https://joliot.cea.fr/drf/joliot/en/Pages/news/Science/2023/Cone-marine-toxin-melanocortin-receptor-antagonist.aspx Website of the Frédéric-Joliot Institute of Life Sciences which includes 4 departments: I2BC, DMTS, NeuroSpin and Service hospitalier Frédéric Joliot (SHFJ). The teams are mainly located at the CEA Paris-Saclay center and at the Orsay hospital. en-US https://www.cea.fr/Style%20Library/Themes/drf/instituts/images/logo-cea-joliot-2023.png https://joliot.cea.fr/drf/joliot/en https://www.cea.fr/drf/joliot/en/Pages/news/Science/2026/Biomarkers-hypoxic-brain-injury-choroid-plexus-organoids.aspx A team from the SPI (DMTS) investigated the effects of hypoxia on the interface between the choroid plexus and cerebrospinal fluid using organoids derived from human pluripotent stem cells. The aim was to investigate how cerebral hypoxia at birth, which causes hypoxic-ischaemic encephalopathy, disrupts this cerebral barrier, which has not yet been extensively studied. Brain ; Diseases ; Proteomics SPI Scientific result ; Article Fri, 17 Apr 2026 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Transport-trastuzumab-nanoparticles-nasal-epithelium.aspx ​Researchers from SPI (DMTS) developed a formulation of PLGA nanoparticles loaded with the anticancer trastuzumab (NP-TZB) and measured their ability to cross a cellular model of the nasal epithelial barrier. This first validated step supports a potential nose-to-brain (N2B) delivery route. Nanomedicine ; Cancer ; Pharmacology SPI Scientific result Wed, 12 Nov 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/alpha-synucleine-formes-tronquees-MS.aspx A team from LI-MS (SPI/DMTS) combines a robust α-synuclein immunoprecipitation protocol with high-resolution mass spectrometry and characterizes novel truncated forms of the protein. Proteomics ; Biomarkers Researchers SPI Scientific result ; Article Mon, 20 Oct 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/PET-imaging-OATP-function-impacts-sex-age.aspx Researchers from BioMaps (SHFJ) investigated the hepatic activity of organic anion-transporting polypeptides (OATPs), key players in the elimination of certain drugs, using a PET imaging approach with 11C-glyburide, which revealed differences in tracer pharmacokinetics between men and women. Pharmacology ; Positron Emission Tomography ; Medical imaging SHFJ Scientific result Wed, 15 Oct 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Radioligands-TEP-neuroinflammation.aspx Des chercheurs du SHFJ, en collaboration avec le CEA-Jacob, le CRN à Lyon et le PharmaCenter à Bonn ont imaginé, synthétisé et caractérisé deux radiotraceurs TEP ciblant P2Y12, une protéine impliquée dans l’activation de la microglie durant la neuroinflammation.​ Positron Emission Tomography ; Pharmacology Researchers MIRcen Scientific result préclinique;modèle animal; Fri, 03 Oct 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Ultrasound-counter-exposure-neurotoxic-agent.aspx Researchers from BioMaps (SHFJ), NeuroSpin, and the french IRBA developed an innovative approach using focused ultrasound to improve brain delivery of an antidote, oxime, following exposure to an organophosphorus neurotoxic agent in a murine model. Pharmacology ; Toxicology ; Brain ; CBRN-E threats Neurospin Scientific result preclinic;animal models; Thu, 28 Aug 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Drug-candidate-for-treatment-neonatal-encephalopathy.aspx Researchers from the SPI (DMTS) and the Women & Infants Hospital in Providence have laid the molecular basis for the neuroprotection of a purine derivative in a preclinical model of neonatal hypoxic-ischemic encephalopathy (HIE). The promising results support the development of this drug candidate to treat HIE in neonates. Pharmacology ; Brain ; Molecular mechanisms ; Diseases SPI Scientific result animal models;preclinic; Thu, 26 Jun 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2025/COVID-PATH.aspx ​​The COVID-PATH project was officially launched on March 12, 2025, to investigate the gastrointestinal impact of SARS-CoV-2 and its link to Long COVID​. Infectious diseases ; Proteomics ; Metagenomics ; Virus Researchers SPI Europe ; Academic partnerships ; Article Thu, 10 Apr 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/PET-monitoring-central-effects-innovative-smoking-cessation-therapy.aspx A BioMaps team has used PET imaging to monitor glucose metabolism as a marker of the cerebral impact of smoking cessation, as well as the effects of a promising drug-candidate for the treatment of such cessation. By revealing the restoration of normal activity in the brain area associated with craving, these results offer hope for smoking cessation in humans Positron Emission Tomography ; Medical imaging ; Pharmacology ; Brain SHFJ Scientific result Preclinical;animal models;murine model; Thu, 29 Aug 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Multiplex-proteotyping-for-identification-microbial-isolates.aspx Researchers at SPI are proposing an innovative multiplexing method for rapid identification of several microbial isolates in a single mass spectrometry analysis. This approach opens up prospects for the large-scale identification of microorganisms resulting from culturomics programs. High-throughput screening ; Methodologies for life sciences ; Proteomics ; Bacteria SPI Scientific result Fri, 24 Nov 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Impact-metabolism-PET-imaging-neuroinflammation.aspx Researchers at BioMaps evaluated the effect of several factors on the distribution of [18F]DPA-714 in 201 subjects who participated in SHFJ PET imaging protocols to better understand the role of neuroinflammation in various neurological diseases. They conclude that measures of individual metabolism are important in image interpretation. Positron Emission Tomography ; Medical imaging ; Pharmacology SHFJ Scientific result Thu, 12 Oct 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Proteins-involved-pathogenesis-creatine-transporter-deficiency.aspx Researchers at SPI (DMTS) have identified by mass spectrometry and bioinformatics analysis several biomarkers linked to the creatine transporter deficiency disorder (CTD) using two original models : mice with the clinical characteristics of CTD subjects and brain organoids derived from CTD patient cells. Mass spectrometry ; Genetic diseases ; Biomarkers ; Proteomics SPI Scientific result Thu, 22 Jun 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Identification-cystic-fibrosis-lung-microbiota-metaproteomics.aspx A Li2D (SPI/DMTS) team used tandem mass spectrometry to identify microorganisms in sputum samples from cystic fibrosis patients. A promising proteotyping approach that provides an expanded and unbiased view of the cystic fibrosis microbiota and could be complementary to microbiological monitoring of patients. Large-scale biology ; Methodologies for life sciences ; Proteomics SPI Scientific result Tue, 14 Feb 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Cone-marine-toxin-melanocortin-receptor-antagonist.aspx A SIMoS team discovered a toxin in the venom of a marine cone that it engineers into a high affinity antagonistic peptide for the melanocortin receptor, a major regulator of energy homeostasis. A step towards the development of innovative treatments for certain eating disorders Pharmacology ; High-throughput screening ; Proteomics ; Transcriptomics SIMOPRO Scientific result Thu, 09 Feb 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/In-vivo-evaluation-antibody-drug-conjugate.aspx A team from SIMoS, in collaboration with the SCBM (DMTS), has developed an original bioanalytical approach based on the double 14C-3H isotopic labeling of an antibody-drug conjugate, allowing the simultaneous in vivo monitoring of the two components in mouse models as well as their precise quantification in the organs. Pharmacology ; Cell and molecular imaging SIMOPRO Scientific result Mon, 22 Aug 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Link-intestinal-microbiota-Covid-19.aspx A team from SPI used mass spectrometry to analyze the degree of alteration of the intestinal microbiota of Covid-19 patients and to look for signatures of intestinal infection by the SARS-CoV-2 virus. The level of the observed gut dysbiosis would be an indicator of the stage and extent of the infection. Mass spectrometry ; Proteomics ; Biomarkers ; Infectious diseases SPI Scientific result ; Article Thu, 12 May 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Interaction-buprenorphine-benzodiazepine.aspx ​A collaboration between the SHFJ and the UMR-S 1144 (University of Paris) shows that the deleterious effect of the buprenorphine/benzodiazepine combination would result from the combined action of each drug on its target. Diagnosis and innovative treatment ; Pharmacology Researchers SHFJ Scientific result ; Article pharmacodynamics;opioids; Fri, 25 Mar 2022 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2021/Deeptope-start-up-Simos.aspx Deeptope, founded in February 2021 from a technology developed at the DMTS Laboratory of Cellular Immunology and Biotechnology (LICB), is a company of therapeutic antibody engineering that provides antibody optimization and characterization services to biotech or pharmaceutical firms with the goal of increasing the quality of antibodies in a very short timeframe. Biotechnology ; Pharmacology News ; Article Mon, 29 Nov 2021 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Metaproteomics-data-science-soil-microbiota.aspx Researchers from Li2D (SPI/DMTS, Marcoule) and LSCE have developed an innovative methodology for analyzing soil microbiota based on an optimal computational interpretation of metaproteomic databases, which should lead to a better understanding of the impact of pollutants on soil quality and to the prediction of their restoration potential. Environment ; Proteomics ; Mass spectrometry ; Bacteria Scientific result Thu, 07 Oct 2021 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Immunogenicity-therapeutic-peptides.aspx A team from SIMoS (DMTS) in collaboration with Sanofi shows that the introduction of non-natural sequences into an immunogenic peptide attenuates the immune response against this peptide, an approach that could guide the design of less immunogenic, and therefore more effective, therapeutic peptides. Health ＆ life sciences ; Pharmacology Scientific result Tue, 01 Jun 2021 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/PETimaging-neuropharmacology-buprenorphine.aspx Researchers at BioMaps (SHFJ) have succeeded in determining the interaction dynamics of buprenorphine, an opioid drug with a particularly complex pharmacology, with its brain receptors in vivo. To do so, they developed an original PET imaging approach based on the use of the radiolabeled molecule (11C-buprenorphine). Brain ; Positron Emission Tomography ; Pharmacology Scientific result Wed, 05 May 2021 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/How-works-Mambalgin-1.aspx Teams from IPMC and SIMoS (DMTS) defined the molecular determinants of the interaction between Mambalgin-1, an analgesic peptide isolated from black mamba venom, and its target, ASIC1 (Acid-Sensing Ion Channels), to model, using molecular dynamics, this complex. The resulting model provides clues to develop blockers of ASIC1, interesting targets for clinical pain relief applications. Pharmacology Scientific result Thu, 08 Apr 2021 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Retro1-new-molecule-against-intracellular-pathogens.aspx The SCBM and SIMoS collaborated to optimize the activity of Retro-1, a benzodiazepine compound, inhibitor of Shiga toxins and ricin, derived from high-throughput biological screening. They succeeded in obtaining an analog 70 times more protective against the cytotoxicity of Shiga toxins, Retro-1.1. Chemistry ; High-throughput screening ; CBRN-E threats Scientific result Mon, 14 Sep 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Composition-microbiota-animals-in-natura-mass-spectro.aspx A team from SPI in Marcoule, in collaboration with INRAE, characterized the intestinal microbiota of a small crustacean, Gammarus fossarum, used as a sentinel of water quality in France, by combining proteogenomics and metaproteomics approaches, thus opening up interesting perspectives for the analysis of host/microbiota interactions in other animal models. Mass spectrometry ; Bacteria ; Metagenomics ; Proteomics Scientific result Mon, 24 Aug 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Venomics-2-toxines-MC4R.aspx In an article published in the Journal of Medicinal Chemistry, the Venomics consortium led by a SIMoS team shows the interest of creating toxin banks to identify molecules regulating therapeutic targets. High-throughput screening ; Proteomics ; Transcriptomics SIMOPRO Scientific result Thu, 23 Jul 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/New-taxonomy-bacteria-archea.aspx The discovery of myriads of new species of bacteria and archaea, linked to the explosion of metagenomics, is leading microbiologists to consider rethinking how to map certain branches of life. Tools, such as the phylopeptidomics developed at Li2D, could help them do so. Mass spectrometry ; Bacteria ; Proteomics Researchers SPI Mon, 20 Jul 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Proteomic-analysis-SARS-CoV-2-infected-cells.aspx In order to optimize the amplification of quality inactivated virus, for the manufacture of a vaccine, a team from SPI (CEA Marcoule) used mass spectrometry to analyze the dynamics of the proteome of SARS-CoV-2 infected cells, at two multiplicities of infection. With more than 3,220 identified host proteins, researchers are also starting to decipher the processes and cellular networks impacted by this virus. Virus ; Mass spectrometry ; Proteomics News Mon, 06 Jul 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Proteomics-SARS-CoV-2-signature-peptides.aspx SPI researchers (Marcoule) used proteomics to identify signature peptides of the SARS-CoV-2 virus expressed in vitro. A "short list" of 14 identified and characterized peptides allows to consider developments in targeted mass spectrometry, making this direct and rapid large-scale approach, implantable in hospitals, a potential tool of choice in the detection of the virus responsible for Covid-19. Proteomics ; Virus Scientific result Fri, 05 Jun 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Phylopeptidomics-analysis-microbiota.aspx ​Researchers at the "Laboratoire Innovations technologiques pour la Détection et le Diagnostic" (LI2D, in Marcoule) of the Department of Medicines and Technologies for Health (DMTS) have developed a mathematical method to identify in a metaproteomics dataset the contribution of each of the organisms that make up a microbiota. This robust method, called phylopeptidomics, is described in the journal Microbiome. Proteomics ; Biodiversity SPI Scientific result Microbiology; Mon, 06 Apr 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/therapeutic-innovation-creatine-transporter-deficiency.aspx ​Two teams from JOLIOT (SPI / SCBM), in collaboration with the University of Cincinnati, confirm the interest of a drug candidate to treat the congenital creatine deficiency syndrome, a rare neurological childhood disease, responsible for developmental delays and intellectual disability. The results obtained in an animal model of the disease show that it is possible to administer, nasally, dodecyl creatine ester-loaded microspheres, thus improving the cognitive functions of treated animals. Genetic diseases ; Pharmacology Scientific result Fri, 17 May 2019 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2019/IBiSA-screening-saclay-plateau.aspx ​The union of the Saclay Plateau screening platforms under a single banner C @ PS (Criblage sur le Plateau de Saclay) has just obtained the IBiSA label. Jean-Christophe Cintrat (Joliot / SCBM) is in charge of the overall infrastructure. Chemistry ; High-throughput screening News Tue, 26 Mar 2019 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/pain-promising-toxin-spider-venom.aspx A collaboration between SIMOPRO, Sanofi R & D, Smartox Laboratories and the Thorax Institute, has isolated a toxin with antinociceptive properties from a high-throughput electrophysiological screening of a collection of more than 100 venoms. Cyriotoxin-1a has been identified, sequenced, chemically synthesized and functionally characterized - from cell to organism in vivo. Pharmacology ; High-throughput screening SIMOPRO Scientific result antinociception;venoms;sodium channel;Pain; Mon, 11 Mar 2019 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/new-protein-interface.aspx ​A SB2SM Research Team (I2BC@Saclay) solved by crystallography the structure of a ternary protein complex at the interface between the nuclear envelope (emerin and lamin A / C) and the genome (BAF). In collaboration with Teams from Paris-Sud and Paris-Diderot Universities, the structure analysis, as well as in vitro interaction and proximity experiments in cellulo, suggests that a lack of interaction between the lamina A / C (nucleoskeleton) and chromatin-associated protein (BAF) may be one of the mechanisms responsible for premature aging syndromes. Proteomics Scientific result Thu, 20 Sep 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/server-predict-structure-protein-complexes.aspx A team from I2BC@Saclay (SB2SM), in collaboration with the RPBS platform, has put online a server for structural prediction of interactions between proteins. This server, designed for biologists, uses the information provided by the coevolution of protein sequences and predicts the structure of protein complexes, essential information for understanding their functional role. Proteomics Scientific result Thu, 07 Jun 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/ghosts-of-fluorescence.aspx Cell biology uses fluorescent labeling, an essential technique to follow the life of the cell. But fluorescent proteins have their limits, which researchers from IBS and I2BC @ Saclay (SB2SM) are trying to repel. Structural biology ; Proteomics Scientific result Wed, 28 Mar 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/ultrasound-drug-delivery-brain.aspx Researchers from NeuroSpin (Frédéric Joliot Institute/CEA) and MIRCen (François Jacob Institute/CEA Institute of Biology) have just developed an ultrasound device guided by magnetic resonance imaging (MRI) to increase temporarily and locally the vascular permeability in non-human primates, which could be used to effectively deliver drugs to the brain. Brain ; Health ＆ life sciences ; Pharmacology Scientific result Mon, 19 Feb 2018 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/disruptor-late-endosomes.aspx A SIMOPRO Research Team, in collaboration with a SCBM Team, has identified, by screening a library of small chemical molecules, a compound capable of reducing the sensitivity of cells to a plant toxin, that is ricin. By collaborating with seven Teams of microbiologists, researchers have shown that this compound, called ABMA, protects cells by blocking an intracellular transport pathway borrowed by many other bacterial and intracellular pathogenic toxins. ABMA defines a new family of broad-spectrum anti-infective agents.​ Health ＆ life sciences ; High-throughput screening ; Bacteria Scientific result Tue, 16 Jan 2018 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2017/Protein_interactome_of_nanoparticles_and_its_role_in_cellular_impact.aspx Two Research Teams led by Odette Prat of the Institute of Biosciences and Biotechnologies (BIAM) and Jean Armengaud of the Frédéric Joliot Institute (LI2D, Marcoule) have joined forces thanks to an ANR funding to deepen knowledge of the importance of the nature of protein crowns on the cellular impact of nanoparticles. The results from their three recent publications reveal a new concept: "the protein interactome applied to the corona of nanoparticles". Health ＆ life sciences ; Proteomics ; Nanosciences Scientific result Fri, 20 Oct 2017 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2015/a-nano-drug-for-protecting-neurons.aspx A nano-drug has been developed for treating certain neurological diseases such as brain ischemia, as well as injuries to bone marrow. It is composed of a therapeutic molecule, adenosine, and the vector squalene, which allows it to circulate in the body and reach the areas to be treated. Brain ; Pharmacology IBITECS Scientific result Thu, 05 Mar 2015 11:00:00 GMT