https://joliot.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2013/Lynch-Syndrome-structural-biology-in-the-service-of-diagnostic-support.aspx Website of the Frédéric-Joliot Institute of Life Sciences which includes 4 departments: I2BC, DMTS, NeuroSpin and Service hospitalier Frédéric Joliot (SHFJ). The teams are mainly located at the CEA Paris-Saclay center and at the Orsay hospital. en-US https://www.cea.fr/Style%20Library/Themes/drf/instituts/images/logo-cea-joliot-2023.png https://joliot.cea.fr/drf/joliot/en https://www.cea.fr/drf/joliot/en/Pages/news/Science/2026/CAR-macrophages-cancers-solides.aspx Researchers from our DMTS department have published a study providing the first proof of concept for a CAR-macrophage therapy targeting the endothelin B receptor, which is overexpressed in melanoma cells. Immune system ; Cancer ; Diagnosis and innovative treatment Researchers SPI Scientific result Mon, 09 Mar 2026 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Cerebral-tumour-diagnosis-passive-elastography.aspx Researchers at SHFJ and NeuroSpin applied a passive MRI elastography sequence to patients with brain tumors. This non-invasive approach provided information on tumor stiffness and nature, and could support early detection, surgical planning, and treatment monitoring. Medical imaging ; MRI ; Cancer ; Brain Neurospin Scientific result Wed, 26 Nov 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Protection-telomeres-fusions-chromosomiques.aspx Researchers from CEA-Jacob and the Genome Integrity team at I2BC, in collaboration with Gustave Roussy and the Institut Pasteur, demonstrate that the Rap1 protein prevents the translocation of the Ku protein— a major factor in double-strand break repair — thereby avoiding deleterious fusions between chromosomes. Structural biology Researchers SB2SM Scientific result microscopie électronique; Mon, 17 Nov 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Transport-trastuzumab-nanoparticles-nasal-epithelium.aspx ​Researchers from SPI (DMTS) developed a formulation of PLGA nanoparticles loaded with the anticancer trastuzumab (NP-TZB) and measured their ability to cross a cellular model of the nasal epithelial barrier. This first validated step supports a potential nose-to-brain (N2B) delivery route. Nanomedicine ; Cancer ; Pharmacology SPI Scientific result Wed, 12 Nov 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Cyanine-5-huwentoxin-IV-imaging-agent-lung-cancer.aspx A team from SIMoS (DMTS) has demonstrated the ability of a peptide derived from a spider venom toxin to detect overexpressed sodium channels in a metastatic non-small cell lung cancer (NSCLC) cell line. Biotechnology ; Biomarkers ; Cell and molecular imaging ; Cancer SIMOPRO Scientific result Mon, 10 Nov 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Mitose-KIF2C.aspx A study led by the I2BC shows that the formation of condensates of the enzyme KIF2C enables the concentration of two other proteins, PLK1 and phosphorylated BRCA2, on kinetochore microtubules during mitosis. This would serve to control chromosome alignment on the spindle and contribute to their stability. DNA ; Structural biology ; Cancer Researchers SB2SM Scientific result Mon, 08 Sep 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Sequence-desordonnee-Rad52-assemblage-Rad51.aspx En utilisant Saccharomyces cerevisiae comme modèle, des chercheurs des instituts CEA-Jacob et CEA-Joliot, et de l’Institut Curie, avec leurs partenaires du synchrotron SOLEIL, ont révélé comment la protéine Rad52 agit comme un chaperon pour guider et stabiliser l’assemblage de Rad51, une étape clé de la recombinaison homologue.​ Structural biology ; Cellular mechanisms ; Molecular mechanisms Researchers SB2SM Scientific result Mon, 28 Jul 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Cancer-mertansine-prodrogue.aspx Une équipe du laboratoire BioMaps, en collaboration avec l’Institut Galien Paris-Saclay a mis au point une stratégie innovante associant une prodrogue polymère et l'imagerie par tomographie par émission de positons (TEP) pour améliorer l'efficacité de la mertansine, un agent antitumoral puissant mais toxique. Medical imaging ; Diagnosis and innovative treatment ; Cancer Researchers SHFJ Scientific result ; Article préclinique;modèle animal; Tue, 01 Jul 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Interactions-of-alpha-synuclein-with-polyethylene-nanoplastics.aspx A team from I2BC, in collaboration with the NIMBE (CEA-Iramis), is unveiling the nature of the interactions of human alpha-synuclein (hαSn) with polyethylene nanoplastics, using molecular dynamics simulations and experimental methods. Nanotoxicology ; Simulation ＆ modelling ; Structural biology Iramis Scientific result Tue, 27 May 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Theranostic-antibodies-endothelin-receptors-models-glioblastoma-melanoma.aspx Researchers from SPI (DMTS) propose immunodiagnostic and immunotherapeutic approaches based on the use of innovative antibodies targeting two subtypes of endothelin receptors (ETA and ETB), recognised as relevant therapeutic targets in oncology. Health ＆ life sciences ; Cancer ; Medical imaging ; Positron Emission Tomography Neurospin Scientific result preclinical research;animal models; Thu, 22 May 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/interfaces-proteine-ARN.aspx Une équipe de l’I2BC a mené une étude prédictive de la structure des interfaces d’interaction dans les complexes protéine - ARN : bien que de nombreux aspects de ces interfaces soient largement conservés au cours de l’évolution, une grande versatilité existe dans les contacts polaires entre les molécules. Structural biology Researchers SB2SM Scientific result Tue, 20 May 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Synthesis-anti-cancer-drug-cells-using-nanomicelles.aspx A team at SCBM (DMTS) has designed nanomicelles that can be activated by a bioorthogonal reaction releasing a first chemical species, which then reacts with a second compound encapsulated in the micelles. Application to the synthesis of an anti-cancer drug, sorafenib, inside living cells. Chemistry ; Methodologies for life sciences ; Cancer SCBM Scientific result Fri, 11 Apr 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Cancer-immunoprofiling-click-chemistry-mass-spectrometry.aspx Researchers at DMTS and SHFJ have carried out a multiplexed analysis of tumor cells and tissues, based on the use of cleavable therapeutic antibodies carrying mass tags, for the identification and quantification of cancer biomarkers. A proof-of-concept demonstrating the high potential of this tumor immunoprofiling approach Cancer ; Chemistry ; Mass spectrometry ; Diagnosis SIMOPRO Scientific result preclinical research;animal models; Mon, 13 Jan 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Immunotherapie-structure-HER2-trastuzumab-pertuzumab.aspx Des chercheurs de l’I2BC, en collaboration avec Sanofi, l’IMPMC et l’Institut Pasteur, ont modélisé la structure du complexe associant le récepteur membranaire HER2 avec deux fragments de liaison (Fab) de deux anticorps thérapeutiques dirigés contre cette cible, le trastuzumab et le pertuzumab. Structural biology ; Microscope Researchers SB2SM Scientific result Fri, 08 Nov 2024 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Micelles-efficacite-radiotherapeutique-tumeurs-radioresistantes.aspx ​Des équipes du SCBM et du SHFJ, en collaboration avec le CEA-Jacob et l’ISMO ont développé une micelle perfluorée biocompatible pour améliorer l’efficacité des radiothérapies et qui serait particulièrement intéressante dans des environnements tumoraux radiorésistants. Diagnosis and innovative treatment ; Cancer Researchers SCBM Scientific result ; Article Cancer;préclinique;théranostique;modèle animal; Wed, 23 Oct 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Structure-transmembrane-region-SARS-CoV-2-nsp3-protein.aspx An I2BC team has revealed the structure of the C-terminal transmembrane region of the SARS-CoV-2 protein nsp3, essential for virus replication. This region self-assembles into hexamers that form molecular pores on the surface of double-membrane vesicles, the sites of viral genome replication. Nsp3 therefore appears to be a promising therapeutic target. Structural biology ; Virus SB2SM Scientific result Thu, 08 Aug 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/DNA-recombination-lock.aspx Teams from I2BC, Institut Curie and IRB shed light on how the human nuclease MRN works. Structural predictions obtained with AlphaFold2 and confirmed by in vitro and in vivo experiments show that the phosphorylated Sae2/CtIP protein forms a network of interactions with MRN that favours the removal of its autoinhibition. Structural biology ; DNA ; Molecular mechanisms ; Artificial intelligence Researchers SB2SM Scientific result Tue, 25 Jun 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/HROB-MCM8-MCM9.aspx Researchers from the AMIG team (I2BC department), in collaboration with the IRB (Switzerland), have modeled the interaction between HROB and the helicases MCM8-MCM9, some mutations of which predispose individuals to infertility or cancer. They demonstrate that HROB promotes the catalytic activity of the MCM8-MCM9 complex but does not play a role in its recruitment or stability. Structural biology ; Molecular mechanisms Researchers SB2SM Scientific result ; Article AlphaFold;AlphaFold2; Wed, 22 May 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Response-intra-tumoral-immunotherapy-by-immunoPET.aspx A team from BioMaps (SHFJ), in partnership with the Gustave Roussy Institute, has used immunoPET imaging to assess the influence of tissue distribution on the efficacy of cancer immunotherapy, administered intra-tumor and intravenously in mice. Intratumoral administration is more effective and reduces overall exposure of organs at risk Medical imaging ; Positron Emission Tomography ; Cancer SHFJ Scientific result preclinical research;animal models; Fri, 19 Apr 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Epigenetics-CAF-1.aspx A team from the I2BC, in collaboration with the Institut Curie and Soleil, has shown that the CAF-1 protein combines flexible regions and rigid modules in its spatial organisation to deposit histones on DNA and effectively couple this process to DNA synthesis. Epigenetics ; Structural biology Researchers SB2SM Scientific result ; Article Tue, 26 Mar 2024 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Cryo-EM-ring-BRCA2-HSF2BP.aspx A collaboration involving the I2BC has modelled the structure of the complex between HSF2BP and a fragment of BRCA2, which is essential for DNA repair by homologous recombination. The researchers propose a mechanism for regulating the unexpected ring-like assembly of this complex. Structural biology Researchers SB2SM Scientific result ; Article Thu, 08 Feb 2024 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/proteins-proteins-interactions-AlphaFold2.aspx In an article published in Nature Communications, researchers from the I2BC show that applying a fragmentation strategy to the protein partners of assemblies depending on intrinsically disordered regions very significantly improves AlphaFold2's prediction capacity. Structural biology ; Artificial intelligence Researchers SB2SM Scientific result Mon, 29 Jan 2024 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/phytic-acid-DNA-repair.aspx In an article published in the journal Nucleic Acids Research, scientists from the I2BC, lPBS and the Institute for Structural and Chemical Biology (University of Leicester, UK) demonstrate how phytic acid, a product of cellular metabolism, stabilises the assembly of a complex enabling the repair of DNA breaks in humans. DNA ; Structural biology Researchers SB2SM Scientific result ; Article Mon, 04 Dec 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Multiplier-chimeres-mieux-comprendre-interactions-inhibiteur-cible-proteique.aspx En substituant des segments d’hélice alpha​ par des segments d’oligo-urées dans un peptide inhibiteur d’ASF1, lui conférant ainsi une résistance accrue aux protéases, des chercheurs de l’I2BC en collaboration avec l’IECB explorent les modes de liaison de ces chimères peptide-urée à leur cible. Molecular mechanisms ; Structural biology Researchers SB2SM Scientific result ; Article Tue, 12 Sep 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/PET-imaging-antibody-endothelin-receptors-glioblastoma-tumors.aspx Researchers at BioMaps (SHFJ) and SPI (DMTS) have studied the pharmacokinetics of a novel immuno-radioligand targeting the endothelin A receptor (ETA), overexpressed in many cancers, particularly glioblastoma. The immunoPET imaging approach used in this study in a preclinical model confirms the theranostic potential of this antibody. Positron Emission Tomography ; Cancer ; Medical imaging Neurospin Scientific result Thu, 07 Sep 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Metabolomic-signatures-high-grade-breast-tumors.aspx The TIRO laboratory of the SHFJ (Nice) identifies for the first time discriminating biomarkers of high-grade invasive breast tumors, using a non-targeted metabolomics approach performed on surgical specimens and cytoponctions from patients at different stages of malignancy. Metabolomics ; Cancer ; Biomarkers SHFJ Scientific result Fri, 04 Aug 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Reparation-ADN-PAXX.aspx An international collaboration led by researchers from I2BC/CEA-Joliot and IPBS (Toulouse) has solved the atomic structure of molecular assemblies involved in the repair of DNA double-strand breaks. The diversity of assemblies involving the PAXX protein identified in this study highlights the great flexibility of the repair machinery, which could reflect its ability to adapt to biological conditions. The results were published in Science Advances. Structural biology ; Molecular mechanisms Researchers SB2SM Scientific result cryoEM;radiocristallographie; Tue, 06 Jun 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Radiomarquage-crizotinib-fluor-18-nouvel-outil-TEP.aspx Des chercheurs du SHFJ ont mis au point la radiosynthèse au fluor-18 du crizotinib, un médicament qui ne pénètre pas dans le cerveau. Ce nouvel outil pour l’imagerie TEP permettra d’explorer de futures stratégies visant à faire passer la barrière hémato-encéphalique à ce médicament pour traiter certaines métastases cérébrales. Positron Emission Tomography ; Cancer ; Diagnosis and innovative treatment Researchers SHFJ Scientific result ; Article Thu, 27 Apr 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Virus-hepatite-E-AlphaFold.aspx I2BC researchers unveil an atomic model of the hepatitis E virus replication polyprotein obtained with the AlphaFold artificial intelligence program. The model provides a better understanding of how this RNA virus multiplies its genome in infected cells. Structural biology ; Simulation ＆ modelling ; Artificial intelligence Researchers SB2SM Scientific result AlphaFold2;RNA virus;in vitro translation; Wed, 08 Feb 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/BAF-numerical-simulation-phosphorylation.aspx Using molecular dynamics simulation and NMR studies, I2BC researchers detail the restriction mechanisms of BAF protein dynamics due to its phosphorylation. Molecular mechanisms ; Structural biology ; Simulation ＆ modelling Researchers SB2SM Scientific result Mon, 16 Jan 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Intrahepatic-cholestasis-biochemistry-structure-ATP8B1.aspx A collaborative study involving an I2BC team unveils the mechanism of autoinhibition of the human flippase ATP8B1, as well as its regulation by lipids and phosphorylation. The study provides a better understanding of the impact of flippase mutations responsible for intrahepatic cholestasis on its enzymatic activity. Molecular mechanisms ; Structural biology Researchers SB2SM Scientific result ATP;hydrolyse;protéine membranaire;modifications post-traductionnelles;expression hétérologue;membranes;cryo-EM; Thu, 09 Jun 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Radioligands-immunoPET-PD-1-PD-L1.aspx Researchers from the SHFJ and the DMTS have developed optimized radioligands for immunoPET imaging. The objective is to better predict the effectiveness of anti-PD1/anti-PDL1 immunotherapy used to fight certain cancers. Positron Emission Tomography ; Cancer Researchers SIMOPRO Scientific result programmed cell death-ligand 1; Tue, 12 Apr 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Autophagy-senescence.aspx Researchers from the Frédéric Joliot Institute have identified ouabain and chloroquine as two selective senolytic molecules that are effective in eliminating certain senescent cells. The study has been published in the journal Aging Cell. Cancer ; Cellular mechanisms Researchers SCBM Scientific result Tue, 15 Mar 2022 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/structure-nanotubes-lanreotide.aspx ​Thanks to recent developments in cryo-electron microscopy, a study led by a team from the I2BC reveals, at the atomic scale, the unsuspected structural complexity of lanreotide nanotubes, a drug used in the treatment of acromegaly and some neuro-endocrine cancers. Structural biology Researchers SB2SM Scientific result Thu, 20 Jan 2022 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Modeling-pairing-crossover-meiosis.aspx In a study conducted by a team from the Institut Curie, researchers from the CEA-Joliot (B3S/I2BC department) have modeled in silico protein-protein interactions and thus contributed to establish at the molecular level the mechanisms that coordinate the pairing and recombination of homologous chromosomes during meiosis. Simulation ＆ modelling ; Structural biology ; Molecular mechanisms Researchers SB2SM Article ; Scientific result recombinaison homologue;AlphaFold;crossing-over;InterEvDock3; Thu, 13 Jan 2022 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/PET-MRI-imaging-tumors-supervoxel-level.aspx A collaborative study led by BioMaps researchers (SHFJ) demonstrates that fully integrated quantitative multiparametric analysis of non-small cell lung cancer in hybrid 18F-FDG PET/MRI 3T imaging is clinically feasible and could enable biological characterization of tumors at the supervoxel scale. Medical imaging ; Positron Emission Tomography ; MRI ; Cancer Scientific result Wed, 10 Nov 2021 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2021/High-performance-computing-molecular-modelisation.aspx A project at the interface between quantum chemistry and molecular dynamics for the study of complex molecular assemblies, led by Michel Masella (Joliot) and Luigi Genovese (IRIG), makes it possible, for applications in biology/health, to take full advantage of the new supercomputers of the Public Procurement of Innovations for High-Performance Computing (PPI4HPC, H2020) project hosted at the Très Grand Centre de Calcul (TGCC) of the CEA-Bruyères-le-Châtel. Computing ; Simulation ＆ modelling ; Supercomputers ; Structural biology News ; Article Tue, 14 Sep 2021 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/BRCA2-HFS2BP-meiosis.aspx By solving the three-dimensional structure of a fragment of the BRCA2-HSF2BP complex, a collaboration involving teams from I2BC and ERASMUS MC identifies the precise BRCA2 motif that causes the very high affinity between the two partners and shows that, in vivo, this complex has no function in the recruitment of Rad51 to meiotic sites of homologous recombination. Structural biology Researchers SB2SM Article ; Scientific result RMN;radiocristallographie; Mon, 13 Sep 2021 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/InterEvDock3.aspx Researchers at I2BC/CEA-Joliot, in collaboration with the RPBS platform, have developed the third version of their InterEvDock server for structural modelling of protein-protein interactions. The server integrates new algorithms for exploiting sequence evolution information. Structural biology Researchers SB2SM Scientific result HADDOCK;FRODOCK;coMSAs;CAPRI; Mon, 21 Jun 2021 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Mlh1-Mlh3.aspx Researchers from I2BC/CEA-Joliot in collaboration with teams from Institut Curie and IRCM/CEA-Jacob, lay the molecular basis to explain the dual role of the Mlh1-Mlh3 complex in DNA mismatch repair and, quite uniquely, in one of the key steps of genetic mixing during meiosis. Structural biology Researchers SB2SM Scientific result cristallography;repair;recombination; Mon, 07 Jun 2021 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/phosphorylation-BAF-interaction.aspx ​A study by researchers from I2BC department shows in vitro the effect of mitotic phosphorylation of the BAF protein on its structure and its interactions with DNA and lamina and unveils consequences on genome organization and on mechanisms responsible for progeroid syndromes. Molecular mechanisms ; DNA ; Structural biology Researchers SB2SM Scientific result NMR;radiocristallography; Mon, 29 Mar 2021 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Foldamer-inhibitor-ASF1.aspx I2BC researchers, in collaboration with the European Institute of Chemistry and Biology (University of Bordeaux, CNRS), have developed a chimeric peptide/foldamer molecule that is resistant to proteolysis and inhibits ASF1, a potential target for anticancer treatment. The resolution of the structure of this chimera in interaction with its target, the first of its kind, reveals an unsuspected plasticity of the urea-based backbone that hugs the surface of ASF1. Structural biology ; Molecular mechanisms ; Epigenetics ; Cancer Researchers SB2SM Scientific result NMR;radiocristallography; Fri, 19 Mar 2021 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Functional-characterization-PcATP2-essential-Plasmodium-flippase.aspx I2BC researchers, in collaboration with the Autonomous University of Barcelona, have provided the first studies of the function and structural organization of a flippase encoded by a parasite responsible for malaria, a first step towards understanding the essential physiological function of this transporter and its potential use as an antimalarial target. Structural biology ; Infectious diseases Scientific result Wed, 17 Mar 2021 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Micellar-probe-fluorine-MRI-tumor.aspx A SCBM (DMTS) team, in collaboration with researchers at NeuroSpin and I2BC, is describing micellar nanometric vectors targeting tumors that have been imaged by fluorine magnetic resonance imaging (MRI). The observed 19F signal made it possible to precisely delimit the volume of the tumor zone in a mouse model and to quantify the probe accumulated in the target tissue. Chemistry ; Nanomedicine ; Cancer ; MRI Scientific result Thu, 04 Mar 2021 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/ImmunoPET-BBB-Ab.aspx Researchers from SHFJ, NeuroSpin and DMTS have demonstrated, by immunoPET imaging, the impact of transient BBB permeabilization on brain exposure to an anti-EGFR antibody. Promising prospects for targeted immunotherapy of glioblastoma. Cancer ; Medical imaging ; Positron Emission Tomography SIMOPRO Scientific result radiomarquage;zirconium;IRM; Tue, 06 Oct 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2020/Lamines-Progeria-Structural-Biology.aspx A team from the I2BC publishes in FEBS Journal an exhaustive review of the various mutations affecting the structure of type A lamins, proteins that make up the envelope of the cell nucleus (nuclear lamina), which lead to premature aging in people with the disease (Progeria). Structural biology ; Diseases Mon, 24 Aug 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/BRCA2-breast-cancer.aspx ​In a study conducted by a team from the Institut Curie, I2BC researchers have used their NMR know-how to study the phosphorylation of BRCA2 and have thus contributed to revealing a mechanism potentially at the origin of chromosomal aberrations observed in breast BRCA2-mutated tumors. Molecular mechanisms ; Cancer SB2SM Scientific result homologous recombination;Rad51;kinase; Mon, 27 Apr 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Innovative-approach-radiolabel-peptides-fluorine-18-PET-imaging.aspx Radiochemists from the BioMaps unit (SHFJ) have developed and automated a new fluor-18 radiolabelling method for peptides used to characterize specific pathological molecular signatures and thus target treatments. Peptides were conjugated to a specific tag, then radiolabeled in a single step under mild conditions, making this approach an innovative solution for PET imaging of peptides labeled with fluorine-18. Chemistry ; Positron Emission Tomography ; Cancer Scientific result Mon, 17 Feb 2020 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Glucocorticoids-better-evaluation-effect-cancers.aspx Senescence specialists (SBIGEM), in collaboration with the SCBM and the CNRGH (Jacob Institute), show that glucocorticoids can delay or even short-circuit it and disrupt its function as a tumor suppressor. Cellular mechanisms ; Molecular mechanisms ; Cancer Fontenay-aux-Roses Scientific result MEK/ERK;oncogenesis;Senescence; Mon, 09 Sep 2019 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/New-prediction-biomarker-tumor-progression-PET-images.aspx The SHFJ/IMIV laboratory (Inserm 1023/CNRS/CEA/UP-Sud), in collaboration with hospital-university teams, has shown that, in patients with advanced-stage large cell lymphoma (B type), automatic quantitative measurements of tumor dissemination detected by whole-body PET imaging have a predictive value of progression-free survival (tumor stabilization) and overall survival. Medical imaging ; Positron Emission Tomography ; Cancer Scientific result Tue, 16 Jul 2019 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Drs2-Cdc50-CryoEM-Structure-Nature.aspx Researchers from I2BC@Saclay, the University of Aarhus and the Max Planck Institute of Biophysics in Frankfurt reveals the first cryo-EM high-resolution structures of one of the P4-ATPases. Study has been published in Nature. It give a better insight towards the understanding of the transport mechanisms of membrane lipids. A lipid pathway through the protein membrane domain is suggested. Structural biology ; Molecular mechanisms Saclay Press release ; Scientific result lipid asymetry;P4-ATPase;membrane lipid translocation; Thu, 27 Jun 2019 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2019/Genopole-structural-biology-platforms-joins-FRISBI.aspx The French National Infrastructure of Integrated Structural Biology (FRISBI) is now integratinf Genopole's structural biology platform into its Paris-Sud node. Structural biology Researchers Saclay Academic partnerships i;microscope à force atomique;plateforme; Fri, 10 May 2019 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Click-Release-chemistry-targeted-delivery-drug-invivo.aspx A team from the SCBM, in collaboration with the SPI, the IC2MP and the University Hospital of Poitiers, has developed a bioorthogonal chemistry strategy that allows, in vivo, the controlled release of active ingredients contained in micelles-targeting cancerous tumors. These results pave the way for new strategies for targeted drug delivery. Chemistry ; Cancer ; Nanomedicine Scientific result Fri, 15 Mar 2019 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Towards-better-detection-glioblastoma-infiltration.aspx Glioblastoma is a very aggressive cancer of the central nervous system, mainly because of its ability to infiltrate the surrounding areas. A collaboration led by a team of SHFJ and involving NeuroSpin demonstrates the interest of two imaging techniques for the early detection of tumor infiltration. Cancer ; Medical imaging ; Positron Emission Tomography Scientific result PET imaging;glioblastoma; Tue, 26 Feb 2019 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/TEP-18FFludarabine-lymphome-cerebral.aspx A SHFJ research team (LDM-TEP, GIP Cyceron, Caen) has previously developed and produced a radiopharmaceutical, the [18F]-Fludarabine, to detect lymphomas using PET scan. The team has recently conducted a preclinical study that shows the molecule can help in diagnosis of cerebral lymphoma by differentiate it from glioblastoma, the main brain tumor. A clinical study should be launched before the end of the year. Brain ; Medical imaging ; Cancer ; Diagnosis Joliot Scientific result FDG;lymphoma;glioblastoma; Mon, 08 Oct 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/DNA-repair-zoom-first-steps.aspx A research team from the SB2SM (I2BC@Saclay), in collaboration with the CNRS, SOLEIL , Universities of Paris-Sud, Aix-Marseille and Paul Sabatier - Toulouse III and Gustave Roussy, has resolved structures of two complexes involved in radiation-induced DNA damages. These results were published in Nature Structural & Molecular Biology on October, the 5th. DNA ; Structural biology ; Molecular mechanisms SB2SM Press release Mon, 08 Oct 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/relationship-variants-BRCA1-cancer.aspx Research Teams from the Curie Institute, the Gustave Roussy Institute, as well as the biophysics teams from the Institute of Chemistry of Natural Substances and SB2SM (I2BC@Saclay) met to systematically identify structural defects and BRCA1 proteins encoded by variants of the BRCA1 gene, a gene predisposing to breast and ovarian cancer. Their results make it possible to propose a classification of these variants (neutral versus causal). Cancer ; Structural biology ; DNA Scientific result Fri, 28 Sep 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/myristoylation-decoded.aspx An I2BC Research Team, in collaboration with the ICSN and the Ecole Polytechnique, has mapped for the first time, in man and the model plant Arabidopsis thaliana, the myristoylome, namely the whole proteins modified with a fatty acid, myristate. This modification is important because it targets these proteins to the membranes and thus contributes to their subcellular compartmentalization. These data represent an important resource, available to the community of biologists. Structural biology News Tue, 26 Jun 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/functionalized-micellar-nanovectors.aspx ​As part of a collaboration with MIRCen (Institute of Biology François Jacob) and SBIGeM, SCBM researchers have developed functional micellar nanovectors capable of targeting a population of cancer cells. Chemistry ; Cancer Scientific result Thu, 12 Apr 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/ghosts-of-fluorescence.aspx Cell biology uses fluorescent labeling, an essential technique to follow the life of the cell. But fluorescent proteins have their limits, which researchers from IBS and I2BC @ Saclay (SB2SM) are trying to repel. Structural biology ; Proteomics Scientific result Wed, 28 Mar 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/biotechnological-approach-new-bioactive-molecules.aspx ​Muriel Gondry's Research Team (I2BC@Saclay / SBIGeM), in collaboration with SIMOPRO and Biomolecules Laboratory of the Sorbonne University's one, produced 200 cyclodipeptides containing non-natural amino acids by luring and diverting the cellular machinery for the synthesis of proteins. This unprecedented approach significantly increases the diversity of these bioactive molecules. Biotechnology ; Structural biology Scientific result Mon, 05 Mar 2018 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2017/New_MOOC_on_biological_crystallography.aspx Paris-Saclay University is pleased to present the MOOC "Journey to the heart of life with X-rays: crystallography", result of a close collaboration between the Department I2BC @ Saclay (pedagogical director: Marie-Hélène Le Du ), the Sun Synchrotron, the Ecole Polytechnique, the CNRS, and the University Paris Sud. Institutional ; Health ＆ life sciences ; Structural biology News Mon, 18 Sep 2017 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/News/Science_news/2017/fludarabine_hope.aspx A Research Team of the SHFJ (LDM-TEP) has just developed an innovative radiopharmaceutical for lymphoproliferative diseases, [18F] Fludarabine. Cancer ; Medical imaging Scientific result Mon, 29 May 2017 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2017/Pierre_fabre_h_immune.aspx ​After its creation by Michel Léonetti, a researcher at SPI / LERI, and Luc Boblet, external holder at the CEA, backed by the IDEX Paris-Saclay funding among other things, the H-Immune start-up recently signed a partnership agreement with the Pierre Fabre Innovation Fund to develop cancer immunotherapy treatments. Cancer ; Institutional News Wed, 03 May 2017 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2017/Monitoring_hadrontherapy_to_improve_patient_safety.aspx Evaluating the biological impact of hadrontherapy in healthy tissue upstream of a tumor is essential to assess the risk of radiation-induced sequelae. In the treatment of bone tumors, healthy articular cartilages are present in the path of the carbon ion beams. The development of 3D models has enabled IRCM's LARIA Research Team, in collaboration with IRAMIS and IBITECS (SBIGeM), to have relevant evaluation systems for these tissues. Cancer ; Health ＆ life sciences Scientific result Mon, 13 Mar 2017 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2015/Micellar_nanovectors_tumor_imaging.aspx In the context of a collaboration with the I²BM institute, researchers from SCBM have designed micellar vectors for targeting and visual delineation of tumors. Nanomedicine ; Cancer News Tue, 15 Dec 2015 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2015/cyclodipeptide_synthases_elucidated-.aspx Teams of IBITECS and Ecole Polytechnique (Palaiseau) have deciphered the mechanism used by the cyclodipeptide synthases (CDPS) to catalyze the formation of peptide bonds. Structural biology ; Cellular mechanisms News Fri, 01 May 2015 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2013/Lynch-Syndrome-structural-biology-in-the-service-of-diagnostic-support.aspx Researchers at the CEA, CNRS and Université Paris-Sud have presented the first model of the architecture of the MLH1 protein associated with Lynch syndrome, a genetic predisposition to colorectal cancer. This atomic level “image” of MLH1 will lead to better understanding of the genetic processes that cause the disease. Structural biology ; Cancer IBITECS Scientific result Mon, 25 Feb 2013 11:00:00 GMT