Frédéric Joliot Institute for Life Sciences - Sur le même thème

Toward CAR-macrophage-based cellular immunotherapy for treating certain solid tumors?

Mon, 09 Mar 2026 11:00:00 GMT

Researchers from our DMTS department have published a study providing the first proof of concept for a CAR-macrophage therapy targeting the endothelin B receptor, which is overexpressed in melanoma cells.

An Innovative Non-Targeted Data Analysis Method in Mass Spectrometry to Reveal Our Environmental Exposures

Thu, 26 Feb 2026 11:00:00 GMT

Researchers from the DMTS have developed a method for exploring the chemical exposome in large, complex mass spectrometry datasets. They applied it to the analysis of meconium samples from a cohort.

Toward an integrated analysis of metabolism using carbon-13 isotopic labeling

Mon, 09 Feb 2026 11:00:00 GMT

A collaborative study between the BIAM and Joliot (SPI/DMTS) institutes demonstrates the feasibility of near-complete whole-body carbon-13 isotopic labeling in mice and lays the foundation for a global, quantitative, and unbiased metabolomics approach. This unprecedented strategy could also enable the investigation of certain metabolic troubles.

Using Light to Switch Off the MRI Signal of Micellar Probes for Diagnostic Purposes

Fri, 05 Dec 2025 11:00:00 GMT

Researchers at the SCBM and BAOBAB have developed a new version of their nanometric micellar vector designed for fluorine-19 magnetic resonance tumor imaging. This version is intended to enhance MRI contrast by switching off the signal on demand in certain areas, while preserving it in pathological regions to be imaged.

Seismic-wave physics for diagnosing brain tumors with passive MRI elastography

Wed, 26 Nov 2025 11:00:00 GMT

Researchers at SHFJ and NeuroSpin applied a passive MRI elastography sequence to patients with brain tumors. This non-invasive approach provided information on tumor stiffness and nature, and could support early detection, surgical planning, and treatment monitoring.

Nitriles marqués : une nouvelle génération d’outils grâce à un procédé innovant

Fri, 14 Nov 2025 11:00:00 GMT

Des chercheurs du SCBM en collaboration avec le SHFJ décrivent un nouveau paradigme pour le marquage isotopique au carbone de composés nitriles : plus simple, plus propre et universel, ouvrant la voie à une production élargie de molécules marquées d’intérêt en santé et en agrochimie.

Proof of concept for the passage of trastuzumab formulated in nanoparticles through an in vitro-reconstituted nasal epithelium.

Wed, 12 Nov 2025 11:00:00 GMT

Researchers from SPI (DMTS) developed a formulation of PLGA nanoparticles loaded with the anticancer trastuzumab (NP-TZB) and measured their ability to cross a cellular model of the nasal epithelial barrier. This first validated step supports a potential nose-to-brain (N2B) delivery route.

Cyanine 5-huwentoxin-IV : a new imaging agent for non-small cell lung cancer ?

Mon, 10 Nov 2025 11:00:00 GMT

A team from SIMoS (DMTS) has demonstrated the ability of a peptide derived from a spider venom toxin to detect overexpressed sodium channels in a metastatic non-small cell lung cancer (NSCLC) cell line.

mineMS2: a new approach to pattern recognition in mass spectra to facilitate compound identification in metabolomics

Fri, 07 Nov 2025 11:00:00 GMT

A LI-MS team presents an innovative strategy and software for structural elucidation in metabolomics using tandem mass spectrometry.

Encapsulation de l'Astate, un radionucléide émetteur alpha : une application prometteuse pour la radiothérapie vectorisée des cancers ?

Wed, 29 Oct 2025 11:00:00 GMT

Des chercheurs du SCBM (DMTS) rapportent pour la première fois qu'un bambusuril, un macrocycle synthétisé dans leur laboratoire, est capable d'encapsuler un anion astate-211, un radionucléide émetteur de rayonnements , très prometteur pour des applications en radiothérapie interne vectorisée.

Mitosis: condense to better attach

Mon, 08 Sep 2025 10:00:00 GMT

A study led by the I2BC shows that the formation of condensates of the enzyme KIF2C enables the concentration of two other proteins, PLK1 and phosphorylated BRCA2, on kinetochore microtubules during mitosis. This would serve to control chromosome alignment on the spindle and contribute to their stability.

A new technique for analyzing polarized light-emitting molecules

Wed, 03 Sep 2025 10:00:00 GMT

Scientists at the EPFL, in collaboration with a team from SCBM (DMTS), have developed a new technique that enables, with unprecedented sensitivity, the measurement of circularly polarized light emitted by luminescent materials over time. This work has been published in Nature.

Cancer : transformer la mertansine en prodrogue pour une chimiothérapie ciblée et moins toxique grâce à une approche théranostique.

Tue, 01 Jul 2025 10:00:00 GMT

Une équipe du laboratoire BioMaps, en collaboration avec l’Institut Galien Paris-Saclay a mis au point une stratégie innovante associant une prodrogue polymère et l'imagerie par tomographie par émission de positons (TEP) pour améliorer l'efficacité de la mertansine, un agent antitumoral puissant mais toxique.

Theranostic antibodies targeting endothelin receptors in preclinical models of glioblastoma and melanoma

Thu, 22 May 2025 10:00:00 GMT

Researchers from SPI (DMTS) propose immunodiagnostic and immunotherapeutic approaches based on the use of innovative antibodies targeting two subtypes of endothelin receptors (ETA and ETB), recognised as relevant therapeutic targets in oncology.

Synthesis of an anti-cancer drug in living cells using micelle-based nanoreactors

Fri, 11 Apr 2025 10:00:00 GMT

A team at SCBM (DMTS) has designed nanomicelles that can be activated by a bioorthogonal reaction releasing a first chemical species, which then reacts with a second compound encapsulated in the micelles. Application to the synthesis of an anti-cancer drug, sorafenib, inside living cells.

Deutération : le déblocage d'un verrou méthodologique au potentiel industriel

Thu, 13 Feb 2025 11:00:00 GMT

Une étude menée par le SCBM présente une approche innovante permettant de relever les défis actuels des méthodes d'échange isotopique hydrogène - deutérium en offrant un processus efficace, reproductible et évolutif. Ave à la clef, de possibles développements industriels dans les domaines des médicaments et des technologies OLED.

Universal identification of pathogenic viruses by LC-MS/MS proteotyping

Wed, 29 Jan 2025 11:00:00 GMT

Researchers at Li2D (SPI/DMTS, Marcoule) have proposed an innovative tandem mass spectrometry proteotyping method for the universal identification of pathogenic viruses, requiring no prior knowledge of sample composition. A step towards improved diagnosis of viral infections

Marquage par échange isotopique de l’azote : la pyridine au cœur de la stratégie

Fri, 24 Jan 2025 11:00:00 GMT

Des chercheurs du SCBM présentent une solution innovante de marquage par échange isotopique de l’azote des dérivés de la pyridine, un hétérocycle aromatique très représenté dans l’agro-industrie et l’industrie pharmaceutique.

Un test bandelette pour détecter les infections à Candida auris

Mon, 20 Jan 2025 11:00:00 GMT

Des chercheurs du LERI (SPI/DMTS), en collaboration avec NG Biotech, ont développé un test-bandelette de détection de Candida auris, un champignon à l’origine d’infections nosocomiales de plus en plus fréquentes. Leurs premiers résultats sur des souches isolées indiquent d’excellentes performances du dispositif.

Immunological profiling of cancer : when click-chemistry meets mass spectrometry

Mon, 13 Jan 2025 11:00:00 GMT

Researchers at DMTS and SHFJ have carried out a multiplexed analysis of tumor cells and tissues, based on the use of cleavable therapeutic antibodies carrying mass tags, for the identification and quantification of cancer biomarkers. A proof-of-concept demonstrating the high potential of this tumor immunoprofiling approach

Micelles : comment améliorer l’efficacité radiothérapeutique lorsque les tumeurs résistent ?

Wed, 23 Oct 2024 10:00:00 GMT

Des équipes du SCBM et du SHFJ, en collaboration avec le CEA-Jacob et l’ISMO ont développé une micelle perfluorée biocompatible pour améliorer l’efficacité des radiothérapies et qui serait particulièrement intéressante dans des environnements tumoraux radiorésistants.

Marquage par échange isotopique : après l’hydrogène et le carbone, le soufre ?

Tue, 09 Jul 2024 10:00:00 GMT

Une équipe du SCBM met au point une méthode d’échange isotopique du soufre pour le marquage de molécules biologiquement actives. Telle une plateforme isotopique multi-échangeable, le procédé permet également un échange isotopique du carbone et d’hydrogène donnant accès à un grand nombre d’isotopologues. L’équipe met en avant le potentiel de la méthode pour vérifier l’authenticité de molécules organiques commerciales.

Nanosciences: Towards a new type of micellar phototherapy?

Wed, 12 Jun 2024 10:00:00 GMT

SCBM researchers have designed nanometric micelles that can be activated by light and constructed by self-assembly of amphiphiles derived from ferrocene, which carries a hidden therapeutic activity in the absence of activation.

Breaking a bridge and rebuilding it to radiolabel a molecule

Fri, 24 May 2024 10:00:00 GMT

Researchers at BioMaps have developed a "re-bridging agent" for the radiolabelling of biomolecules containing disulphide bridges. Their strategy has enabled several molecules of therapeutic interest to be labelled with fluorine-18, copper-64 and zirconium-89.

Response to intra-tumoral immunotherapy assessed by immunoPET in mice

Fri, 19 Apr 2024 10:00:00 GMT

A team from BioMaps (SHFJ), in partnership with the Gustave Roussy Institute, has used immunoPET imaging to assess the influence of tissue distribution on the efficacy of cancer immunotherapy, administered intra-tumor and intravenously in mice. Intratumoral administration is more effective and reduces overall exposure of organs at risk

Improved diagnosis of acute hepatic porphyrias using mass spectrometry

Fri, 23 Feb 2024 11:00:00 GMT

A collaborative study between SPI and a team from Hôpital Louis Mourier demonstrates the contribution of liquid chromatography coupled with mass spectrometry to the day-to-day analytical needs of a clinical laboratory. Application to the rapid quantification of biomarkers in acute hepatic porphyrias.

Validation of a new elasticity biomarker for biological tissue diagnosis

Wed, 24 Jan 2024 11:00:00 GMT

SHFJ researchers have validated the use of a new biomarker, the nonlinear shear modulus, to measure the elasticity of biological tissues, by comparing results obtained using echography with those obtained using MRI imaging and digital simulation. This biomarker is of particular interest for the diagnosis of certain breast cancers.

Photocatalytic carbon dioxide reduction for radiolabeled drug synthesis

Wed, 22 Nov 2023 11:00:00 GMT

Researchers from SCBM (DMTS) and SB2SM (I2BC) describe a novel and optimized approach to the total photoreduction of 13C-labelled CO2 to carbon monoxide (CO), and the immediate reuse of the latter for the synthesis of high value-added compounds. A step towards a radiochemistry of carbon isotopes potentially useful in human health.

Click-Chemistry: optimized drug delivery from nanomicelles into tumor cells

Fri, 10 Nov 2023 11:00:00 GMT

Researchers at SCBM have used a click-and-release chemistry approach to mass-release an anti-cancer drug into cells from cleavable nanomicelles, thanks to a bioorthogonal activation process. A step towards the development of new nanomedicines

Chimie : passer par le radical anion du CO2 pour le radiomarquage de médicament est possible

Tue, 24 Oct 2023 10:00:00 GMT

Des chercheurs de l'institut montrent qu’une stratégie fondée sur la formation du radical anion CO2●- marqué au carbone 14 ou carbone 11 s’avère payante pour radiomarquer en conditions douces des médicaments.

PET imaging monitoring of an antibody targeting endothelin receptors expressed by glioblastoma tumors

Thu, 07 Sep 2023 10:00:00 GMT

Researchers at BioMaps (SHFJ) and SPI (DMTS) have studied the pharmacokinetics of a novel immuno-radioligand targeting the endothelin A receptor (ETA), overexpressed in many cancers, particularly glioblastoma. The immunoPET imaging approach used in this study in a preclinical model confirms the theranostic potential of this antibody.

Un composé radiosensible pour combiner radiothérapie et chimiothérapie ?

Tue, 05 Sep 2023 10:00:00 GMT

Des chercheurs du SCBM et de l’Iramis publient une étude preuve-de-concept d’un composé radiosensible qui pourrait servir à « libérer » in vivo des médicaments anti-tumoraux, et ainsi de combiner les effets d’une radiothérapie et d’une chimiothérapie.

After ISOTOPICS, ISOBIOTICS, the renewal of isotope labeling to strengthen european therapeutic innovation

Wed, 09 Aug 2023 10:00:00 GMT

The SCBM was awarded funding from the Horizon Europe program for the ISOBIOTICS project, coordinated by Christophe Dugave. This project will enable the theoretical and practical training of 11 PhD students, including two at SCBM and one at SHFJ, on the development of innovative methods for the isotopic labeling of biodrugs

Identification of metabolomic signatures of high-grade breast tumors

Fri, 04 Aug 2023 10:00:00 GMT

The TIRO laboratory of the SHFJ (Nice) identifies for the first time discriminating biomarkers of high-grade invasive breast tumors, using a non-targeted metabolomics approach performed on surgical specimens and cytoponctions from patients at different stages of malignancy.

Creatine transporter deficiency: use of two original models to characterize this rare genetic disease

Thu, 22 Jun 2023 10:00:00 GMT

Researchers at SPI (DMTS) have identified by mass spectrometry and bioinformatics analysis several biomarkers linked to the creatine transporter deficiency disorder (CTD) using two original models : mice with the clinical characteristics of CTD subjects and brain organoids derived from CTD patient cells.

Radiomarquage du crizotinib au fluor-18 : un nouvel outil pour suivre par TEP la biodistribution de ce médicament

Thu, 27 Apr 2023 10:00:00 GMT

Des chercheurs du SHFJ ont mis au point la radiosynthèse au fluor-18 du crizotinib, un médicament qui ne pénètre pas dans le cerveau. Ce nouvel outil pour l’imagerie TEP permettra d’explorer de futures stratégies visant à faire passer la barrière hémato-encéphalique à ce médicament pour traiter certaines métastases cérébrales.

Click chemistry: new "electrophilic" iminosydnones

Thu, 02 Feb 2023 11:00:00 GMT

Researchers at the Joliot Institute have developed two new families of iminosydnones that allow the bio-orthogonal release of electrophilic species. These molecules constitute "building blocks" of click-and-release chemistry, useful for reactions with nucleophilic compounds contained in cells.

Detection of monkeypox: Mass spectrometry proves once again its effectiveness

Mon, 28 Nov 2022 11:00:00 GMT

A Li2D team has released the peptidomic profile of the virus that causes monkeypox, which they established using tandem mass spectrometry. These data should help to better understand the evolution of the epidemic and allow the creation of targeted tests to potentially detect the threat more quickly and prevent a new epidemic.

Fight against antibiotic resistance: two additional rapid lateral flow immuno-assays

Tue, 02 Aug 2022 10:00:00 GMT

Researchers at the LERI together with the AP-HP have developed 2 rapid and inexpensive immunological tests to detect antibiotic resistance. The novelty: the tests detect the activity of bacterial enzymes that hydrolyze extended-spectrum cephalosporins.

A novel fluorine-18 thiol carrier for labeling biomolecules used in PET imaging

Tue, 28 Jun 2022 10:00:00 GMT

Radiochemists from the BioMaps unit (SHFJ) have developed and automated the synthesis of an 18F-fluoropyridine containing a thiol function (-SH), allowing its conjugation to model biomolecules within 45 minutes. A step towards rapid radiolabeling of complex biological molecules for PET imaging.

New perspectives for CO2 photoreduction by iron porphyrins

Thu, 16 Jun 2022 10:00:00 GMT

Researchers from ICMMO* and ISMO**, in collaboration with a team from I2BC, show that the urea-decorated iron porphyrin catalysts they developed previously for the electro-catalysis of CO2, can be successfully employed in a photo-catalytic approach.

A possible link between changes in gut microbiota and fecal SARS-CoV-2 load ?

Thu, 12 May 2022 10:00:00 GMT

A team from SPI used mass spectrometry to analyze the degree of alteration of the intestinal microbiota of Covid-19 patients and to look for signatures of intestinal infection by the SARS-CoV-2 virus. The level of the observed gut dysbiosis would be an indicator of the stage and extent of the infection.

New radioligands for anti-PD-1/PD-L1 immunoPET

Tue, 12 Apr 2022 10:00:00 GMT

Researchers from the SHFJ and the DMTS have developed optimized radioligands for immunoPET imaging. The objective is to better predict the effectiveness of anti-PD1/anti-PDL1 immunotherapy used to fight certain cancers.

Facilitating access to deuterated and tritiated molecules: towards more diversity!

Wed, 06 Apr 2022 10:00:00 GMT

Researchers from the SCBM describe a hydrogen isotope labeling process that is easy to implement and whose starting point is a "simple" mixture, in a solvent, of the product to be labeled with a pre-catalyst. Explanations of this process which finds applications in many fields including drug development or medical imaging.

ProMetIS: open bioinformatics data and tools for multi-omics phenotyping of mouse models

Mon, 04 Apr 2022 10:00:00 GMT

A consortium of researchers, led by SPI/DMTS, presents ProMetIS, a pilot study for the deep phenotyping of murine models by combining proteomic and metabolomic approaches. A significant advance for the functional characterization of genes and the development of bioinformatics integration approaches.

Inhibiting autophagy: a new line to fight cellular senescence?

Tue, 15 Mar 2022 11:00:00 GMT

Researchers from the Frédéric Joliot Institute have identified ouabain and chloroquine as two selective senolytic molecules that are effective in eliminating certain senescent cells. The study has been published in the journal Aging Cell.

Biochemical analysis and mass spectrometry for the diagnosis of congenital disorders of glycosylation

Tue, 04 Jan 2022 11:00:00 GMT

A collaboration initiated in 2017 between AP-HP (Bichat Hospital), Paris-Saclay University (Inserm 1193) and the Laboratoire d’Études du Métabolisme des Médicaments (LEMM/SPI/DMTS), leading to 4 publications in 2021, is advancing knowledge on the origin of certain congenital disorders of glycosylation, through the identification of specific biochemical biomarkers.

Multiparametric PET-MRI imaging: toward a biological characterization of tumors at the supervoxel level

Wed, 10 Nov 2021 11:00:00 GMT

A collaborative study led by BioMaps researchers (SHFJ) demonstrates that fully integrated quantitative multiparametric analysis of non-small cell lung cancer in hybrid 18F-FDG PET/MRI 3T imaging is clinically feasible and could enable biological characterization of tumors at the supervoxel scale.

Metaproteomics and data science for an eco-health diagnosis of soil microbiota

Thu, 07 Oct 2021 10:00:00 GMT

Researchers from Li2D (SPI/DMTS, Marcoule) and LSCE have developed an innovative methodology for analyzing soil microbiota based on an optimal computational interpretation of metaproteomic databases, which should lead to a better understanding of the impact of pollutants on soil quality and to the prediction of their restoration potential.

Characteristics of the initial symptoms of Alzheimer's disease in young patients

Thu, 10 Jun 2021 10:00:00 GMT

Researchers from BioMaps (SHFJ) and the Department of Memory and Language Neurology (Ste Anne's Hospital) studied the early clinical signs of Alzheimer's disease (AD) reported by young patients (< 62 years old) compared to those reported in classic AD of the elderly (> 65 years old). They show that these signs are misleading and often appear in the professional context.

Société Chimique de France: two prizes for two researchers from the Institute

Thu, 27 May 2021 10:00:00 GMT

The members of the Organic Chemistry Division (DCO) of the French Chemical Society met on Monday 10 May to award the DCO 2021 prizes. Sophie Feuillastre and Davide Audisio, both researchers at the SCBM (CEA-Joliot Department of Medicines and Technology for Health) are among the lucky winners.

Carbon labeling by isotopic exchange of nitriles

Fri, 30 Apr 2021 10:00:00 GMT

Researchers at the CEA-Joliot Institute (Carbon-14 labeling Laboratory), in collaboration with teams from AstraZeneca, Sanofi and Nimbe (CEA-Iramis), have developed a labeling method, based on nitrile exchange using nickel catalysis. This method is currently under study at Sanofi for the labeling of a drug candidate.

Anti-cancer therapeutic strategy: a chimera to inhibit ASF1

Fri, 19 Mar 2021 11:00:00 GMT

I2BC researchers, in collaboration with the European Institute of Chemistry and Biology (University of Bordeaux, CNRS), have developed a chimeric peptide/foldamer molecule that is resistant to proteolysis and inhibits ASF1, a potential target for anticancer treatment. The resolution of the structure of this chimera in interaction with its target, the first of its kind, reveals an unsuspected plasticity of the urea-based backbone that hugs the surface of ASF1.

Food poisoning? Targeted mass spectrometry brings an answer

Thu, 18 Mar 2021 11:00:00 GMT

SPI (DMTS), in collaboration with ANSES, has developed a test based on immuno-capture and targeted mass spectrometry for the quantitative and multiplex identification, in dairy products, of the eight main enterotoxins of Staphylococcus aureus, responsible for food poisoning epidemics.

Première étape vers un test quantitatif par spectrométrie de masse pour le diagnostic spécifique de la COVID-19 ?

Tue, 09 Mar 2021 11:00:00 GMT

Le LEMM, en collaboration avec le LI2D et l’AP-HP, développe un test de diagnostic spécifique de la Covid-19 par spectrométrie de masse qui permettrait aussi la quantification de la charge virale du patient. Objectif à terme : adapter la méthode pour la rendre plus sensible et compatible avec les équipements d’analyse des hôpitaux.

A micellar probe for fluorine magnetic resonance tumor imaging

Thu, 04 Mar 2021 11:00:00 GMT

A SCBM (DMTS) team, in collaboration with researchers at NeuroSpin and I2BC, is describing micellar nanometric vectors targeting tumors that have been imaged by fluorine magnetic resonance imaging (MRI). The observed 19F signal made it possible to precisely delimit the volume of the tumor zone in a mouse model and to quantify the probe accumulated in the target tissue.

Carbon labeling with light

Wed, 24 Feb 2021 11:00:00 GMT

Researchers from the LMC (DMTS), in collaboration with a team from AstraZeneca, have developed a labeling method, based on the exchange of carbon dioxide, simply using visible blue light and a photocatalyst.

SPI is committed to precision medicine for autoimmune and inflammatory diseases

Thu, 14 Jan 2021 11:00:00 GMT

Coordinated by the Imagine Institute for Genetic Diseases, the ATRACTion program is based on a consortium of 11 academic and industrial partners, including SPI (DMTS), and aims to develop a precision medicine for patients with autoimmune and inflammatory diseases associated with primary immune deficiencies.

Chemical synthesis and characterization of a non-radioactive chiral probe for studying enzymatic reaction mechanisms

Tue, 24 Nov 2020 11:00:00 GMT

Chemists of CEA-Joliot have synthesized the two enantiomers of a molecule containing a deuterated chiral ethyl group and characterized their chiral properties using advanced spectroscopic tools. These two compounds will be useful for probing the reaction mechanism of enzymes, as alkyl transferases.

Seeing tomorrow's OLED display technology emerge

Thu, 22 Oct 2020 10:00:00 GMT

A team from SCBM, in collaboration with IRAMIS, LETI, ENS Paris-Saclay, the Universities of Rennes and San José (USA), has developed new electroluminescent molecules with properties that improve the energy consumption and light production of organic light-emitting diodes (OLEDs). This is the first study correlating the structure and properties of this type of materials, with a promising future in display technologies.

Permeabilizing the blood-brain barrier to deliver therapeutic antibodies into the brain? ImmunoPET imaging provides answers

Tue, 06 Oct 2020 10:00:00 GMT

Researchers from SHFJ, NeuroSpin and DMTS have demonstrated, by immunoPET imaging, the impact of transient BBB permeabilization on brain exposure to an anti-EGFR antibody. Promising prospects for targeted immunotherapy of glioblastoma.

A new molecule to fight against intracellular pathogens

Mon, 14 Sep 2020 10:00:00 GMT

The SCBM and SIMoS collaborated to optimize the activity of Retro-1, a benzodiazepine compound, inhibitor of Shiga toxins and ricin, derived from high-throughput biological screening. They succeeded in obtaining an analog 70 times more protective against the cytotoxicity of Shiga toxins, Retro-1.1.

Development of a general strategy for the isotopic labelling of carbamates by incorporation of CO2

Thu, 10 Sep 2020 10:00:00 GMT

In a study published in Chemical Communications, the Joliot Institute Carbon labeling laboratory (LMC), in collaboration with the SHFJ, provides proof of concept of a "click" strategy for carbon isotope marking of pharmaceutical molecules containing carbamates.

Hydrogen isotopes in the race for new drugs

Tue, 01 Sep 2020 10:00:00 GMT

The Grégory Pieters' team (LMT/SCBM) publishes, in the prestigious Angewandte Chemie, two major advances in the field of carbon-hydrogen bonds activation involving the two isotopes of hydrogen, deuterium and tritium, facilitating in particular access to labeled analogues of complex molecules, a prerequisite for the development of new drugs.

Composition of the microbiota of animals in natura: a challenge met by mass spectrometry

Mon, 24 Aug 2020 10:00:00 GMT

A team from SPI in Marcoule, in collaboration with INRAE, characterized the intestinal microbiota of a small crustacean, Gammarus fossarum, used as a sentinel of water quality in France, by combining proteogenomics and metaproteomics approaches, thus opening up interesting perspectives for the analysis of host/microbiota interactions in other animal models.

SARS-CoV-2 detection: mass spectrometry shows its potential for rapidity.

Thu, 06 Aug 2020 10:00:00 GMT

A team from SPI in Marcoule detected by mass spectrometry, in 3 minutes and without specific reagents, signature peptides of the SARS-CoV-2 virus in clinical samples (nasopharyngeal swabs). It thus provides a proof of concept of the use of this method as a possible alternative to PCR, currently the reference method.

Bacteria and archaea: a new taxonomy to better describe the unknowns?

Mon, 20 Jul 2020 10:00:00 GMT

The discovery of myriads of new species of bacteria and archaea, linked to the explosion of metagenomics, is leading microbiologists to consider rethinking how to map certain branches of life. Tools, such as the phylopeptidomics developed at Li2D, could help them do so.

Proteomic analysis of SARS-CoV-2 infected cells

Mon, 06 Jul 2020 10:00:00 GMT

In order to optimize the amplification of quality inactivated virus, for the manufacture of a vaccine, a team from SPI (CEA Marcoule) used mass spectrometry to analyze the dynamics of the proteome of SARS-CoV-2 infected cells, at two multiplicities of infection. With more than 3,220 identified host proteins, researchers are also starting to decipher the processes and cellular networks impacted by this virus.

Chemistry: releasing two fluorophores into living cells by "click and release".

Mon, 29 Jun 2020 10:00:00 GMT

Researchers from the LMC have developed a new series of iminosydnones that can split in two and release two fluorophores. They are providing a proof of concept that this "click and release" reaction can be triggered in living cells.

Clickable bambusurils to access promising multivalent architectures.

Mon, 04 May 2020 10:00:00 GMT

A team from SCBM, in collaboration with researchers from I2BC, SHFJ and IRAMIS, has synthesized new neutral macrocycles called bambusurils (BUs). These BUs can be functionalized by “click chemistry” to obtain multivalent architectures decorated with 8 to 12 ligands of interest, an alternate topology which gives them remarkable supramolecular properties.

BRCA2 and breast cancer: a new mechanism revealed?

Mon, 27 Apr 2020 10:00:00 GMT

In a study conducted by a team from the Institut Curie, I2BC researchers have used their NMR know-how to study the phosphorylation of BRCA2 and have thus contributed to revealing a mechanism potentially at the origin of chromosomal aberrations observed in breast BRCA2-mutated tumors.

Characterization of a predictive survival biomarker in the event of septic shock

Tue, 24 Mar 2020 11:00:00 GMT

Two recent studies conducted by SPI researchers, in collaboration with Inserm and AP/HP teams, reveal the value of measuring plasma levels of calgranulins as biomarkers for the prediction of mortality risk of patients with septic shock, admitted in intensive care unit.

Launch of FLIX, a European project for the isotopic labeling of molecules with high added values

Wed, 19 Feb 2020 11:00:00 GMT

In June 2019, the SCBM obtained a European FET-Open funding for the FLIX project (FLow chemistry for Isotopic eXchange), a radically innovative concept of isotopic labeling of molecules with high added values. This 4-year project, coordinated by CEA/SCBM, with an overall budget of 3.5 million euros started on January 1, 2020 and consists of seven European academic or industrial partners in five countries.

Innovative approach to radiolabel peptides with fluorine-18 for PET imaging

Mon, 17 Feb 2020 11:00:00 GMT

Radiochemists from the BioMaps unit (SHFJ) have developed and automated a new fluor-18 radiolabelling method for peptides used to characterize specific pathological molecular signatures and thus target treatments. Peptides were conjugated to a specific tag, then radiolabeled in a single step under mild conditions, making this approach an innovative solution for PET imaging of peptides labeled with fluorine-18.

Davide Audisio (SCBM), winner of a « 2019 Consolidator Grant » from the European Research Council

Tue, 10 Dec 2019 11:00:00 GMT

The European Research Council (ERC) announced, on December 10, 2019, the winners of the 2019 ERC "Consolidator Grants". Three CEA researchers are rewarded for the excellence of their work in astrophysics, particle physics and chemistry. In Joliot, chemistry is honored with the award of the research grant to Davide Audisio, SCBM, for his expertise in labeling molecules of interest with 14Carbone.

Light to release the tension of cycles

Tue, 03 Dec 2019 11:00:00 GMT

A team from SCBM, in collaboration with Mauritian modelers, has shown that carboxylic acids can be easily converted into small rings with four carbon atoms, the cyclobutanes, using blue LEDs and an iridium catalyst. Cyclobutanes are increasingly used in the design of new drugs and the method described here will help to significantly expand the chemical space explored in "drug discovery".

Alzheimer's or Lewy bodies dementia? The answer with high-resolution mass spectrometry

Thu, 07 Nov 2019 11:00:00 GMT

A team from SPI, in collaboration with the metabolic biochemistry service and the Institute of Memory and Alzheimer's Disease (IM²A) of the university hospitals Pitié-Salpêtrière, has developed a method for the simultaneous quantification of tau and α-synuclein proteins in human cerebrospinal fluid by high-resolution mass spectrometry. A promising new approach for the differential diagnosis of Lewy bodies dementia and Alzheimer's disease.

Glucocorticoids: a better evaluation of their effects in specific cancers?

Mon, 09 Sep 2019 10:00:00 GMT

Senescence specialists (SBIGEM), in collaboration with the SCBM and the CNRGH (Jacob Institute), show that glucocorticoids can delay or even short-circuit it and disrupt its function as a tumor suppressor.

See a tumor in PET imaging by « click-chemistry » in vivo

Tue, 03 Sep 2019 10:00:00 GMT

A new PET imaging method by antibody pretargeting was developed at SHFJ, in collaboration with teams of SCBM and SPI. It consists in reacting in vivo a molecule labeled with 18Fluor with an antibody previously fixed on a tumor and this, in an extremely fast and selective manner, thanks to a « click-chemistry » reaction. The very good results obtained allow to consider the use of pre-targeted antibodies in nuclear medicine.

A new biomarker to predict tumor progression from whole body PET images.

Tue, 16 Jul 2019 10:00:00 GMT

The SHFJ/IMIV laboratory (Inserm 1023/CNRS/CEA/UP-Sud), in collaboration with hospital-university teams, has shown that, in patients with advanced-stage large cell lymphoma (B type), automatic quantitative measurements of tumor dissemination detected by whole-body PET imaging have a predictive value of progression-free survival (tumor stabilization) and overall survival.

A new generation of nanovectors for anticancer therapies.

Wed, 12 Jun 2019 10:00:00 GMT

As part of a collaboration with MIRCen (Jacob Institute), researchers of SCBM have developed functional micellar vectors that can effectively target tumors and whose therapeutic activity is intrinsically carried by the constitutive unit of the micelle. This combination leads to better drug load and avoids premature drug release.

IBiSA labeling of the Saclay plateau screening platforms (C@PS)

Tue, 26 Mar 2019 11:00:00 GMT

The union of the Saclay Plateau screening platforms under a single banner C @ PS (Criblage sur le Plateau de Saclay) has just obtained the IBiSA label. Jean-Christophe Cintrat (Joliot / SCBM) is in charge of the overall infrastructure.

« Click and Release » chemistry for the targeted delivery of drugs in vivo

Fri, 15 Mar 2019 11:00:00 GMT

A team from the SCBM, in collaboration with the SPI, the IC2MP and the University Hospital of Poitiers, has developed a bioorthogonal chemistry strategy that allows, in vivo, the controlled release of active ingredients contained in micelles-targeting cancerous tumors. These results pave the way for new strategies for targeted drug delivery.

Incorporating in a single step hydrogene isotopes into nucleic acid derivatives

Thu, 28 Feb 2019 11:00:00 GMT

Facilitating the deuterium and tritium labeling of molecules containing nucleic bases such as many compounds of pharmacological interest? This is what researchers from SCBM in partnership with teams from SPI and Toulouse managed to achieve.

Towards a better detection of glioblastoma infiltration

Tue, 26 Feb 2019 11:00:00 GMT

Glioblastoma is a very aggressive cancer of the central nervous system, mainly because of its ability to infiltrate the surrounding areas. A collaboration led by a team of SHFJ and involving NeuroSpin demonstrates the interest of two imaging techniques for the early detection of tumor infiltration.

Helicenes: the familly gets bigger

Tue, 22 Jan 2019 11:00:00 GMT

Helicenes are synthetic molecules with attractive properties for physicists expert in materials but also for biologists. A collaboration led by chemists from the SCBM (CEA-Joliot) and involving the NIMBE (CEA-Iramis) allowed the synthesis of a particular class of helicenes.

CO2 and copper to radiolabel pharmaceutical compounds

Fri, 11 Jan 2019 11:00:00 GMT

Researchers from the SCBM and the IRAMIS (CEA/CNRS) have develop a 14C labeling method for therapeutic molecules based on dynamic Misspelled Wordcarbone dioxide exchange. This one step method generates far less radioactive waste. By facilitating some preclinical and clinical steps, it should eventually help to speed up the marketing applications of some new drug discoveries.

Cerebral lymphoma: a new indication for [18F]Fludarabine?

Mon, 08 Oct 2018 10:00:00 GMT

A SHFJ research team (LDM-TEP, GIP Cyceron, Caen) has previously developed and produced a radiopharmaceutical, the [18F]-Fludarabine, to detect lymphomas using PET scan. The team has recently conducted a preclinical study that shows the molecule can help in diagnosis of cerebral lymphoma by differentiate it from glioblastoma, the main brain tumor. A clinical study should be launched before the end of the year.

A reliable and accessible algorithm based on EEG to diagnose states of consciousness

Fri, 05 Oct 2018 10:00:00 GMT

An international collaboration, led by the Institut du Cerveau et de la Moelle épinière – ICM (Brain & Spine Institute) and involving researchers from NeuroSpin, offers a new electroencephalogram (EEG) tool that helps the diagnosis of disorders of consciousness. Unlike other tools developed so far and dedicated to a few expert centers, “DoC-Forest” would be accessible to most of the hospitals worldwide.

What is the relationship between variants of the BRCA1 gene and susceptibility to cancer?

Fri, 28 Sep 2018 10:00:00 GMT

Research Teams from the Curie Institute, the Gustave Roussy Institute, as well as the biophysics teams from the Institute of Chemistry of Natural Substances and SB2SM (I2BC@Saclay) met to systematically identify structural defects and BRCA1 proteins encoded by variants of the BRCA1 gene, a gene predisposing to breast and ovarian cancer. Their results make it possible to propose a classification of these variants (neutral versus causal).

Mass spectrometry for quality control of vaccines

Thu, 05 Jul 2018 10:00:00 GMT

A SPI Research Team (LI2D, Marcoule), in collaboration with CIRAD and AU-PANVAC, proposes a new quality control technique for veterinary vaccines, based on very high resolution mass spectrometry. This strategy, based on the use of an ad hoc database to measure the proportion of antigens and contaminants in the vaccine preparation, will improve the quality control of vaccines against contagious caprine pleuropneumonia.

A new method for ultra-rapid isotope labeling of drugs

Tue, 19 Jun 2018 10:00:00 GMT

A SCBM Research Team, in collaboration with SHFJ, SIMOPRO and Karolinska Institute, has discovered a method inspired by the "click" chemistry which, from radioactive carbon dioxide, can synthesize in just five minutes radiolabeled molecules containing a cyclic urea moiety. This method has been used for the ultra-rapid isotope labeling of drugs, without modification of their structure and with an unequaled efficiency.

Importance of chemical modifications of proteins for their interactions with nanoparticles

Thu, 24 May 2018 10:00:00 GMT

Two Research Teams from I2BC@Saclay and SPI (LI2D, Marcoule), in collaboration with IRAMIS, highlight the very strong affinity of silica nanoparticles for proteins with RGG motifs (family of binding proteins). RNA), especially when these are methylated. These results are important for the development of safe by design approaches.

Metabolomic analysis facilitated by very high resolution mass spectrometry

Wed, 25 Apr 2018 10:00:00 GMT

In a study published in Analytical Chemistry, the Mass Spectrometry Research Team of the Laboratory Drug Metabolism Research Laboratory (SPI) demonstrated the interest of Orbitrap Fusion, a state-of-the-art mass spectrometer for the identification of relevant metabolites based on their masses and isotopes measured with high accuracy.

Functionalized micellar nanovectors for targeted tumor therapy

Thu, 12 Apr 2018 10:00:00 GMT

As part of a collaboration with MIRCen (Institute of Biology François Jacob) and SBIGeM, SCBM researchers have developed functional micellar nanovectors capable of targeting a population of cancer cells.

A rapid isotopic labeling method for complex molecules containing a sulfur atom

Thu, 22 Mar 2018 11:00:00 GMT

Researchers from SCBM, in collaboration with Paris-Sud University and INSA Toulouse, developed the first general method for tritium and deuterium labeling of complex molecules with thioether-type motifs (including sulfur atom). This method allows rapid access to tritiated or deuterated molecules used in the pharmaceutical industry for in vivo monitoring or the biological assay of substances of interest.

To link and to release selectively molecules in biological media

Tue, 24 Oct 2017 10:00:00 GMT

A Research Team of the SCBM (Frédéric Joliot Institute), in collaboration with the SIMOPRO (Frédéric Joliot Institute), Strasbourg University and the start-up Syndivia, has just discovered a new chemical reaction allowing both to bind and to cleave molecules in biological media ("click and release" reaction).

[18F] Fludarabine, a hope for lymphoma imaging

Mon, 29 May 2017 10:00:00 GMT

A Research Team of the SHFJ (LDM-TEP) has just developed an innovative radiopharmaceutical for lymphoproliferative diseases, [18F] Fludarabine.

Pierre Fabre and H-Immune: a strategic research partnership for the development of immunotherapies in the field of cancer.

Wed, 03 May 2017 10:00:00 GMT

After its creation by Michel Léonetti, a researcher at SPI / LERI, and Luc Boblet, external holder at the CEA, backed by the IDEX Paris-Saclay funding among other things, the H-Immune start-up recently signed a partnership agreement with the Pierre Fabre Innovation Fund to develop cancer immunotherapy treatments.

Monitoring hadrontherapy to improve patient safety

Mon, 13 Mar 2017 11:00:00 GMT

Evaluating the biological impact of hadrontherapy in healthy tissue upstream of a tumor is essential to assess the risk of radiation-induced sequelae. In the treatment of bone tumors, healthy articular cartilages are present in the path of the carbon ion beams. The development of 3D models has enabled IRCM's LARIA Research Team, in collaboration with IRAMIS and IBITECS (SBIGeM), to have relevant evaluation systems for these tissues.