard Prize, named after the founder of the French Foundation for Medical Research (FRM), honors scientists whose research greatens public knowledge in health. This year, the FRM presented the Jean Bernard Prize to Prof. François Desgrandchamps of the Immuno-Hematology Research Unit (CEA-Jacob). Cancer ; Immune system general public ; Researchers ; Journalists DRF Live in the center ; News ; Highlight Tue, 03 Nov 2020 11:00:00 GMT A breakthrough in the understanding of natural HIV infection control mechanisms https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/breakthrough-understanding-natural-HIV-infection-control-mechanisms.aspx Researchers from IDMIT (CEA-Jacob) and the Institut Pasteur teamed for a study in which they showed that the antiviral activity of CD8+ T lymphocytes remained limited in the first two weeks of infection but grew progressively and durably thereafter in macaques able to control simian immunodeficiency virus infection (the equivalent of HIV infection in non-human primates). Their results suggest that the early development of highly effective memory CD8+ T-cells is essential for achieving viral control. Diagnosis and innovative treatment ; Vaccine ; Infectious diseases ; AIDS ; Virus Researchers ; general public ; Journalists IDMIT Highlight ; Scientific result HIV-AIDS;HIV;vaccine;human infectious diseases;SIV;lymphocytes;Immune system; Thu, 08 Oct 2020 10:00:00 GMT Experimental models and Covid-19 https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/experimental-models-Covid-19.aspx The COVID-19 pandemic has underlined how important intense preclinical research is to the development and validation of therapeutics. In this context, a WHO-mandated group of experts, including Roger le Grand and Pauline Maisonnasse from IDMIT (CEA-Jacob), have published an article in Nature that presents existing COVID-19 animal models and explores their pertinence for studying the pathology and identifying paths toward novel treatments for it. Infectious diseases ; Virus general public ; Researchers ; Journalists DRF Scientific result coronavirus;viral infectious;animal models;COVID 19;experimental models;preclinical studies; Fri, 02 Oct 2020 10:00:00 GMT Hydroxychloroquine and preclinical studies: a world tour in five experimental models https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Hydroxychloroquine-preclinical-studies-world-tour-five-experimental-models.aspx An international study involving IDMIT's (CEA-Jacob) Roger Le Grand and other researchers from more than 80 countries concluded that chloroquine and hydroxychloroquine likely provide no clinical benefits in the treatment of COVID-19. Infectious diseases ; Virus Researchers ; Journalists ; general public DRF Scientific result ; Highlight preclinical studies;pathology modeling;COVID-19;chloroquine;hydroxychloroquine;human infectious diseases; Fri, 28 Aug 2020 10:00:00 GMT Launch of Corona Accelerated R&D in Europe: IDMIT steps up to the plate https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/Launch-of-CARE-program-IDMIT-steps-up-to-the-plate.aspx IDMIT (CEA-Jacob) is participating in CARE, a public-private consortium of 37 organizations brought together to speed the development of treatments for COVID-19 and future coronavirus epidemics. Infectious diseases ; Virus ; Diagnosis and innovative treatment Journalists ; Researchers ; general public IDMIT News ; Headlines research;european project;Europe;funding;COVID 19;vaccine;consortium;infectious diseases; Thu, 27 Aug 2020 10:00:00 GMT Anti-HIV antibodies: predicting in vivo efficacy in vitro https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Anti-HIV-antibodies-predicting-in-vivo-efficacy-in-vitro.aspx A study performed by an IDMIT team (CEA-Jacob) has resulted in an in vitro approach for predicting the in vivo efficacy of antibodies used for the prevention of HIV-1 transmission. The work identified antibodies capable of efficaciously blocking intercellular viral transmission in infected semen. Vaccine ; AIDS ; Infectious diseases ; Diagnosis and innovative treatment ; Biotechnology ; Virus Researchers ; general public ; Journalists IDMIT Scientific result ; Highlight intercellular transmission;sperm;vaccine;Antibody;HIV;AIDS; Fri, 07 Aug 2020 10:00:00 GMT Angiogenesis and immunity: a double target for kidney cancer treatment https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/angiogenesis-immunity-double-target-kidney-cancer-treatment.aspx Researchers from SRHI (CEA-Jacob) have demonstrated a correlation between VEGF expression and the HLA-G/IL4 immune checkpoint in the most common form of kidney cancer. Their study, published in BMC Cancer, opens new horizons for the deployment of novel therapeutic protocols. Cancer ; Immune system Researchers ; general public ; Journalists DRF News ; Scientific result Immune system;bevacizumab;therapeutic targets;HLA-G;immune checkpoint;VEGF;Angiogenesis;kidney cancer;therapeutic antibodies;Cancer; Wed, 05 Aug 2020 10:00:00 GMT Questioning COVID-19 and hydroxychloroquine: a new preclinical study https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/questioning-COVID-19-hydroxychloroquine-new-preclinical-study.aspx A new preclinical study piloted by IDMIT and employing experimental infection models for SARS-CoV-2 found no therapeutic antiviral efficacy for hydroxychloroquine. The team behind the study tested the compound both alone and in combination with azithromycin, and as a prophylactic and in early and late infection. Their results have been published on Nature. Virus ; Infectious diseases Journalists ; Researchers ; general public DRF Scientific result ; Highlight COVID 19;SARS-CoV-2;virus;virology;idmit;translational approaches;preclinical research;azythromycine; Wed, 22 Jul 2020 10:00:00 GMT The brain: a careful balance between stability and genetic variability https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/The-brain-balance-stability-variability.aspx In a study published in DNA Repair, an IRCM (CEA-Jacob) team has elucidated mechanisms through which neural stem and progenitor cells maintain genome integrity more efficaciously than other cell types. The team's work contributes to a better understanding of the high-fidelity transmission of genetic information so crucial to brain development. Brain ; DNA ; Stem cells ; Stress response Researchers ; general public ; Journalists DRF Scientific result ; Highlight adaptive response;chromosome stability;genetic diversity;neural progenitor cells;Brain;DNA repair;development;radiation;genotoxic stress;non-homologous end-joining;Neural stem cells; Mon, 20 Jul 2020 10:00:00 GMT HIV transmission: a role for genital tract inflammation and immunity https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/HIV-transmission-inflammation-immunity.aspx In a study on the HIV-specific immune response in semen, published in Frontiers in Immunology, researchers from IDMIT (CEA-Jacob) have shed light on a complex interaction between immunity and inflammation in modulating semen infectivity and the risk of HIV transmission. Infectious diseases ; AIDS Researchers ; general public ; Journalists Jacob Scientific result ; Highlight Inflammation;immunity;HIV-AIDS;infectious diseases;HIV;AIDS;human infectious diseases; Tue, 07 Jul 2020 10:00:00 GMT COVID-19: two projects retained for the Paris-Saclay University exceptional research program https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/COVID-19-two-projects-retained-Paris-Saclay-University-exceptional-research-program.aspx Paris-Saclay University as well as its component institutions and member-associated universities , their partner national research organisms, and the LERMIT, CHARMMMAT, LASIPS and NanoSaclay laboratories of excellence (LabExs) collectively decided to release funds for research projects targeting the COVID-19 pandemic. Among the laureates are the CNRGH and IRCM, with their respective projects COVIDOGEN and BIOTHETARCOVI. Infectious diseases Researchers ; Journalists ; general public DRF Highlight Inflammation;COVID 19;LRTS;CNRGH;idmit;iRCM; Sun, 21 Jun 2020 10:00:00 GMT Multiple system atrophy: tracking down epigenetic markers https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/multiple-system-atrophy-tracking-down-epigenetic-markers.aspx In a study published in Acta Neuropathologica Communications, researchers from LEE (CNRGH/CEA-Jacob) and the LRSN (Bispebjerg-Frederiksberg University Hospital, Copenhagen) joined forces to characterize DNA methylation profiles in patients with multiple system atrophy (MSA). The team brought to light epigenetic aspects that suggest an active neuro-immune response in patients with MSA. Their work contributes to a better understanding of the diseases and opens new horizons for therapeutic strategies. Epigenetics Researchers ; general public ; Journalists Jacob Scientific result ; Highlight dna methylation;epigenetics;Neurodegenerative disease;SMA; Wed, 17 Jun 2020 10:00:00 GMT Immune checkpoints: new targets in kidney cancer https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/immune-checkpoints-new-targets-kidney-cancer.aspx Researchers from SRHI in partnership with the MICS lab (CentraleSupélec, Paris-Saclay University) have identified new immune checkpoints as potential targets in clear cell renal cell carcinoma. The team's results, obtained by pairing statistics and biological analyses, have been published in Cancer Immunology, Immunotherapy. Cancer ; Immune system Researchers ; Journalists ; general public Jacob Scientific result immunotherapy;PD-L1;Cancer;clear cell renal cell carcinoma;HLA-G; Fri, 22 May 2020 10:00:00 GMT Flash ANR Covid-19: IDMIT engaged in a project selected by the ANR https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/Flash-ANR-Covid-19-IDMIT-engaged-in-a-project-selected-by-the-ANR.aspx As a part of the Covid-19 Flash call launched on March 6, 2020, the ANR selected 86 research projects for immediate funding, covering a large number of issues related to the Covid-19 epidemic. Among the selected projects, one project coordinated by Roger Le Grand (IDMIT) focuses on the study of the pathogenesis of the SARS-Cov-2 infection in a pre-clinical study model. Infectious diseases ; Virus Researchers ; Journalists DRF Highlight coronavirus;COVID 19; Sun, 12 Apr 2020 10:00:00 GMT Tissue repair: when macrophages lead the way https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Tissue-repair-when-macrophages-lead-the-way.aspx Through an international collaboration, researchers from the LRTS laboratory (IRCM/CEA-Jacob) have characterized the cellular and molecular events regulating the balance between fibrotic repair and tissue regeneration and have identified a key player in this balance : macrophages. This study, published in Science Advances, opens up a new therapeutic perspective for the treatment of pathological tissue lesions. Immune system Researchers ; Journalists DRF Highlight ; Scientific result Inflammation;phagocytosis;tissue repair;Macrophages;fibrosis;skin;healing; Tue, 31 Mar 2020 10:00:00 GMT Innate immune memory and vaccination: a controlled schedule for improved benefit https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Innate-immune-memory-and-vaccination-a-controlled-schedule-for-improved-benefit.aspx A study led by IMVA-HB/IDMIT researchers, published in NPJ Vaccines, has shown the influence of the delay between vaccinations (primary and booster) on the specific humoral immune response. This work also suggests the establishment of a trained immune memory. Vaccine ; Infectious diseases ; Immune system Researchers ; Journalists DRF Highlight ; News ; Scientific result immunization;immune response;vaccine;Immune memory;Immune system;Vaccination Immunogenicity; Thu, 19 Mar 2020 11:00:00 GMT IDMIT on point against COVID-19 https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/IDMIT-on-point-against-COVID-19.aspx With the support of the Ministry of Solidarity and Health and the Ministry of Higher Education, Research and Innovation, 20 scientific initiatives were selected by REACTing's scientific board and presented at a press conference on 11 March. Among them, IDMIT is piloting a fundamental research project on the evolution of Covid-19 in a specific pre-clinical study model. Infectious diseases Researchers ; Journalists DRF Highlight ; News virus;Infectious Disease;idmit; Fri, 13 Mar 2020 11:00:00 GMT European research gets organised against tuberculosis https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/European-research-gets-organised-against-tuberculosis.aspx To develop new treatments for tuberculosis, the world's leading cause of death from infectious diseases, the European Union and the European Federation of Pharmaceutical Industries and Associations are launching the ERA4TB (European Regimen Accelerator for Tuberculosis) consortium combining academic and private research, of which the IDMIT department is a partner Infectious diseases Researchers ; Journalists DRF Highlight ; News tuberculosis;Tuberculosis Bacterium;Infectious Disease; Mon, 17 Feb 2020 11:00:00 GMT Helicobacter pylori: please don't share… https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/Helicobacter-pylori-please-do-not-share.aspx ...or how finding the unique link may be a path toward curing gastric infections. In a study published in Nature Communications, researchers from LRIG (IRCM) identified a protein that is essential for an antibiotic resistance propagation pathway in the bacterium Helicobacter pylori. Infectious diseases ; Bacteria Researchers ; Journalists Highlight ; News ; Scientific result recombination;DNA repair;bacteria;infectious diseases;Helicobacter pylori; Thu, 28 Nov 2019 11:00:00 GMT On track to eradicating stomach infections in half the world's population https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2019/On-track-to-eradicating-stomach-infections-in-half-the-world's-population.aspx Health & life sciences ; Diseases ; Bacteria ; Infectious diseases News ; Press release ; Focus Wed, 27 Nov 2019 11:00:00 GMT A bit of air please... https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/A-bit-of-air-please-.aspx ...or how small amounts of oxygen contribute to the preservation of lymphocyte progenitors in humans. In an article published in Cell Reports, researchers from LSHL (IRCM) shared new findings on the role of hypoxia in human lymphocyte differentiation. Stem cells ; Immune system Researchers ; Journalists Jacob News ; Highlight ; Scientific result hematopoietic differentiation;T lymphocytes;Hematopoietic stem cells;hypoxia;Immune system; Tue, 19 Nov 2019 11:00:00 GMT The genome of the pea assembled for the first time https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2019/The-genome-of-the-pea-assembled-for-the-first-time.aspx Fundamental Research ; Science & society ; Health & life sciences ; Methodologies for life sciences ; Molecular mechanisms ; Cellular mechanisms ; Genomics Press release ; News ; Focus Tue, 03 Sep 2019 10:00:00 GMT ZNA: A new genetic support for biology and medicine https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/ZNA-A-new-genetic-support-biology-medicine.aspx Genoscope contributed to a study describing a novel synthesized nucleic acid with a previously undescribed molecular backbone. This new genetic support expands the biotech armamentarium for tomorrow's medicine. Genomics ; DNA Researchers ; Journalists DRF Scientific result DNA;RNA;Gene Sequence;genome;xenobiology;genomics; Fri, 09 Aug 2019 10:00:00 GMT DNA breakage: a rescue pathway identified in Saccharomyces cerevisiae https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/DNA-breakage-a-rescue-pathway-identified-in-Saccharomyces-cerevisiae.aspx In a study recently published in the journal Molecular Cell, IRCM researchers describe the key elements of a pathway that protects chromosomes from certain radiation-induced rearrangements. Radiobiology ; Radiosensitivity ; Cancer ; DNA Researchers ; general public ; Journalists IRCM News ; Scientific publications ; Scientific result ; Highlight radiobiology;Cancer;DNA;radiosensitivity; Fri, 14 Jun 2019 10:00:00 GMT The brain: a key participant in the development of cancer? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/The-brain-a-key-participant-in-the-development-of-cancer.aspx A French team from IRCM (CEA/Inserm) recently published a study in the scientific journal Nature showing that neurons can develop within the tumoral microenvironment and thus contribute to the development of certain types of cancer. Brain ; Cancer ; Health & life sciences ; Cellular mechanisms Researchers ; Journalists ; general public Paris-Saclay Scientific publications ; Scientific result ; News health;Cancer;neural network;Brain;neuron;neurosciences; Fri, 17 May 2019 10:00:00 GMT 8th international Conference on HLA-G https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2019/8th-international-Conference-on-HLA-G.aspx The 8th International Conference on HLA-G will take place at the Ministry of Health and Solidarity (Ministère de la Santé et des Solidarités) in Paris on 8, 9 and 10 July 2019. Cancer ; Health & life sciences ; Immune system Researchers ; Journalists Agenda ; News ; Institute ; Highlight ; Conference ; Seminars Cancer;HLA-G;Immune system; Fri, 03 May 2019 10:00:00 GMT Complete plant chromosomes reconstructed via sequencing and optical mapping https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/Complete-plant-chromosomes-reconstructed-sequencing-optical-mapping.aspx A Genoscope team has reconstructed compete plant chromosomes by combining DNA long-read sequencing and optical mapping technologies. Earth sciences ; Biodiversity ; DNA ; Vegetal physiology Fontenay-aux-Roses Scientific result sequencing;chromosome;plants genomes; Tue, 04 Dec 2018 11:00:00 GMT New function discovered for the protein Rad52, a serious therapeutic target in breast cancer https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/New-function-discovered-protein-Rad52-serious-therapeutic-target-breast-cancer.aspx Rad52 has garnered great attention lately as a promising target in the battle against certain types of breast cancer. A team from IRCM, in partnership with researchers from the Frédéric-Joliot and Gustave Roussy Institutes, has shed new light on this protein. Stress response ; Molecular mechanisms Jacob Scientific result Rad51 filament;budding yeast;Srs2; Fri, 12 Oct 2018 10:00:00 GMT Revealing molecular mechanisms that prevent measles virus replication https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2018/Revealing-molecular-mechanisms-that-prevent-measles-virus-replication.aspx Researchers discovered a novel interaction between two proteins from the measles virus. This ultra-weak interaction, involving only four amino acids situated in a very flexible and dynamic protein region, is essential for measles virus replication. This newly discovered interaction constitutes a new target to treat measles infection, but also infection by other viruses from the same family, that comprises highly dangerous human pathogens. Health & life sciences ; Virus ; Proteomics ; Diagnosis and innovative treatment ; Diseases ; Molecular mechanisms ; DNA ; Immune system general public ; Journalists ; Researchers Grenoble News ; Scientific publications ; Scientific result Measles; Wed, 22 Aug 2018 18:00:00 GMT DNA repair: the importance of proximity https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/DNA-repair-importance-proximity.aspx Researchers at IRCM have shown that certain mechanisms involved in DNA repair are influenced by the intramolecular and intranuclear spatial organization of the macromolecule. Fundamental Research ; Radiobiology ; DNA Scientific result genotoxic stress; Wed, 11 Apr 2018 10:00:00 GMT Huntington's disease and DCLK3: a vicious circle of gene transcription deregulation? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/Huntington-DCLK3-vicious-circle-transcription-deregulation.aspx The results of a study performed by a research team at MIRCen suggest that the protein DCLK3 plays a key role in transcription regulation, and its deficit in Huntington's disease a key role in neurodegeneration. Neurodegenerative diseases ; Cellular mechanisms ; Molecular mechanisms Fontenay-aux-Roses Scientific result chromatin remodeling;transcription;DCLK3; Mon, 26 Mar 2018 10:00:00 GMT Neurofibrillary tangles: a protective role in Alzheimer's disease? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/neurofibrillary-tangles-protective-role-alzheimer.aspx Neurofibrillary tangles are large aggregates of tau protein found in the neurons of people with Alzheimer's disease. Historically, they have been thought to be at least partially responsible for the pathology. However, the results of a study performed by researchers at MIRCen (François Jacob Institute of Biology/CEA) suggest to the contrary that neurofibrillary tangles may be protective. Alzheimer's disease ; Molecular mechanisms Fontenay-aux-Roses Scientific result neurofibrillary tangles;tau protein;hyperphosphorylation; Thu, 08 Mar 2018 11:00:00 GMT White fat, brown fat, and preventing obesity https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/white-fat-brown-fat.aspx A team from the Innovative Therapies Unit (STI) has discovered a molecular mechanism that regulates the balance between white and brown fat. Their work defines a novel category of potential targets in the quest to control fat mass. Molecular mechanisms ; Cellular mechanisms Fontenay-aux-Roses Scientific result FOG-2;pRb;adipogenesis; Fri, 09 Feb 2018 11:00:00 GMT MicroRNA: a possible treatment for Sjögren syndrome? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/microRNA-possible-treatment-sjogren-syndrome.aspx An epigenetics analysis of lymphocytes in the setting of Sjögren syndrome may have shed light on a possible treatment for this autoimmune disorder. Epigenetics ; Molecular mechanisms ; Health & life sciences Scientific result microRNA;Sjögren syndrome;autoimmune disorder; Fri, 22 Dec 2017 11:00:00 GMT HIV "elite controllers" starting to share their secrets https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/HIV-Elite-controllers.aspx What are the mechanisms preventing viral progression in HIV "elite controllers"? Researchers at the François Jacob Institute of Biology and their partners have shed light on some particularities of CD8+ T cells. AIDS Researchers ; general public ; Journalists Jacob Scientific result Fri, 28 Jul 2017 10:00:00 GMT A blood test to predict bladder cancer recurrence https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/blood-test-bladder-cancer.aspx In a 100-patient cohort at the Saint-Louis Hospital in Paris, researchers from the CEA and Paris-Diderot University have shown that the rate of certain immune cells in the blood is predictive of bladder cancer recurrence or progression. They suggest using their patented blood test to predict recurrence in other types of cancers. Cancer ; Biomarkers Researchers ; general public ; Journalists Jacob Scientific result Tue, 18 Jul 2017 10:00:00 GMT Promising Tests of a Vaccine against Chikungunya virus https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/promising-tests-of-a-vaccine-against-chikungunya-virus.aspx A team from the CEA François-Jacob Institute has demonstrated the preclinical efficacy of three vaccine candidates against chikungunya. Health & life sciences ; Virus ; Chikungunya general public ; Journalists ; Researchers Jacob Scientific result Tue, 25 Apr 2017 10:00:00 GMT Chikungunya: Pain Caused by the Immune System https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/chikungunya-pain-caused-by-the-immune-system.aspx Joint damage in people infected with chikungunya remains poorly understood. Scientists from the CEA François-Jacob Institute and their partners have identified an actor of the antiviral immune response whose inhibition paradoxically reduces the severity of the symptoms. Infectious diseases ; Chikungunya ; Diagnosis and innovative treatment general public ; Journalists ; Researchers Jacob Scientific result Mon, 13 Mar 2017 11:00:00 GMT Chronic Myeloid Leukemia: a New Therapy Proves Successful https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/Chronic-Myeloid-Leukemia-a-New-Therapy-Proves-Successful.aspx In a phase 2 clinical trial, scientists showed the efficiency of targeting cancer stem cells—an approach imagined and developed at the CEA François-Jacob Institute for the treatment of leukemia, chronic myeloid leukemia in particular. Cancer ; Gene and cell therapy general public ; Journalists ; Researchers Jacob Scientific result Tue, 28 Feb 2017 11:00:00 GMT