https://joliot.cea.fr/drf/joliot/en/Pages/news/Science/2022/ptairMS-COVs-biomarkers.aspx Website of the Frédéric-Joliot Institute of Life Sciences which includes 4 departments: I2BC, DMTS, NeuroSpin and Service hospitalier Frédéric Joliot (SHFJ). The teams are mainly located at the CEA Paris-Saclay center and at the Orsay hospital. en-US https://www.cea.fr/Style%20Library/Themes/drf/instituts/images/logo-cea-joliot-2023.png https://joliot.cea.fr/drf/joliot/en https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Cyanine-5-huwentoxin-IV-imaging-agent-lung-cancer.aspx A team from SIMoS (DMTS) has demonstrated the ability of a peptide derived from a spider venom toxin to detect overexpressed sodium channels in a metastatic non-small cell lung cancer (NSCLC) cell line. Biotechnology ; Biomarkers ; Cell and molecular imaging ; Cancer SIMOPRO Scientific result Mon, 10 Nov 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/alpha-synucleine-formes-tronquees-MS.aspx A team from LI-MS (SPI/DMTS) combines a robust α-synuclein immunoprecipitation protocol with high-resolution mass spectrometry and characterizes novel truncated forms of the protein. Proteomics ; Biomarkers Researchers SPI Scientific result ; Article Mon, 20 Oct 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Next-generation-sequencing-chess-game.aspx A team from I2BC has proposed a thought experiment -the Next Generation Sequencing chess problem-, which treats sequencing data as a superimposed image of several independent chess games. A more realistic approach to the dynamics of cellular processes within each cell, revealing the limits of NGS approaches to temporal analysis. Bioinformatic ; DNA ; Molecular mechanisms ; Simulation ＆ modelling SBIGEM Scientific result Mon, 17 Feb 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Diagnosis-acute-hepatic-porphyrias-mass-spectrometry.aspx A collaborative study between SPI and a team from Hôpital Louis Mourier demonstrates the contribution of liquid chromatography coupled with mass spectrometry to the day-to-day analytical needs of a clinical laboratory. Application to the rapid quantification of biomarkers in acute hepatic porphyrias. Diagnosis ; Mass spectrometry ; Biomarkers SPI Scientific result ; Article Fri, 23 Feb 2024 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Metabolomic-signatures-high-grade-breast-tumors.aspx The TIRO laboratory of the SHFJ (Nice) identifies for the first time discriminating biomarkers of high-grade invasive breast tumors, using a non-targeted metabolomics approach performed on surgical specimens and cytoponctions from patients at different stages of malignancy. Metabolomics ; Cancer ; Biomarkers SHFJ Scientific result Fri, 04 Aug 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Proteins-involved-pathogenesis-creatine-transporter-deficiency.aspx Researchers at SPI (DMTS) have identified by mass spectrometry and bioinformatics analysis several biomarkers linked to the creatine transporter deficiency disorder (CTD) using two original models : mice with the clinical characteristics of CTD subjects and brain organoids derived from CTD patient cells. Mass spectrometry ; Genetic diseases ; Biomarkers ; Proteomics SPI Scientific result Thu, 22 Jun 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/PeakForest-digital-infrastructure-metabolomic-analysis.aspx A consortium of researchers, including SPI/DMTS metabolomics specialists, presents PeakForest, a database of NMR and mass spectra, which provides storage and annotation services for spectra of reference compounds and metabolic profiles of biological matrices. An open resource to address the evolving needs of the discipline. Large-scale biology ; Metabolomics ; Bioinformatic SPI Scientific result Tue, 22 Nov 2022 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Link-intestinal-microbiota-Covid-19.aspx A team from SPI used mass spectrometry to analyze the degree of alteration of the intestinal microbiota of Covid-19 patients and to look for signatures of intestinal infection by the SARS-CoV-2 virus. The level of the observed gut dysbiosis would be an indicator of the stage and extent of the infection. Mass spectrometry ; Proteomics ; Biomarkers ; Infectious diseases SPI Scientific result ; Article Thu, 12 May 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/ptairMS-COVs-biomarkers.aspx The ptairMS software, developed in the framework of a collaboration led by the CEA-Joliot, allows the processing and analysis of proton transfer mass spectrometry data, an ideal method for the real-time study of volatile organic compounds (VOCs) present in exhaled breath. Bioinformatic ; Biomarkers Researchers List Scientific result Tue, 26 Apr 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/ProMetIS-open-database-multi-omics-phenotyping.aspx A consortium of researchers, led by SPI/DMTS, presents ProMetIS, a pilot study for the deep phenotyping of murine models by combining proteomic and metabolomic approaches. A significant advance for the functional characterization of genes and the development of bioinformatics integration approaches. Mass spectrometry ; Large-scale biology ; Bioinformatic SPI Scientific result Mon, 04 Apr 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Diagnosis-MS-congenital-disorders-glycosylation.aspx A collaboration initiated in 2017 between AP-HP (Bichat Hospital), Paris-Saclay University (Inserm 1193) and the Laboratoire d’Études du Métabolisme des Médicaments (LEMM/SPI/DMTS), leading to 4 publications in 2021, is advancing knowledge on the origin of certain congenital disorders of glycosylation, through the identification of specific biochemical biomarkers. Mass spectrometry ; Biomarkers ; Genetic diseases SPI Scientific result Tue, 04 Jan 2022 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/biomarkers-lipids-cirrhosis.aspx European research teams, including one from the CEA's Joliot Institute, have analyzed the blood lipidome of patients with cirrhosis. They highlight specific biomarkers of the different stages of the disease. Methodologies for life sciences ; Biomarkers ; Diseases Researchers SPI Scientific result Mon, 06 Dec 2021 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/diffusion-MRI-characterizes-radiation-induced-neurological-impairments.aspx A team comprising iRCM (CEA-Jacob) and NeuroSpin (CEA-Joliot) researchers analyzed the consequences of irradiation on brain development and neurogenesis in a preclinical model. That work, published in Radiation Research, lays a path for the use of diffusion imaging for the early detection of neurological abnormalities resulting from different types of stress. Brain ; Impacts on living (organisms) ; MRI ; Biomarkers ; Radiobiology Researchers ; Journalists ; general public DRF Scientific result ; Highlight ionizing radiations;Brain;neurodevelopmental disorder;neurogenesis;MRI;structural MRI;diffusion MRI; Thu, 24 Jun 2021 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Carbon-labeling_light.aspx Researchers from the LMC (DMTS), in collaboration with a team from AstraZeneca, have developed a labeling method, based on the exchange of carbon dioxide, simply using visible blue light and a photocatalyst. Chemistry ; Biomarkers ; Diagnosis and innovative treatment Researchers SCBM Scientific result ; Europe radiolabeling; Wed, 24 Feb 2021 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Characterization-predictive-survival-biomarker-septic-shock.aspx Two recent studies conducted by SPI researchers, in collaboration with Inserm and AP/HP teams, reveal the value of measuring plasma levels of calgranulins as biomarkers for the prediction of mortality risk of patients with septic shock, admitted in intensive care unit. Biomarkers ; Mass spectrometry ; Infectious diseases Scientific result Tue, 24 Mar 2020 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/MRI-and-AI-to-develop-virtual-brain-biopsy-tool.aspx ​Imaging the brain of a patient at the microscopic scale is as of yet not possible but might turn into a reality thanks to a new tool for creating virtual biopsies. This algorithm has been developed by a team of NeuroSpin (CEA-Joliot) in collaboration with the Institute of NeuroScience and Medicine of Juelich as part of the European Human Brain Project. A first study demontrsating the potentiel of the algorithm ot simulate white matter samples has been published in NeuroImage. Brain ; MRI ; Bioinformatic Neurospin Scientific result IA;algorithme;intelligence artificielle;IRM de diffusion;Human Brain Project;HBP; Wed, 03 Apr 2019 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Biomarkers-metabolomics-follow-up-cirrhotic-patients.aspx Researchers from SPI, in collaboration with teams from an European foundation, EF Clif, carried out global and targeted metabolomic analyzes which made possible to highlight, in cirrhotic patients, an activation of the kynurenine metabolic pathway (tryptophan degradation pathway). The imbalance of this pathway is probably the cause of the symptoms observed during cirrhotic decompensation, when the body can no longer compensate for liver dysfunctions. Metabolomics ; Biomarkers ; Diseases Scientific result Thu, 07 Feb 2019 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2017/A_new_biomarker_of_senescence_in_humans.aspx In an article published the 10th of May in Nature Communications, some Research Teams of the Frédéric Joliot Institute (SBIGeM, SPI) discovered that a new histone variant called H2A.J accumulates in human fibroblasts in senescence. Health ＆ life sciences ; Genomics ; Biomarkers Scientific result Wed, 14 Jun 2017 10:00:00 GMT