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Scientific result | MRI | Brain | Neurodegenerative diseases
A crossover study in neuroimaging and genetics has linked genetic mutations to variations in the size of deep brain structures. This is a new step in evaluating the risk factors for developing a neurodegenerative disease.
The subcortical regions, buried within the brain, constitute a bridge between the cortex and the peripheral areas particularly dedicated to motor skills and memory. Their size has an effect on cognitive performance, a phenomenon observed in Alzheimer’s disease. An international study involving 193 laboratories compared MRI imaging data with genetic analyses from 30,700 individuals, in order to find possible genetic variants responsible for variations in the size of the subcortical regions.
This study was published on January 21 in the journal Nature.
Common genetic variants influence human subcortical brain structures | Nature
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.