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Laboratory


SCBM

Analysis

Published on 12 April 2017
Our group collaborates with the synthetic chemists of the different groups of SCBM and IBITECS. The missions of our group consist in the set-up and realization of small- to large-scale purification processes followed by a detailed analysis of organic molecules prepared by chemists from SCBM. For this purpose, different techniques are routinely used: HPLC, Mass spectrometry, NMR, UV and IR spectroscopy.

Manager
David Buisson
01 69 08 66 38
david.buisson@cea.fr

Staff

David-Alexandre Buisson, Engineer
Céline Puente, Research Technician

 

Types of analyses

HPLC separation applied to
  •  Titration
  • Enantiomeric excess measurement
  • Purification
     
Structure elucidation /Caracterization
Radioactive activity measurement
 Mass Spectrometry

 

 

 

 

 

 

 Purification

Techniques and equipment

NMR 400 MHz Bruker Avance Spectrometer
  • broad band probe:
    RMN 1D et 2D 1H, 13C, 31P, 11B, 15N…
  • 19F probe
  • 3H probe 
UV and IR-TF Spectrometer
Liquid scintillation counter
Activity measurement
(14C, 3H, 125I)
Mass spectrometer (ESI/TOF)
  • Structure elucidation 
  • Characterization
  • Isotopic enrichment of labeled compounds
HPLC analytic pumps/UV/PDA/MS detector
  • Reverse and normal phase chromatography conditions settling
  • Titration
  • Enantiomeric excess measurement (chiral phases)
Autopurify Waters systems

HPLC analytic/preparative pumps equipped with automatic sampler-fraction collector/UV-PDA/MS Detection

  • Reverse and normal phase chromatography conditions settling
  • Scale-up, purification up to 1g  
Radioactive HPLC analytic equipped with Alliance System and ZQ/UV-PDA Detection
  •  Reverse and normal phase chromatography conditions settling (non-UV products)
  • Titration
  • Reaction media analysis (LC/MS coupling)
Low Voltage electron microscopes LVEM5
 
 
 
 
 
 
 
 
 
 
 
 
 
 
electron microscope