François Jacob Institute of biology - Sur le même thème https://jacob.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2021/CEA-contributing-European-AI-powered-personalized-medicine-project-KATY.aspx Website of the François Jacob Institute of Biology en-US https://jacob.cea.fr/drf/ifrancoisjacob/SiteAssets/logo-cea-JACOB.png François Jacob Institute of biology - Sur le même thème https://jacob.cea.fr/drf/ifrancoisjacob/english A passive immunization approach prevents SHIV infection https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/passive-immunization-shiv-infection.aspx In a study published in Nature Communications, IDMIT researchers demonstrated the efficacy of a neutralizing antibody against cell-associated infection by simian-human immunodeficiency virus. AIDS ; Infectious diseases ; Vaccine Researchers ; Journalists DRF Scientific result ; Highlight immunization;SHIV;HIV;preclinical studies;Antibody;bNAb;AIDS; Wed, 01 Nov 2023 11:00:00 GMT LMN/MIRCen team wins "Équipe FRM 2023" accreditation https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2023/lmn-mircen-frm-team.aspx Carole Escartin's Reactive Astrocytes team (UMR9199, Neurodegenerative Diseases Laboratory, MIRCen) has received the Équipe FRM 2023 label for its project on the role of astrocytes in the control of neuronal activity. Institutional ; Fundamental Research ; Brain ; Diagnosis and innovative treatment ; Gene and cell therapy ; Alzheimer's disease Researchers ; Journalists ; general public DRF Live in the center ; Highlight astrocytes;Alzheimer's Disease; Wed, 29 Mar 2023 10:00:00 GMT MXD4/MAD4 : a target of interest for ex vivo stem cell preservation https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/MXD4-MAD4-stel-cell-preservation.aspx In a study published in the Journal of Investigative Dermatology, researchers from LGRK (iRCM) identified the transcription factor MXD4/MAD4 as an element of the pathway regulating the stemness of keratinocyte precursors and their skin regeneration capacities. Diagnosis and innovative treatment ; Stem cells Researchers ; Journalists ; general public DRF Scientific result ; Highlight MXD4/MAD4;bioengineering;skin;skin repair;graft;stemness;cutaneous; Fri, 03 Feb 2023 11:00:00 GMT On the path toward a chikungunya vaccine https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/chikungunya-vaccine.aspx In a study published in JCI Insight, researchers from IDMIT have demonstrated the vaccinal effectiveness of serum transfers from volunteers vaccinated against the chikungunya virus to an animal model. This work is an important step toward vaccine marketing approval, as the nature of chikungunya epidemics hampers the deployment of conventional efficacy trials. Health & life sciences ; Vaccine ; Infectious diseases ; Chikungunya Researchers ; Journalists DRF Scientific result ; Highlight vaccine;chikungunya;idmit; Fri, 16 Dec 2022 11:00:00 GMT An in vitro model to study infertility https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/in-vitro-model-study-infertility.aspx In a work published in Scientific Reports, researchers from IRCM, the Sup'Biotech/SEPIA partnership lab and Imagine Institute teamed to develop an in vitro, model of infertility wherein induced pluripotent stem cells generated from the erythroblasts of infertile men presenting genetic abnormalities were used to successfully generate primordial germ-like cells. Diagnosis and innovative treatment ; Stem cells Researchers ; Journalists ; general public IRCM Highlight ; Scientific result stem cells;infertility;azoospermia; Mon, 28 Nov 2022 11:00:00 GMT ComFC, a key protein in the transmission of antibiotic resistance among bacteria https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/ComFC-transmission-antibiotic-resistance-bacteria.aspx A team of researchers from IRCM (CEA-Jacob) and I2BC have shed light on the role of ComFC, a bacterial protein involved in natural transformation, itself a driving mechanism for the propagation of antibiotic resistance genes and virulence factors. Cellular mechanisms ; Molecular mechanisms ; Antibiotics Researchers ; general public ; Journalists SCSR Highlight ; Scientific result bacteria;Antibiotic;Antibiotic Resistance;Molecular mechanisms; Tue, 19 Apr 2022 10:00:00 GMT Preclinical multimodal imaging and Huntington's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/preclinical-multimodal-imaging-huntington-disease.aspx A preclinical multimodal imaging study conducted by the Neurodegenerative Diseases Laboratory (LMN/MIRCen) and published in Human Molecular Genetics has shed light on cerebral alterations in Huntington's disease. Neurodegenerative diseases ; MRI Researchers ; Journalists ; general public DRF Highlight ; Scientific result gluCEST;Imaging;huntington;Brain;brain imaging;cerebral; Tue, 12 Apr 2022 10:00:00 GMT The beneficial role of reactive astrocytes in Huntington's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/huntington-disease-reactive-astrocytes.aspx In a new study published in Brain, researchers MIRCen used mouse models of Huntington's disease to show that stimulating reactive astrocyte formation favors the elimination of mutant huntingtin protein, reducing both the quantity and size of the aggregates. Neurodegenerative diseases ; Diagnosis and innovative treatment Researchers ; Journalists ; general public MIRcen Scientific result ; Highlight huntington;neuron;reactive astrocytes;astrocytes;JAK2-STAT3;huntingtin;preclinical research; Mon, 28 Mar 2022 10:00:00 GMT Diffusion MRI characterizes radiation-induced neurological impairments https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/diffusion-MRI-characterizes-radiation-induced-neurological-impairments.aspx A team comprising iRCM (CEA-Jacob) and NeuroSpin (CEA-Joliot) researchers analyzed the consequences of irradiation on brain development and neurogenesis in a preclinical model. That work, published in Radiation Research, lays a path for the use of diffusion imaging for the early detection of neurological abnormalities resulting from different types of stress. Brain ; Impacts on living (organisms) ; MRI ; Biomarkers ; Radiobiology Researchers ; Journalists ; general public DRF Scientific result ; Highlight ionizing radiations;Brain;neurodevelopmental disorder;neurogenesis;MRI;structural MRI;diffusion MRI; Thu, 24 Jun 2021 10:00:00 GMT MULTILAYER: a new tool to digitize biological tissues https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/Multilayer-tool-digitize-biological-tissues.aspx In a study published in Cell Systems, the SysFate laboratory (UMR8030/Genoscope/CEA-Jacob) presented MULTILAYER, an algorithm that provides digital functional maps of biological organs or tissues. Genomics ; Cell and molecular imaging Researchers ; Journalists ; general public DRF Highlight ; Scientific result digitize;multilayer;spatial transcriptomics; Tue, 15 Jun 2021 10:00:00 GMT CEA contributing to the European AI-powered personalized medicine project KATY https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2021/CEA-contributing-European-AI-powered-personalized-medicine-project-KATY.aspx The institutes IRIG and Jacob of the CEA's Fundamental Research Division and CEA-List joined forces to participate in KATY, a European Horizon 2020 project aimed at creating an artificial-intelligence-powered personalized medicine program. Diagnosis and innovative treatment ; Methodologies for life sciences Researchers ; general public ; Journalists Live in the center Mon, 14 Jun 2021 10:00:00 GMT Beta thalassemia: toward a more effective therapeutic strategy https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/beta-thalassemia-more-effective-therapeutic-strategy.aspx In a study published in Molecular Therapy, LCSAT (IDMIT, CEA-Jacob) researchers present a novel, optimized, lentiviral gene therapy for β-thalassemia. Gene and cell therapy Researchers ; general public ; Journalists STI Scientific result ; Highlight lentiglobin;lentiviral gene therapy;beta-thalassemia;he; Thu, 20 May 2021 10:00:00 GMT A potential therapeutic role for PPAR-γ in myelofibrosis https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/potential-therapeutic-role-PPAR-gamma-myelofibrosis.aspx In a study published in the Journal of Clinical Investigation, researchers from IDMIT's LCSAT lab (CEA-Jacob) evaluated PPAR-γ ligands in the development of myelofibrosis. Diagnosis and innovative treatment ; Cancer Researchers ; Journalists ; general public IDMIT Scientific result ; Highlight therapy;Inflammation;myeloid cells;PPAR-γ;Hematopoietic stem cells;fibrosis; Tue, 18 May 2021 10:00:00 GMT Preclinical study sheds light on a new vaccine candidate for Covid-19 https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/preclinical-study-sheds-light-new-vaccine-candidate-Covid-19.aspx A new international study, published in Cell, co-leaded by IDMIT (CEA-Jacob) and the Department of Medical Microbiology of the University of Amsterdam, presents the results of preclinical trials of a new protein vaccine candidate against Covid-19. Infectious diseases ; Virus ; Vaccine Researchers ; Journalists ; general public DRF Highlight ; Scientific result COVID 19;SARS-CoV-2;vaccine;Nanoparticles;Preclinical; Mon, 08 Mar 2021 11:00:00 GMT Determining antibiotic resistance with artificial intelligence https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/determining-antibiotic-resistance-artificial-intelligence.aspx Under the coordination of the MSF Foundation, researchers and engineers from the University of Évry, the CEA, the CNRS, Médecins Sans Frontières and the Bacteriology/Virology Department of the Henri-Mondor hospital (AP-HP) teamed to develop a mobile application to ease the determination of antibiotic resistance.This application aimed at addressing a major public health issue will be freely available to medical personnel worldwide once clinically validated and CE certified. The demonstration of the technical feasibility of their approach was published on 19 February 2021 in Nature Communications. Antibiotics ; Artificial intelligence Researchers ; Journalists ; general public DRF Scientific result ; Highlight ; News Antibiotic Resistance;artificial intelligence;machine learning; Tue, 23 Feb 2021 11:00:00 GMT POSCOVD : a new project from Genoscope for the diagnosis of COVID-19 https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2021/POSCOVD-project-diagnosis-Covid-19-Genoscope.aspx ​At the most-recent DIM ELICIT colloquium, Marco Mendoza, team leader at SysFate (UMR8030/Genoscope/CEA-Jacob), presented his project POSCOVD, financed by the special Fight-SARS-Cov2 call for projects. POSCOVD seeks to develop a large-scale COVID-19 screening methodology, building particularly upon high throughput sequencing technologies (Oxford Nanopore Sequencing). Genomics ; Diagnosis ; Virus Researchers ; general public ; Journalists DRF Live in the center sequencing;nanopore;DIM ELICIT;Covid19;COVID 19;SARS-CoV-2;diagnosis; Sat, 06 Feb 2021 11:00:00 GMT PET Imaging to visualize neuroinflammation in patients with Parkinson's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/PET-imaging-visualize-neuroinflammation-patients-Parkinson-disease.aspx Researchers from MIRCen (CEA-Jacob) teamed with the Frédéric Joliot Medical Imaging Center (SHFJ; CEA-Joliot) and the Henri-Mondor and Saint-Anne Hospitals to analyze neuroinflammatory response in a cohort of patients with Parkinson's disease and reported a correlation between it and disease progression. Their study, published in Parkinsonism & Related Disorders, sets a path toward the use of a radiotracer, [¹⁸F]-DPA714, for the evaluation of anti-inflammatories pertinent to the treatment of Parkinson's disease. Parkinson's disease ; Medical imaging ; MRI ; Positron Emission Tomography ; Brain Journalists ; Researchers ; general public DRF Scientific result TSPO;brain imaging;radiotracer;neuroinflammatory processes;neuroinflammation;dopamine;Neurodegenerative disease;PET imaging;Parkinson's disease; Fri, 18 Dec 2020 11:00:00 GMT Brain function in the world's smallest primate—in 3D https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Brain-function-world-smallest-primate-3D.aspx In an article published in NeuroImage, a CEA/CNRS/Paris-Saclay University team from MIRCen (CEA-Jacob) has described neuronal networks in the mouse lemur (Microcebus murinus), one of the smallest primates and one of the most genetically-distant from humans. Brain ; Cognition ; MRI ; Medical imaging Researchers ; Journalists MIRcen Scientific result ; Highlight high field MRI;in vivo imaging;3D imaging;Brain;functional MRI;MRI;brain imaging; Wed, 16 Dec 2020 11:00:00 GMT A breakthrough in the understanding of natural HIV infection control mechanisms https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/breakthrough-understanding-natural-HIV-infection-control-mechanisms.aspx Researchers from IDMIT (CEA-Jacob) and the Institut Pasteur teamed for a study in which they showed that the antiviral activity of CD8+ T lymphocytes remained limited in the first two weeks of infection but grew progressively and durably thereafter in macaques able to control simian immunodeficiency virus infection (the equivalent of HIV infection in non-human primates). Their results suggest that the early development of highly effective memory CD8+ T-cells is essential for achieving viral control. Diagnosis and innovative treatment ; Vaccine ; Infectious diseases ; AIDS ; Virus Researchers ; general public ; Journalists IDMIT Highlight ; Scientific result HIV-AIDS;HIV;vaccine;human infectious diseases;SIV;lymphocytes;Immune system; Thu, 08 Oct 2020 10:00:00 GMT Launch of Corona Accelerated R&D in Europe: IDMIT steps up to the plate https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/Launch-of-CARE-program-IDMIT-steps-up-to-the-plate.aspx IDMIT (CEA-Jacob) is participating in CARE, a public-private consortium of 37 organizations brought together to speed the development of treatments for COVID-19 and future coronavirus epidemics. Infectious diseases ; Virus ; Diagnosis and innovative treatment Journalists ; Researchers ; general public IDMIT News ; Headlines research;european project;Europe;funding;COVID 19;vaccine;consortium;infectious diseases; Thu, 27 Aug 2020 10:00:00 GMT Anti-HIV antibodies: predicting in vivo efficacy in vitro https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Anti-HIV-antibodies-predicting-in-vivo-efficacy-in-vitro.aspx A study performed by an IDMIT team (CEA-Jacob) has resulted in an in vitro approach for predicting the in vivo efficacy of antibodies used for the prevention of HIV-1 transmission. The work identified antibodies capable of efficaciously blocking intercellular viral transmission in infected semen. Vaccine ; AIDS ; Infectious diseases ; Diagnosis and innovative treatment ; Biotechnology ; Virus Researchers ; general public ; Journalists IDMIT Scientific result ; Highlight intercellular transmission;sperm;vaccine;Antibody;HIV;AIDS; Fri, 07 Aug 2020 10:00:00 GMT Two technologies are better than one for understanding Huntington's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Two-technologies-for-understanding-Huntington-s-disease.aspx Researchers at MIRCen (CEA-Jacob) combined spectroscopy and metabolic imaging to identify novel biomarkers for Huntington's disease. Their approach enables the monitoring of disease course and may prove useful for exploring other neurodegenerative diseases or testing future treatments. Neurodegenerative diseases ; Genetic diseases ; MRI ; Cell and molecular imaging Researchers ; general public ; Journalists MIRcen Scientific result ; Highlight glutamate;gluCEST;huntington;NMR;neurodegenerative diseases; Fri, 31 Jul 2020 10:00:00 GMT Federating research organisms to extend the reach of preclinical imaging research https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/federating-research-organisms-to-extend-the-reach-of-preclinical-imaging-research.aspx A study on preclinical imaging involving several national research organisms (Inserm, CNRS, CEA, Universities) has produced MRI relaxometry maps for healthy rat brains. The impetus for that work is to be found in the France Life Imaging (FLI) initiative and its continuing momentum manifests today as the Small Animal Imaging Network (SAIN), which unites about ten French imaging facilities. The study, published in Frontiers in Neuroinformatics, demonstrates the feasibility of large-scale, multicenter, MRI studies in the preclinical setting. Brain ; MRI Journalists ; Researchers ; general public DRF Scientific result preclinic;relaxometry;brain imaging;mapping;MRI;in vivo imaging;Brain;neurosciences; Mon, 22 Jun 2020 10:00:00 GMT Innate immune memory and vaccination: a controlled schedule for improved benefit https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Innate-immune-memory-and-vaccination-a-controlled-schedule-for-improved-benefit.aspx A study led by IMVA-HB/IDMIT researchers, published in NPJ Vaccines, has shown the influence of the delay between vaccinations (primary and booster) on the specific humoral immune response. This work also suggests the establishment of a trained immune memory. Vaccine ; Infectious diseases ; Immune system Researchers ; Journalists DRF Highlight ; News ; Scientific result immunization;immune response;vaccine;Immune memory;Immune system;Vaccination Immunogenicity; Thu, 19 Mar 2020 11:00:00 GMT Rapid genome analysis provides invaluable aid for hospitalized newborns https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/Rapid-genome-analysis-provides-invaluable-aid-for-hospitalized-newborns.aspx In their work entitled Fastgenomics, the Dijon Bourgogne University Hospital, Inserm and the CEA's National Center of Human Genomics Research (CNRGH) studied a rapid high-throughput genome sequencing process in 30 hospitalized newborns. The team was able to reduce the time needed for this process from an average of 18 months to only a month and a half at most (38 to 49 days), thus enabling rapid diagnoses for two-thirds of the patients. Genetic diseases ; Diagnosis Researchers ; Journalists DRF Highlight ; News ; Scientific result Genetic diseases;Gene Sequence; Wed, 18 Dec 2019 11:00:00 GMT New knowledge for cell therapies in neurodegenerative diseases https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/New-knowledge-for-cell-therapies-in-neurodegenerative-diseases.aspx MIRCen contributed to a study that showed that the use of histocompatible neuronal grafts did not eliminate the need for immunosuppressive drugs in a primate model. Those results provide important knowledge for the clinical use of certain cell therapies under development for the treatment of neurodegenerative diseases. Brain ; Neurodegenerative diseases ; Gene and cell therapy Scientific result Wed, 09 Oct 2019 10:00:00 GMT The genome of the pea assembled for the first time https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2019/The-genome-of-the-pea-assembled-for-the-first-time.aspx Fundamental Research ; Science & society ; Health & life sciences ; Methodologies for life sciences ; Molecular mechanisms ; Cellular mechanisms ; Genomics Press release ; News ; Focus Tue, 03 Sep 2019 10:00:00 GMT Three-dimensional histology for PET quantification of brain imaging https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/Three-dimensional-histology-for-PET-quantification-of-brain-imaging0830-8788.aspx With 3D histology, researchers from MIRCen highlighted, among nine methods of neuroinflammation PET quantification methods, the optimal performances of one of them. Brain ; Health & life sciences ; Positron Emission Tomography Highlight ; Scientific publications ; Scientific result Fri, 30 Aug 2019 10:00:00 GMT A new generation of lentivirus for gene therapy https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/A-new-generation-of-lentivirus-for-gene-therapy.aspx Researchers from STI have developed a new generation of lentivirus, paving the way for the use of Mauritian cynomolgus macaque as a pre-clinical study model for the development of new gene therapy products. Health & life sciences ; Gene and cell therapy Researchers ; Journalists STI Highlight ; Scientific result DNA;Gene and cell therapy;pre-clinical; Mon, 22 Jul 2019 10:00:00 GMT Alzheimer's disease: blocking reactive astrocytes to help neurons https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/Alzheimer-disease-blocking-reactive-astrocytes-help-neurons.aspx Researchers from MIRCen have shown that inhibiting reactive astrocytes is beneficial for certain characteristics of Alzheimer's disease. Their results could lead to novel therapies that act upon astrocytes to improve neuron function. Brain ; Gene and cell therapy ; Alzheimer's disease ; Cellular mechanisms Paris-Saclay Scientific result Alzheimer;astrocytes;neuron; Mon, 29 Oct 2018 11:00:00 GMT Revealing molecular mechanisms that prevent measles virus replication https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2018/Revealing-molecular-mechanisms-that-prevent-measles-virus-replication.aspx Researchers discovered a novel interaction between two proteins from the measles virus. This ultra-weak interaction, involving only four amino acids situated in a very flexible and dynamic protein region, is essential for measles virus replication. This newly discovered interaction constitutes a new target to treat measles infection, but also infection by other viruses from the same family, that comprises highly dangerous human pathogens. Health & life sciences ; Virus ; Proteomics ; Diagnosis and innovative treatment ; Diseases ; Molecular mechanisms ; DNA ; Immune system general public ; Journalists ; Researchers Grenoble News ; Scientific publications ; Scientific result Measles; Wed, 22 Aug 2018 18:00:00 GMT Darwinian selection happens in test tubes too https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/Darwinian-selection-in-test-tubes.aspx Bringing successive mutations to DNA and RNA in test tubes has been possible for several decades now. A MIRCen team has shown that high throughput sequencing can, with unequaled precision, reconstitute the evolutionary path taken by these macromolecules during their in vitro selection process, and furthermore that this path respects Darwinian theory. Methodologies for life sciences ; Diagnosis and innovative treatment ; Neurodegenerative diseases ; Evolution Fontenay-aux-Roses Scientific result in vitro selection;aptamers; Tue, 17 Jul 2018 10:00:00 GMT Idmit: inauguration of a new biology and health research infrastructure devoted to human infectious diseases and immunology https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2018/Idmit-inauguration-of-a-new-biology-and-health-research-infrastructure-devoted-to-human-infectious-diseases-and-immunology.aspx Institutional ; Diagnosis and innovative treatment ; Diseases ; Methodologies for life sciences Press release ; Inauguration ; Focus Fri, 22 Jun 2018 10:00:00 GMT A new success in gene therapy for beta thalassemia https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/New-success-in-gene-therapy-for-beta-thalassemia.aspx ​The efficacy of a gene therapy developed at the François Jacob Institute of Biology and Harvard University has been demonstrated in phase I/II clinical trials. Gene and cell therapy ; Genetic diseases Scientific result ; Press release Thu, 19 Apr 2018 10:00:00 GMT Theranexus signs partnership with the Collège de France https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2018/Theranexus-partnership-College-de-France.aspx Theranexus, a CEA-born biopharmaceutical company, signs a three-year research partnership agreement with the Collège de France. Pharmacology ; Brain Researchers ; general public ; Journalists Jacob Academic partnerships glial cells;narcolepsy;psychotropic medications; Thu, 15 Mar 2018 11:00:00 GMT Getting medicines to the brain with ultrasound https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/getting-medicines-brain-ultrasound.aspx Researchers from NeuroSpin (Frédéric-Joliot Institute/CEA) and MIRCen (François Jacob Institute of Biology/CEA) recently developed an MRI-guided focused ultrasound system that increases, temporarily and locally, cerebral vascular permeability in non-human primates. The system could improve the delivery of medicines to the brain. Diagnosis and innovative treatment ; MRI Fontenay-aux-Roses Scientific result MRI-guided focused ultrasound system;blood-brain barrier; Mon, 19 Feb 2018 11:00:00 GMT NeurATRIS : Call for collaborative projects on neurodegenerative diseases https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2018/Neuratris-call.aspx ​NeurATRIS lance un appel à projets pour initier des projets collaboratifs entre les membres de NeurATRIS, les laboratoires académiques et les sociétés de biotechnologies. A la clé, un financement à hauteur de 50K€. Diagnosis and innovative treatment ; Gene and cell therapy ; Neurodegenerative diseases News ; Academic partnerships ; Industrial partnerships Thu, 18 Jan 2018 11:00:00 GMT Hemoglobinopathies: a gene therapy modifies 100% of targeted cells https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/Hemoglobinopathies-amelioration-therapie-genique.aspx ​The researchers at the François Jacob Institute's Department of Innovative Therapies are pursuing the development of their gene therapy for hereditary blood diseases. They are looking to increase the performance of their strategy so that it can bring benefits to the greatest number of patients possible. Genetic diseases ; Gene and cell therapy STI Scientific result Thu, 21 Dec 2017 11:00:00 GMT A camera for visualizing and quantifying actinide contamination https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/visualize-quantify-actinide-contamination.aspx Researchers at the IRCM and their partner at the University of Arizona compared three imaging tools used to visualize actinides present in contaminated biological tissues. Their analysis provides information on the performance and limitations of each of these autoradiographic techniques. The digital technique is the most recent, and offers certain advantages such as real-time imaging. Nuclear Toxicology ; Methodologies for life sciences IRCM Scientific result Thu, 09 Nov 2017 11:00:00 GMT A blood test to predict bladder cancer recurrence https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/blood-test-bladder-cancer.aspx In a 100-patient cohort at the Saint-Louis Hospital in Paris, researchers from the CEA and Paris-Diderot University have shown that the rate of certain immune cells in the blood is predictive of bladder cancer recurrence or progression. They suggest using their patented blood test to predict recurrence in other types of cancers. Cancer ; Biomarkers Researchers ; general public ; Journalists Jacob Scientific result Tue, 18 Jul 2017 10:00:00 GMT Chikungunya: Pain Caused by the Immune System https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/chikungunya-pain-caused-by-the-immune-system.aspx Joint damage in people infected with chikungunya remains poorly understood. Scientists from the CEA François-Jacob Institute and their partners have identified an actor of the antiviral immune response whose inhibition paradoxically reduces the severity of the symptoms. Infectious diseases ; Chikungunya ; Diagnosis and innovative treatment general public ; Journalists ; Researchers Jacob Scientific result Mon, 13 Mar 2017 11:00:00 GMT Sickle Cell Disease: Remission in the First Patient Treated by Gene Therapy https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/sickle-cell-disease-remission-first-patient-treated-by-gene-therapy.aspx A patient with severe sickle cell disease has undergone gene therapy developed at the CEA François-Jacob Institute. Two years after treatment, the remission of clinical signs was complete. Health & life sciences ; Genetic diseases ; Diagnosis and innovative treatment general public ; Journalists ; Researchers Jacob Scientific result Thu, 02 Mar 2017 11:00:00 GMT Sickle cell disease: remission of the signs of the disease in the first patient in the world treated with gene therapy https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2017/Sickle-cell-disease-remission-signs-disease-first-patient-treated-gene-therapy.aspx A patient aged of 13 years with severe sickle cell disease has been treated succesfully by a gene therapy. This innovative treatment allowed complete remission of clinical signs of disease and correction of biological signs. Gene and cell therapy ; Genetic diseases ; Diagnosis and innovative treatment ; Health & life sciences general public ; Journalists ; Researchers Paris-Saclay Press release ; Scientific publications sickle cell anemia;Diagnosis and innovative treatment;Genetic diseases;Gene and cell therapy;Health & life sciences; Thu, 02 Mar 2017 00:00:00 GMT Chronic Myeloid Leukemia: a New Therapy Proves Successful https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/Chronic-Myeloid-Leukemia-a-New-Therapy-Proves-Successful.aspx In a phase 2 clinical trial, scientists showed the efficiency of targeting cancer stem cells—an approach imagined and developed at the CEA François-Jacob Institute for the treatment of leukemia, chronic myeloid leukemia in particular. Cancer ; Gene and cell therapy general public ; Journalists ; Researchers Jacob Scientific result Tue, 28 Feb 2017 11:00:00 GMT Discovery of a gene associated with radiosensitivity and post-radiotherapy complications https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2016/Discovery-of-a-gene-associated-with-radiosensitivity-and-post-radiotherapy-complications.aspx ​Scientists at the CEA’s Institute of Cellular and Molecular Radiation Biology, in collaboration with INSERM, Université Paris-Sud, and international partners, have demonstrated a connection between the expression of the TRAIL gene, which plays a role in cell death, and the radiosensitivity of certain human T lymphocytes. Health & life sciences ; Diagnosis and innovative treatment ; Cellular mechanisms Researchers ; general public DRF Press release ; Scientific result Mon, 21 Mar 2016 11:00:00 GMT Modulating cerebral cholesterol: a new avenue of research to treat Alzheimer’s disease? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2015/Modulating-cerebral-cholesterol-new-avenue-research-treat-Alzheimer.aspx Two French research teams have recently shown in a rodent model that overexpression of an enzyme capable of eliminating excess cholesterol in the brain can act in a beneficial way on the tau component of the disease to completely correct it. Alzheimer's disease ; Gene and cell therapy ; Biotechnology MIRcen Scientific result Mon, 14 Sep 2015 10:00:00 GMT