François Jacob Institute of biology - On the same theme https://jacob.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Radioactive-iodine-thyroid-cancer-Chernobyl-Fukushima.aspx Website of the François Jacob Institute of Biology en-US https://jacob.cea.fr/drf/ifrancoisjacob/SiteAssets/logo-cea-JACOB.png François Jacob Institute of biology - On the same theme https://jacob.cea.fr/drf/ifrancoisjacob/english Rad51-mediated homologous recombination: insights into aging and tumorigenesis https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/rad-medited-homologous-recombination-aging-tumorigenesis.aspx Using a murine preclinical model wherein Rad51 was selectively inhibited, researchers from the Laboratory of Development of the Gonads (iRCM:CEA-Jacob) and the Institut Cochin showed that in vivo alteration of Rad51-mediated homologous recombination does not favor the development of cancers, it reduces it. The team's work was published in The Embo Journal. Cellular mechanisms ; Stress response ; DNA Researchers ; Journalists IRCM Scientific result ; Highlight DNA;homologous recombination;premature aging; Wed, 18 Oct 2023 10:00:00 GMT The nuclear pore: a safe place for gene expression https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/nuclear-pore-safe-place-gene-expression.aspx In an article published in Nature Communications, researchers from Institut Jacques-Monod and iRCM (CEA-Jacob) merged imaging and biochemistry approaches to show that the genes involved in expression are conducted to nuclear pores in order to protect the genome. DNA ; Cellular mechanisms ; Molecular mechanisms Researchers ; Journalists IRCM Highlight ; Scientific result R-loop;RNA;gene;nuclear; Tue, 03 Oct 2023 10:00:00 GMT A key complex for the repair of single-strand DNA gaps at replication forks https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/complex-repair-single-strand-DNA-replication-forks.aspx Researchers from iRCM identified new key proteins involved in the repair of single-strand DNA gaps, which occur when base lesions hamper DNA replication mechanisms. Molecular mechanisms ; DNA ; Fundamental Research Researchers ; general public ; Journalists SCSR Highlight ; Scientific result Yeast;replication;mutagenesis;Molecular mechanisms;DNA repair; Fri, 24 Mar 2023 11:00:00 GMT The role of epigenetics in tree-fungus symbiosis https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/epigenetics-tree-fungus-symbiosis.aspx Working with a model poplar line, researchers from the University of Orléans, Inrae, the University of Lorraine and CEA-Jacob's CNRGH have shown that the tree's epigenetics controls the development of ectomycorrhizas, i.e., the symbiotic relationship between the roots of certain trees and soil fungi. Environment ; Agronomy ; Molecular mechanisms ; Epigenetics Researchers ; Journalists DRF Highlight ; Scientific result dna methylation;Tree;Fungus;mycorrhization;epigenetics; Mon, 06 Mar 2023 11:00:00 GMT In utero germ-cell exposure to bisphenols: a role for oxidative damage in oocyte aneuploidy https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/in-utero-germ-cell-exposure-bisphenols-oocyte-aneuploidy.aspx In a work published in Environmental Pollution, researchers from iRCM's LDG laboratory explored the effects of exposure to two bisphenol A substitutes, BADGE and BPAF, on murine germ cells, and more specifically on oocytes and their precursors. DNA ; Toxicology ; Impacts on living (organisms) Researchers ; Journalists IRCM Highlight ; Scientific result bisphenol;germ cells;oocyte;oogenesis;oxidative lesions;DNA;aneuploidy; Tue, 17 Jan 2023 11:00:00 GMT Uncultured planktonic eukaryotes finally reveal their secrets https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/uncultured-planktonic-eukaryotes-secrets.aspx With massively parallel sequencing of DNA collected from the surfaces of the earth's oceans and seas (Tara Oceans expeditions) and more than ten years of analysis, an international team piloted by researchers from Genoscope (CEA-Jacob) and the CNRS has solved one of environmental biology's greatest puzzles. Environment ; DNA ; Oceanography Researchers ; Journalists ; general public GENOSCOPE Highlight ; Scientific result Tara Oceans;plankton;DNA;eukaryotic;Environmental impact;genomic;eukaryotes; Fri, 29 Apr 2022 10:00:00 GMT ComFC, a key protein in the transmission of antibiotic resistance among bacteria https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/ComFC-transmission-antibiotic-resistance-bacteria.aspx A team of researchers from IRCM (CEA-Jacob) and I2BC have shed light on the role of ComFC, a bacterial protein involved in natural transformation, itself a driving mechanism for the propagation of antibiotic resistance genes and virulence factors. Cellular mechanisms ; Molecular mechanisms ; Antibiotics Researchers ; general public ; Journalists SCSR Highlight ; Scientific result bacteria;Antibiotic;Antibiotic Resistance;Molecular mechanisms; Tue, 19 Apr 2022 10:00:00 GMT 'FRM 2022 team': an iRCM team awarded the label https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2022/team-iRCM-label-FRM-2022.aspx Stéphane Marcand's team (Telomeres and Chromosome Repair Laboratory / UMR SGCSR - iRCM) has just been labelled 'FRM 2022 Team' for its project on the regulation of DNA repair at telomeres and its consequences on genome stability. DNA ; Institutional ; Fundamental Research Researchers ; Journalists ; general public DRF Live in the center ; Highlight DNA repair;chromosome;telomere; Tue, 12 Apr 2022 10:00:00 GMT Phthalate exposition during pregnancy and DNA methylation https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/phthalate-exposition-pregnancy-DNA-methylation.aspx The Epigenetic and Environment Laboratory (CNRGH) was part of a study that characterized associations between placental DNA methylation and the concentrations of 11 phthalate-derived metabolites in urine samples from pregnant women. The samples used for the analysis, published in Environment International, were obtained from EDEN, a cohort of French mothers and children. Epigenetics ; DNA Researchers ; Journalists ; general public DRF Highlight ; Scientific result epigenetic;DNA;methylation;phtalate;pregnancy; Tue, 08 Mar 2022 11:00:00 GMT Gene editing to pull the plug on HLA-G: a novel antitumoral? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/gene-editing-HLAG-antitumoral.aspx As part of a international partnership, researchers from SRHI have shown that Crispr/Cas9 can be used to inactivate HLA-G expression in human cancer cell lines. Their unprecedented findings, published in Scientific Reports, suggest the possibility of novel treatment strategies to supplement current tumor immunotherapies. Cancer ; Immune system general public ; Journalists ; Researchers DRF Highlight ; Scientific result crispr-cas9;HLA-G;Cancer;immune checkpoint;Immune system;gene editing;Tumor; Tue, 22 Feb 2022 11:00:00 GMT Homologous recombination or non-homologous end joining? Sir3 points the way https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/homologous-recombination-Sir3.aspx Researchers from IRCM furnish initial information on the mechanisms regulating DNA double-strand break repair in yeast heterochromatin. Sir3 plays an essential role in the choice of a repair pathway. Molecular mechanisms ; DNA Researchers ; general public ; Journalists IRCM Highlight ; Scientific result Molecular mechanisms;DNA repair;genome stability;heterochromatin; Wed, 09 Feb 2022 11:00:00 GMT HLA-G : a new therapeutic target in cancer https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/HLA-G-therapeutic-target-cancer.aspx In a study published in Cancer Letters, SRHI's researchers (CEA-Jacob) highlight the therapeutic value of targeting the HLA-G/IL2 immune checkpoint in clear cell renal cell carcinoma. Immune system ; Cancer Researchers ; Journalists ; general public DRF Scientific result ; Highlight therapeutic antibodies;HLA-G;immune checkpoint;Cancer; Tue, 24 Aug 2021 10:00:00 GMT Trees, drought tolerance and epigenetics https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/Trees-drought-tolerance-epigenetics.aspx A team of researchers from Inrae, Orleans University, the University of Oregon (USA), CEA-Jacob and IRD studied the role of epigenetics in drought tolerance in poplars. Their results, published in New Phytologist, suggest that epigenetic changes during droughts affect the genes involved in the tree's hormonal response to water deficits and may result in genetic mutations. Epigenetics ; Environment ; Climate Researchers ; Journalists ; general public DRF Scientific result ; Highlight Drought;Trees;epigenetic;climate change;poplars;hormonal response;DNA;methylation; Mon, 05 Jul 2021 10:00:00 GMT Diffusion MRI characterizes radiation-induced neurological impairments https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/diffusion-MRI-characterizes-radiation-induced-neurological-impairments.aspx A team comprising iRCM (CEA-Jacob) and NeuroSpin (CEA-Joliot) researchers analyzed the consequences of irradiation on brain development and neurogenesis in a preclinical model. That work, published in Radiation Research, lays a path for the use of diffusion imaging for the early detection of neurological abnormalities resulting from different types of stress. Brain ; Impacts on living (organisms) ; MRI ; Biomarkers ; Radiobiology Researchers ; Journalists ; general public DRF Scientific result ; Highlight ionizing radiations;Brain;neurodevelopmental disorder;neurogenesis;MRI;structural MRI;diffusion MRI; Thu, 24 Jun 2021 10:00:00 GMT The telomere mystery: a protection mechanism decrypted https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/telomere-mystery-protection-mechanism-decrypted.aspx The mechanisms that control the stability of telomeres, structures located at the ends of chromosomes, remain largely mysterious. One of them however has been decrypted by researchers from IRCM (CEA-Jacob) and I2BC (CEA-Joliot) in a work carried out in yeasts. Their results, published in Nature Communications, could help identify new therapeutic targets in human cancers. Molecular mechanisms ; DNA ; Cancer Researchers ; Journalists ; general public SCSR Highlight ; Scientific result telomere;Yeast;DNA repair;chromosome stability;modeling;genetic;Cancer;DNA; Thu, 27 May 2021 10:00:00 GMT A potential therapeutic role for PPAR-γ in myelofibrosis https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/potential-therapeutic-role-PPAR-gamma-myelofibrosis.aspx In a study published in the Journal of Clinical Investigation, researchers from IDMIT's LCSAT lab (CEA-Jacob) evaluated PPAR-γ ligands in the development of myelofibrosis. Diagnosis and innovative treatment ; Cancer Researchers ; Journalists ; general public IDMIT Scientific result ; Highlight therapy;Inflammation;myeloid cells;PPAR-γ;Hematopoietic stem cells;fibrosis; Tue, 18 May 2021 10:00:00 GMT Cellular prion protein at the heart of radioresistance in solid tumors https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/cellular-prion-protein-radioresistance-solid-tumors.aspx In an article published in Oncogene, researchers from LRTS and LRIG (IRCM/CEA-Jacob) have shown that an increase in the expression of cellular prion protein driven by the ATM/TAK1/JUNK signaling pathway contributes to solid tumor radioresistance. Radiotherapy ; Radiosensitivity ; Cancer Researchers ; Journalists ; general public DRF Scientific result prion;DNA damage;DNA damage response;cellular prion protein;ionizing radiation;radioresistance; Wed, 28 Apr 2021 10:00:00 GMT Mapping DNA methylation in simian immunodeficiency virus infection https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/mapping-dna-methylation-simian-immunodeficiency-infection.aspx In a partnership with IDMIT (CEA-Jacob) and Institut Pasteur, the Epigenetic and Environment Laboratory (LEE; CNRGH/CEA-Jacob) carried out two studies to evaluate DNA methylation in non-human primate models of immunodeficiency virus infections. Virus ; Epigenetics Researchers ; Journalists ; general public DRF Scientific result ; Highlight HIV;epigenetic;SIV;methylation; Mon, 05 Apr 2021 10:00:00 GMT Targeting HIF1α or JMY in glioblastoma: if not one why not the other? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/HIF1-JMY-glioblastoma-targeting.aspx Glioblastomas are highly aggressive brain tumors with a very poor prognosis. Even with aggressive treatment, recurrence is nearly systematic. Researchers from IRCM (CEA-Jacob) have decrypted molecular mechanisms that enable treatment resistance and escape for a subpopulation of cells. Brain ; Cancer ; Stem cells Researchers ; Journalists ; general public SCSR Highlight ; Scientific result Brain;glioblastoma;Cancer;invasion;Tumor;ionizing radiations;HIF1α; Thu, 01 Apr 2021 10:00:00 GMT A new molecular signature to better identify radiosensitive patients https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/new-molecular-signature-identify-radiosensitive-patients.aspx A study co-piloted by researchers from LGRK (IRCM/CEA-Jacob) and Claude Bernard Lyon 1 University and performed on cells from patients who experienced severe adverse effects after radiation therapy enabled the identification of a novel molecular signature of excessive radiosensitivity in healthy tissues. Radiotherapy ; Radiosensitivity Researchers ; general public ; Journalists DRF Scientific result ; Highlight radiosensitivity;Radiation Therapy;NFATC2;fibroblasts;skin;DNA repair;radioresistance; Wed, 03 Feb 2021 11:00:00 GMT The placenta knows you smoked https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/placenta-knows-you-smoked.aspx The CNRGH contributed to a work showing that tobacco exposure, even when stopped before becoming pregnant, leaves traces in the placenta in the form of epigenetic modifications to its DNA. Epigenetics Researchers ; Journalists ; general public Jacob Scientific result tobacco;epigenetic;placenta;methylation; Tue, 26 Jan 2021 11:00:00 GMT Radioactive iodine and thyroid cancer: lessons from Chernobyl and Fukushima https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Radioactive-iodine-thyroid-cancer-Chernobyl-Fukushima.aspx The nuclear power plant accidents at Chernobyl and Fukushima released enormous amounts of radioactive iodine into the atmosphere. Researchers from IRCM (CEA-Jacob) propose an analysis of data on the health consequences of those accidents and particularly the effects they had on the thyroid. Radioactivity ; Radiobiology ; Radiotherapy ; Molecular mechanisms ; Cancer Researchers ; general public ; Journalists IRCM Scientific result ; Highlight molecular signature;prophylaxis;ionizing radiations;thyroid;nuclear accident;radioactive iodine;radiation-induced cancers;Cancer; Tue, 01 Dec 2020 11:00:00 GMT FLASH radiotherapy for the treatment of acute lymphoblastic leukemia https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/FLASH-radiotherapy-treatment-acute-lymphoblastic-leukemia.aspx The LSHL (IRCM/CEA-Jacob) and the radiation oncology department of the Lausanne University Hospital teamed to compare FLASH radiotherapy to conventional radiotherapy in the setting of acute lymphoblastic leukemia. Their results, published in the International Journal of Radiation Oncology * Biology * Physics, open new paths to treat this type of leukemia while preserving normal hematopoiesis. Cancer ; Radiotherapy Researchers ; Journalists ; general public DRF Highlight ; News ; Scientific result FLASH-RT;FLASH radiotherapy;conventional radiotherapy;Radiotherapy;Leukemia;pediatric leukemia;acute lymphoblastic leukemia; Thu, 19 Nov 2020 11:00:00 GMT Immune response: not all are equal in interferon β production https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Immune-response-not-all-equal-interferon-beta-production.aspx Researchers from IRCM (CEA-Jacob) have identified a DNA sequence polymorphism that leads to reduced production of interferon β by myeloid cells. The substitution, which is present in about 30% of the population, could affect immune response to infections and tumors. Molecular mechanisms ; Cancer ; Infectious diseases ; Immune system Researchers ; general public ; Journalists IRCM Scientific result ; Highlight radiation-induced tumor;myeloid cells;infection;immunity;regulation of gene expression;virus;polymorphism; Wed, 18 Nov 2020 11:00:00 GMT Professor François Desgrandchamps wins FRM's 2020 Jean Bernard Prize https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/Professor-Desgrandchamps-wins-FRM-2020-Jean-Bernard-Prize.aspx The Jean Bernard Prize, named after the founder of the French Foundation for Medical Research (FRM), honors scientists whose research greatens public knowledge in health. This year, the FRM presented the Jean Bernard Prize to Prof. François Desgrandchamps of the Immuno-Hematology Research Unit (CEA-Jacob). Cancer ; Immune system general public ; Researchers ; Journalists DRF Live in the center ; News ; Highlight Tue, 03 Nov 2020 11:00:00 GMT Skin and ionizing radiation: sensitivity under surveillance https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/skin-ionizing-radiation-sensitivity-under-surveillance.aspx In a study published in Cells, researchers from LGRK (IRCM/CEA-Jacob) showed that human skin stem cells are sensitive to low doses of genotoxic stress in the setting of active regeneration. Stem cells ; Radiobiology ; Radiosensitivity ; Radiotherapy Researchers ; Journalists DRF Scientific result ; Highlight epidermis;skin;organoids;ionizing radiation;keratinocyte stem cells;medical imaging;radiosensitivity; Wed, 07 Oct 2020 10:00:00 GMT Angiogenesis and immunity: a double target for kidney cancer treatment https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/angiogenesis-immunity-double-target-kidney-cancer-treatment.aspx Researchers from SRHI (CEA-Jacob) have demonstrated a correlation between VEGF expression and the HLA-G/IL4 immune checkpoint in the most common form of kidney cancer. Their study, published in BMC Cancer, opens new horizons for the deployment of novel therapeutic protocols. Cancer ; Immune system Researchers ; general public ; Journalists DRF News ; Scientific result Immune system;bevacizumab;therapeutic targets;HLA-G;immune checkpoint;VEGF;Angiogenesis;kidney cancer;therapeutic antibodies;Cancer; Wed, 05 Aug 2020 10:00:00 GMT The brain: a careful balance between stability and genetic variability https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/The-brain-balance-stability-variability.aspx In a study published in DNA Repair, an IRCM (CEA-Jacob) team has elucidated mechanisms through which neural stem and progenitor cells maintain genome integrity more efficaciously than other cell types. The team's work contributes to a better understanding of the high-fidelity transmission of genetic information so crucial to brain development. Brain ; DNA ; Stem cells ; Stress response Researchers ; general public ; Journalists DRF Scientific result ; Highlight adaptive response;chromosome stability;genetic diversity;neural progenitor cells;Brain;DNA repair;development;radiation;genotoxic stress;non-homologous end-joining;Neural stem cells; Mon, 20 Jul 2020 10:00:00 GMT Multiple system atrophy: tracking down epigenetic markers https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/multiple-system-atrophy-tracking-down-epigenetic-markers.aspx In a study published in Acta Neuropathologica Communications, researchers from LEE (CNRGH/CEA-Jacob) and the LRSN (Bispebjerg-Frederiksberg University Hospital, Copenhagen) joined forces to characterize DNA methylation profiles in patients with multiple system atrophy (MSA). The team brought to light epigenetic aspects that suggest an active neuro-immune response in patients with MSA. Their work contributes to a better understanding of the diseases and opens new horizons for therapeutic strategies. Epigenetics Researchers ; general public ; Journalists Jacob Scientific result ; Highlight dna methylation;epigenetics;Neurodegenerative disease;SMA; Wed, 17 Jun 2020 10:00:00 GMT Immune checkpoints: new targets in kidney cancer https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/immune-checkpoints-new-targets-kidney-cancer.aspx Researchers from SRHI in partnership with the MICS lab (CentraleSupélec, Paris-Saclay University) have identified new immune checkpoints as potential targets in clear cell renal cell carcinoma. The team's results, obtained by pairing statistics and biological analyses, have been published in Cancer Immunology, Immunotherapy. Cancer ; Immune system Researchers ; Journalists ; general public Jacob Scientific result immunotherapy;PD-L1;Cancer;clear cell renal cell carcinoma;HLA-G; Fri, 22 May 2020 10:00:00 GMT Radiation and oxidative stress: helping blood stem cells avoid a rough day https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Radiation-and-oxidative-stress-helping-blood-stem-cells-avoid-a-rough-day.aspx An IRCM team (CEA/Inserm) has shown that exposure to low-dose ionizing radiation causes functional losses in human hematopoietic stem cells. Their results, published in Haematologica, suggest the need for complementary care during radiation therapy regimens. Radiotherapy ; Radiosensitivity Researchers ; Journalists DRF Highlight ; News ; Scientific result Radiotherapy;oxydative stress;hematopoiesis;Hematopoietic stem cells; Fri, 24 Jan 2020 11:00:00 GMT QST-NIRS seminar: CEA and IRSN presented their research activities https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2019/QST-NIRS-seminar-CEA-and-IRSN-presented-their-research-activities.aspx CEA and IRSN presented their research activities in radiobiology, radiopathology, epidemiology and dosimetry in a tripartite seminar organized on 28-29 October 2019 by the QST-NIRS in Chiba, Japan. Radiobiology Researchers ; Journalists DRF News ; Colloquium radiobiology; Wed, 30 Oct 2019 09:14:59 GMT The genome of the pea assembled for the first time https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2019/The-genome-of-the-pea-assembled-for-the-first-time.aspx Fundamental Research ; Science & society ; Health & life sciences ; Methodologies for life sciences ; Molecular mechanisms ; Cellular mechanisms ; Genomics Press release ; News ; Focus Tue, 03 Sep 2019 10:00:00 GMT ZNA: A new genetic support for biology and medicine https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/ZNA-A-new-genetic-support-biology-medicine.aspx Genoscope contributed to a study describing a novel synthesized nucleic acid with a previously undescribed molecular backbone. This new genetic support expands the biotech armamentarium for tomorrow's medicine. Genomics ; DNA Researchers ; Journalists DRF Scientific result DNA;RNA;Gene Sequence;genome;xenobiology;genomics; Fri, 09 Aug 2019 10:00:00 GMT DNA breakage: a rescue pathway identified in Saccharomyces cerevisiae https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/DNA-breakage-a-rescue-pathway-identified-in-Saccharomyces-cerevisiae.aspx In a study recently published in the journal Molecular Cell, IRCM researchers describe the key elements of a pathway that protects chromosomes from certain radiation-induced rearrangements. Radiobiology ; Radiosensitivity ; Cancer ; DNA Researchers ; general public ; Journalists IRCM News ; Scientific publications ; Scientific result ; Highlight radiobiology;Cancer;DNA;radiosensitivity; Fri, 14 Jun 2019 10:00:00 GMT The brain: a key participant in the development of cancer? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/The-brain-a-key-participant-in-the-development-of-cancer.aspx A French team from IRCM (CEA/Inserm) recently published a study in the scientific journal Nature showing that neurons can develop within the tumoral microenvironment and thus contribute to the development of certain types of cancer. Brain ; Cancer ; Health & life sciences ; Cellular mechanisms Researchers ; Journalists ; general public Paris-Saclay Scientific publications ; Scientific result ; News health;Cancer;neural network;Brain;neuron;neurosciences; Fri, 17 May 2019 10:00:00 GMT 8th international Conference on HLA-G https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2019/8th-international-Conference-on-HLA-G.aspx The 8th International Conference on HLA-G will take place at the Ministry of Health and Solidarity (Ministère de la Santé et des Solidarités) in Paris on 8, 9 and 10 July 2019. Cancer ; Health & life sciences ; Immune system Researchers ; Journalists Agenda ; News ; Institute ; Highlight ; Conference ; Seminars Cancer;HLA-G;Immune system; Fri, 03 May 2019 10:00:00 GMT Complete plant chromosomes reconstructed via sequencing and optical mapping https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/Complete-plant-chromosomes-reconstructed-sequencing-optical-mapping.aspx A Genoscope team has reconstructed compete plant chromosomes by combining DNA long-read sequencing and optical mapping technologies. Earth sciences ; Biodiversity ; DNA ; Vegetal physiology Fontenay-aux-Roses Scientific result sequencing;chromosome;plants genomes; Tue, 04 Dec 2018 11:00:00 GMT New function discovered for the protein Rad52, a serious therapeutic target in breast cancer https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/New-function-discovered-protein-Rad52-serious-therapeutic-target-breast-cancer.aspx Rad52 has garnered great attention lately as a promising target in the battle against certain types of breast cancer. A team from IRCM, in partnership with researchers from the Frédéric-Joliot and Gustave Roussy Institutes, has shed new light on this protein. Stress response ; Molecular mechanisms Jacob Scientific result Rad51 filament;budding yeast;Srs2; Fri, 12 Oct 2018 10:00:00 GMT Revealing molecular mechanisms that prevent measles virus replication https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2018/Revealing-molecular-mechanisms-that-prevent-measles-virus-replication.aspx Researchers discovered a novel interaction between two proteins from the measles virus. This ultra-weak interaction, involving only four amino acids situated in a very flexible and dynamic protein region, is essential for measles virus replication. This newly discovered interaction constitutes a new target to treat measles infection, but also infection by other viruses from the same family, that comprises highly dangerous human pathogens. Health & life sciences ; Virus ; Proteomics ; Diagnosis and innovative treatment ; Diseases ; Molecular mechanisms ; DNA ; Immune system general public ; Journalists ; Researchers Grenoble News ; Scientific publications ; Scientific result Measles; Wed, 22 Aug 2018 18:00:00 GMT DNA repair: the importance of proximity https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/DNA-repair-importance-proximity.aspx Researchers at IRCM have shown that certain mechanisms involved in DNA repair are influenced by the intramolecular and intranuclear spatial organization of the macromolecule. Fundamental Research ; Radiobiology ; DNA Scientific result genotoxic stress; Wed, 11 Apr 2018 10:00:00 GMT Huntington's disease and DCLK3: a vicious circle of gene transcription deregulation? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/Huntington-DCLK3-vicious-circle-transcription-deregulation.aspx The results of a study performed by a research team at MIRCen suggest that the protein DCLK3 plays a key role in transcription regulation, and its deficit in Huntington's disease a key role in neurodegeneration. Neurodegenerative diseases ; Cellular mechanisms ; Molecular mechanisms Fontenay-aux-Roses Scientific result chromatin remodeling;transcription;DCLK3; Mon, 26 Mar 2018 10:00:00 GMT Neurofibrillary tangles: a protective role in Alzheimer's disease? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/neurofibrillary-tangles-protective-role-alzheimer.aspx Neurofibrillary tangles are large aggregates of tau protein found in the neurons of people with Alzheimer's disease. Historically, they have been thought to be at least partially responsible for the pathology. However, the results of a study performed by researchers at MIRCen (François Jacob Institute of Biology/CEA) suggest to the contrary that neurofibrillary tangles may be protective. Alzheimer's disease ; Molecular mechanisms Fontenay-aux-Roses Scientific result neurofibrillary tangles;tau protein;hyperphosphorylation; Thu, 08 Mar 2018 11:00:00 GMT White fat, brown fat, and preventing obesity https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/white-fat-brown-fat.aspx A team from the Innovative Therapies Unit (STI) has discovered a molecular mechanism that regulates the balance between white and brown fat. Their work defines a novel category of potential targets in the quest to control fat mass. Molecular mechanisms ; Cellular mechanisms Fontenay-aux-Roses Scientific result FOG-2;pRb;adipogenesis; Fri, 09 Feb 2018 11:00:00 GMT MicroRNA: a possible treatment for Sjögren syndrome? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/microRNA-possible-treatment-sjogren-syndrome.aspx An epigenetics analysis of lymphocytes in the setting of Sjögren syndrome may have shed light on a possible treatment for this autoimmune disorder. Epigenetics ; Molecular mechanisms ; Health & life sciences Scientific result microRNA;Sjögren syndrome;autoimmune disorder; Fri, 22 Dec 2017 11:00:00 GMT The yin and yang of low-dose irradiation on hematopoiesis https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/Yin-Yang-low-dose-irradiation-hematopoiesis.aspx Researchers at the CEA's François Jacob Institute of Biology and their partners show that exposure to low-dose irradiation causes a loss of function in hematopoietic stem cells. Which is bad. And good. Radiobiology ; Low doses Researchers ; Journalists ; general public Fontenay-aux-Roses Scientific result Fri, 29 Sep 2017 10:00:00 GMT A blood test to predict bladder cancer recurrence https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/blood-test-bladder-cancer.aspx In a 100-patient cohort at the Saint-Louis Hospital in Paris, researchers from the CEA and Paris-Diderot University have shown that the rate of certain immune cells in the blood is predictive of bladder cancer recurrence or progression. They suggest using their patented blood test to predict recurrence in other types of cancers. Cancer ; Biomarkers Researchers ; general public ; Journalists Jacob Scientific result Tue, 18 Jul 2017 10:00:00 GMT Chronic Myeloid Leukemia: a New Therapy Proves Successful https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/Chronic-Myeloid-Leukemia-a-New-Therapy-Proves-Successful.aspx In a phase 2 clinical trial, scientists showed the efficiency of targeting cancer stem cells—an approach imagined and developed at the CEA François-Jacob Institute for the treatment of leukemia, chronic myeloid leukemia in particular. Cancer ; Gene and cell therapy general public ; Journalists ; Researchers Jacob Scientific result Tue, 28 Feb 2017 11:00:00 GMT