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Laboratory


LCV

Chemistry for life sciences laboratory

Published on 12 April 2017
This laboratory is composed of two expert teams in peptide or pseudo-peptide synthesis, exploiting parallel or combinatorial approaches in various fields: synthesis of inhibitors or probes dedicated to the functional study of zinc metalloproteases; design and synthesis of mini-proteins mimicking the activity of proteins involved in human diseases; development of new protein ligands that can be used as specific probes for molecular imaging; characterization of the cellular immune response and identification of immunogenic protein sequences for diagnostic or vaccine applications.
Manager

Bernard Maillère
bernard.maillere@cea.fr
33 1 69 08 94 47

Human resources

Bernard Maillère, Researcher
Catherine Menier, Researcher
Sarah Brégant, Researcher
Laurent Devel, Researcher
Vincent Dive, Researcher
Alain Lecoq, Research Engineer
Fabrice Beau, Research Engineer
Evelyne Cassar, Technician
Carole Malgorn, Technician
Hervé Nozach, Research Engineer
Carole Fruchart, Research Engineer
Marion Helle, Postdoctoral Fellow
Thomas Bordenave, Postdoctoral Fellow
Ha Phuong Ta, Postdoctoral Fellow
Elodie Marcon
Moustafa Hamze
Sylvain Meunier
Pierre Bonnesoeur
Nicole Van‘t Wout Hofland

 

(a)
 
(b)
 
(c)

The understanding of protein-ligand interactions at the molecular level (a) allows the design of molecular mimics of reduced size , small proteins (b) or pseudo-peptides (c).

LCV is working on two main themes:

Function of metalloproteases

Manager
Vincent Dive

Immunochemistry of the cellular immune response

Manager
Bernard Maillère