https://joliot.cea.fr/drf/joliot/en/Pages/news/Science/2022/fluorine-18-thiol-labeking-biomolecules-TEP.aspx Website of the Frédéric-Joliot Institute of Life Sciences which includes 4 departments: I2BC, DMTS, NeuroSpin and Service hospitalier Frédéric Joliot (SHFJ). The teams are mainly located at the CEA Paris-Saclay center and at the Orsay hospital. en-US https://www.cea.fr/Style%20Library/Themes/drf/instituts/images/logo-cea-joliot-2023.png https://joliot.cea.fr/drf/joliot/en https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Ketamine-TEP-synaptogenese.aspx Des chercheurs de BioMaps (SHFJ) et de MOODS ont validé une approche innovante de neuroimagerie moléculaire permettant de suivre, de manière non-invasive, les effets de la kétamine sur la densité synaptique dans un modèle préclinique de dépression. Positron Emission Tomography ; Diagnosis and innovative treatment Researchers SHFJ Scientific result préclinique;modèle animal; Mon, 22 Dec 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Reconstruction-TEP-regularisation-Plug-and-Play-convergente.aspx A team of researchers from BioMaps (SHFJ) is proposing a new reconstruction method for PET imaging that combines optimization algorithms with deep neural networks. Their “plug-and-play” regularization approach ensures improved image quality thanks to PET-specific reconstruction learning, while guaranteeing stability and robustness—two critical aspects in the use of AI-based medical techniques. Positron Emission Tomography ; Artificial intelligence Researchers SHFJ Scientific result Tue, 16 Dec 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/lux-eteindre-signal-IRM-sondes-micellaires--PERFECTA.aspx Researchers at the SCBM and BAOBAB have developed a new version of their nanometric micellar vector designed for fluorine-19 magnetic resonance tumor imaging. This version is intended to enhance MRI contrast by switching off the signal on demand in certain areas, while preserving it in pathological regions to be imaged. MRI ; Chemistry ; Diagnosis Researchers Neurospin Scientific result Fri, 05 Dec 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Nitriles-marques-nouvelle-agent-cyanation.aspx ​Des chercheurs du SCBM en collaboration avec le SHFJ décrivent un nouveau paradigme pour le marquage isotopique au carbone de composés nitriles : plus simple, plus propre et universel, ouvrant la voie à une production élargie de molécules marquées d’intérêt en santé et en agrochimie. Chemistry ; Medical imaging Researchers SCBM Scientific result ; Europe Fri, 14 Nov 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Encapsulation-Astate-Bambusuril.aspx Des chercheurs du SCBM (DMTS) rapportent pour la première fois qu'un bambusuril, un macrocycle synthétisé dans leur laboratoire, est capable d'encapsuler un anion astate-211, un radionucléide émetteur de rayonnements , très prometteur pour des applications en radiothérapie interne vectorisée. Chemistry ; Radiotherapy Researchers SCBM Scientific result ; Europe Wed, 29 Oct 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/PET-imaging-OATP-function-impacts-sex-age.aspx Researchers from BioMaps (SHFJ) investigated the hepatic activity of organic anion-transporting polypeptides (OATPs), key players in the elimination of certain drugs, using a PET imaging approach with 11C-glyburide, which revealed differences in tracer pharmacokinetics between men and women. Pharmacology ; Positron Emission Tomography ; Medical imaging SHFJ Scientific result Wed, 15 Oct 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Radioligands-TEP-neuroinflammation.aspx Des chercheurs du SHFJ, en collaboration avec le CEA-Jacob, le CRN à Lyon et le PharmaCenter à Bonn ont imaginé, synthétisé et caractérisé deux radiotraceurs TEP ciblant P2Y12, une protéine impliquée dans l’activation de la microglie durant la neuroinflammation.​ Positron Emission Tomography ; Pharmacology Researchers MIRcen Scientific result préclinique;modèle animal; Fri, 03 Oct 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/New-technique-for-analyzing-CPL-emitting-molecules.aspx Scientists at the EPFL, in collaboration with a team from SCBM (DMTS), have developed a new technique that enables, with unprecedented sensitivity, the measurement of circularly polarized light emitted by luminescent materials over time. This work has been published in Nature. Chemistry ; Materials SCBM Scientific result ; Article Wed, 03 Sep 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Tolerance-opioid-PET.aspx A study combining PET imaging and pharmacology, conducted by researchers at BioMaps (SHFJ), suggests that decreased availability of opioid receptors and altered neuronal energy metabolism constitute molecular signatures of opioid tolerance. These observations, made in an animal model, could help improve understanding and treatment of opioid dependence. Positron Emission Tomography ; Molecular mechanisms Researchers SHFJ Scientific result ; Article opiate;preclinical model; Wed, 06 Aug 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Correlation-neuroinflammation-epileptogenic-zone-TSPO-PET.aspx A study by SHFJ researchers has established a strong correlation between biomarkers of neuroinflammation, revealed by original PET imaging, and intracranial electroencephalographic recordings of epileptogenic activity. This offers hope for drug-resistant patients who are candidates for surgery. Positron Emission Tomography ; Medical imaging ; Brain SHFJ Scientific result ; Article Tue, 15 Jul 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Theranostic-antibodies-endothelin-receptors-models-glioblastoma-melanoma.aspx Researchers from SPI (DMTS) propose immunodiagnostic and immunotherapeutic approaches based on the use of innovative antibodies targeting two subtypes of endothelin receptors (ETA and ETB), recognised as relevant therapeutic targets in oncology. Health ＆ life sciences ; Cancer ; Medical imaging ; Positron Emission Tomography Neurospin Scientific result preclinical research;animal models; Thu, 22 May 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Synthesis-anti-cancer-drug-cells-using-nanomicelles.aspx A team at SCBM (DMTS) has designed nanomicelles that can be activated by a bioorthogonal reaction releasing a first chemical species, which then reacts with a second compound encapsulated in the micelles. Application to the synthesis of an anti-cancer drug, sorafenib, inside living cells. Chemistry ; Methodologies for life sciences ; Cancer SCBM Scientific result Fri, 11 Apr 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Deuteration.aspx ​Une étude menée par le SCBM présente une approche innovante permettant de relever les défis actuels des méthodes d'échange isotopique hydrogène - deutérium en offrant un processus efficace, reproductible et évolutif. Ave à la clef, de possibles développements industriels dans les domaines des médicaments et des technologies OLED. Chemistry ; Diagnosis and innovative treatment ; Innovation for industry Researchers SCBM Scientific result Thu, 13 Feb 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Marquage-NIE-azote-pyridine.aspx Des chercheurs du SCBM présentent une solution innovante de marquage par échange isotopique de l’azote des dérivés de la pyridine, un hétérocycle aromatique très représenté dans l’agro-industrie et l’industrie pharmaceutique. ​ Chemistry Researchers SCBM Scientific result Fri, 24 Jan 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Cancer-immunoprofiling-click-chemistry-mass-spectrometry.aspx Researchers at DMTS and SHFJ have carried out a multiplexed analysis of tumor cells and tissues, based on the use of cleavable therapeutic antibodies carrying mass tags, for the identification and quantification of cancer biomarkers. A proof-of-concept demonstrating the high potential of this tumor immunoprofiling approach Cancer ; Chemistry ; Mass spectrometry ; Diagnosis SIMOPRO Scientific result preclinical research;animal models; Mon, 13 Jan 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/neuromodulatory-nuclei-Alzheimer-and-related-disorders.aspx A team from GHU Paris and SHFJ has used brain MRI to study the integrity of the locus coeruleus and nucleus basalis of Meynert in patients with early-onset Alzheimer's disease (AD), age-related TDP-43 encephalopathy (LATE) and fronto-temporal dementia (FTD). Both structures are altered in early AD, LATE and probably FTD, making these neuromodulatory areas potential therapeutic targets Diseases ; Brain ; Cognition ; MRI ; Positron Emission Tomography ; Alzheimer's disease Neurospin Scientific result Wed, 16 Oct 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/PET-image-reconstruction-deep-learning-clearmind-detector.aspx Three DES and DRF laboratories have developed an innovative Machine Learning algorithm to improve the reconstruction of PET images acquired as part of the ClearMind project, a technology based on the detection of gamma photons by a monolithic lead tungstate crystal detector. A step towards more accurate PET imaging Positron Emission Tomography ; Methodologies for life sciences ; Artificial intelligence Irfu Scientific result Mon, 07 Oct 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/PET-monitoring-central-effects-innovative-smoking-cessation-therapy.aspx A BioMaps team has used PET imaging to monitor glucose metabolism as a marker of the cerebral impact of smoking cessation, as well as the effects of a promising drug-candidate for the treatment of such cessation. By revealing the restoration of normal activity in the brain area associated with craving, these results offer hope for smoking cessation in humans Positron Emission Tomography ; Medical imaging ; Pharmacology ; Brain SHFJ Scientific result Preclinical;animal models;murine model; Thu, 29 Aug 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Marquage-echange-isotopique-soufre.aspx Une équipe du SCBM met au point une méthode d’échange isotopique du soufre pour le marquage de molécules biologiquement actives. Telle une plateforme isotopique multi-échangeable, le procédé permet également un échange isotopique du carbone et d’hydrogène donnant accès à un grand nombre d’isotopologues. L’équipe met en avant le potentiel de la méthode pour vérifier l’authenticité de molécules organiques commerciales. Chemistry ; Diagnosis and innovative treatment ; Medical imaging Researchers SCBM Scientific result Tue, 09 Jul 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2024/NOMATEN-training.aspx As a stakeholder in the NOMATEN Centre of Excellence for innovative multifunctional materials, the CEA-Joliot Institute supports its development by regularly organizing training sessions for its staff. The latest examples. Medical imaging ; Radioactivity ; Materials Academic partnerships ; Europe ; Article Fri, 05 Jul 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/phototherapy-micells.aspx SCBM researchers have designed nanometric micelles that can be activated by light and constructed by self-assembly of amphiphiles derived from ferrocene, which carries a hidden therapeutic activity in the absence of activation. Chemistry ; Diagnosis and innovative treatment ; Nanomedicine Researchers SCBM Scientific result ; Article Wed, 12 Jun 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/disulphide-bridge-radiolabeling.aspx Researchers at BioMaps have developed a "re-bridging agent" for the radiolabelling of biomolecules containing disulphide bridges. Their strategy has enabled several molecules of therapeutic interest to be labelled with fluorine-18, copper-64 and zirconium-89. Chemistry ; Diagnosis and innovative treatment ; Medical imaging Researchers SIMOPRO Scientific result ; Article Fri, 24 May 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Response-intra-tumoral-immunotherapy-by-immunoPET.aspx A team from BioMaps (SHFJ), in partnership with the Gustave Roussy Institute, has used immunoPET imaging to assess the influence of tissue distribution on the efficacy of cancer immunotherapy, administered intra-tumor and intravenously in mice. Intratumoral administration is more effective and reduces overall exposure of organs at risk Medical imaging ; Positron Emission Tomography ; Cancer SHFJ Scientific result preclinical research;animal models; Fri, 19 Apr 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Photocatalytic-CO2-reduction-for-radiolabeled-drug-synthesis.aspx Researchers from SCBM (DMTS) and SB2SM (I2BC) describe a novel and optimized approach to the total photoreduction of 13C-labelled CO2 to carbon monoxide (CO), and the immediate reuse of the latter for the synthesis of high value-added compounds. A step towards a radiochemistry of carbon isotopes potentially useful in human health. Bio-inspired catalysis ; Chemistry ; Green Chemistry ; Carbon cycle SHFJ Scientific result Wed, 22 Nov 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Click-Chemistry-optimized-drug-delivery-nanomicelles.aspx Researchers at SCBM have used a click-and-release chemistry approach to mass-release an anti-cancer drug into cells from cleavable nanomicelles, thanks to a bioorthogonal activation process. A step towards the development of new nanomedicines Chemistry ; Biotechnology SCBM Scientific result Fri, 10 Nov 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Radical-anion-CO2-radiomarquage.aspx Des chercheurs de l'institut montrent qu’une stratégie fondée sur la formation du radical anion CO2●- marqué au carbone 14 ou carbone 11 s’avère payante pour radiomarquer en conditions douces des médicaments. Chemistry ; Diagnosis and innovative treatment Researchers SHFJ Scientific result ; Article préclinique; Tue, 24 Oct 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Impact-metabolism-PET-imaging-neuroinflammation.aspx Researchers at BioMaps evaluated the effect of several factors on the distribution of [18F]DPA-714 in 201 subjects who participated in SHFJ PET imaging protocols to better understand the role of neuroinflammation in various neurological diseases. They conclude that measures of individual metabolism are important in image interpretation. Positron Emission Tomography ; Medical imaging ; Pharmacology SHFJ Scientific result Thu, 12 Oct 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/PET-imaging-antibody-endothelin-receptors-glioblastoma-tumors.aspx Researchers at BioMaps (SHFJ) and SPI (DMTS) have studied the pharmacokinetics of a novel immuno-radioligand targeting the endothelin A receptor (ETA), overexpressed in many cancers, particularly glioblastoma. The immunoPET imaging approach used in this study in a preclinical model confirms the theranostic potential of this antibody. Positron Emission Tomography ; Cancer ; Medical imaging Neurospin Scientific result Thu, 07 Sep 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Composé-radiosensible-combiner-radiotherapie-et-chimiotherapie.aspx Des chercheurs du SCBM et de l’Iramis publient une étude preuve-de-concept d’un composé radiosensible qui pourrait servir à « libérer » in vivo des médicaments anti-tumoraux, et ainsi de combiner les effets d’une radiothérapie et d’une chimiothérapie. Chemistry ; Radiotherapy Researchers SCBM Scientific result ; Article Tue, 05 Sep 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2023/ISOBIOTICS-renewal-isotope-labeling-biodrugs.aspx The SCBM was awarded funding from the Horizon Europe program for the ISOBIOTICS project, coordinated by Christophe Dugave. This project will enable the theoretical and practical training of 11 PhD students, including two at SCBM and one at SHFJ, on the development of innovative methods for the isotopic labeling of biodrugs Chemistry SCBM News ; Article ; Europe ; European ＆ international partnerships Wed, 09 Aug 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Longitudinal-monitoring-tauopathy-PET-imaging.aspx A joint team from GHU Paris and BioMaps (SHFJ) conducted a 2-year longitudinal study of 27 people with Alzheimer's disease, tracking the progression of tau pathology measured by PET imaging, of cortical atrophy using MRI, and their links with cognitive decline. Alzheimer's disease ; Medical imaging ; MRI ; Positron Emission Tomography SHFJ Scientific result ; Article Wed, 02 Aug 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/rabbit-motif-PET-imaging-diagnostic-evaluation-parkinsonian-syndromes.aspx BioMaps researchers compared the diagnostic performance of the rabbit visual pattern observed in 18F-DOPA PET imaging with the standard procedure approved by the international nuclear imaging societies for the diagnosis of parkinsonian syndromes in PET/MRI and obtained encouraging results, which may validate the clinical utility of such a model Positron Emission Tomography ; Medical imaging ; Parkinson's disease ; Brain SHFJ Scientific result Tue, 23 May 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Radiomarquage-crizotinib-fluor-18-nouvel-outil-TEP.aspx Des chercheurs du SHFJ ont mis au point la radiosynthèse au fluor-18 du crizotinib, un médicament qui ne pénètre pas dans le cerveau. Ce nouvel outil pour l’imagerie TEP permettra d’explorer de futures stratégies visant à faire passer la barrière hémato-encéphalique à ce médicament pour traiter certaines métastases cérébrales. Positron Emission Tomography ; Cancer ; Diagnosis and innovative treatment Researchers SHFJ Scientific result ; Article Thu, 27 Apr 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Nanoparticles-to-improve-radiotherapy.aspx Researchers from the SHFJ laboratory at ISMO have demonstrated the value of platinum nanoparticles as potential radiosensitizing agents for radiation therapy. Diagnosis and innovative treatment ; Positron Emission Tomography Researchers SHFJ Scientific result Radiotherapy;biodistribution;platinum nanoparticles; Tue, 21 Feb 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/New-radiolabeling-strategy-immunoTEP.aspx Researchers from the BioMaps laboratory (SHFJ) and the Molecular Engineering for Health Service (SIMoS, DMTS) developed an enzymatic approach for radiofluorination of an anti-PD-L1 Fab and compared its in vivo properties to the same Fab stochastically labeled by two conventional methods. Diagnosis and innovative treatment ; Positron Emission Tomography Researchers SHFJ Scientific result PD-L1;radiomarquage;lipoate-protéine ligase;radiofluoration; Tue, 21 Feb 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Glioblastoma-FUS-cetuximab.aspx Researchers from the SHFJ, in collaboration with NeuroSpin, show that the use of focused ultrasound does not increase the therapeutic effects of cetuximab on glioblastoma although the opening of the blood-brain barrier is transiently effective. Positron Emission Tomography ; Diagnosis and innovative treatment Researchers Neurospin Scientific result Wed, 15 Feb 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/click-electrophilic-iminosydnones.aspx Researchers at the Joliot Institute have developed two new families of iminosydnones that allow the bio-orthogonal release of electrophilic species. These molecules constitute "building blocks" of click-and-release chemistry, useful for reactions with nucleophilic compounds contained in cells. Chemistry Researchers SCBM Scientific result Thu, 02 Feb 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/fluorine-18-thiol-labeking-biomolecules-TEP.aspx Radiochemists from the BioMaps unit (SHFJ) have developed and automated the synthesis of an 18F-fluoropyridine containing a thiol function (-SH), allowing its conjugation to model biomolecules within 45 minutes. A step towards rapid radiolabeling of complex biological molecules for PET imaging. Radioactivity ; Chemistry ; Positron Emission Tomography SHFJ Scientific result Tue, 28 Jun 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Photoreduction-of-CO2-by-iron-porphyrins.aspx ​Researchers from ICMMO* and ISMO**, in collaboration with a team from I2BC, show that the urea-decorated iron porphyrin catalysts they developed previously for the electro-catalysis of CO2, can be successfully employed in a photo-catalytic approach. Chemistry ; Bio-inspired catalysis ; Photosynthesis SB2SM Scientific result Thu, 16 Jun 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Radioligands-immunoPET-PD-1-PD-L1.aspx Researchers from the SHFJ and the DMTS have developed optimized radioligands for immunoPET imaging. The objective is to better predict the effectiveness of anti-PD1/anti-PDL1 immunotherapy used to fight certain cancers. Positron Emission Tomography ; Cancer Researchers SIMOPRO Scientific result programmed cell death-ligand 1; Tue, 12 Apr 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Deuterated-tritiated-molecules-more-dversity.aspx Researchers from the SCBM describe a hydrogen isotope labeling process that is easy to implement and whose starting point is a "simple" mixture, in a solvent, of the product to be labeled with a pre-catalyst. Explanations of this process which finds applications in many fields including drug development or medical imaging. Chemistry ; Diagnosis and innovative treatment ; Medical imaging Researchers SCBM Scientific result marquage isotopique;biomolécule;activation C-H;ADME-DMPK; Wed, 06 Apr 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/PET-MRI-imaging-epilepsy-detection.aspx A team from BioMaps (SHFJ), in collaboration with several hospital groups, shows that hybrid PET/MRI imaging significantly improves the detection of epileptogenic foci and, consequently, the outcome of surgical treatment of epilepsy. Medical imaging ; Positron Emission Tomography ; MRI SHFJ Scientific result Tue, 05 Apr 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Alzheimer-Tau-PET-imaging.aspx A joint team from GHU Paris and SHFJ shows the predictive value of PET imaging data of the Tau protein in the progression of Alzheimer's disease. Alzheimer's disease ; Positron Emission Tomography Researchers SHFJ Scientific result ; Press release radiotracer; Sun, 03 Apr 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/PET-MRI-imaging-tumors-supervoxel-level.aspx A collaborative study led by BioMaps researchers (SHFJ) demonstrates that fully integrated quantitative multiparametric analysis of non-small cell lung cancer in hybrid 18F-FDG PET/MRI 3T imaging is clinically feasible and could enable biological characterization of tumors at the supervoxel scale. Medical imaging ; Positron Emission Tomography ; MRI ; Cancer Scientific result Wed, 10 Nov 2021 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Amyloid-tau-imaging-diagnosis-progressive-amnesia.aspx Researchers from BioMaps (SHFJ) and the Service de Neurologie de la Mémoire et du Langage (Hôpital Ste-Anne) show, through amyloid and tau molecular imaging in patients followed for 2 years, that the diagnosis of progressive amnesia in the elderly is not necessarily Alzheimer's disease and may be caused by other mechanisms clearly distinguishable from it. Positron Emission Tomography ; Medical imaging ; Alzheimer's disease Scientific result Thu, 04 Nov 2021 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2021/SCF-2-prizé-2-researchers-SCBM.aspx The members of the Organic Chemistry Division (DCO) of the French Chemical Society met on Monday 10 May to award the DCO 2021 prizes. Sophie Feuillastre and Davide Audisio, both researchers at the SCBM (CEA-Joliot Department of Medicines and Technology for Health) are among the lucky winners. Chemistry Researchers SCBM Article radiolabeling; Thu, 27 May 2021 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/PETimaging-neuropharmacology-buprenorphine.aspx Researchers at BioMaps (SHFJ) have succeeded in determining the interaction dynamics of buprenorphine, an opioid drug with a particularly complex pharmacology, with its brain receptors in vivo. To do so, they developed an original PET imaging approach based on the use of the radiolabeled molecule (11C-buprenorphine). Brain ; Positron Emission Tomography ; Pharmacology Scientific result Wed, 05 May 2021 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Nitrile-carbon-isotope-labeling.aspx Researchers at the CEA-Joliot Institute (Carbon-14 labeling Laboratory), in collaboration with teams from AstraZeneca, Sanofi and Nimbe (CEA-Iramis), have developed a labeling method, based on nitrile exchange using nickel catalysis. This method is currently under study at Sanofi for the labeling of a drug candidate. Chemistry Scientific result ; Europe Fri, 30 Apr 2021 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Micellar-probe-fluorine-MRI-tumor.aspx A SCBM (DMTS) team, in collaboration with researchers at NeuroSpin and I2BC, is describing micellar nanometric vectors targeting tumors that have been imaged by fluorine magnetic resonance imaging (MRI). The observed 19F signal made it possible to precisely delimit the volume of the tumor zone in a mouse model and to quantify the probe accumulated in the target tissue. Chemistry ; Nanomedicine ; Cancer ; MRI Scientific result Thu, 04 Mar 2021 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Carbon-labeling_light.aspx Researchers from the LMC (DMTS), in collaboration with a team from AstraZeneca, have developed a labeling method, based on the exchange of carbon dioxide, simply using visible blue light and a photocatalyst. Chemistry ; Biomarkers ; Diagnosis and innovative treatment Researchers SCBM Scientific result ; Europe radiolabeling; Wed, 24 Feb 2021 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/chiral-probe-study-transferases.aspx Chemists of CEA-Joliot have synthesized the two enantiomers of a molecule containing a deuterated chiral ethyl group and characterized their chiral properties using advanced spectroscopic tools. These two compounds will be useful for probing the reaction mechanism of enzymes, as alkyl transferases. Chemistry Researchers SCBM Scientific result isotopic labeling; Tue, 24 Nov 2020 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Seeing-tomorrow-OLED-display-technology-emerge.aspx A team from SCBM, in collaboration with IRAMIS, LETI, ENS Paris-Saclay, the Universities of Rennes and San José (USA), has developed new electroluminescent molecules with properties that improve the energy consumption and light production of organic light-emitting diodes (OLEDs). This is the first study correlating the structure and properties of this type of materials, with a promising future in display technologies. Chemistry ; Technologies Scientific result Thu, 22 Oct 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/ImmunoPET-BBB-Ab.aspx Researchers from SHFJ, NeuroSpin and DMTS have demonstrated, by immunoPET imaging, the impact of transient BBB permeabilization on brain exposure to an anti-EGFR antibody. Promising prospects for targeted immunotherapy of glioblastoma. Cancer ; Medical imaging ; Positron Emission Tomography SIMOPRO Scientific result radiomarquage;zirconium;IRM; Tue, 06 Oct 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Retro1-new-molecule-against-intracellular-pathogens.aspx The SCBM and SIMoS collaborated to optimize the activity of Retro-1, a benzodiazepine compound, inhibitor of Shiga toxins and ricin, derived from high-throughput biological screening. They succeeded in obtaining an analog 70 times more protective against the cytotoxicity of Shiga toxins, Retro-1.1. Chemistry ; High-throughput screening ; CBRN-E threats Scientific result Mon, 14 Sep 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/carbamates-CO2-isotope-labeling.aspx In a study published in Chemical Communications, the Joliot Institute Carbon labeling laboratory (LMC), in collaboration with the SHFJ, provides proof of concept of a "click" strategy for carbon isotope marking of pharmaceutical molecules containing carbamates. Chemistry ; Diagnosis and innovative treatment SCBM Scientific result ; Europe Thu, 10 Sep 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Hydrogen-isotopes-race-new-drugs.aspx ​The Grégory Pieters' team (LMT/SCBM) publishes, in the prestigious Angewandte Chemie, two major advances in the field of carbon-hydrogen bonds activation involving the two isotopes of hydrogen, deuterium and tritium, facilitating in particular access to labeled analogues of complex molecules, a prerequisite for the development of new drugs. Chemistry Scientific result Tue, 01 Sep 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/SENIOR-cohort-cerebral-aging.aspx The SENIOR study, conducted by several NeuroSpin teams, consists in monitoring, since March 2012, a cohort of 100 subjects aged 50 to 70 years by annual MRI imaging over a period of 10 years, to establish a normal aging brain imaging biomarkers mapping. This publication in Alzheimer's Research & Therapy describes the baseline experimental protocol and presents first promising results. Neurodegenerative diseases ; Brain ; MRI ; Positron Emission Tomography Scientific result Tue, 04 Aug 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Click-and-release-liberation-2-fluorophores-dans-cellule.aspx Researchers from the LMC have developed a new series of iminosydnones that can split in two and release two fluorophores. They are providing a proof of concept that this "click and release" reaction can be triggered in living cells. Chemistry SCBM Scientific result Diels-Alder;cycloaddition;BCN;pyrazole; Mon, 29 Jun 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Clickable-bambusurils.aspx A team from SCBM, in collaboration with researchers from I2BC, SHFJ and IRAMIS, has synthesized new neutral macrocycles called bambusurils (BUs). These BUs can be functionalized by “click chemistry” to obtain multivalent architectures decorated with 8 to 12 ligands of interest, an alternate topology which gives them remarkable supramolecular properties. Chemistry Scientific result Mon, 04 May 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2020/Launch-of-FLIX.aspx In June 2019, the SCBM obtained a European FET-Open funding for the FLIX project (FLow chemistry for Isotopic eXchange), a radically innovative concept of isotopic labeling of molecules with high added values. This 4-year project, coordinated by CEA/SCBM, with an overall budget of 3.5 million euros started on January 1, 2020 and consists of seven European academic or industrial partners in five countries. Chemistry News ; Europe ; Article Wed, 19 Feb 2020 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Innovative-approach-radiolabel-peptides-fluorine-18-PET-imaging.aspx Radiochemists from the BioMaps unit (SHFJ) have developed and automated a new fluor-18 radiolabelling method for peptides used to characterize specific pathological molecular signatures and thus target treatments. Peptides were conjugated to a specific tag, then radiolabeled in a single step under mild conditions, making this approach an innovative solution for PET imaging of peptides labeled with fluorine-18. Chemistry ; Positron Emission Tomography ; Cancer Scientific result Mon, 17 Feb 2020 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2019/Davide-Audisio-winner-Consolidator-Grant-ERC.aspx The European Research Council (ERC) announced, on December 10, 2019, the winners of the 2019 ERC "Consolidator Grants". Three CEA researchers are rewarded for the excellence of their work in astrophysics, particle physics and chemistry. In Joliot, chemistry is honored with the award of the research grant to Davide Audisio, SCBM, for his expertise in labeling molecules of interest with 14Carbone. Chemistry News ; Europe Tue, 10 Dec 2019 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Light-release-tension-of-cycles.aspx A team from SCBM, in collaboration with Mauritian modelers, has shown that carboxylic acids can be easily converted into small rings with four carbon atoms, the cyclobutanes, using blue LEDs and an iridium catalyst. Cyclobutanes are increasingly used in the design of new drugs and the method described here will help to significantly expand the chemical space explored in "drug discovery". Chemistry Scientific result Tue, 03 Dec 2019 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/See-tumor-PET-imaging-click-chemistry-in-vivo.aspx A new PET imaging method by antibody pretargeting was developed at SHFJ, in collaboration with teams of SCBM and SPI. It consists in reacting in vivo a molecule labeled with 18Fluor with an antibody previously fixed on a tumor and this, in an extremely fast and selective manner, thanks to a « click-chemistry » reaction. The very good results obtained allow to consider the use of pre-targeted antibodies in nuclear medicine. Positron Emission Tomography ; Chemistry Scientific result Tue, 03 Sep 2019 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/New-prediction-biomarker-tumor-progression-PET-images.aspx The SHFJ/IMIV laboratory (Inserm 1023/CNRS/CEA/UP-Sud), in collaboration with hospital-university teams, has shown that, in patients with advanced-stage large cell lymphoma (B type), automatic quantitative measurements of tumor dissemination detected by whole-body PET imaging have a predictive value of progression-free survival (tumor stabilization) and overall survival. Medical imaging ; Positron Emission Tomography ; Cancer Scientific result Tue, 16 Jul 2019 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/New-nanovectors-anticancer-therapies.aspx As part of a collaboration with MIRCen (Jacob Institute), researchers of SCBM have developed functional micellar vectors that can effectively target tumors and whose therapeutic activity is intrinsically carried by the constitutive unit of the micelle. This combination leads to better drug load and avoids premature drug release. Chemistry ; Nanosciences ; Nanomedicine Scientific result Wed, 12 Jun 2019 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2019/IBiSA-screening-saclay-plateau.aspx ​The union of the Saclay Plateau screening platforms under a single banner C @ PS (Criblage sur le Plateau de Saclay) has just obtained the IBiSA label. Jean-Christophe Cintrat (Joliot / SCBM) is in charge of the overall infrastructure. Chemistry ; High-throughput screening News Tue, 26 Mar 2019 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Click-Release-chemistry-targeted-delivery-drug-invivo.aspx A team from the SCBM, in collaboration with the SPI, the IC2MP and the University Hospital of Poitiers, has developed a bioorthogonal chemistry strategy that allows, in vivo, the controlled release of active ingredients contained in micelles-targeting cancerous tumors. These results pave the way for new strategies for targeted drug delivery. Chemistry ; Cancer ; Nanomedicine Scientific result Fri, 15 Mar 2019 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Single-step-incorporation-hydrogen-isotopes-in-nucleobases.aspx Facilitating the deuterium and tritium labeling of molecules containing nucleic bases such as many compounds of pharmacological interest? This is what researchers from SCBM in partnership with teams from SPI and Toulouse managed to achieve. Chemistry SPI Scientific result tritium;deuterium;ruthenium;nucleic base;isotopic labeling; Thu, 28 Feb 2019 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Towards-better-detection-glioblastoma-infiltration.aspx Glioblastoma is a very aggressive cancer of the central nervous system, mainly because of its ability to infiltrate the surrounding areas. A collaboration led by a team of SHFJ and involving NeuroSpin demonstrates the interest of two imaging techniques for the early detection of tumor infiltration. Cancer ; Medical imaging ; Positron Emission Tomography Scientific result PET imaging;glioblastoma; Tue, 26 Feb 2019 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Helicenes-familly-gets-bigger.aspx Helicenes are synthetic molecules with attractive properties for physicists expert in materials but also for biologists. A collaboration led by chemists from the SCBM (CEA-Joliot) and involving the NIMBE (CEA-Iramis) allowed the synthesis of a particular class of helicenes. Chemistry SCBM Scientific result helicenes;regioselectivity; Tue, 22 Jan 2019 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/CO2-copper-carbon-label-pharmaceutical-compounds.aspx Researchers from the SCBM and the IRAMIS (CEA/CNRS) have develop a 14C labeling method for therapeutic molecules based on dynamic Misspelled Wordcarbone dioxide exchange. This one step method generates far less radioactive waste. By facilitating some preclinical and clinical steps, it should eventually help to speed up the marketing applications of some new drug discoveries. Chemistry SCBM News échange isotopique;carbone 14;CO2; Fri, 11 Jan 2019 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Alzheimer-disease-role-neuroimmune-reaction.aspx A collaboration involving the Sainte-Anne Hospital, the SHFJ, the Saint-Antoine research center and the ICM identified, through a PET brain imaging study in patients with Alzheimer's disease, two distinct kinetic profiles of the cerebral neuroimmune response, that impact the disease progression differently. Researchers propose an original model of neuroinflammation, likely to open new therapeutic avenues. Brain ; Alzheimer's disease ; Positron Emission Tomography Scientific result Thu, 10 Jan 2019 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/Physicist-pharmacologists-to-better-understand-BBB.aspx Thanks to complementary imaging techniques, researchers from the SHFJ and NeuroSpin have shown that the physical blood-brain barrier (BBB) disruption is not necessarly enough to deliver some drugs into the brain, especially when there are recognized and supported by efflux transporters. Medical imaging ; MRI ; Positron Emission Tomography ; Cellular mechanisms SHFJ News Thu, 20 Dec 2018 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/LIFEx-popular.aspx ​IMIV unit (SHFJ), in collaboration with the Gustave Roussy Institute, has developed the free software platform LIFEx that allows to characterize the tumor heterogeneity from any type of medical images: PET, MRI, scanner, ultrasound. With nearly 900 members, this platform has an international success because it facilitates the realization of radiomic studies, conducted in the context of personalized medicine. Positron Emission Tomography ; MRI ; Medical imaging Scientific result Thu, 05 Jul 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/ultra-rapid-isotope-labeling.aspx ​A SCBM Research Team, in collaboration with SHFJ, SIMOPRO and Karolinska Institute, has discovered a method inspired by the "click" chemistry which, from radioactive carbon dioxide, can synthesize in just five minutes radiolabeled molecules containing a cyclic urea moiety. This method has been used for the ultra-rapid isotope labeling of drugs, without modification of their structure and with an unequaled efficiency. Chemistry Scientific result Tue, 19 Jun 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/modifications-proteins-nanoparticules.aspx ​Two Research Teams from I2BC@Saclay and SPI (LI2D, Marcoule), in collaboration with IRAMIS, highlight the very strong affinity of silica nanoparticles for proteins with RGG motifs (family of binding proteins). RNA), especially when these are methylated. These results are important for the development of safe by design approaches. Chemistry Scientific result Thu, 24 May 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/fludarabine-lymphoma-imaging.aspx ​The SHFJ LDM-PET team (GIP Cyceron, Caen), in collaboration with the University Hospital of Caen, successfully used, for the first time in the clinic, the radiopharmaceutical drug developed and produced by the researchers of the team. , the [18F] Fludarabine. This drug, which is innovative for lymphoproliferative diseases, has been shown to be more effective in terms of specificity and sensitivity than its current counterpart, [18F] FDG. Positron Emission Tomography ; Medical imaging Scientific result Wed, 23 May 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/metabolomic-analysis-facilitated-by-mass-spectrometry.aspx In a study published in Analytical Chemistry, the Mass Spectrometry Research Team of the Laboratory Drug Metabolism Research Laboratory (SPI) demonstrated the interest of Orbitrap Fusion, a state-of-the-art mass spectrometer for the identification of relevant metabolites based on their masses and isotopes measured with high accuracy. Chemistry ; Metabolomics ; Mass spectrometry Scientific result Wed, 25 Apr 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/functionalized-micellar-nanovectors.aspx ​As part of a collaboration with MIRCen (Institute of Biology François Jacob) and SBIGeM, SCBM researchers have developed functional micellar nanovectors capable of targeting a population of cancer cells. Chemistry ; Cancer Scientific result Thu, 12 Apr 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/isotopic-labeling-complex-molecules.aspx ​Researchers from SCBM, in collaboration with Paris-Sud University and INSA Toulouse, developed the first general method for tritium and deuterium labeling of complex molecules with thioether-type motifs (including sulfur atom). This method allows rapid access to tritiated or deuterated molecules used in the pharmaceutical industry for in vivo monitoring or the biological assay of substances of interest. Chemistry Scientific result Thu, 22 Mar 2018 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/pharmacokinetic-model-neuroinflammation.aspx ​Research Teams from SHFJ, MIRCen and NeuroSpin tested a pharmacokinetic analysis model of Positron-emission tomography (PET) data at 18F-DPA-714, taking into account endothelial cell activity not specifically associated with an inflammatory state. This model allows a more precise interpretation of PET images of neuroinflammation present in most neurodegenerative pathologies. Positron Emission Tomography ; Brain ; Health ＆ life sciences Scientific result Thu, 22 Feb 2018 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2017/pet_brain_damage_alcohol.aspx A Research Team from the SHFJ (IMIV) highlights, through a preclinical model of exposure to alcohol, an immediate and persistent neuro-immune response, several months after the initial exposure of alcohol. These results confirm the occurrence of brain damage that may play a key role in the neurological deficits reported in teenagers who like "binge-drinking", that is to say an excessive consumption of alcohol over a very short time. Brain ; Positron Emission Tomography Scientific result Tue, 07 Nov 2017 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2017/link_and_release_selectively_molecules_in_biological_media.aspx A Research Team of the SCBM (Frédéric Joliot Institute), in collaboration with the SIMOPRO (Frédéric Joliot Institute), Strasbourg University and the start-up Syndivia, has just discovered a new chemical reaction allowing both to bind and to cleave molecules in biological media ("click and release" reaction). Chemistry ; Health ＆ life sciences Scientific result Tue, 24 Oct 2017 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2017/New_method_for_quantifying_images_in_PET_MRI.aspx Deriving from a collaboration between the SHFJ and MIRCen, this work presents a new and original method of quantification of positron emission tomography (PET) images adapted to hybrid PET / MRI cameras, developed by combining the expertise of MIRCen in MRI preclinical and SHFJ expertise in preclinical PET. Health ＆ life sciences ; Positron Emission Tomography ; MRI ; Medical imaging Scientific result Fri, 30 Jun 2017 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2017/It_happened_at_the_SHFJ.aspx The "First international course on PET in Epilepsy", organized by the SHFJ in early June, brought together about thirty international specialists in the field. The challenge was to disseminate know-how widely developed at SHFJ: the pre-surgical localization of epileptic foci by PET in patients with focal drug-resistant epilepsies, candidates for resection neurosurgery. Institutional ; Brain ; Positron Emission Tomography News Tue, 27 Jun 2017 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/I2BM_anglais/News/Scientific_news/Articles/2016/Measuring-tumor-heterogeneity-from-PET-images-a-first-biological-validation.aspx Recent work from the IMIV research lab suggests that tumor heterogeneity measured in vivo using PET images actually reflects the biological heterogeneity as measured ex vivo using pathological slides. Positron Emission Tomography SHFJ Scientific result Fri, 03 Jun 2016 07:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2014/Performing-chemistry-within-the-cell.aspx Researchers from the CEA-IBITECS in collaboration with a team from the University of Strasbourg (UDS) have developed new reagents known as “chelating azides”, which can rapidly and selectively couple to any compound equipped with an alkyne group. The reaction can take place in any environment, including within a cell. Chemistry ; Methodologies for life sciences Saclay Scientific result Tue, 06 May 2014 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2013/Quantum-dot-a-promising-new-imaging-agent.aspx The drawback to current optical imaging markers is their short life. Researchers are now developing fluorescent nanocrystals (quantum dots) to supplant these markers. A team from the CEA-iBiTec-S, in collaboration with the CEA-I2BM and ESPCI, has developed a new surface chemistry for these particularly effective nanoparticles. Cell and molecular imaging ; Nanomedicine ; Chemistry Fontenay-aux-Roses Scientific result Fri, 22 Mar 2013 11:00:00 GMT