Frédéric Joliot Institute for Life Sciences - Sur le même thème

Early auditory environment influences superior temporal sulcus depth in the neonatal period

Mon, 23 Feb 2026 11:00:00 GMT

A team from NeuroSpin investigated the impact of contrasting auditory environments on the morphology of the superior temporal sulcus (STS) in preterm newborns. By showing that exposure to music is associated with a deeper STS, the authors suggest that early auditory experience influences the structural development of temporal brain regions.

Characterization of novel anti-ricin monoclonal antibodies using an original large-scale approach

Wed, 21 Jan 2026 11:00:00 GMT

DMTS teams have characterised 17 monoclonal antibody-candidates targeting ricin using two original biophysical approaches. The identification of ricin residues involved in functional antibody recognition paves the way for the development of powerful monoclonal therapeutic antibodies against this natural toxin, which is a bioterrorism agent.

Opening the BBB to Deliver Drugs to the Brain: Removing Noise Signals to Optimize Focused Ultrasound Pressure Control Protocol

Wed, 14 Jan 2026 11:00:00 GMT

Des équipes du SHFJ, de NeuroSpin et du CEA-Jacob optimisent leur stratégie d'ouverture de la barrière hémato-encéphalique par ultrasons focalisés (FUS). Leur nouveauté : un algorithme masquant la cavitation extracrânienne induite par les muscles temporaux épais, particulièrement chez les grands mâles primates, qui vient masquer le signal dans la région d'intérêt.

Seismic-wave physics for diagnosing brain tumors with passive MRI elastography

Wed, 26 Nov 2025 11:00:00 GMT

Researchers at SHFJ and NeuroSpin applied a passive MRI elastography sequence to patients with brain tumors. This non-invasive approach provided information on tumor stiffness and nature, and could support early detection, surgical planning, and treatment monitoring.

Proof of concept for the passage of trastuzumab formulated in nanoparticles through an in vitro-reconstituted nasal epithelium.

Wed, 12 Nov 2025 11:00:00 GMT

Researchers from SPI (DMTS) developed a formulation of PLGA nanoparticles loaded with the anticancer trastuzumab (NP-TZB) and measured their ability to cross a cellular model of the nasal epithelial barrier. This first validated step supports a potential nose-to-brain (N2B) delivery route.

PET imaging of OATP transporter-mediated drug elimination: impacts of sex and age

Wed, 15 Oct 2025 10:00:00 GMT

Researchers from BioMaps (SHFJ) investigated the hepatic activity of organic anion-transporting polypeptides (OATPs), key players in the elimination of certain drugs, using a PET imaging approach with 11C-glyburide, which revealed differences in tracer pharmacokinetics between men and women.

Quand les modèles mathématiques donnent un coup de pouce à l’IRM fonctionnelle pour mieux définir et prédire les états de conscience

Thu, 09 Oct 2025 10:00:00 GMT

Deux études récentes menées par des équipes de NeuroSpin proposent d’appliquer des méthodes combinant des modèles mathématiques d’analyse de données à l’IRM fonctionnelle pour mieux modéliser les connectivités fonctionnelles du cerveau.

Développement de radioligands pour l’imagerie TEP de la neuroinflammation

Fri, 03 Oct 2025 10:00:00 GMT

Des chercheurs du SHFJ, en collaboration avec le CEA-Jacob, le CRN à Lyon et le PharmaCenter à Bonn ont imaginé, synthétisé et caractérisé deux radiotraceurs TEP ciblant P2Y12, une protéine impliquée dans l’activation de la microglie durant la neuroinflammation.

An ever more efficient GMR-sensor biochip: application to the detection of cancer cells for point-of-care diagnostics

Tue, 30 Sep 2025 10:00:00 GMT

Researchers from IRAMIS and SPI (DMTS) evaluated their GMR-sensor biochip prototype for its ability to detect cancer cells in a complex medium. This approach, which combines sensor physics with medical biology, aims to develop simpler and portable diagnostic tools that meet the WHO criteria for point-of-care testing.

Ultrasound to counteract the cerebral effects of exposure to a neurotoxic agent

Thu, 28 Aug 2025 10:00:00 GMT

Researchers from BioMaps (SHFJ), NeuroSpin, and the french IRBA developed an innovative approach using focused ultrasound to improve brain delivery of an antidote, oxime, following exposure to an organophosphorus neurotoxic agent in a murine model.

Monitoring microstructural and functional brain development in preterm and full-term infants using multimodal MRI

Mon, 04 Aug 2025 10:00:00 GMT

A team from NeuroSpin studied the microstructural and functional connectivity profiles of infants’ brains to understand how these characteristics evolve and relate to each other during early neurodevelopment. The results indicate that connectivity, which is altered by prematurity, strengthens with maturation, and that the associated networks become increasingly similar.

Statistical learning beyond words in human neonates

Tue, 22 Jul 2025 10:00:00 GMT

Ghislaine Dehaene's team (NeuroSpin) carried out EEG experiments on neonates to find out whether statistical learning was a mechanism dedicated solely to language acquisition. By exploiting the speaker identity and phonemes, the researchers conclude that statistical learning mechanisms are universal and not limited to linguistic characteristics.

Correlation between neuroinflammation and epileptogenic zone in drug-resistant focal epilepsy

Tue, 15 Jul 2025 10:00:00 GMT

A study by SHFJ researchers has established a strong correlation between biomarkers of neuroinflammation, revealed by original PET imaging, and intracranial electroencephalographic recordings of epileptogenic activity. This offers hope for drug-resistant patients who are candidates for surgery.

A promising drug candidate for the treatment of neonatal hypoxic-ischemic encephalopathy

Thu, 26 Jun 2025 10:00:00 GMT

Researchers from the SPI (DMTS) and the Women & Infants Hospital in Providence have laid the molecular basis for the neuroprotection of a purine derivative in a preclinical model of neonatal hypoxic-ischemic encephalopathy (HIE). The promising results support the development of this drug candidate to treat HIE in neonates.

Computational modeling reveals the nature of human alpha-synuclein interactions with polyethylene nanoplastics

Tue, 27 May 2025 10:00:00 GMT

A team from I2BC, in collaboration with the NIMBE (CEA-Iramis), is unveiling the nature of the interactions of human alpha-synuclein (hαSn) with polyethylene nanoplastics, using molecular dynamics simulations and experimental methods.

How does our brain remember the duration of events?

Mon, 05 May 2025 10:00:00 GMT

A behavioural study conducted by a NeuroSpin team assessed the brain's processing of duration in working memory by having participants memorise a sequence of time intervals and then reproduce the duration of each interval. The results suggest that the brain processes the duration of each event as separate information.

Devenir adolescent après avoir eu un AVC à la naissance : la croissance cérébrale dépend-elle du sexe ?

Fri, 18 Apr 2025 10:00:00 GMT

Une étude dirigée par une équipe de NeuroSpin confirme la vulnérabilité spécifique du cerveau du bébé masculin après un AVC autour de la naissance.

Promising anti-ricin antibodies for effective passive immunotherapy

Fri, 28 Mar 2025 11:00:00 GMT

The LERI (SPI/DMTS) has developed a new generation of anti-ricin antibodies with a high affinity for the D and E isoforms of the protein, providing effective protection for model mice intoxicated with ricin.

Une nouvelle stratégie de détection de la ricine

Wed, 19 Feb 2025 11:00:00 GMT

Une équipe du LI-MS (SPI/DMTS) a mis au point une méthode de détection de la ricine combinant l’enrichissement des échantillons grâce à l’affinité de la ricine pour une glycoprotéine et la spectrométrie de masse à haute résolution.

Universal identification of pathogenic viruses by LC-MS/MS proteotyping

Wed, 29 Jan 2025 11:00:00 GMT

Researchers at Li2D (SPI/DMTS, Marcoule) have proposed an innovative tandem mass spectrometry proteotyping method for the universal identification of pathogenic viruses, requiring no prior knowledge of sample composition. A step towards improved diagnosis of viral infections

QSM4SENIOR : une cartographie quantitative inédite de la charge en fer des noyaux centraux du cerveau humain dans le vieillissement naturel

Tue, 26 Nov 2024 11:00:00 GMT

Les premières données du projet QSM4SENIOR, porté par des équipes de NeuroSpin et de la société VENTIO, ont été publiées dans Frontiers in Neuroimaging. Elles permettent de dresser une cartographie très précise de l’évolution de la charge en fer au cours du vieillissement cérébral normal, une aide précieuse pour les scientifiques spécialistes des maladies neurodégénératives.

QSM4SENIOR : unprecedented quantitative mapping of the iron load in the central nuclei of the human brain during natural ageing

Tue, 26 Nov 2024 11:00:00 GMT

The first data from the QSM4SENIOR project, led by teams from NeuroSpin and VENTIO, have been published in Frontiers in Neuroimaging. They provide a highly accurate map of changes in iron levels during normal brain ageing, a valuable aid for scientists specialising in neurodegenerative diseases.

A comparative analysis of the chimpanzee and human brain superficial structural connectivities

Fri, 22 Nov 2024 11:00:00 GMT

A team from NeuroSpin has proposed a classification of the morphology of short white matter bundles (SWMBs) in human and chimpanzee brains. A wide variety of shapes was observed, as well as differences. This study provides valuable information on SWMB morphology and its potential implications for human cognitive development

IBC 3, high-resolution mapping of cognitive functions in response to naturalistic stimuli

Wed, 30 Oct 2024 11:00:00 GMT

Several NeuroSpin researchers have taken part in the Individual Brain Charting (IBC) project, aimed at creating a precise map of the cognitive functions of the human brain. In this third phase, they are using the Fast Shared Response Model to analyze large-scale fMRI data and model responses to natural stimuli involving the visual, auditory and language systems.

Iseult : après les images, la publication scientifique

Mon, 28 Oct 2024 11:00:00 GMT

L’équipe de NeuroSpin en charge de l’acquisition des premières images de cerveau de volontaires à 11,7 teslas a publié dans Nature Methods les détails de son protocole d’étude exploratoire menée à ce champ magnétique inégalé.

SplineBeam : un algorithme réaliste et rapide pour prédire les champs de pression des ultrasons.

Thu, 24 Oct 2024 10:00:00 GMT

Les applications thérapeutiques des ultrasons sont nombreuses, notamment en neurologie. Prédire en temps réel le champ de pression acoustique à appliquer est indispensable. C’est ce que permet de faire l’algorithme SplineBeam développé par une équipe du SHFJ en collaboration avec le CEA-List, NeuroSpin et le CHU Grenoble-Alpes.

Study of subcortical neuromodulatory systems alteration in Alzheimer's disease and related disorders

Wed, 16 Oct 2024 10:00:00 GMT

A team from GHU Paris and SHFJ has used brain MRI to study the integrity of the locus coeruleus and nucleus basalis of Meynert in patients with early-onset Alzheimer's disease (AD), age-related TDP-43 encephalopathy (LATE) and fronto-temporal dementia (FTD). Both structures are altered in early AD, LATE and probably FTD, making these neuromodulatory areas potential therapeutic targets

Studying functional brain connectivity to understand the different emotional states in bipolar disorder

Mon, 30 Sep 2024 10:00:00 GMT

A study conducted by NeuroSpin researchers reveals abnormalities in functional brain connectivity in the sub-nucleus region of the amygdala (emotion center), in patients with bipolar disorder. These anomalies, which depend on whether the patient is depressed or manic, are potential biomarkers of interest.

PET imaging evaluation of the central effects of a drug-candidate to aid smoking cessation

Thu, 29 Aug 2024 10:00:00 GMT

A BioMaps team has used PET imaging to monitor glucose metabolism as a marker of the cerebral impact of smoking cessation, as well as the effects of a promising drug-candidate for the treatment of such cessation. By revealing the restoration of normal activity in the brain area associated with craving, these results offer hope for smoking cessation in humans

Associative learning explains human sensitivity to complex auditory sequences

Wed, 17 Jul 2024 10:00:00 GMT

A NeuroSpin team analyzed the MEG response of volunteers exposed to auditory sequences organized in network. Finding that participants' brain activity was sensitive to the structure of the network, it concluded that learning the structure of auditory sequences involves a single cognitive process, associative learning.

Cerebellum and cognitive function: anatomical correlations revealed from a large transdiagnostic sample

Fri, 05 Jul 2024 10:00:00 GMT

A collaborative study led by NeuroSpin researchers analyzed anatomical MRI images of 662 young subjects from the Healthy Brain Network cohort, to map different features of cognitive function linked to cerebellar structure. It shows that there is a complex association between key cognitive functions and particular lobules of the cerebellum.

A world premiere: the living brain imaged with unrivaled clarity thanks to the world’s most powerful MRI machine

Tue, 02 Apr 2024 10:00:00 GMT

The CEA is revealing a series of in vivo human brain images acquired with the Iseult MRI machine and its unmatched 11.7 teslas magnetic field strength. This success is the fruit of more than 20 years of R&D as part of the Iseult project, with one pillar goal being to design and build the world’s most powerful MRI machine. Its ambition is to study healthy and diseased human brains with an unprecedented resolution, allowing us to discover new details relating to the brain’s anatomy, connections, and activity.

Towards a neurodevelopmental model for the prediction of psychotic transition

Thu, 21 Mar 2024 11:00:00 GMT

A NeuroSpin team has built a predictive model for the onset of psychosis using a combination of supervised learning analyses and a model of neuroanatomical age, based on neuroimaging data from healthy subjects and those at risk of psychotic transition.

What do cognitive neurosciences have to say about our perception of time?

Tue, 27 Feb 2024 11:00:00 GMT

A team from NeuroSpin has recently published 3 papers that address the question of how we perceive time from a cognitive neuroscience perspective, using real-life temporal experiments, laboratory experiments and MEG brainwave measurements indicative of the passage of time, and that shed light on how the brain constructs our experience of lived time.

First complete atlas of chimpanzee brain connectivity

Mon, 12 Feb 2024 11:00:00 GMT

NeuroSpin researchers map chimpanzee brain structural connectivity for the first time using diffusion MRI data. New image processing enabled them to create two atlases of deep and superficial white matter connectivity. A step towards a better understanding of the evolution of the hominid brain.

Where and how is the representation of quantities generated in the brain? Study using ultra-high field functional MRI

Wed, 31 Jan 2024 11:00:00 GMT

In a study published in Nature Communications, researchers from UNICOG and BAOBAB use high-field functional MRI to reveal the brain areas where the representations of quantities generated by a mental arithmetic operation are encoded.

Dyslexia: some of the devices sold to make reading easier are not effective

Sun, 28 Jan 2024 11:00:00 GMT

Devices such as lights and strobe glasses that are supposed to make reading easier for dyslexic people actually have no impact. These are the findings of a study conducted by a team from UNICOG (NeuroSpin) and published in the journal Proceedings Royal Society.

38 million euros secured for EBRAINS

Thu, 11 Jan 2024 11:00:00 GMT

Neural representation of uncertainty: towards a consensus?

Fri, 17 Nov 2023 11:00:00 GMT

In a review article published in Nature Neuroscience, researchers, including Florent Meyniel from UNICOG (NeuroSpin), show that the two dominant approaches to the neural representation of uncertainty are complementary and would benefit from being used synergistically.

Characterization of low-frequency neuronal oscillations in human magnetoencephalography

Wed, 18 Oct 2023 10:00:00 GMT

NeuroSpin researchers show that spontaneous neuronal oscillations in the 'delta' frequency band (0.5-3 Hz), the wave of unconscious states, can be observed in awake human volunteers using MEG. A step towards characterizing underlying physiological signals?

Impact of metabolic variations on PET imaging of neuroinflammation in humans

Thu, 12 Oct 2023 10:00:00 GMT

Researchers at BioMaps evaluated the effect of several factors on the distribution of [18F]DPA-714 in 201 subjects who participated in SHFJ PET imaging protocols to better understand the role of neuroinflammation in various neurological diseases. They conclude that measures of individual metabolism are important in image interpretation.

Autophagy, a cellular self-defense mechanism, is involved in protecting cells against ricin

Thu, 28 Sep 2023 10:00:00 GMT

A team from SIMoS and SCBM, in collaboration with researchers from I2BC, has shown that autophagic degradation is at work when mammalian cells are poisoned by ricin. Stimulating this process could provide additional protection against this deadly toxin.

Understanding the relationship between cerebellar structure and social abilities in young subjects with autism-related symptoms

Tue, 12 Sep 2023 10:00:00 GMT

A collaborative study by NeuroSpin researchers, using anatomical MRI data and a dimensional approach in 850 subjects from the Healthy Brain Network cohort, shows how the social skills of these children and adolescents are linked to the structure of their cerebellum

Rentrée « en mode kick-off » pour l’équipe MIND

Mon, 11 Sep 2023 10:00:00 GMT

Le 07 septembre, l'équipe MIND organisait son kick-off meeting, symbolisant la volonté commune de sestutell es, CEA et Inria, de consolider et de créer des synergies en intelligence artificielle et machine learning pour les neurosciences.

kick-off meeting for the MIND team

Mon, 11 Sep 2023 10:00:00 GMT

On 07 September, the young MIND team organised its kick-off meeting, symbolising the shared desire of its two supervisory administrations, the CEA and Inria, to consolidate and create synergies in artificial intelligence and machine learning for neuroscience.

L’IA pour l’IRM à haut champ : les multiples pistes développées par l’équipe MIND pour ne plus choisir entre temps et qualité de l’image

Wed, 30 Aug 2023 10:00:00 GMT

Comment le cerveau intègre-t-il efficacement les informations visuelles et auditives de la parole ?

Tue, 25 Jul 2023 10:00:00 GMT

Une étude dirigée par une équipe d’UNICOG montre que le cerveau humain optimise l’intégration des informations auditives et visuelles de la parole à différentes échelles anatomiques et fonctionnelles, grâce à un ensemble de réseaux neuronaux hiérarchiquement imbriqués et synchronisés.

The "rabbit motif" in 18F-DOPA PET imaging for a simplified diagnostic evaluation of parkinsonian syndromes

Tue, 23 May 2023 10:00:00 GMT

BioMaps researchers compared the diagnostic performance of the rabbit visual pattern observed in 18F-DOPA PET imaging with the standard procedure approved by the international nuclear imaging societies for the diagnosis of parkinsonian syndromes in PET/MRI and obtained encouraging results, which may validate the clinical utility of such a model

Characterization of the neural representation of confidence during probabilistic learning

Wed, 10 May 2023 10:00:00 GMT

Using a dynamic probability learning task and high-field (7T) fMRI, a NeuroSpin team identifies regions in parietal and frontal cortex involved in the neural representation of prediction confidence during human learning

Mise en exploitation de l’IRM 11.7 T Iseult : revue de détails

Fri, 28 Apr 2023 10:00:00 GMT

La mise en exploitation de l’IRM 11.7 T Iseult en 2021 a couronné près de 20 ans de recherche et développement du CEA. Dans un article publié dans le journal Magnetic Resonance Materials in Physics, Biology and Medecine, Nicolas Boulant et Lionel Quettier, chefs du projet Iseult pour les instituts Joliot et Irfu du CEA, passent en revue les détails de cette mise en service.

Genetic variations in evolutionarily acquired DNA regulatory regions affect the morphology of certain sulci in the human cerebral cortex

Mon, 27 Feb 2023 11:00:00 GMT

Using UK Biobank imaging-genetics data, a collaborative study led by NeuroSpin found that variation in genomic regions, known as enhancers, could affect the morphology of cortical sulci and be associated with the evolution of locomotion in primates and bipedalism in our hominin ancestors.

From a marine toxin to a melanocortin receptor antagonist, a therapeutic target for energy metabolism disorders

Thu, 09 Feb 2023 11:00:00 GMT

A SIMoS team discovered a toxin in the venom of a marine cone that it engineers into a high affinity antagonistic peptide for the melanocortin receptor, a major regulator of energy homeostasis. A step towards the development of innovative treatments for certain eating disorders

Anatomical atypia in autistic people ? Fine morphological analyses contradict the results of the last decade

Mon, 06 Feb 2023 11:00:00 GMT

By studying the morphology of the cerebellar gray matter, an international consortium coordinated by NeuroSpin researchers concludes that there are no anatomical atypia in the cerebellum of people with autism.

ERC Starting Grant for Timo van Kerkoerle at NeuroSpin!

Tue, 22 Nov 2022 11:00:00 GMT

Timo van Kerkoerle, researcher at NeuroSpin, is one of the 408 winners of the prestigious ERC Starting Grant 2022 call of the European Research Council. Another European success for the Institute.

First results of the "Confined time" study released in Blursday, a resource to understand our perception of time during lockdown

Mon, 19 Sep 2022 10:00:00 GMT

The participative study on our time perception during the confinement, led by Virginie van Wassenhove (NeuroSpin), provides the first open database, Blursday, which analyzes the nature of the alterations in our relationship to time during physical and social distancing, as we experienced during the Covid-19 pandemic.

Specificity of reading and face recognition cerebral circuits during reading acquisition

Mon, 12 Sep 2022 10:00:00 GMT

By measuring fMRI responses to written words, faces, houses and checkerboards in three groups of children, pre-readers and beginning readers aged 6 and advanced readers aged 9, a team from UNICOG (NeuroSpin) shows that reading acquisition recycles and specializes a pre-existing but plastic visual circuit connected to language areas.

Dual labeling and digital imaging for the evaluation of protein-drug conjugates in preclinical models

Mon, 22 Aug 2022 10:00:00 GMT

A team from SIMoS, in collaboration with the SCBM (DMTS), has developed an original bioanalytical approach based on the double 14C-3H isotopic labeling of an antibody-drug conjugate, allowing the simultaneous in vivo monitoring of the two components in mouse models as well as their precise quantification in the organs.

Predicting all cognitive activities from images of the functionning brain, it's possible

Thu, 30 Jun 2022 10:00:00 GMT

A NeuroSpin team succeeded in decoding a large set of human mental processes by training neural networks to predict cognitive labels from a cognitive atlas and by leveraging the data set of NeuroVault, a web-based database for collecting and sharing statistical maps of the human brain.

First atlas of anatomical brain connectivities in quail!

Tue, 31 May 2022 10:00:00 GMT

The expertise of NeuroSpin in diffusion MRI has allowed to establish the first atlas of the anatomical connectivities of the Japanese quail brain at a resolution of 150 m in three dimensions.

What if the shape of the early brain sulci could predict certain pathologies?

Fri, 20 May 2022 10:00:00 GMT

Neurospin researchers conducted a longitudinal brain imaging study in very premature infants to analyze the variability of the shape of the central sulcus early in its development and its functional implications.

Multisensory integration may be a matter of temporal coincidences

Wed, 18 May 2022 10:00:00 GMT

A team at NeuroSpin, in collaboration with the University of Ulm (Germany), published a study in Nature Communications that suggests the existence of multisensory correlation detectors in the human brain.

Object detection facilitates segmentation of rare brain tumors in MR imaging

Thu, 05 May 2022 10:00:00 GMT

A study led by NeuroSpin researchers proposes an optimized delineation of rare brain tumors, based on a combined approach of object detection and deep learning segmentation in tumor images, a key step in the characterization of cancers.

The New York Times is interested in the studies on the sensitivity to geometry conducted at NeuroSpin

Thu, 31 Mar 2022 10:00:00 GMT

In an article in the New York Times, Stanislas Dehaene (NeuroSpin director) and Mathias Sablé-Meyer (PhD student) discuss recent results obtained in collaboration with the Collège de France, the CNRS and the University of Paris 8 that show that humans have a universal capacity to understand abstract geometric concepts.

Deep brain stimulation of the thalamus restores signatures of consciousness

Sat, 26 Mar 2022 11:00:00 GMT

Using fMRI and EEG, NeuroSpin and ICM researchers show that deep brain stimulation of the central part of the thalamus restores the richness of brain activity specific to consciousness, which is "switched off" in an anesthetized non-human primate. This work paves the way for clinical studies in patients with consciousness disorders.

Buprenorphine/benzodiazepine interaction: why is it more dangerous?

Fri, 25 Mar 2022 11:00:00 GMT

A collaboration between the SHFJ and the UMR-S 1144 (University of Paris) shows that the deleterious effect of the buprenorphine/benzodiazepine combination would result from the combined action of each drug on its target.

7T Sodium MRI confirms early metabolic damage in Alzheimer's disease

Mon, 07 Mar 2022 11:00:00 GMT

7T Sodium MRI may well prove increasingly useful in the study of physiological processes in inflammatory and neurodegenerative diseases and brain tumors. An example is a study on Alzheimer's disease, led by a NeuroSpin team.

Brain aging: European funding to evaluate an early biomarker

Wed, 02 Mar 2022 11:00:00 GMT

The QSM4SENIOR project, led by NeuroSpin and the company VENTIO, aims at developing an original early biomarker of aging by using data from the SENIOR study of NeuroSpin. QSM4SENIOR has just been funded by the EOSC-Life.

AI: predicting simply and efficiently like the brain

Thu, 17 Feb 2022 11:00:00 GMT

Two researchers of UNICOG/NeuroSpin show that a gated recurrence model of neural networks would allow to make efficient and simple predictions, like our brain, in different environments. In addition to being biologically plausible, this model would be generalizable.

The genetic architecture of language functional connectivity revealed

Mon, 14 Feb 2022 11:00:00 GMT

Using data from the UK Biobank, the world's largest general population imaging-genetics cohort, a collaboration led by a team at BAOBAB (NeuroSpin) has identified genes involved in the genetic architecture of language functional connectivity. These genes could be a priority for studying natural language.

Brain development and mental health in adolescents and young adults

Tue, 25 Jan 2022 11:00:00 GMT

A NeuroSpin team has exploited data on mental health and brain developmental disorders of subjects in the Healthy Brain Network cohort. It established a link between certain symptoms, precursors of possible mood disorders, and structural changes in the developing brain in more than 650 young people.

Minimal computational models accounting for emergence of a specific region underlying orthographic coding

Tue, 30 Nov 2021 11:00:00 GMT

Researchers from NeuroSpin designed, trained and tested biologically plausible artificial deep neural networks to identify pictures and written words. They show that these may suffice to account for emergence during reading acquisition of the visual word form area, a specific region underlying orthographic coding.

Deeptope: accelerating the development of therapeutic antibodies via high-throughput functional tests

Mon, 29 Nov 2021 11:00:00 GMT

Deeptope, founded in February 2021 from a technology developed at the DMTS Laboratory of Cellular Immunology and Biotechnology (LICB), is a company of therapeutic antibody engineering that provides antibody optimization and characterization services to biotech or pharmaceutical firms with the goal of increasing the quality of antibodies in a very short timeframe.

The most powerful MRI scanner in the world delivers its first images!

Thu, 07 Oct 2021 05:00:00 GMT

September 2021, the 11.7 Tesla MRI of the Iseult project, the most powerful in the world for human imaging, has just unveiled its first images.

A combinatorial neural code for speech is present in the infant

Tue, 14 Sep 2021 10:00:00 GMT

Researchers at UNICOG (NeuroSpin) show, using a high-resolution electroencephalographic system, that speech, an extremely complex and variable acoustic signal, is perceived by infants as a sequence of stable and invariant segments through an encoding based on distinctive and orthogonal phonetic features, such as manner and place of articulation, which are secondarily combined into phonemes, such as ″b″ or ″m″.

Automatic recognition of brain "lines"

Mon, 23 Aug 2021 10:00:00 GMT

Researchers at NeuroSpin (CEA-Joliot) propose to automate the classification and recognition of folding patterns on the surface of the cortex that may be related to the occurrence of psychiatric diseases or cognitive disorders using artificial intelligence algorithms. A path towards deciphering the "lines" of the brain.

A marine neurotoxin, seafood contaminant, is able to cross physiological barriers

Thu, 05 Aug 2021 10:00:00 GMT

In a study published in Science of the Total Environment, researchers from SIMoS (DMTS/CEA-Joliot), in collaboration with the Faculty of Pharmacy of Paris and MIRCen (CEA-Jacob) have shown for the first time in an animal model the capacity of Pinnatoxin-G, a marine neurotoxin, to cross physiological barriers to reach its molecular targets.

Diffusion MRI characterizes radiation-induced neurological impairments

Thu, 24 Jun 2021 10:00:00 GMT

A team comprising iRCM (CEA-Jacob) and NeuroSpin (CEA-Joliot) researchers analyzed the consequences of irradiation on brain development and neurogenesis in a preclinical model. That work, published in Radiation Research, lays a path for the use of diffusion imaging for the early detection of neurological abnormalities resulting from different types of stress.

Characteristics of the initial symptoms of Alzheimer's disease in young patients

Thu, 10 Jun 2021 10:00:00 GMT

Researchers from BioMaps (SHFJ) and the Department of Memory and Language Neurology (Ste Anne's Hospital) studied the early clinical signs of Alzheimer's disease (AD) reported by young patients (< 62 years old) compared to those reported in classic AD of the elderly (> 65 years old). They show that these signs are misleading and often appear in the professional context.

Evaluation of the immunogenicity of peptide-drugs containing non-natural modifications

Tue, 01 Jun 2021 10:00:00 GMT

A team from SIMoS (DMTS) in collaboration with Sanofi shows that the introduction of non-natural sequences into an immunogenic peptide attenuates the immune response against this peptide, an approach that could guide the design of less immunogenic, and therefore more effective, therapeutic peptides.

PET imaging reveals the neuropharmacology of buprenorphine

Wed, 05 May 2021 10:00:00 GMT

Researchers at BioMaps (SHFJ) have succeeded in determining the interaction dynamics of buprenorphine, an opioid drug with a particularly complex pharmacology, with its brain receptors in vivo. To do so, they developed an original PET imaging approach based on the use of the radiolabeled molecule (11C-buprenorphine).

Humans Share an Exceptional Sense of Geometry

Fri, 23 Apr 2021 10:00:00 GMT

Research from CEA, Collège de France, CNRS and Université Paris 8 shows that humans share a universal ability to understand abstract geometric concepts. This human ability does not depend on age, culture or education, but does not exist in the non-human primates tested. PNAS has just published their results.

Brain sulci imaging and genetics: the UK Biobank cohort has spoken.

Mon, 19 Apr 2021 10:00:00 GMT

Researchers from NeuroSpin and CNRGH (Jacob Institute) have studied, on a genome-wide scale, the potential associations of haplotypes (set of variants located side by side on a chromosome) with the opening value of imaged brain sulci, indicator of brain aging, from the UK Biobank neuroimaging-genetics cohort.

How works Mambalgin-1, an analgesic peptide from black mamba venom

Thu, 08 Apr 2021 10:00:00 GMT

Teams from IPMC and SIMoS (DMTS) defined the molecular determinants of the interaction between Mambalgin-1, an analgesic peptide isolated from black mamba venom, and its target, ASIC1 (Acid-Sensing Ion Channels), to model, using molecular dynamics, this complex. The resulting model provides clues to develop blockers of ASIC1, interesting targets for clinical pain relief applications.

Aloïse Mabondzo receives exceptional funding from NIH !

Mon, 29 Mar 2021 10:00:00 GMT

Aloïse Mabondzo, research director, head of the Neurovascular Pharmacology Group of the SPI (DMTS), co-founder and scientific director (CSO) of CERES BRAIN THERAPEUTICS, has just obtained funding of nearly one million US dollars from the prestigious National Institute of Health for his project « Neuroprotective Strategy: Novel Purine Derivatives for Neonatal Hypoxia-ischemia ».

Food poisoning? Targeted mass spectrometry brings an answer

Thu, 18 Mar 2021 11:00:00 GMT

SPI (DMTS), in collaboration with ANSES, has developed a test based on immuno-capture and targeted mass spectrometry for the quantitative and multiplex identification, in dairy products, of the eight main enterotoxins of Staphylococcus aureus, responsible for food poisoning epidemics.

Metabolomics for the clinician and the development of a neuroprotective strategy in acute stroke

Thu, 04 Feb 2021 11:00:00 GMT

The TIRO team (SHFJ), in collaboration with the neurovascular clinicians of the Nice and Marseille University Hospitals, carried out analyses of the metabolome of cerebral clots at the origin of the occlusion of a cerebral artery responsible for a cerebral vascular accident (stroke). A pilot study that improved the understanding of the complex relationship between blood glucose levels and patients' functional prognosis.

Towards a transcranial echography

Tue, 19 Jan 2021 11:00:00 GMT

Jean-Luc Gennisson (BioMaps/SHFJ) coordinated, in partnership with the CEA-List (Sylvain Chatillon), the EchoBrain project (ATTRACT/H2020) aimed at adapting the digital tools developed by the List (CIVA platform) to significantly increase the quality of brain echography images, simple alternative compared to the methods (MRI, X-ray scanner) currently used for the diagnosis of strokes.

Launch of AROMA, a european project to exploit the full potential of NeuroSpin's future 11.7 T scanner.

Wed, 06 Jan 2021 11:00:00 GMT

AROMA, a FET-Open H2020 project, aims to develop the methodology necessary for the optimal operation of the future 11.7 T MRI being installed at NeuroSpin. This 5-year project, coordinated by Nicolas Boulant (NeuroSpin), with an overall budget of 3.6 million euros, involving six partners from five countries representing academia and industry, started on January 1, 2021.

Amazing discovery: Variovorax, a bacterium that lives in the heart of a working nuclear reactor!

Thu, 17 Dec 2020 11:00:00 GMT

Researchers from I2BC and SPI (DMTS, Marcoule), in collaboration with CEA Grenoble and the Belgian nuclear research center, discovered, by using two meta-omic approaches, living bacteria in the core pool of the CEA Paris-Saclay research reactor, Osiris, in operation, thus opening up perspectives for the discovery of new radioresistant species.

An atypical cerebral organization for language

Wed, 09 Dec 2020 11:00:00 GMT

Researchers from the Neurofunctional Imaging Group (GIN, NeuroSpin, Bordeaux) studied by functional MRI, the organization of the brain network of sentence processing in individuals "atypical" for language, i.e. with a major role of the right hemisphere.

CEA carries for France the EBRAINS infrastructure inscription on the ESFRI roadmap

Wed, 09 Dec 2020 11:00:00 GMT

EBRAINS (European Brain ReseArch INfrastructureS) is a european research infrastructure designed by the scientific community which, based on a set of state-of-the-art digital platforms, aims to answer the analysis and processing needs of large brain data sets. CEA carries for France EBRAINS inscription on the European Strategy Forum on Research Infrastructures roadmap, which was submitted in early September 2020.

BRICON, a project of the Human Brain Project for NeuroSpin (UNICOG)

Thu, 29 Oct 2020 11:00:00 GMT

Theofanis Panagiotaropoulos (NeuroSpin) obtains funding from the Human Brain Project for BRICON (Brain Inspired Consciousness), a project of HBP's neuroscience activities.

Analysis of multitask functional MRI data for the establishment of a neurocognitive atlas of the human brain

Thu, 08 Oct 2020 10:00:00 GMT

In this study, NeuroSpin researchers leveraged the Individual Brain Charting (IBC) dataset, acquired by high-resolution functional MRI during the performance of behavioural tasks, to investigate the feasibility of individual mapping of the cognitive components underlying the tasks. They thus individualized six regions of interest in the language network and established their cognitive profile.

Functional neuroanatomy of number processing at high-resolution

Wed, 23 Sep 2020 10:00:00 GMT

NeuroSpin researchers used ultra-high field (7 Tesla) functional magnetic resonance imaging (fMRI) to better localize the processing and manipulation of numbers in the human brain. The results, which enrich our understanding of the functional organization of the intra-parietal sulcus, the cerebral center of digitization, are published in NeuroImage.

Towards a new generation of antennas for ultra-high field imaging of the brain

Tue, 22 Sep 2020 08:06:13 GMT

The European Commission once more places its trust on Multiwave company and its partners, Aix-Marseille Université , CEA and Université Catholique de Louvain to revolutionize ultra-high field magnetic resonance imaging of the brain.

Predicting brain age using a computer model

Mon, 14 Sep 2020 10:00:00 GMT

Researchers from the PARIETAL team (Inria/CEA) at NeuroSpin and the University of Zurich have developed a computer model capable of accurately determining brain age. This model could be used to combine different types of brain function tests to predict, for example, cognitive decline or depression.

A new molecule to fight against intracellular pathogens

Mon, 14 Sep 2020 10:00:00 GMT

The SCBM and SIMoS collaborated to optimize the activity of Retro-1, a benzodiazepine compound, inhibitor of Shiga toxins and ricin, derived from high-throughput biological screening. They succeeded in obtaining an analog 70 times more protective against the cytotoxicity of Shiga toxins, Retro-1.1.

Methylglyoxal detoxification revisited in cyanobacteria

Fri, 04 Sep 2020 10:00:00 GMT

A team from I2BC (SB2SM) used a combination of in vitro and in vivo approaches in the model cyanobacterium Synechocystis to establish a logical, but as yet never described, link between the detoxification of methylglyoxal, a toxic metabolite, and glutathione S-transferase, an enzyme of the xenobiotic metabolism, conserved during evolution.

SARS-CoV-2 detection: mass spectrometry shows its potential for rapidity.

Thu, 06 Aug 2020 10:00:00 GMT

A team from SPI in Marcoule detected by mass spectrometry, in 3 minutes and without specific reagents, signature peptides of the SARS-CoV-2 virus in clinical samples (nasopharyngeal swabs). It thus provides a proof of concept of the use of this method as a possible alternative to PCR, currently the reference method.

Mapping of normal brain aging: unprecedented results from the SENIOR cohort

Tue, 04 Aug 2020 10:00:00 GMT

The SENIOR study, conducted by several NeuroSpin teams, consists in monitoring, since March 2012, a cohort of 100 subjects aged 50 to 70 years by annual MRI imaging over a period of 10 years, to establish a normal aging brain imaging biomarkers mapping. This publication in Alzheimer's Research & Therapy describes the baseline experimental protocol and presents first promising results.