https://joliot.cea.fr/drf/joliot/en/Pages/news/Science/2026/Photosynthese-carence-de-manganese-mutants-transporteur-mn-Arabidopsis.aspx Website of the Frédéric-Joliot Institute of Life Sciences which includes 4 departments: I2BC, DMTS, NeuroSpin and Service hospitalier Frédéric Joliot (SHFJ). The teams are mainly located at the CEA Paris-Saclay center and at the Orsay hospital. en-US https://www.cea.fr/Style%20Library/Themes/drf/instituts/images/logo-cea-joliot-2023.png https://joliot.cea.fr/drf/joliot/en https://www.cea.fr/drf/joliot/en/Pages/news/Science/2026/proteins-nanoplastics.aspx Peptides and proteins adsorb onto plastic nanoparticles, forming a corona. Researchers from I2BC and CEA-Iramis, using molecular modeling, reveal distinct adsorption behaviors depending on their amino acid sequences. They thus establish a mechanical basis for predicting peptide-plastic interactions, a crucial element for assessing the risks these interactions pose to health and ecosystems. Molecular mechanisms ; Simulation ＆ modelling Researchers SB2SM Scientific result ; Article Mon, 16 Mar 2026 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2026/Photosynthese-carence-de-manganese-mutants-transporteur-mn-Arabidopsis.aspx Researchers from the I2BC show that two Arabidopsis thaliana mutants deficient in manganese transport do not regulate photosynthetic electron transport in the same way, with different consequences for photosynthesis. Molecular mechanisms ; Photosynthesis Researchers SB2SM Scientific result ; Article induction de fluorescence;fluorescence de la chlorophylle;quenching non photochimique;transitions d’état; Thu, 12 Mar 2026 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2026/Regulation-Fe–S-cluster-biosynthesis-elucidated.aspx A team from I2BC has uncovered the key steps governing the assembly and regulation of iron–sulfur cluster biosynthesis, essential metallic cofactors involved in numerous biological functions. Defects in this process lead to pathologies such as Friedreich’s ataxia. These studies represent major advances toward the development of future therapies. Cellular mechanisms ; Molecular mechanisms ; Diseases SBIGEM Scientific result Fri, 16 Jan 2026 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Effet-qualite-lumiere-sur-photosynthese.aspx Une étude menée par une équipe de l'I2BC montre que la surexcitation du photosystème II est responsable de la faible valeur de qL, un paramètre de fluorescence, chez des mutants d’Arabidopsis thaliana incapables de réaliser des « transitions d’état ». Photosynthesis ; Molecular mechanisms ; Cell and molecular imaging Researchers SB2SM Scientific result ; Article Fri, 26 Sep 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Mitose-KIF2C.aspx A study led by the I2BC shows that the formation of condensates of the enzyme KIF2C enables the concentration of two other proteins, PLK1 and phosphorylated BRCA2, on kinetochore microtubules during mitosis. This would serve to control chromosome alignment on the spindle and contribute to their stability. DNA ; Structural biology ; Cancer Researchers SB2SM Scientific result Mon, 08 Sep 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Tolerance-opioid-PET.aspx A study combining PET imaging and pharmacology, conducted by researchers at BioMaps (SHFJ), suggests that decreased availability of opioid receptors and altered neuronal energy metabolism constitute molecular signatures of opioid tolerance. These observations, made in an animal model, could help improve understanding and treatment of opioid dependence. Positron Emission Tomography ; Molecular mechanisms Researchers SHFJ Scientific result ; Article opiate;preclinical model; Wed, 06 Aug 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Sequence-desordonnee-Rad52-assemblage-Rad51.aspx En utilisant Saccharomyces cerevisiae comme modèle, des chercheurs des instituts CEA-Jacob et CEA-Joliot, et de l’Institut Curie, avec leurs partenaires du synchrotron SOLEIL, ont révélé comment la protéine Rad52 agit comme un chaperon pour guider et stabiliser l’assemblage de Rad51, une étape clé de la recombinaison homologue.​ Structural biology ; Cellular mechanisms ; Molecular mechanisms Researchers SB2SM Scientific result Mon, 28 Jul 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Drug-candidate-for-treatment-neonatal-encephalopathy.aspx Researchers from the SPI (DMTS) and the Women & Infants Hospital in Providence have laid the molecular basis for the neuroprotection of a purine derivative in a preclinical model of neonatal hypoxic-ischemic encephalopathy (HIE). The promising results support the development of this drug candidate to treat HIE in neonates. Pharmacology ; Brain ; Molecular mechanisms ; Diseases SPI Scientific result animal models;preclinic; Thu, 26 Jun 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/thylakoid-3D-organisation-high-resolution-fluorescence-microscopy.aspx A team from I2BC has applied a novel fluorescence microscopy method to reconstruct 3D chloroplast volumes from 2D images. A promising approach for monitoring variations in the volume of the photosynthetic membrane network in response to environmental fluctuations in plants. Photosynthesis ; Microscope SB2SM Scientific result ; Article Tue, 08 Apr 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/perylene-fission-singulet.aspx Une étude internationale menée par un laboratoire de l’I2BC montre qu’un phénomène quantique appelé fission du singulet peut se produire lorsqu’une molécule modèle est mise en solution aqueuse et qu’elle se dimérise. L’étude spectroscopique exhaustive ouvre de nouvelles voies de recherche pour le développement de systèmes photocatalytiques efficients en milieu aqueux. Photosynthesis ; Bio-inspired catalysis Researchers SB2SM Scientific result Mon, 24 Mar 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Next-generation-sequencing-chess-game.aspx A team from I2BC has proposed a thought experiment -the Next Generation Sequencing chess problem-, which treats sequencing data as a superimposed image of several independent chess games. A more realistic approach to the dynamics of cellular processes within each cell, revealing the limits of NGS approaches to temporal analysis. Bioinformatic ; DNA ; Molecular mechanisms ; Simulation ＆ modelling SBIGEM Scientific result Mon, 17 Feb 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/New-model-redox-regulation-photosystem-I.aspx A team from I2BC has studied the regulation of oxygen reduction to superoxide at photosystem I (PSI) in several redox mutants of the plant A.thaliana, grown during different photoperiods. The results enable to propose a new model of PSI-specific redox regulation, capable of rapid adaptation according to light conditions Photosynthesis SB2SM Scientific result Tue, 05 Nov 2024 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Nucleosome-positioning-yeast-genome.aspx A team from I2BC has studied the positioning of nucleosomes in the yeast S cerevisiae genome, using an original mathematical method to analyze next-generation sequencing data. This mapping highlights the role of chromatin remodeling complexes in nucleosome organization. DNA ; Large-scale biology SBIGEM Scientific result Fri, 28 Jun 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/DNA-recombination-lock.aspx Teams from I2BC, Institut Curie and IRB shed light on how the human nuclease MRN works. Structural predictions obtained with AlphaFold2 and confirmed by in vitro and in vivo experiments show that the phosphorylated Sae2/CtIP protein forms a network of interactions with MRN that favours the removal of its autoinhibition. Structural biology ; DNA ; Molecular mechanisms ; Artificial intelligence Researchers SB2SM Scientific result Tue, 25 Jun 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/HROB-MCM8-MCM9.aspx Researchers from the AMIG team (I2BC department), in collaboration with the IRB (Switzerland), have modeled the interaction between HROB and the helicases MCM8-MCM9, some mutations of which predispose individuals to infertility or cancer. They demonstrate that HROB promotes the catalytic activity of the MCM8-MCM9 complex but does not play a role in its recruitment or stability. Structural biology ; Molecular mechanisms Researchers SB2SM Scientific result ; Article AlphaFold;AlphaFold2; Wed, 22 May 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Epigenetics-CAF-1.aspx A team from the I2BC, in collaboration with the Institut Curie and Soleil, has shown that the CAF-1 protein combines flexible regions and rigid modules in its spatial organisation to deposit histones on DNA and effectively couple this process to DNA synthesis. Epigenetics ; Structural biology Researchers SB2SM Scientific result ; Article Tue, 26 Mar 2024 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Rapid-genome-replication-role-of-Rif1-protein.aspx I2BC researchers show that the Rif1 protein restrains the replication program and the recruitment of replication initiation factors during early embryonic divisions in X laevis. A step towards elucidating the molecular mechanisms involved in diseases resulting from Rif1 mutations in humans Molecular mechanisms ; DNA SBIGEM Scientific result ; Article Thu, 21 Dec 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Potential-drought-resistance-mechanism-plants.aspx I2BC researchers identify drought-resistant mutants of the model plant A. thaliana. These mutants are no longer able to carry out the state transition, a process that enables plants to adjust the absorption of light by their two photosystems in an optimal way. They could constitute a way of improving crop resistance to drought. Photosynthesis SB2SM Scientific result Thu, 07 Dec 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/phytic-acid-DNA-repair.aspx In an article published in the journal Nucleic Acids Research, scientists from the I2BC, lPBS and the Institute for Structural and Chemical Biology (University of Leicester, UK) demonstrate how phytic acid, a product of cellular metabolism, stabilises the assembly of a complex enabling the repair of DNA breaks in humans. DNA ; Structural biology Researchers SB2SM Scientific result ; Article Mon, 04 Dec 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Multiplier-chimeres-mieux-comprendre-interactions-inhibiteur-cible-proteique.aspx En substituant des segments d’hélice alpha​ par des segments d’oligo-urées dans un peptide inhibiteur d’ASF1, lui conférant ainsi une résistance accrue aux protéases, des chercheurs de l’I2BC en collaboration avec l’IECB explorent les modes de liaison de ces chimères peptide-urée à leur cible. Molecular mechanisms ; Structural biology Researchers SB2SM Scientific result ; Article Tue, 12 Sep 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/New-role-Mediator-transcription-chromatin-organization.aspx A team from I2BC has shown that the Mediator of transcription from the yeast S.cerevisiae physically interacts with the chromatin remodeling complex, and that by co-localizing with this complex on DNA promoter regions, it contributes to chromatin organization favorable to transcription initiation. Health ＆ life sciences ; DNA ; Molecular mechanisms SBIGEM Scientific result Mon, 24 Jul 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/proteines-dispersion-microplastiques-dans-eau.aspx Des chercheurs de l’I2BC ont contribué à une étude menée par l’Iramis qui dévoile le rôle des protéines dans la dispersion des microplastiques dans l’eau. Leurs résultats permettent d’imaginer de nouvelles stratégies low tech pour débarrasser l’eau de cette pollution. Impacts on living (organisms) ; Molecular mechanisms ; Remediation Researchers SB2SM Scientific result surfactant;polypropylène;polyéthylène; Wed, 12 Jul 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/HTA-toxine-animale-recepteur-angiotensine-II.aspx SIMoS researchers have identified and characterised an animal toxin (A-CTX-Mila) as a ligand for angiotensin II receptors, which are involved in one of the signalling pathways targeted by antihypertensive drugs. A tool of choice for studying the cellular mechanisms controlled by these receptors. Molecular mechanisms ; Diseases Researchers SIMOPRO Scientific result Fri, 16 Jun 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Reparation-ADN-PAXX.aspx An international collaboration led by researchers from I2BC/CEA-Joliot and IPBS (Toulouse) has solved the atomic structure of molecular assemblies involved in the repair of DNA double-strand breaks. The diversity of assemblies involving the PAXX protein identified in this study highlights the great flexibility of the repair machinery, which could reflect its ability to adapt to biological conditions. The results were published in Science Advances. Structural biology ; Molecular mechanisms Researchers SB2SM Scientific result cryoEM;radiocristallographie; Tue, 06 Jun 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Manganese-homeostasis-functioning-photosynthesis.aspx A team from I2BC shows, by using super-resolution fluorescence microscopy and transmission electron microscopy approaches, that both excess and deficiency of Mn affect the organization of thylakoid membranes and photosynthetic electron transport in the plant Marchantia polymorpha Photosynthesis SB2SM Scientific result ; Article Thu, 20 Apr 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Model-cyanobacterium-production-high-value-terpenes.aspx Through two publications, an I2BC team demonstrates the high biotechnological potential of the model cyanobacterium Synechocystis PCC 6803 for the photosynthetic production of high value-added organic compounds, the terpenes. Photosynthesis ; Microalgae ; Biotechnology SB2SM Scientific result Fri, 10 Feb 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/BAF-numerical-simulation-phosphorylation.aspx Using molecular dynamics simulation and NMR studies, I2BC researchers detail the restriction mechanisms of BAF protein dynamics due to its phosphorylation. Molecular mechanisms ; Structural biology ; Simulation ＆ modelling Researchers SB2SM Scientific result Mon, 16 Jan 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Mathematical-model-repair-genome.aspx The protocols applied for in vivo mapping of nuclear processes, at the genome scale and at very high spatial resolution, do not allow for high temporal resolution. A team from the I2BC has therefore demonstrated that such an understanding could be wrong by using a mathematical model. This model can be applied to any process that can be modeled by a transition between two states. DNA ; Cellular mechanisms Researchers IBITECS Scientific result XR-seq;réparation de l’ADN;NER; Tue, 13 Dec 2022 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Mediator-transcription-gene-expression-regulation-DNA-repair.aspx An I2BC team has analyzed, at the genome scale of the yeast S.cerevisiae, the functional interactions between the Mediator of gene transcription and DNA repair proteins, reinforcing the idea that these two fundamental cellular processes are closely linked. Molecular mechanisms ; Cellular mechanisms ; DNA SBIGEM Scientific result Mon, 26 Sep 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Photoreduction-of-CO2-by-iron-porphyrins.aspx ​Researchers from ICMMO* and ISMO**, in collaboration with a team from I2BC, show that the urea-decorated iron porphyrin catalysts they developed previously for the electro-catalysis of CO2, can be successfully employed in a photo-catalytic approach. Chemistry ; Bio-inspired catalysis ; Photosynthesis SB2SM Scientific result Thu, 16 Jun 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Intrahepatic-cholestasis-biochemistry-structure-ATP8B1.aspx A collaborative study involving an I2BC team unveils the mechanism of autoinhibition of the human flippase ATP8B1, as well as its regulation by lipids and phosphorylation. The study provides a better understanding of the impact of flippase mutations responsible for intrahepatic cholestasis on its enzymatic activity. Molecular mechanisms ; Structural biology Researchers SB2SM Scientific result ATP;hydrolyse;protéine membranaire;modifications post-traductionnelles;expression hétérologue;membranes;cryo-EM; Thu, 09 Jun 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Electron-spectroscopy-DNA-photorepair.aspx A team from the I2BC has just demonstrated, using transient absorption spectroscopy, that the repair of UV-induced damage in DNA by a repair enzyme (6-4) photolyase occurs in two successive photoreactions. Photosynthesis SB2SM News ; Article Wed, 23 Mar 2022 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Modeling-pairing-crossover-meiosis.aspx In a study conducted by a team from the Institut Curie, researchers from the CEA-Joliot (B3S/I2BC department) have modeled in silico protein-protein interactions and thus contributed to establish at the molecular level the mechanisms that coordinate the pairing and recombination of homologous chromosomes during meiosis. Simulation ＆ modelling ; Structural biology ; Molecular mechanisms Researchers SB2SM Article ; Scientific result recombinaison homologue;AlphaFold;crossing-over;InterEvDock3; Thu, 13 Jan 2022 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/senescence_biomarkers_chromatin.aspx Researchers from the DMTS and I2BC depatments of the Joliot Institute's " identify three potential new biomarkers of senescent cells containing persistent DNA damage. Molecular mechanisms Researchers SBIGEM Scientific result Wed, 17 Nov 2021 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Singlet-Fission-Plants-Carotenoids.aspx Researchers from I2BC (CEA-Joliot/CNRS/UPSay, in collaboration with the JP Bourgin Institute and the University of Vilnius, decipher for the first time the energy dissipation process called "singlet fission" in two natural flower carotenoids, a fundamental mechanism for the design of new and more efficient multi-electron photocatalysts. Solar energy ; Photosynthesis ; Quantum Physics Scientific result Mon, 30 Aug 2021 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Plants-dissipation-exces-energy.aspx In a study published in JBC, a team from I2BC/CEA-Joliot, in collaboration with the Beijing Botanical Institute (China), describes for the first time an intermediate state of the light-harvesting antenna of higher plants that provides a better understanding of the changes that take place at the molecular level during the activation of a plant's photoprotection mechanism. Photosynthesis ; Molecular mechanisms Researchers SB2SM Scientific result Raman analyzer; Mon, 05 Jul 2021 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Small-RNA-regulates-photoprotection-cyanobacteria.aspx A team of the I2BC (LMB/SB2SM), in collaboration with the Institute of Biology (Freiburg University), discovered a posttranscriptional regulatory mechanism linking the expression of the cyanobacterial Orange Carotenoid Protein, related to photoprotection, directly and in an inverse fashion, to the synthesis of the light collector complexes (phycobilisomes), via a 3’ end-derived small RNA. Photosynthesis ; Microalgae ; Molecular mechanisms Scientific result Wed, 23 Jun 2021 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/accumulation-mutations-microfluidique.aspx Teams from CEA-Iramis and CEA-Joliot (team "Genome transcriptional regulation /I2BC) have joined forces to develop and validate an innovative microfluidic-based system that automatizes cell culture over many generations. It enables with considerable time savings large-scale experiments to be carried out, which are essential for understanding the cellular mechanisms involved in DNA mutation events. DNA ; Cellular mechanisms Researchers Iramis Scientific result Fri, 11 Jun 2021 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/phosphorylation-BAF-interaction.aspx ​A study by researchers from I2BC department shows in vitro the effect of mitotic phosphorylation of the BAF protein on its structure and its interactions with DNA and lamina and unveils consequences on genome organization and on mechanisms responsible for progeroid syndromes. Molecular mechanisms ; DNA ; Structural biology Researchers SB2SM Scientific result NMR;radiocristallography; Mon, 29 Mar 2021 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Foldamer-inhibitor-ASF1.aspx I2BC researchers, in collaboration with the European Institute of Chemistry and Biology (University of Bordeaux, CNRS), have developed a chimeric peptide/foldamer molecule that is resistant to proteolysis and inhibits ASF1, a potential target for anticancer treatment. The resolution of the structure of this chimera in interaction with its target, the first of its kind, reveals an unsuspected plasticity of the urea-based backbone that hugs the surface of ASF1. Structural biology ; Molecular mechanisms ; Epigenetics ; Cancer Researchers SB2SM Scientific result NMR;radiocristallography; Fri, 19 Mar 2021 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Sarcolipin.aspx By combining molecular dynamics and in vitro experiments, researchers at the LPSM (I2BC) have revealed the mode of action of sarcolipin in regulating the activity of SERCA1a, responsible for muscle relaxation. Molecular mechanisms ; Fundamental Research Researchers Saclay Scientific result Fri, 05 Mar 2021 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/E340-SERCA-communication.aspx A study led by Oxford University researchers and involving researchers from the Institut Joliot (I2BC) and the University of Århus reveals the crucial role of the E340 residue in the inter-domain communication of the calcium transporter SERCA. Molecular mechanisms Researchers SB2SM Scientific result fluorescence;mutagenesis;tryptophan; Fri, 15 Jan 2021 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Depression-gut-microbiota.aspx A study led by the Institut Pasteur and involving CEA-Joliot has shown, in a mouse model, that a modification of the intestinal microbiota caused by chronic stress is accompanied by modifications of the metabolome which induce a defect in the signaling pathway for endogenous cannabinoids in the hippocampus, which may explain the mood disorders observed. Metabolomics ; Molecular mechanisms Researchers SPI Scientific result Microbiology;neural circuits; Tue, 15 Dec 2020 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2020/Bruno-Robert-awarded-Honoris-causa-Professor-Vilnius.aspx This appointment comes after more than 15 years of close scientific collaboration between Bruno Robert's team in CEA Paris-Saclay and the Physics Department of the University of Vilnius. Quantum Physics ; Photosynthesis News ; Article Thu, 19 Nov 2020 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Cyanothece-PCC7425-new-model-cyanobacterium-limonene.aspx I2BC and SCBM teams have identified and reprogrammed a new model of cyanobacterium, Cyanothece PCC 7425, for the photosynthetic production of a high value-added monoterpene, limonene, used in many industrial applications. Photosynthesis ; Microalgae Scientific result Tue, 17 Nov 2020 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Mambaquaretin-theranostic.aspx In pursuing their work on mambaquaretin, SIMoS researchers conducted a collaborative study confirming the therapeutic potential of the toxin and paving the way for its use as a diagnostic tool. Diagnosis and innovative treatment ; Molecular mechanisms ; Cellular mechanisms SIMOPRO Scientific result PET Scan;PK/PD; Tue, 10 Nov 2020 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/DUB-virale-ubiquitin.aspx A study led by a team from the Institut Joliot (I2BC/B3S) reveals an unusual mode of interaction between a viral deubiquitinase and a ubiquitin, which appears to be optimized to finely control virus replication. Molecular mechanisms SB2SM Scientific result crystal structure;deubiquitinilation;viral protease; Tue, 08 Sep 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Methylglyoxal-detoxification-in-cyanobacteria.aspx A team from I2BC (SB2SM) used a combination of in vitro and in vivo approaches in the model cyanobacterium Synechocystis to establish a logical, but as yet never described, link between the detoxification of methylglyoxal, a toxic metabolite, and glutathione S-transferase, an enzyme of the xenobiotic metabolism, conserved during evolution. Photosynthesis ; Toxicology ; Microalgae News Fri, 04 Sep 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Artificial-photosynthesis-nano-polymer-mimicking-PSII.aspx Researchers from the I2BC (SB2SM), in collaboration with CNRS (LCP, ICMMO) have designed an original artificial photosynthesis approach, based on the use of semiconductor nanopolymers composed of PolyDiPhenylButadiyne, capable of reproducing the full photo-redox reaction of plant Photosystem II, that is the production of O2 by photo-oxidation of water and the reduction of a quinone. Photosynthesis ; Bio-inspired catalysis Scientific result Tue, 07 Jul 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Dynamics-PTOX-thylakoides.aspx A collaboration led by I2BC researchers presents, in the Journal of Experimental Botany, a body of evidence for a dynamic association of the PTOX protein with thylakoid membranes, dependent on proton motive force. Bioenergy ; Molecular mechanisms SB2SM Scientific result photosystem;ATP; Sat, 02 May 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/BRCA2-breast-cancer.aspx ​In a study conducted by a team from the Institut Curie, I2BC researchers have used their NMR know-how to study the phosphorylation of BRCA2 and have thus contributed to revealing a mechanism potentially at the origin of chromosomal aberrations observed in breast BRCA2-mutated tumors. Molecular mechanisms ; Cancer SB2SM Scientific result homologous recombination;Rad51;kinase; Mon, 27 Apr 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Mobile-laboratory-study-genetic-material-extinct-species.aspx A collaboration between researchers from I2BC@Saclay, the french Muséum National d'Histoire Naturelle and owners of prehistoric sites shows the possibility of using a mobile laboratory to quickly identify DNA of archaeological specimens. Evolution ; DNA Scientific result Wed, 08 Apr 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Characterization-new-player-tolerance-thermal-oxidative-stress.aspx Researchers from SB2SM (I2BC@Saclay) have shown for the first time in vivo in the model cyanobacterium Synechocystis that a cellular detoxification enzyme, the membrane glutathione-S-transferase (GST), maintained in part by evolution, plays a major role in resistance to thermal and oxidative stress, making this cellular model a valuable tool for the study of GSTs conserved from bacteria to plants, down to Humans. Photosynthesis ; Stress response Scientific result Tue, 18 Feb 2020 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/A-clean-efficient-photocatalysis-production-compounds-interest.aspx A team from I2BC@Saclay, in collaboration with the CNRS (ICMMO, UPSud and ISM2, Aix-Marseille University) has shown that the use of a reversible electron acceptor, able to accept and transfer an electron, in place of a sacrificial electron donor optimizes efficient and clean photocatalysis reactions for the production of organic compounds of interest. Photosynthesis ; Bio-inspired catalysis Scientific result Fri, 18 Oct 2019 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/A-ferredoxin-to-fuel-metabolic-pathways.aspx Researchers at BIAM and I2BC@Saclay, in collaboration with Japanese colleagues from Okayama University and Ehime, have characterized in a cyanobacterium a minor protein that diverts part of the energy from photosynthesis to secondary metabolic pathways. This discovery is promising to exploit these metabolic pathways in a biotechnological process of bioenergy production. Biotechnology ; Bioenergy ; Photosynthesis Scientific result Mon, 14 Oct 2019 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Molecular-evolution-Orange-Carotenoid-Protein-elucidated.aspx A new phylogenetic analysis of the Orange Carotenoid Proteins (OCPs) family, responsible for photoprotection in cyanobacteria, coupled with a functional study, was conducted by a team from I2BC@Saclay. This is the first functional study of the ancestral OCPX which, when compared to OCP1 and OCP2, revealed the molecular determinants that govern the photocycle of these proteins and in particular the fundamental role of the linker connecting the two domains of OCPs. Photosynthesis Scientific result Fri, 04 Oct 2019 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Lanreotide-nanoscrolls.aspx By studying the self-assembly of a hormone-derived peptide in the presence of lipid membranes, a team of the SB2SM (Joliot Institute / I2BC) in collaboration with the University of Rennes 1 and Ipsen biopharmaceutical group, shows how the interactions electrostatic type modify the structures of the assemblies formed by each of these molecules alone in solution. Molecular mechanisms ; Cell and molecular imaging SB2SM Scientific result Mon, 23 Sep 2019 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Elucidation-activation-mechanism-new-photoreceptor.aspx In collaboration with teams from ENS (Paris) and the University of Marburg, researchers from I2BC@Saclay have elucidated, by optical time-resolved spectroscopy, the complete phooactivation mechanism of a new cryptochrome of the green alga Chlamydomonas reinhardtii, CraCRY. Photosynthesis Scientific result Thu, 19 Sep 2019 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Glucocorticoids-better-evaluation-effect-cancers.aspx Senescence specialists (SBIGEM), in collaboration with the SCBM and the CNRGH (Jacob Institute), show that glucocorticoids can delay or even short-circuit it and disrupt its function as a tumor suppressor. Cellular mechanisms ; Molecular mechanisms ; Cancer Fontenay-aux-Roses Scientific result MEK/ERK;oncogenesis;Senescence; Mon, 09 Sep 2019 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Friedreich-Ataxia-reliable-in-vitro-model-function-frataxin.aspx By improving the in vitro reconstitution of the iron-sulfur clusters biosynthesis machinery, a team from SBIGEM (CEA-Joliot / I2BC), with its French, German and Spanish collaborators, clarifies the function of frataxin, a protein involved in Friedreich’s ataxia. Molecular mechanisms SBIGEM Scientific result Frataxin;Mössbauer;circular dichroism; Fri, 06 Sep 2019 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Transcription-and-DNA-repair.aspx Recent work by SBIGeM (I2BC@Saclay) highlights how two essential components of DNA transcription into RNA coordinate to recruit the Rad2/XPG DNA repair protein, thus linking these two fundamental cellular processes. Molecular mechanisms ; DNA Scientific result Thu, 22 Aug 2019 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Drs2-Cdc50-CryoEM-Structure-Nature.aspx Researchers from I2BC@Saclay, the University of Aarhus and the Max Planck Institute of Biophysics in Frankfurt reveals the first cryo-EM high-resolution structures of one of the P4-ATPases. Study has been published in Nature. It give a better insight towards the understanding of the transport mechanisms of membrane lipids. A lipid pathway through the protein membrane domain is suggested. Structural biology ; Molecular mechanisms Saclay Press release ; Scientific result lipid asymetry;P4-ATPase;membrane lipid translocation; Thu, 27 Jun 2019 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/New-light-on-photosynthesis-regulation-in-the-ancient-cyanobacteria-.aspx Plants, algae, cyanobacteria regulate their photosynthesis so that it is as effective as possible and not deleterious. A sutdy led by a SB2SM team unveils one of the mechanisms of regulation in cyanobacteria and show that it is very different from that equivalent in plants and algae. Photosynthesis SB2SM Scientific result plastoquinone;cytochrome b6f;photosystem;cyanobacteria; Wed, 20 Mar 2019 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/Recycle-carbone-dioxide-efficiently-cleanly.aspx A collaboration involving the SB2SM (I2BC@Saclay) works on bio-inspired processes to recycle carbon dioxide (CO2), a major environmental problem. Researchers have formulated a new catalyzer very efficient for reducing CO2 in water. The study has been published in Chemical Communications. Recovery of CO2 ; Photosynthesis SB2SM Scientific result Tue, 27 Nov 2018 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/New-function-discovered-protein-Rad52-serious-therapeutic-target-breast-cancer.aspx Rad52 has garnered great attention lately as a promising target in the battle against certain types of breast cancer. A team from IRCM, in partnership with researchers from the Frédéric-Joliot and Gustave Roussy Institutes, has shed new light on this protein. Stress response ; Molecular mechanisms Jacob Scientific result Rad51 filament;budding yeast;Srs2; Fri, 12 Oct 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/DNA-repair-zoom-first-steps.aspx A research team from the SB2SM (I2BC@Saclay), in collaboration with the CNRS, SOLEIL , Universities of Paris-Sud, Aix-Marseille and Paul Sabatier - Toulouse III and Gustave Roussy, has resolved structures of two complexes involved in radiation-induced DNA damages. These results were published in Nature Structural & Molecular Biology on October, the 5th. DNA ; Structural biology ; Molecular mechanisms SB2SM Press release Mon, 08 Oct 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/relationship-variants-BRCA1-cancer.aspx Research Teams from the Curie Institute, the Gustave Roussy Institute, as well as the biophysics teams from the Institute of Chemistry of Natural Substances and SB2SM (I2BC@Saclay) met to systematically identify structural defects and BRCA1 proteins encoded by variants of the BRCA1 gene, a gene predisposing to breast and ovarian cancer. Their results make it possible to propose a classification of these variants (neutral versus causal). Cancer ; Structural biology ; DNA Scientific result Fri, 28 Sep 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/valorisation-carbon-dioxide.aspx ​In studies published in ChemPhotoChem, I2BC@Saclay, SCBM and ICMMO researchers have developed a gentle method for photo-CO2 reduction by molecular catalysts, followed by a carbonylation reaction that immediately reuse the CO produced. This device can be used for the introduction of radioactive carbon atoms into molecules of therapeutic interest. Green Chemistry ; Photosynthesis Scientific result Thu, 06 Sep 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/advance-exchanges-recombination.aspx Collaborative work between the SBIGeM (I2BC@Saclay) and the Marseille Cancer Research Center, published in Molecular Cell, illuminates the mechanistic basis and genetic control of homologous recombination, a mechanism for repairing DNA breaks responsible for chromosome exchange during meiosis. However, canonical models do not explain the complexity of meiotic recombination profiles and this study, which reconstructs reaction intermediates, constitutes a major advance in the understanding of this mechanism. DNA ; Genomics News Tue, 15 May 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/artificial-photosynthesis-second-electron.aspx A Research Team from I2BC@Saclay (SB2SM), in collaboration with ISMO and ICMMO teams (CNRS / Univ.Paris-Sud, Univ.Paris-Saclay) measured accumulation kinetics of electrical charges within a molecular system designed for studies on artificial photosynthesis. These works, published in Angewandte Chemie, show for the first time the second electron of this fundamental process about the conversion of light energy into fuel. Health ＆ life sciences ; Photosynthesis Scientific result Wed, 21 Feb 2018 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2017/A-plant-strategy-for-betterenergy_technology.aspx Researchers from SB2SM and four other Research Teams (Yale University, Arizona State University, Argonne National Lab and Institute for High Performance Computing, Singapore) have identified a photosynthesis mechanism that protects plants from excess light energy . These results could contribute to the development of more efficient energy systems in new solar technologies. Photosynthesis ; Solar energy Scientific result Fri, 07 Jul 2017 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2017/MOMENTOM_project_at_the_SB2SM.aspx Winfried Leibl (SB2SM) is a member of the steering committee of the MOMENTOM project (MOlecules and Materials for the ENergy of TOMorrow, IRS PARIS-SACLAY, 2017-2020) This project, funded within the framework of the Strategic Research Initiatives (IRS) of Paris-Saclay University, concerns molecules and materials for the energy of tomorrow. Institutional ; Photosynthesis ; Bioenergy News Mon, 26 Jun 2017 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2016/Epigenetics_how_reach_inaccessible_genes.aspx ​Biologists have brought to light the operation of "chromatin remodellers", key enzymes in cells. They have discovered how the genetic material, condensed in the nucleus of the cell, needs to be remodelled so that the cell machinery can access the genes. This work, initiated by IBITECS/SBIGeM, coordinated by researchers from a CEA/CNRS/Université Paris-Sud laboratory, under an international collaborative project with Pennsylvania State University (USA) and Guangzhou University (China), was published in Nature on 4 February 2016.​​ Epigenetics News Wed, 12 Apr 2017 13:23:30 GMT https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2016/Mediator_transcriptional_regulation.aspx ​A genomic study of the role of the Mediator of transcriptional regulation, carried out by a SBIGeM team, shows that this multiprotein complex coordinate the multiple stages of the setting up of the transcriptional machinery in vivo.​​ DNA News Wed, 12 Apr 2017 13:23:19 GMT https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2015/High-light-induced-hydrogen-peroxide-production-.aspx The rate of oxygen reduction by photosynthetic electron transport is significant in the presence of high concentrations of CO2 and not under CO2 limitation. Photosynthesis News Wed, 12 Apr 2017 13:22:22 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2017/A_new_vision_of_the_in_vivo_function_of_the_transcription_mediator.aspx An in vivo, in vitro and in silico study of the Mediator of Transcriptional Regulation has shown how the function of this multiprotein complex is coordinated with another essential component of the transcription machinery, the TFIIB factor, and the architecture of the promoter. This study, led by SBIGeM, was conducted in collaboration with several other Research Teams (CNRS, CEA, INRA). DNA ; Health ＆ life sciences Scientific result Tue, 31 Jan 2017 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2017/Bicarbonate_new_redox_regulator_for_Photosystem_II.aspx ​This work, stemming from a collaboration between researchers from Imperial College London and an SB2SM Research Team, resolved a long-standing ambiguity about the redox potential (Em) value of the primary quinone, QA, of the Photosystem II (PSII). In addition, the authors discovered a new and very important phenomenon for the PSII: a reversible control effect of the redox potential of QA induced by binding of bicarbonate. Photosynthesis Scientific result Tue, 31 Jan 2017 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2015/Protection_from_too_much_light.aspx Photosynthetic organisms protect themselves from too much light using pigment photoswitches that absorb excess energy. American scientists (Berkeley, Michigan State University) and French researchers (SB2SM team) analyzed the structure of an active, energy-dissipating form of the orange carotenoid protein (OCP) from a cyanobacterium. Photosynthesis News Fri, 26 Jun 2015 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2015/Hug1_and_RNR.aspx ​A study, coordinated by a SBIGeM team in collaboration with a SB2SM team, allowed to describe the role of the Hug1 protein in regulating the activity of the ribonucleotide reductase complex (RNR). The level of active RNR is controlled during cell cycle and in response to DNA damages. DNA ; Stress response ; Cell division News Mon, 04 May 2015 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2015/How-does-mobile-DNA-sequence-find-target.aspx Certain mobile DNA sequences shape genomes and are maintained over the course of generations. How is this explained? The interaction between two proteins, which is essential for their integration into a specific area of the yeast genome, has been identified. This finding has interesting implications for gene therapy. DNA ; Gene and cell therapy Saclay Scientific result Fri, 01 May 2015 10:00:00 GMT