Frédéric Joliot Institute for Life Sciences - On the same theme

Toward an integrated analysis of metabolism using carbon-13 isotopic labeling

Mon, 09 Feb 2026 11:00:00 GMT

A collaborative study between the BIAM and Joliot (SPI/DMTS) institutes demonstrates the feasibility of near-complete whole-body carbon-13 isotopic labeling in mice and lays the foundation for a global, quantitative, and unbiased metabolomics approach. This unprecedented strategy could also enable the investigation of certain metabolic troubles.

Opening the BBB to Deliver Drugs to the Brain: Removing Noise Signals to Optimize Focused Ultrasound Pressure Control Protocol

Wed, 14 Jan 2026 11:00:00 GMT

Des équipes du SHFJ, de NeuroSpin et du CEA-Jacob optimisent leur stratégie d'ouverture de la barrière hémato-encéphalique par ultrasons focalisés (FUS). Leur nouveauté : un algorithme masquant la cavitation extracrânienne induite par les muscles temporaux épais, particulièrement chez les grands mâles primates, qui vient masquer le signal dans la région d'intérêt.

L’imagerie TEP révèle les effets de la kétamine sur la plasticité synaptique dans un modèle de dépression

Mon, 22 Dec 2025 11:00:00 GMT

Des chercheurs de BioMaps (SHFJ) et de MOODS ont validé une approche innovante de neuroimagerie moléculaire permettant de suivre, de manière non-invasive, les effets de la kétamine sur la densité synaptique dans un modèle préclinique de dépression.

Using Light to Switch Off the MRI Signal of Micellar Probes for Diagnostic Purposes

Fri, 05 Dec 2025 11:00:00 GMT

Researchers at the SCBM and BAOBAB have developed a new version of their nanometric micellar vector designed for fluorine-19 magnetic resonance tumor imaging. This version is intended to enhance MRI contrast by switching off the signal on demand in certain areas, while preserving it in pathological regions to be imaged.

Proof of concept for the passage of trastuzumab formulated in nanoparticles through an in vitro-reconstituted nasal epithelium.

Wed, 12 Nov 2025 11:00:00 GMT

Researchers from SPI (DMTS) developed a formulation of PLGA nanoparticles loaded with the anticancer trastuzumab (NP-TZB) and measured their ability to cross a cellular model of the nasal epithelial barrier. This first validated step supports a potential nose-to-brain (N2B) delivery route.

mineMS2: a new approach to pattern recognition in mass spectra to facilitate compound identification in metabolomics

Fri, 07 Nov 2025 11:00:00 GMT

A LI-MS team presents an innovative strategy and software for structural elucidation in metabolomics using tandem mass spectrometry.

Préparation de l’échantillon avant spectrométrie de masse pour une identification plus exhaustive des formes tronquées d’alpha-synucléine

Mon, 20 Oct 2025 10:00:00 GMT

Une équipe du LI-MS (SPI/DMTS) combine un protocole robuste d’immunoprécipitation de l’alpha-synucléine à de la spectrométrie de masse haute résolution et caractérise des formes tronquées inédites de la protéine.

PET imaging of OATP transporter-mediated drug elimination: impacts of sex and age

Wed, 15 Oct 2025 10:00:00 GMT

Researchers from BioMaps (SHFJ) investigated the hepatic activity of organic anion-transporting polypeptides (OATPs), key players in the elimination of certain drugs, using a PET imaging approach with 11C-glyburide, which revealed differences in tracer pharmacokinetics between men and women.

Développement de radioligands pour l’imagerie TEP de la neuroinflammation

Fri, 03 Oct 2025 10:00:00 GMT

Des chercheurs du SHFJ, en collaboration avec le CEA-Jacob, le CRN à Lyon et le PharmaCenter à Bonn ont imaginé, synthétisé et caractérisé deux radiotraceurs TEP ciblant P2Y12, une protéine impliquée dans l’activation de la microglie durant la neuroinflammation.

Ultrasound to counteract the cerebral effects of exposure to a neurotoxic agent

Thu, 28 Aug 2025 10:00:00 GMT

Researchers from BioMaps (SHFJ), NeuroSpin, and the french IRBA developed an innovative approach using focused ultrasound to improve brain delivery of an antidote, oxime, following exposure to an organophosphorus neurotoxic agent in a murine model.

Cancer : transformer la mertansine en prodrogue pour une chimiothérapie ciblée et moins toxique grâce à une approche théranostique.

Tue, 01 Jul 2025 10:00:00 GMT

Une équipe du laboratoire BioMaps, en collaboration avec l’Institut Galien Paris-Saclay a mis au point une stratégie innovante associant une prodrogue polymère et l'imagerie par tomographie par émission de positons (TEP) pour améliorer l'efficacité de la mertansine, un agent antitumoral puissant mais toxique.

A promising drug candidate for the treatment of neonatal hypoxic-ischemic encephalopathy

Thu, 26 Jun 2025 10:00:00 GMT

Researchers from the SPI (DMTS) and the Women & Infants Hospital in Providence have laid the molecular basis for the neuroprotection of a purine derivative in a preclinical model of neonatal hypoxic-ischemic encephalopathy (HIE). The promising results support the development of this drug candidate to treat HIE in neonates.

COVID-PATH: Unveiling the gut’s role in COVID-19 and Long COVID

Thu, 10 Apr 2025 10:00:00 GMT

The COVID-PATH project was officially launched on March 12, 2025, to investigate the gastrointestinal impact of SARS-CoV-2 and its link to Long COVID.

Next-generation sequencing data modeled like a chess game

Mon, 17 Feb 2025 11:00:00 GMT

A team from I2BC has proposed a thought experiment -the Next Generation Sequencing chess problem-, which treats sequencing data as a superimposed image of several independent chess games. A more realistic approach to the dynamics of cellular processes within each cell, revealing the limits of NGS approaches to temporal analysis.

Deutération : le déblocage d'un verrou méthodologique au potentiel industriel

Thu, 13 Feb 2025 11:00:00 GMT

Une étude menée par le SCBM présente une approche innovante permettant de relever les défis actuels des méthodes d'échange isotopique hydrogène - deutérium en offrant un processus efficace, reproductible et évolutif. Ave à la clef, de possibles développements industriels dans les domaines des médicaments et des technologies OLED.

Un test bandelette pour détecter les infections à Candida auris

Mon, 20 Jan 2025 11:00:00 GMT

Des chercheurs du LERI (SPI/DMTS), en collaboration avec NG Biotech, ont développé un test-bandelette de détection de Candida auris, un champignon à l’origine d’infections nosocomiales de plus en plus fréquentes. Leurs premiers résultats sur des souches isolées indiquent d’excellentes performances du dispositif.

Immunological profiling of cancer : when click-chemistry meets mass spectrometry

Mon, 13 Jan 2025 11:00:00 GMT

Researchers at DMTS and SHFJ have carried out a multiplexed analysis of tumor cells and tissues, based on the use of cleavable therapeutic antibodies carrying mass tags, for the identification and quantification of cancer biomarkers. A proof-of-concept demonstrating the high potential of this tumor immunoprofiling approach

A comparative analysis of the chimpanzee and human brain superficial structural connectivities

Fri, 22 Nov 2024 11:00:00 GMT

A team from NeuroSpin has proposed a classification of the morphology of short white matter bundles (SWMBs) in human and chimpanzee brains. A wide variety of shapes was observed, as well as differences. This study provides valuable information on SWMB morphology and its potential implications for human cognitive development

SplineBeam : un algorithme réaliste et rapide pour prédire les champs de pression des ultrasons.

Thu, 24 Oct 2024 10:00:00 GMT

Les applications thérapeutiques des ultrasons sont nombreuses, notamment en neurologie. Prédire en temps réel le champ de pression acoustique à appliquer est indispensable. C’est ce que permet de faire l’algorithme SplineBeam développé par une équipe du SHFJ en collaboration avec le CEA-List, NeuroSpin et le CHU Grenoble-Alpes.

Micelles : comment améliorer l’efficacité radiothérapeutique lorsque les tumeurs résistent ?

Wed, 23 Oct 2024 10:00:00 GMT

Des équipes du SCBM et du SHFJ, en collaboration avec le CEA-Jacob et l’ISMO ont développé une micelle perfluorée biocompatible pour améliorer l’efficacité des radiothérapies et qui serait particulièrement intéressante dans des environnements tumoraux radiorésistants.

La microfluidique en gouttelettes et l'IA pour détecter la résistance à la colistine

Mon, 30 Sep 2024 10:00:00 GMT

Une collaboration dirigée par le LERI (SPI/DMTS) a mis au point un dispositif de microfluidique en gouttes pour tester rapidement et efficacement la susceptibilité à la colistine, un antibiotique pour lequel des phénomènes de résistance bactérienne ont été observés. L’Intelligence artificielle complète la méthode pour faciliter l’étape d’analyse des images et augmenter la sensibilité du test.

L’épigénétique comme biomarqueur d’efficacité thérapeutique contre le déficit en transporteur de la créatine lié à l’X.

Tue, 17 Sep 2024 10:00:00 GMT

Des résultats obtenus par une équipe du SPI, en collaboration avec CERES Brain Therapeutics et l’Université de Sharjah (Emirats arabes unis), indique que le niveau de méthylation de l’ADN pourrait constituer un biomarqueur intéressant de l’efficacité thérapeutique d’un traitement potentiel du déficit en transporteur de la créatine lié à l’X.

PET imaging evaluation of the central effects of a drug-candidate to aid smoking cessation

Thu, 29 Aug 2024 10:00:00 GMT

A BioMaps team has used PET imaging to monitor glucose metabolism as a marker of the cerebral impact of smoking cessation, as well as the effects of a promising drug-candidate for the treatment of such cessation. By revealing the restoration of normal activity in the brain area associated with craving, these results offer hope for smoking cessation in humans

Marquage par échange isotopique : après l’hydrogène et le carbone, le soufre ?

Tue, 09 Jul 2024 10:00:00 GMT

Une équipe du SCBM met au point une méthode d’échange isotopique du soufre pour le marquage de molécules biologiquement actives. Telle une plateforme isotopique multi-échangeable, le procédé permet également un échange isotopique du carbone et d’hydrogène donnant accès à un grand nombre d’isotopologues. L’équipe met en avant le potentiel de la méthode pour vérifier l’authenticité de molécules organiques commerciales.

Comprehensive analysis of nucleosome positioning across the yeast genome

Fri, 28 Jun 2024 10:00:00 GMT

A team from I2BC has studied the positioning of nucleosomes in the yeast S cerevisiae genome, using an original mathematical method to analyze next-generation sequencing data. This mapping highlights the role of chromatin remodeling complexes in nucleosome organization.

Nanosciences: Towards a new type of micellar phototherapy?

Wed, 12 Jun 2024 10:00:00 GMT

SCBM researchers have designed nanometric micelles that can be activated by light and constructed by self-assembly of amphiphiles derived from ferrocene, which carries a hidden therapeutic activity in the absence of activation.

Breaking a bridge and rebuilding it to radiolabel a molecule

Fri, 24 May 2024 10:00:00 GMT

Researchers at BioMaps have developed a "re-bridging agent" for the radiolabelling of biomolecules containing disulphide bridges. Their strategy has enabled several molecules of therapeutic interest to be labelled with fluorine-18, copper-64 and zirconium-89.

Nanometric micelles for targeted delivery of a prodrug against atherosclerosis

Thu, 14 Mar 2024 11:00:00 GMT

Teams from SCBM and SIMoS (DMTS) have developed nano-micelles for the vectorization of an active principle which regulates cholesterol metabolism towards atherosclerotic lesions.

Food allergies: the impact of E171 (titanium dioxide)

Wed, 28 Feb 2024 11:00:00 GMT

Researchers at the LIAA (SPI/DMTS) have shown that pre- and perinatal exposure of mice to titanium dioxide increases the risk of developing a food allergy, particularly in males.

Improved diagnosis of acute hepatic porphyrias using mass spectrometry

Fri, 23 Feb 2024 11:00:00 GMT

A collaborative study between SPI and a team from Hôpital Louis Mourier demonstrates the contribution of liquid chromatography coupled with mass spectrometry to the day-to-day analytical needs of a clinical laboratory. Application to the rapid quantification of biomarkers in acute hepatic porphyrias.

Functionalization of the B subunit of Shiga toxin as a vaccine tool

Fri, 26 Jan 2024 11:00:00 GMT

Researchers at SIMoS (DMTS) describe the synthesis, engineering and evaluation of the properties of the B subunit of bacterial Shiga toxin (STxB), administered mucosally, as a vaccine tool. Their results confirm the value of using a synthetic STxB in an anti-tumor and anti-infectious vaccination strategy.

Validation of a new elasticity biomarker for biological tissue diagnosis

Wed, 24 Jan 2024 11:00:00 GMT

SHFJ researchers have validated the use of a new biomarker, the nonlinear shear modulus, to measure the elasticity of biological tissues, by comparing results obtained using echography with those obtained using MRI imaging and digital simulation. This biomarker is of particular interest for the diagnosis of certain breast cancers.

Combining in silico and in vitro strategies for better therapeutic antibodies: an example with derivatives of adalimumab, an anti-TNF agent

Thu, 18 Jan 2024 11:00:00 GMT

SIMoS researchers have shown that by combining two approaches, in silico and in vitro, it is possible to select therapeutic antibodies whose functionality is preserved while reducing the risk of them inducing an undesirable immune response.

Deciphering microbiota: multiplex proteotyping speeds up identification of microbial isolates

Fri, 24 Nov 2023 11:00:00 GMT

Researchers at SPI are proposing an innovative multiplexing method for rapid identification of several microbial isolates in a single mass spectrometry analysis. This approach opens up prospects for the large-scale identification of microorganisms resulting from culturomics programs.

Cardiac transplantation: better graft eligibility criteria thanks to metabolomics?

Wed, 15 Nov 2023 11:00:00 GMT

In a study conducted by a team from the Marie Lannelongue Hospital, SPI researchers have established a difference between the metabolomic profiles of heart grafts harvested from pigs in a state of encephalic death or dead after controlled circulatory arrest. This work contributes to the exploration and validation of the use of hearts taken from people who have died after controlled circulatory arrest as a new source of grafts.

Chimie : passer par le radical anion du CO2 pour le radiomarquage de médicament est possible

Tue, 24 Oct 2023 10:00:00 GMT

Des chercheurs de l'institut montrent qu’une stratégie fondée sur la formation du radical anion CO2●- marqué au carbone 14 ou carbone 11 s’avère payante pour radiomarquer en conditions douces des médicaments.

Impact of metabolic variations on PET imaging of neuroinflammation in humans

Thu, 12 Oct 2023 10:00:00 GMT

Researchers at BioMaps evaluated the effect of several factors on the distribution of [18F]DPA-714 in 201 subjects who participated in SHFJ PET imaging protocols to better understand the role of neuroinflammation in various neurological diseases. They conclude that measures of individual metabolism are important in image interpretation.

Identification of metabolomic signatures of high-grade breast tumors

Fri, 04 Aug 2023 10:00:00 GMT

The TIRO laboratory of the SHFJ (Nice) identifies for the first time discriminating biomarkers of high-grade invasive breast tumors, using a non-targeted metabolomics approach performed on surgical specimens and cytoponctions from patients at different stages of malignancy.

Creatine transporter deficiency: use of two original models to characterize this rare genetic disease

Thu, 22 Jun 2023 10:00:00 GMT

Researchers at SPI (DMTS) have identified by mass spectrometry and bioinformatics analysis several biomarkers linked to the creatine transporter deficiency disorder (CTD) using two original models : mice with the clinical characteristics of CTD subjects and brain organoids derived from CTD patient cells.

Radiomarquage du crizotinib au fluor-18 : un nouvel outil pour suivre par TEP la biodistribution de ce médicament

Thu, 27 Apr 2023 10:00:00 GMT

Des chercheurs du SHFJ ont mis au point la radiosynthèse au fluor-18 du crizotinib, un médicament qui ne pénètre pas dans le cerveau. Ce nouvel outil pour l’imagerie TEP permettra d’explorer de futures stratégies visant à faire passer la barrière hémato-encéphalique à ce médicament pour traiter certaines métastases cérébrales.

Combining neuroanatomical markers to strengthen the diagnosis of fetal alcohol spectrum disorder

Mon, 13 Mar 2023 11:00:00 GMT

By analyzing brain imaging data, researchers from InDEV (NeuroSpin / UMR NeuroDiderot) have identified recurrent abnormalities in subjects with fetal alcohol syndrome, the combination of which could have a particularly interesting diagnostic value for non-syndromic forms of fetal alcohol spectrum disorders.

Genetic variations in evolutionarily acquired DNA regulatory regions affect the morphology of certain sulci in the human cerebral cortex

Mon, 27 Feb 2023 11:00:00 GMT

Using UK Biobank imaging-genetics data, a collaborative study led by NeuroSpin found that variation in genomic regions, known as enhancers, could affect the morphology of cortical sulci and be associated with the evolution of locomotion in primates and bipedalism in our hominin ancestors.

Platinum nanoparticles to improve radiotherapy ? PET imaging provides answers

Tue, 21 Feb 2023 11:00:00 GMT

Researchers from the SHFJ laboratory at ISMO have demonstrated the value of platinum nanoparticles as potential radiosensitizing agents for radiation therapy.

Development of a new radiolabeling strategy in immunoPET for precision imaging

Tue, 21 Feb 2023 11:00:00 GMT

Researchers from the BioMaps laboratory (SHFJ) and the Molecular Engineering for Health Service (SIMoS, DMTS) developed an enzymatic approach for radiofluorination of an anti-PD-L1 Fab and compared its in vivo properties to the same Fab stochastically labeled by two conventional methods.

Glioblastoma: Does focused ultrasound increase the therapeutic efficacy of cetuximab?

Wed, 15 Feb 2023 11:00:00 GMT

Researchers from the SHFJ, in collaboration with NeuroSpin, show that the use of focused ultrasound does not increase the therapeutic effects of cetuximab on glioblastoma although the opening of the blood-brain barrier is transiently effective.

Rapid and large-scale identification of the cystic fibrosis lung microbiota by metaproteomics

Tue, 14 Feb 2023 11:00:00 GMT

A Li2D (SPI/DMTS) team used tandem mass spectrometry to identify microorganisms in sputum samples from cystic fibrosis patients. A promising proteotyping approach that provides an expanded and unbiased view of the cystic fibrosis microbiota and could be complementary to microbiological monitoring of patients.

From a marine toxin to a melanocortin receptor antagonist, a therapeutic target for energy metabolism disorders

Thu, 09 Feb 2023 11:00:00 GMT

A SIMoS team discovered a toxin in the venom of a marine cone that it engineers into a high affinity antagonistic peptide for the melanocortin receptor, a major regulator of energy homeostasis. A step towards the development of innovative treatments for certain eating disorders

Detection of monkeypox: Mass spectrometry proves once again its effectiveness

Mon, 28 Nov 2022 11:00:00 GMT

A Li2D team has released the peptidomic profile of the virus that causes monkeypox, which they established using tandem mass spectrometry. These data should help to better understand the evolution of the epidemic and allow the creation of targeted tests to potentially detect the threat more quickly and prevent a new epidemic.

PeakForest, a digital infrastructure for metabolomic analysis and metabolite identification

Tue, 22 Nov 2022 11:00:00 GMT

A consortium of researchers, including SPI/DMTS metabolomics specialists, presents PeakForest, a database of NMR and mass spectra, which provides storage and annotation services for spectra of reference compounds and metabolic profiles of biological matrices. An open resource to address the evolving needs of the discipline.

Dual labeling and digital imaging for the evaluation of protein-drug conjugates in preclinical models

Mon, 22 Aug 2022 10:00:00 GMT

A team from SIMoS, in collaboration with the SCBM (DMTS), has developed an original bioanalytical approach based on the double 14C-3H isotopic labeling of an antibody-drug conjugate, allowing the simultaneous in vivo monitoring of the two components in mouse models as well as their precise quantification in the organs.

Fight against antibiotic resistance: two additional rapid lateral flow immuno-assays

Tue, 02 Aug 2022 10:00:00 GMT

Researchers at the LERI together with the AP-HP have developed 2 rapid and inexpensive immunological tests to detect antibiotic resistance. The novelty: the tests detect the activity of bacterial enzymes that hydrolyze extended-spectrum cephalosporins.

A possible link between changes in gut microbiota and fecal SARS-CoV-2 load ?

Thu, 12 May 2022 10:00:00 GMT

A team from SPI used mass spectrometry to analyze the degree of alteration of the intestinal microbiota of Covid-19 patients and to look for signatures of intestinal infection by the SARS-CoV-2 virus. The level of the observed gut dysbiosis would be an indicator of the stage and extent of the infection.

ptairMS software: real-time study of biomarkers in exhaled breath

Tue, 26 Apr 2022 10:00:00 GMT

The ptairMS software, developed in the framework of a collaboration led by the CEA-Joliot, allows the processing and analysis of proton transfer mass spectrometry data, an ideal method for the real-time study of volatile organic compounds (VOCs) present in exhaled breath.

Facilitating access to deuterated and tritiated molecules: towards more diversity!

Wed, 06 Apr 2022 10:00:00 GMT

Researchers from the SCBM describe a hydrogen isotope labeling process that is easy to implement and whose starting point is a "simple" mixture, in a solvent, of the product to be labeled with a pre-catalyst. Explanations of this process which finds applications in many fields including drug development or medical imaging.

ProMetIS: open bioinformatics data and tools for multi-omics phenotyping of mouse models

Mon, 04 Apr 2022 10:00:00 GMT

A consortium of researchers, led by SPI/DMTS, presents ProMetIS, a pilot study for the deep phenotyping of murine models by combining proteomic and metabolomic approaches. A significant advance for the functional characterization of genes and the development of bioinformatics integration approaches.

Buprenorphine/benzodiazepine interaction: why is it more dangerous?

Fri, 25 Mar 2022 11:00:00 GMT

A collaboration between the SHFJ and the UMR-S 1144 (University of Paris) shows that the deleterious effect of the buprenorphine/benzodiazepine combination would result from the combined action of each drug on its target.

The genetic architecture of language functional connectivity revealed

Mon, 14 Feb 2022 11:00:00 GMT

Using data from the UK Biobank, the world's largest general population imaging-genetics cohort, a collaboration led by a team at BAOBAB (NeuroSpin) has identified genes involved in the genetic architecture of language functional connectivity. These genes could be a priority for studying natural language.

Metaproteomics: together to be stronger!

Mon, 31 Jan 2022 11:00:00 GMT

Metaproteomics provides valuable snapshots of the functional state of microbiota. But the protocols used are still very diverse and the results not always easily comparable. The actors of the discipline, including the LI2D (Marcoule), are organizing themselves to be able to make the technique even more powerful.

Deeptope: accelerating the development of therapeutic antibodies via high-throughput functional tests

Mon, 29 Nov 2021 11:00:00 GMT

Deeptope, founded in February 2021 from a technology developed at the DMTS Laboratory of Cellular Immunology and Biotechnology (LICB), is a company of therapeutic antibody engineering that provides antibody optimization and characterization services to biotech or pharmaceutical firms with the goal of increasing the quality of antibodies in a very short timeframe.

Metaproteomics and data science for an eco-health diagnosis of soil microbiota

Thu, 07 Oct 2021 10:00:00 GMT

Researchers from Li2D (SPI/DMTS, Marcoule) and LSCE have developed an innovative methodology for analyzing soil microbiota based on an optimal computational interpretation of metaproteomic databases, which should lead to a better understanding of the impact of pollutants on soil quality and to the prediction of their restoration potential.

Characteristics of the initial symptoms of Alzheimer's disease in young patients

Thu, 10 Jun 2021 10:00:00 GMT

Researchers from BioMaps (SHFJ) and the Department of Memory and Language Neurology (Ste Anne's Hospital) studied the early clinical signs of Alzheimer's disease (AD) reported by young patients (< 62 years old) compared to those reported in classic AD of the elderly (> 65 years old). They show that these signs are misleading and often appear in the professional context.

Evaluation of the immunogenicity of peptide-drugs containing non-natural modifications

Tue, 01 Jun 2021 10:00:00 GMT

A team from SIMoS (DMTS) in collaboration with Sanofi shows that the introduction of non-natural sequences into an immunogenic peptide attenuates the immune response against this peptide, an approach that could guide the design of less immunogenic, and therefore more effective, therapeutic peptides.

PET imaging reveals the neuropharmacology of buprenorphine

Wed, 05 May 2021 10:00:00 GMT

Researchers at BioMaps (SHFJ) have succeeded in determining the interaction dynamics of buprenorphine, an opioid drug with a particularly complex pharmacology, with its brain receptors in vivo. To do so, they developed an original PET imaging approach based on the use of the radiolabeled molecule (11C-buprenorphine).

Brain sulci imaging and genetics: the UK Biobank cohort has spoken.

Mon, 19 Apr 2021 10:00:00 GMT

Researchers from NeuroSpin and CNRGH (Jacob Institute) have studied, on a genome-wide scale, the potential associations of haplotypes (set of variants located side by side on a chromosome) with the opening value of imaged brain sulci, indicator of brain aging, from the UK Biobank neuroimaging-genetics cohort.

How works Mambalgin-1, an analgesic peptide from black mamba venom

Thu, 08 Apr 2021 10:00:00 GMT

Teams from IPMC and SIMoS (DMTS) defined the molecular determinants of the interaction between Mambalgin-1, an analgesic peptide isolated from black mamba venom, and its target, ASIC1 (Acid-Sensing Ion Channels), to model, using molecular dynamics, this complex. The resulting model provides clues to develop blockers of ASIC1, interesting targets for clinical pain relief applications.

Salmonellosis and shigellosis: a monoclonal antibody induces cross-protection

Thu, 25 Mar 2021 11:00:00 GMT

Researchers at CEA-Joliot (SPI unit in collaboration with SIMoS unit) have developed a monoclonal antibody directed against a common region of two proteins of the bacteria Shigella and Salmonella and capable of inducing cross-protection against infections caused by these bacteria.

Première étape vers un test quantitatif par spectrométrie de masse pour le diagnostic spécifique de la COVID-19 ?

Tue, 09 Mar 2021 11:00:00 GMT

Le LEMM, en collaboration avec le LI2D et l’AP-HP, développe un test de diagnostic spécifique de la Covid-19 par spectrométrie de masse qui permettrait aussi la quantification de la charge virale du patient. Objectif à terme : adapter la méthode pour la rendre plus sensible et compatible avec les équipements d’analyse des hôpitaux.

A micellar probe for fluorine magnetic resonance tumor imaging

Thu, 04 Mar 2021 11:00:00 GMT

A SCBM (DMTS) team, in collaboration with researchers at NeuroSpin and I2BC, is describing micellar nanometric vectors targeting tumors that have been imaged by fluorine magnetic resonance imaging (MRI). The observed 19F signal made it possible to precisely delimit the volume of the tumor zone in a mouse model and to quantify the probe accumulated in the target tissue.

Carbon labeling with light

Wed, 24 Feb 2021 11:00:00 GMT

Researchers from the LMC (DMTS), in collaboration with a team from AstraZeneca, have developed a labeling method, based on the exchange of carbon dioxide, simply using visible blue light and a photocatalyst.

Metabolomics for the clinician and the development of a neuroprotective strategy in acute stroke

Thu, 04 Feb 2021 11:00:00 GMT

The TIRO team (SHFJ), in collaboration with the neurovascular clinicians of the Nice and Marseille University Hospitals, carried out analyses of the metabolome of cerebral clots at the origin of the occlusion of a cerebral artery responsible for a cerebral vascular accident (stroke). A pilot study that improved the understanding of the complex relationship between blood glucose levels and patients' functional prognosis.

SPI is committed to precision medicine for autoimmune and inflammatory diseases

Thu, 14 Jan 2021 11:00:00 GMT

Coordinated by the Imagine Institute for Genetic Diseases, the ATRACTion program is based on a consortium of 11 academic and industrial partners, including SPI (DMTS), and aims to develop a precision medicine for patients with autoimmune and inflammatory diseases associated with primary immune deficiencies.

Depression and gut microbiota: the endocannabinoid system makes the connection

Tue, 15 Dec 2020 11:00:00 GMT

A study led by the Institut Pasteur and involving CEA-Joliot has shown, in a mouse model, that a modification of the intestinal microbiota caused by chronic stress is accompanied by modifications of the metabolome which induce a defect in the signaling pathway for endogenous cannabinoids in the hippocampus, which may explain the mood disorders observed.

Decompensated cirrhosis: involvement of amino acid metabolism in systemic inflammation

Mon, 14 Dec 2020 11:00:00 GMT

A European study involving CEA-Joliot provides the first overview of the amino acids circulating in the blood of patients with decompensated cirrhosis and concludes that there is a strong redistribution of their metabolism in order to provide the fuel necessary for the intense inflammatory response.

World Antimicrobial Awareness Week: the Institute continues its actions

Thu, 19 Nov 2020 11:00:00 GMT

The recent publication, in the journal Diagnostics, of a collaborative study associating AP-HP, NG-Biotech and a team from the Institute, is an opportunity to recall the Institute's commitment to the development of means of detecting antimicrobial resistance, a global phenomenon in the WHO's sights, as recalled by the World Antimicrobial Awareness Week.

Mambaquaretin: therapeutic and diagnostic interest?

Tue, 10 Nov 2020 11:00:00 GMT

In pursuing their work on mambaquaretin, SIMoS researchers conducted a collaborative study confirming the therapeutic potential of the toxin and paving the way for its use as a diagnostic tool.

Development of a general strategy for the isotopic labelling of carbamates by incorporation of CO2

Thu, 10 Sep 2020 10:00:00 GMT

In a study published in Chemical Communications, the Joliot Institute Carbon labeling laboratory (LMC), in collaboration with the SHFJ, provides proof of concept of a "click" strategy for carbon isotope marking of pharmaceutical molecules containing carbamates.

Composition of the microbiota of animals in natura: a challenge met by mass spectrometry

Mon, 24 Aug 2020 10:00:00 GMT

A team from SPI in Marcoule, in collaboration with INRAE, characterized the intestinal microbiota of a small crustacean, Gammarus fossarum, used as a sentinel of water quality in France, by combining proteogenomics and metaproteomics approaches, thus opening up interesting perspectives for the analysis of host/microbiota interactions in other animal models.

SARS-CoV-2 detection: mass spectrometry shows its potential for rapidity.

Thu, 06 Aug 2020 10:00:00 GMT

A team from SPI in Marcoule detected by mass spectrometry, in 3 minutes and without specific reagents, signature peptides of the SARS-CoV-2 virus in clinical samples (nasopharyngeal swabs). It thus provides a proof of concept of the use of this method as a possible alternative to PCR, currently the reference method.

Ty1 retrotransposon: a short peptide sequence determines its insertion into the genome

Wed, 29 Jul 2020 10:00:00 GMT

Researchers at the Institut de Recherche Saint Louis and I2BC identify a protein motif responsible for the specificity of insertion of retrotransposon Ty1 in the yeast genome. This motif could be used to adapt gene therapy vectors and limit their mutagenic potential.

Venomics library: discovery of two toxins regulating the activity of melanocortin receptors

Thu, 23 Jul 2020 10:00:00 GMT

In an article published in the Journal of Medicinal Chemistry, the Venomics consortium led by a SIMoS team shows the interest of creating toxin banks to identify molecules regulating therapeutic targets.

Bacteria and archaea: a new taxonomy to better describe the unknowns?

Mon, 20 Jul 2020 10:00:00 GMT

The discovery of myriads of new species of bacteria and archaea, linked to the explosion of metagenomics, is leading microbiologists to consider rethinking how to map certain branches of life. Tools, such as the phylopeptidomics developed at Li2D, could help them do so.

Proteomic analysis of SARS-CoV-2 infected cells

Mon, 06 Jul 2020 10:00:00 GMT

In order to optimize the amplification of quality inactivated virus, for the manufacture of a vaccine, a team from SPI (CEA Marcoule) used mass spectrometry to analyze the dynamics of the proteome of SARS-CoV-2 infected cells, at two multiplicities of infection. With more than 3,220 identified host proteins, researchers are also starting to decipher the processes and cellular networks impacted by this virus.

Mapping of Ebola T-cell response: towards a new vaccine ?

Wed, 24 Jun 2020 10:00:00 GMT

SIMoS researchers, in collaboration with Genopole, Excellgene, Vaxeal holding SA (Switzerland), used a large-scale approach to map and characterize the response of CD4 T-cells from healthy donors, against two proteins from the Ebola-Zaire virus. They observed a strong response to the viral nucleoprotein (NP) and suggest that components of NP may be included in the design of new Ebola vaccines.

Salmonellosis and shigellosis: first demonstration of cross-protection induced by virulence factors SipD and IpaD

Mon, 22 Jun 2020 10:00:00 GMT

SPI researchers show for the first time, in a mouse model, the induction of cross-protection against Salmonella and Shigella infections, two pathogenic bacteria responsible for gastrointestinal diseases (typhoid, dysentery among others), one of the main causes of morbidity and mortality in several regions of Africa and Asia.

Tracking down SARS-CoV-2 signature peptides is launched !

Fri, 05 Jun 2020 10:00:00 GMT

SPI researchers (Marcoule) used proteomics to identify signature peptides of the SARS-CoV-2 virus expressed in vitro. A "short list" of 14 identified and characterized peptides allows to consider developments in targeted mass spectrometry, making this direct and rapid large-scale approach, implantable in hospitals, a potential tool of choice in the detection of the virus responsible for Covid-19.

How the identification of attenuated forms of the SARS-CoV-2 virus could help to control the current epidemic ?

Tue, 12 May 2020 10:00:00 GMT

An opinion article, published in Environmental Microbiology, and written by an international consortium initiated by three researchers of Joliot Institute, proposes an original way of research on Covid-19 through the identification by sequencing of attenuated variants of the SARS-CoV-2 virus in populations at risk with little or no symptoms.

A mobile laboratory to study the genetic material of extinct…or emerging species

Wed, 08 Apr 2020 10:00:00 GMT

A collaboration between researchers from I2BC@Saclay, the french Muséum National d'Histoire Naturelle and owners of prehistoric sites shows the possibility of using a mobile laboratory to quickly identify DNA of archaeological specimens.

Phylopeptidomics: a new tool for microbiota analysis

Mon, 06 Apr 2020 10:00:00 GMT

Researchers at the "Laboratoire Innovations technologiques pour la Détection et le Diagnostic" (LI2D, in Marcoule) of the Department of Medicines and Technologies for Health (DMTS) have developed a mathematical method to identify in a metaproteomics dataset the contribution of each of the organisms that make up a microbiota. This robust method, called phylopeptidomics, is described in the journal Microbiome.

Lassa fever: a vaccine soon to be tested.

Wed, 09 Oct 2019 10:00:00 GMT

Researchers from Pasteur Institute, in collaboration with seven research teams, including SPI (LI2D/Marcoule), developed and evaluated the efficacy of several vaccine candidates against the virus responsible for Lassa haemorrhagic fever, endemic in Western Africa. They identified one of them as being the most effective, likely to quickly enter clinical trials in humans. Results are published in the journal Science Translational Medicine.

A new generation of nanovectors for anticancer therapies.

Wed, 12 Jun 2019 10:00:00 GMT

As part of a collaboration with MIRCen (Jacob Institute), researchers of SCBM have developed functional micellar vectors that can effectively target tumors and whose therapeutic activity is intrinsically carried by the constitutive unit of the micelle. This combination leads to better drug load and avoids premature drug release.

A promising therapeutic innovation for creatine transporter deficiency.

Fri, 17 May 2019 10:00:00 GMT

Two teams from JOLIOT (SPI / SCBM), in collaboration with the University of Cincinnati, confirm the interest of a drug candidate to treat the congenital creatine deficiency syndrome, a rare neurological childhood disease, responsible for developmental delays and intellectual disability. The results obtained in an animal model of the disease show that it is possible to administer, nasally, dodecyl creatine ester-loaded microspheres, thus improving the cognitive functions of treated animals.

MRI and AI to develop a virtual brain biopsy tool

Wed, 03 Apr 2019 10:00:00 GMT

Imaging the brain of a patient at the microscopic scale is as of yet not possible but might turn into a reality thanks to a new tool for creating virtual biopsies. This algorithm has been developed by a team of NeuroSpin (CEA-Joliot) in collaboration with the Institute of NeuroScience and Medicine of Juelich as part of the European Human Brain Project. A first study demontrsating the potentiel of the algorithm ot simulate white matter samples has been published in NeuroImage.

« Click and Release » chemistry for the targeted delivery of drugs in vivo

Fri, 15 Mar 2019 11:00:00 GMT

A team from the SCBM, in collaboration with the SPI, the IC2MP and the University Hospital of Poitiers, has developed a bioorthogonal chemistry strategy that allows, in vivo, the controlled release of active ingredients contained in micelles-targeting cancerous tumors. These results pave the way for new strategies for targeted drug delivery.

Pain: a promising toxin isolated from a spider venom

Mon, 11 Mar 2019 11:00:00 GMT

A collaboration between SIMOPRO, Sanofi R & D, Smartox Laboratories and the Thorax Institute, has isolated a toxin with antinociceptive properties from a high-throughput electrophysiological screening of a collection of more than 100 venoms. Cyriotoxin-1a has been identified, sequenced, chemically synthesized and functionally characterized - from cell to organism in vivo.

The identification of biomarkers by metabolomics should allow a better follow-up of cirrhotic patients

Thu, 07 Feb 2019 11:00:00 GMT

Researchers from SPI, in collaboration with teams from an European foundation, EF Clif, carried out global and targeted metabolomic analyzes which made possible to highlight, in cirrhotic patients, an activation of the kynurenine metabolic pathway (tryptophan degradation pathway). The imbalance of this pathway is probably the cause of the symptoms observed during cirrhotic decompensation, when the body can no longer compensate for liver dysfunctions.

European funding for better management of liver diseases

Fri, 01 Feb 2019 11:00:00 GMT

Europe is committed to better diagnostic and therapeutic management of patients with severe forms of cirrhosis. It finances the MICROB-PREDICT consortium, which aims to better understand the role of the human microbiome in the pathogenesis and evolution of cirrhosis. Final goal is to uture personalized therapeutic strategies and diagnostic tools. The SPI (Joliot Institute) is the main project lead for the CEA.

Cerebral lymphoma: a new indication for [18F]Fludarabine?

Mon, 08 Oct 2018 10:00:00 GMT

A SHFJ research team (LDM-TEP, GIP Cyceron, Caen) has previously developed and produced a radiopharmaceutical, the [18F]-Fludarabine, to detect lymphomas using PET scan. The team has recently conducted a preclinical study that shows the molecule can help in diagnosis of cerebral lymphoma by differentiate it from glioblastoma, the main brain tumor. A clinical study should be launched before the end of the year.

A reliable and accessible algorithm based on EEG to diagnose states of consciousness

Fri, 05 Oct 2018 10:00:00 GMT

An international collaboration, led by the Institut du Cerveau et de la Moelle épinière – ICM (Brain & Spine Institute) and involving researchers from NeuroSpin, offers a new electroencephalogram (EEG) tool that helps the diagnosis of disorders of consciousness. Unlike other tools developed so far and dedicated to a few expert centers, “DoC-Forest” would be accessible to most of the hospitals worldwide.

A new mutated protein interface in premature aging syndromes

Thu, 20 Sep 2018 10:00:00 GMT

A SB2SM Research Team (I2BC@Saclay) solved by crystallography the structure of a ternary protein complex at the interface between the nuclear envelope (emerin and lamin A / C) and the genome (BAF). In collaboration with Teams from Paris-Sud and Paris-Diderot Universities, the structure analysis, as well as in vitro interaction and proximity experiments in cellulo, suggests that a lack of interaction between the lamina A / C (nucleoskeleton) and chromatin-associated protein (BAF) may be one of the mechanisms responsible for premature aging syndromes.

Mass spectrometry for quality control of vaccines

Thu, 05 Jul 2018 10:00:00 GMT

A SPI Research Team (LI2D, Marcoule), in collaboration with CIRAD and AU-PANVAC, proposes a new quality control technique for veterinary vaccines, based on very high resolution mass spectrometry. This strategy, based on the use of an ad hoc database to measure the proportion of antigens and contaminants in the vaccine preparation, will improve the quality control of vaccines against contagious caprine pleuropneumonia.