https://joliot.cea.fr/drf/joliot/en/Pages/news/Institute/2019/Iseult-Project-MRI-magnet-9,51T.aspx Website of the Frédéric-Joliot Institute of Life Sciences which includes 4 departments: I2BC, DMTS, NeuroSpin and Service hospitalier Frédéric Joliot (SHFJ). The teams are mainly located at the CEA Paris-Saclay center and at the Orsay hospital. en-US https://www.cea.fr/Style%20Library/Themes/drf/instituts/images/logo-cea-joliot-2023.png https://joliot.cea.fr/drf/joliot/en https://www.cea.fr/drf/joliot/en/Pages/news/Science/2026/Subject-fingerprinting-task-classification-distinct-connectivity-features.aspx A team from NeuroSpin measured brain connectivity patterns using functional MRI data from a deep-phenotyping dataset involving several tasks (watching movies, listening to stories). The authors showed that sparse partial correlation is more effective for identifying individuals, whereas standard correlation performs better for distinguishing and classifying different cognitive tasks Brain ; Cognition ; MRI ; Artificial intelligence Neurospin Scientific result Fri, 29 May 2026 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2026/Non-monotonic-cerebral-code-event-probability.aspx A team from NeuroSpin designed an original learning paradigm to identify the brain code representing the probability of an event occurring. Results obtained using ultra-high-field functional MRI show that fronto-parietal regions encode this probability and that its representation relies on a highly non-monotonic code. Cognition ; Brain ; MRI Neurospin Scientific result Wed, 22 Apr 2026 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2026/Biomarkers-hypoxic-brain-injury-choroid-plexus-organoids.aspx A team from the SPI (DMTS) investigated the effects of hypoxia on the interface between the choroid plexus and cerebrospinal fluid using organoids derived from human pluripotent stem cells. The aim was to investigate how cerebral hypoxia at birth, which causes hypoxic-ischaemic encephalopathy, disrupts this cerebral barrier, which has not yet been extensively studied. Brain ; Diseases ; Proteomics SPI Scientific result ; Article Fri, 17 Apr 2026 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2026/IA-revele-composante-neurodeveloppementale-troubles-psychiatriques.aspx Researchers from NeuroSpin demonstrate that cortical folding, analyzed using deep learning, holds promising potential for predicting psychiatric disorders. They highlight the value of pre-training to build foundation models on large cohorts and the benefits of a regional approach. Artificial intelligence ; MRI ; Brain Researchers Neurospin Scientific result Tue, 07 Apr 2026 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2026/Epilepsie-IA-SEEG.aspx Researchers from the MIND team (NeuroSpin) and the Neuroscience Center in Helsinki describe a machine learning model that simplifies the interpretation of stereo-electroencephalography (SEEG) data acquired during the presurgical evaluation of drug-resistant epilepsy. This approach improves and facilitates the localization of the epileptogenic network. Artificial intelligence ; Brain ; Diseases Researchers Neurospin Scientific result Thu, 19 Mar 2026 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2026/proteins-nanoplastics.aspx Peptides and proteins adsorb onto plastic nanoparticles, forming a corona. Researchers from I2BC and CEA-Iramis, using molecular modeling, reveal distinct adsorption behaviors depending on their amino acid sequences. They thus establish a mechanical basis for predicting peptide-plastic interactions, a crucial element for assessing the risks these interactions pose to health and ecosystems. Molecular mechanisms ; Simulation ＆ modelling Researchers SB2SM Scientific result ; Article Mon, 16 Mar 2026 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2026/spectrometrie-masse-exposomes.aspx Researchers from the DMTS have developed a method for exploring the chemical exposome in large, complex mass spectrometry datasets. They applied it to the analysis of meconium samples from a cohort. Mass spectrometry Researchers SPI Scientific result Thu, 26 Feb 2026 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2026/Auditory-environment-superior-temporal-sulcus-depth-neonatal.aspx A team from NeuroSpin investigated the impact of contrasting auditory environments on the morphology of the superior temporal sulcus (STS) in preterm newborns. By showing that exposure to music is associated with a deeper STS, the authors suggest that early auditory experience influences the structural development of temporal brain regions. Brain ; MRI ; Cognition Neurospin Scientific result ; Article Mon, 23 Feb 2026 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2026/Origine-artefacts-IRM-ultra-haut-champ.aspx A team from NeuroSpin sheds light on the mechanisms underlying artifacts caused by intra-voxel dephasing, which occur when using ultra-high-field MRI acceleration methods such as GRAPPA. Brain ; MRI Researchers Neurospin Scientific result ; Article Mon, 16 Feb 2026 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2026/facteurs-genetiques-plissements-cortex-cingulaire-anterieur.aspx Researchers from BAOBAB (NeuroSpin) have demonstrated that cortical folding is indeed a biomarker of brain development and that its genetic influences can be detected using deep learning methods. MRI ; Brain Researchers Neurospin Scientific result Fri, 13 Feb 2026 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2026/Analysis-global-metabolism-carbon-13-isotopic-labeling.aspx A collaborative study between the BIAM and Joliot (SPI/DMTS) institutes demonstrates the feasibility of near-complete whole-body carbon-13 isotopic labeling in mice and lays the foundation for a global, quantitative, and unbiased metabolomics approach. This unprecedented strategy could also enable the investigation of certain metabolic troubles. Mass spectrometry ; Metabolomics BIAM Scientific result Mon, 09 Feb 2026 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2026/BBB-FUS-suppress-noise.aspx ​​Teams from BioMaps (SHFJ) and BAOBAB (NeuroSpin), along with CEA-Jacob, are optimizing their strategy for opening the blood-brain barrier (BBB) using focused ultrasound (FUS) to deliver drugs to the brain. Their innovation: an algorithm that identifies and 'eclipses' extracranial cavitation induced by thick temporal muscles—particularly in large male primates—which otherwise masks the signal of interest. Diagnosis and innovative treatment ; Brain Researchers MIRcen Scientific result ; Industrial partnerships animal model;preclinical research; Wed, 14 Jan 2026 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2026/Respiratory-dynamics-3Dspirometry-pulmonary-MRI.aspx A team from SHFJ has developed an original method of 3D spirometry using pulmonary magnetic resonance imaging in a cohort of volunteers breathing freely. This approach has revealed the existence of common patterns among individuals that depend mainly on gravity. This is a step towards a regional pathophysiological characterisation of respiratory diseases. Medical imaging ; MRI SHFJ Scientific result Mon, 12 Jan 2026 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/lux-eteindre-signal-IRM-sondes-micellaires--PERFECTA.aspx Researchers at the SCBM and BAOBAB have developed a new version of their nanometric micellar vector designed for fluorine-19 magnetic resonance tumor imaging. This version is intended to enhance MRI contrast by switching off the signal on demand in certain areas, while preserving it in pathological regions to be imaged. MRI ; Chemistry ; Diagnosis Researchers Neurospin Scientific result Fri, 05 Dec 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Cerebral-tumour-diagnosis-passive-elastography.aspx Researchers at SHFJ and NeuroSpin applied a passive MRI elastography sequence to patients with brain tumors. This non-invasive approach provided information on tumor stiffness and nature, and could support early detection, surgical planning, and treatment monitoring. Medical imaging ; MRI ; Cancer ; Brain Neurospin Scientific result Wed, 26 Nov 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/mineMS2.aspx A LI-MS team presents an innovative strategy and software for structural elucidation in metabolomics using tandem mass spectrometry. Mass spectrometry ; Metabolomics Researchers SPI Article ; Scientific result Fri, 07 Nov 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Conscience-IRM-fonctionnelle-IA.aspx Deux études récentes menées par des équipes de NeuroSpin proposent d’appliquer des méthodes combinant des modèles mathématiques d’analyse de données à l’IRM fonctionnelle pour mieux modéliser les connectivités fonctionnelles du cerveau. MRI ; Brain Researchers Neurospin Scientific result modèle animal; Thu, 09 Oct 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/GMR-sensor-biochip-for-point-of-care-diagnostics.aspx Researchers from IRAMIS and SPI (DMTS) evaluated their GMR-sensor biochip prototype for its ability to detect cancer cells in a complex medium. This approach, which combines sensor physics with medical biology, aims to develop simpler and portable diagnostic tools that meet the WHO criteria for point-of-care testing. Physics ; Biodetection SPI Scientific result ; Article Tue, 30 Sep 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Ultrasound-counter-exposure-neurotoxic-agent.aspx Researchers from BioMaps (SHFJ), NeuroSpin, and the french IRBA developed an innovative approach using focused ultrasound to improve brain delivery of an antidote, oxime, following exposure to an organophosphorus neurotoxic agent in a murine model. Pharmacology ; Toxicology ; Brain ; CBRN-E threats Neurospin Scientific result preclinic;animal models; Thu, 28 Aug 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Monitoring-microstructural-functional-brain-development-in-infants.aspx A team from NeuroSpin studied the microstructural and functional connectivity profiles of infants’ brains to understand how these characteristics evolve and relate to each other during early neurodevelopment. The results indicate that connectivity, which is altered by prematurity, strengthens with maturation, and that the associated networks become increasingly similar. Brain ; MRI ; Medical imaging Neurospin Scientific result Mon, 04 Aug 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Statistical-learning-beyond-words-human-neonates.aspx Ghislaine Dehaene's team (NeuroSpin) carried out EEG experiments on neonates to find out whether statistical learning was a mechanism dedicated solely to language acquisition. By exploiting the speaker identity and phonemes, the researchers conclude that statistical learning mechanisms are universal and not limited to linguistic characteristics. Cognition ; Learning ; Brain Neurospin Scientific result Tue, 22 Jul 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Correlation-neuroinflammation-epileptogenic-zone-TSPO-PET.aspx A study by SHFJ researchers has established a strong correlation between biomarkers of neuroinflammation, revealed by original PET imaging, and intracranial electroencephalographic recordings of epileptogenic activity. This offers hope for drug-resistant patients who are candidates for surgery. Positron Emission Tomography ; Medical imaging ; Brain SHFJ Scientific result ; Article Tue, 15 Jul 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Drug-candidate-for-treatment-neonatal-encephalopathy.aspx Researchers from the SPI (DMTS) and the Women & Infants Hospital in Providence have laid the molecular basis for the neuroprotection of a purine derivative in a preclinical model of neonatal hypoxic-ischemic encephalopathy (HIE). The promising results support the development of this drug candidate to treat HIE in neonates. Pharmacology ; Brain ; Molecular mechanisms ; Diseases SPI Scientific result animal models;preclinic; Thu, 26 Jun 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Interactions-of-alpha-synuclein-with-polyethylene-nanoplastics.aspx A team from I2BC, in collaboration with the NIMBE (CEA-Iramis), is unveiling the nature of the interactions of human alpha-synuclein (hαSn) with polyethylene nanoplastics, using molecular dynamics simulations and experimental methods. Nanotoxicology ; Simulation ＆ modelling ; Structural biology Iramis Scientific result Tue, 27 May 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/How-does-brain-remember-duration-of-events.aspx A behavioural study conducted by a NeuroSpin team assessed the brain's processing of duration in working memory by having participants memorise a sequence of time intervals and then reproduce the duration of each interval. The results suggest that the brain processes the duration of each event as separate information. Brain ; Cognition Neurospin Scientific result ; Article Mon, 05 May 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Devenir-cerveau-adolescent-AVC-neonatal.aspx Une étude dirigée par une équipe de NeuroSpin confirme la vulnérabilité spécifique du cerveau du bébé masculin après un AVC autour de la naissance.​ Brain Researchers Neurospin Scientific result Fri, 18 Apr 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/thylakoid-3D-organisation-high-resolution-fluorescence-microscopy.aspx A team from I2BC has applied a novel fluorescence microscopy method to reconstruct 3D chloroplast volumes from 2D images. A promising approach for monitoring variations in the volume of the photosynthetic membrane network in response to environmental fluctuations in plants. Photosynthesis ; Microscope SB2SM Scientific result ; Article Tue, 08 Apr 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Troubles-psychiatriques-quelle-IA-pour-analyser-IRM.aspx ​​Une étude comparative menée par des chercheurs de l’UMR BAOBAB/NeuroSpin en collaboration avec le LTCI (Télécom Paris) explique pourquoi l’apprentissage profond est plus performant que l’apprentissage automatique standard en neuroimagerie et souligne le potentiel de l’apprentissage par transfert.​ MRI ; Artificial intelligence Scientific result ; Article Thu, 27 Feb 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Next-generation-sequencing-chess-game.aspx A team from I2BC has proposed a thought experiment -the Next Generation Sequencing chess problem-, which treats sequencing data as a superimposed image of several independent chess games. A more realistic approach to the dynamics of cellular processes within each cell, revealing the limits of NGS approaches to temporal analysis. Bioinformatic ; DNA ; Molecular mechanisms ; Simulation ＆ modelling SBIGEM Scientific result Mon, 17 Feb 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/antenne-lobes-temporaux.aspx Une équipe de NeuroSpin en collaboration avec Multiwave Technologies a conçu et développé une antenne de réception pour l’IRM Iseult 11,7 T ciblant uniquement les lobes temporaux, une région d’intérêt pour les neuroscientifiques. MRI Researchers Neurospin Scientific result ; Europe ; Article Thu, 30 Jan 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Universal-identification-pathogenic-viruses-proteotyping.aspx Researchers at Li2D (SPI/DMTS, Marcoule) have proposed an innovative tandem mass spectrometry proteotyping method for the universal identification of pathogenic viruses, requiring no prior knowledge of sample composition. A step towards improved diagnosis of viral infections Virus ; Mass spectrometry ; Biodetection ; CBRN-E threats SPI Scientific result ; Article Wed, 29 Jan 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Cancer-immunoprofiling-click-chemistry-mass-spectrometry.aspx Researchers at DMTS and SHFJ have carried out a multiplexed analysis of tumor cells and tissues, based on the use of cleavable therapeutic antibodies carrying mass tags, for the identification and quantification of cancer biomarkers. A proof-of-concept demonstrating the high potential of this tumor immunoprofiling approach Cancer ; Chemistry ; Mass spectrometry ; Diagnosis SIMOPRO Scientific result preclinical research;animal models; Mon, 13 Jan 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/QSM4SENIOR-cartographie-charge-en-fer-vieillissement-cerveau.aspx Les premières données du projet QSM4SENIOR, porté par des équipes de NeuroSpin et de la société VENTIO, ont été publiées dans Frontiers in Neuroimaging. Elles permettent de dresser une cartographie très précise de l’évolution de la charge en fer au cours du vieillissement cérébral normal, une aide précieuse pour les scientifiques spécialistes des maladies neurodégénératives. ​ Brain ; MRI Researchers Neurospin Scientific result ; Europe ; Industrial partnerships Tue, 26 Nov 2024 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/QSM4SENIOR-Iron-mapping.aspx The first data from the QSM4SENIOR project, led by teams from NeuroSpin and VENTIO, have been published in Frontiers in Neuroimaging. They provide a highly accurate map of changes in iron levels during normal brain ageing, a valuable aid for scientists specialising in neurodegenerative diseases. Brain ; MRI Researchers Neurospin Scientific result ; Europe ; Industrial partnerships Tue, 26 Nov 2024 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Chimpanzee-and-human-brain-superficial-structural-connectivities.aspx A team from NeuroSpin has proposed a classification of the morphology of short white matter bundles (SWMBs) in human and chimpanzee brains. A wide variety of shapes was observed, as well as differences. This study provides valuable information on SWMB morphology and its potential implications for human cognitive development Brain ; Evolution ; MRI Neurospin Scientific result animal sciences; Fri, 22 Nov 2024 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Immunotherapie-structure-HER2-trastuzumab-pertuzumab.aspx Des chercheurs de l’I2BC, en collaboration avec Sanofi, l’IMPMC et l’Institut Pasteur, ont modélisé la structure du complexe associant le récepteur membranaire HER2 avec deux fragments de liaison (Fab) de deux anticorps thérapeutiques dirigés contre cette cible, le trastuzumab et le pertuzumab. Structural biology ; Microscope Researchers SB2SM Scientific result Fri, 08 Nov 2024 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/IBC3-mapping-cognitive-functions-naturalistic-stimuli.aspx Several NeuroSpin researchers have taken part in the Individual Brain Charting (IBC) project, aimed at creating a precise map of the cognitive functions of the human brain. In this third phase, they are using the Fast Shared Response Model to analyze large-scale fMRI data and model responses to natural stimuli involving the visual, auditory and language systems. MRI ; Brain ; Cognition Neurospin Scientific result ; Article Wed, 30 Oct 2024 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Iseult-apres-images-la-publication-scientifique.aspx L’équipe de NeuroSpin en charge de l’acquisition des premières images de cerveau de volontaires à 11,7 teslas a publié dans Nature Methods les détails de son protocole d’étude exploratoire menée à ce champ magnétique inégalé. Brain ; MRI Researchers Neurospin Scientific result ; Article Mon, 28 Oct 2024 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/SplineBeam-algorithme-prediction-champs-pression-ultrasons.aspx Les applications thérapeutiques des ultrasons sont nombreuses, notamment en neurologie. Prédire en temps réel le champ de pression acoustique à appliquer est indispensable. C’est ce que permet de faire l’algorithme SplineBeam développé par une équipe du SHFJ en collaboration avec le CEA-List, NeuroSpin et le CHU Grenoble-Alpes. Diagnosis and innovative treatment ; Brain Researchers Neurospin Scientific result ; Article Thu, 24 Oct 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/neuromodulatory-nuclei-Alzheimer-and-related-disorders.aspx A team from GHU Paris and SHFJ has used brain MRI to study the integrity of the locus coeruleus and nucleus basalis of Meynert in patients with early-onset Alzheimer's disease (AD), age-related TDP-43 encephalopathy (LATE) and fronto-temporal dementia (FTD). Both structures are altered in early AD, LATE and probably FTD, making these neuromodulatory areas potential therapeutic targets Diseases ; Brain ; Cognition ; MRI ; Positron Emission Tomography ; Alzheimer's disease Neurospin Scientific result Wed, 16 Oct 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Functional-brain-connectivity-emotional-states-bipolar-disorder.aspx A study conducted by NeuroSpin researchers reveals abnormalities in functional brain connectivity in the sub-nucleus region of the amygdala (emotion center), in patients with bipolar disorder. These anomalies, which depend on whether the patient is depressed or manic, are potential biomarkers of interest. Brain ; MRI ; Cognition ; Diseases Neurospin Scientific result Mon, 30 Sep 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/PET-monitoring-central-effects-innovative-smoking-cessation-therapy.aspx A BioMaps team has used PET imaging to monitor glucose metabolism as a marker of the cerebral impact of smoking cessation, as well as the effects of a promising drug-candidate for the treatment of such cessation. By revealing the restoration of normal activity in the brain area associated with craving, these results offer hope for smoking cessation in humans Positron Emission Tomography ; Medical imaging ; Pharmacology ; Brain SHFJ Scientific result Preclinical;animal models;murine model; Thu, 29 Aug 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Associative-learning-complex-auditory-sequences.aspx A NeuroSpin team analyzed the MEG response of volunteers exposed to auditory sequences organized in network. Finding that participants' brain activity was sensitive to the structure of the network, it concluded that learning the structure of auditory sequences involves a single cognitive process, associative learning. Cognition ; Brain ; Learning Neurospin Scientific result Wed, 17 Jul 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Correlation-structure-cerebellum-cognitive-functions.aspx A collaborative study led by NeuroSpin researchers analyzed anatomical MRI images of 662 young subjects from the Healthy Brain Network cohort, to map different features of cognitive function linked to cerebellar structure. It shows that there is a complex association between key cognitive functions and particular lobules of the cerebellum. Brain ; Cognition ; MRI Neurospin Scientific result Fri, 05 Jul 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Muscle-biomechanics-ultrasound-elastography.aspx A team from BioMaps (SHFJ) measures for the first time the in vivo local mechanical properties at play in a muscle (elasticity, anisotropy, non-linearity) using a non-invasive method, ultrasonic shear wave elastography. The originality of the approach lies in its ability to perform such measurements in a so complex tissue. Medical imaging ; Physics SHFJ Scientific result Fri, 14 Jun 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Press/2024/world-premiere-living-brain-imaged-with-unrivaled-clarity-thanks-to-world-most-powerful-MRI-machine.aspx ​The CEA is revealing a series of in vivo human brain images acquired with the Iseult MRI machine and its unmatched 11.7 teslas magnetic field strength. This success is the fruit of more than 20 years of R&D as part of the Iseult project, with one pillar goal being to design and build the world’s most powerful MRI machine. Its ambition is to study healthy and diseased human brains with an unprecedented resolution, allowing us to discover new details relating to the brain’s anatomy, connections, and activity. Health ＆ life sciences ; Brain ; Medical imaging ; Neurodegenerative diseases ; Cognition Journalists ; Institutions ; general public ; Researchers ; Young people ; Companies Irfu Press release Tue, 02 Apr 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Neurodevelopmental-model-prediction-psychotic-transition.aspx A NeuroSpin team has built a predictive model for the onset of psychosis using a combination of supervised learning analyses and a model of neuroanatomical age, based on neuroimaging data from healthy subjects and those at risk of psychotic transition. MRI ; Diseases ; Artificial intelligence ; Brain Neurospin Scientific result Thu, 21 Mar 2024 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Cognitive-neurosciences-perception-of-time.aspx A team from NeuroSpin has recently published 3 papers that address the question of how we perceive time from a cognitive neuroscience perspective, using real-life temporal experiments, laboratory experiments and MEG brainwave measurements indicative of the passage of time, and that shed light on how the brain constructs our experience of lived time. Brain ; Cognition Neurospin Scientific result Tue, 27 Feb 2024 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Diagnosis-acute-hepatic-porphyrias-mass-spectrometry.aspx A collaborative study between SPI and a team from Hôpital Louis Mourier demonstrates the contribution of liquid chromatography coupled with mass spectrometry to the day-to-day analytical needs of a clinical laboratory. Application to the rapid quantification of biomarkers in acute hepatic porphyrias. Diagnosis ; Mass spectrometry ; Biomarkers SPI Scientific result ; Article Fri, 23 Feb 2024 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Methodological-developments-emergence-ultra-high-field-MRI.aspx Researchers at NeuroSpin have recently published 3 articles in Magnetic Resonance in Medicine on their technological and methodological developments that will help meet the challenges of ultra-high field MRI for tomorrow's medical brain imaging. MRI ; Technologies Neurospin Scientific result Mon, 19 Feb 2024 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/First-complete-atlas-chimpanzee-brain-connectivity.aspx NeuroSpin researchers map chimpanzee brain structural connectivity for the first time using diffusion MRI data. New image processing enabled them to create two atlases of deep and superficial white matter connectivity. A step towards a better understanding of the evolution of the hominid brain. Brain ; MRI ; Computing Neurospin Scientific result préclinique; Mon, 12 Feb 2024 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Quantities-representation-brain-fMRI-UHF.aspx In a study published in Nature Communications, researchers from UNICOG and BAOBAB use high-field functional MRI to reveal the brain areas where the representations of quantities generated by a mental arithmetic operation are encoded. Cognition Researchers Neurospin Scientific result Wed, 31 Jan 2024 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Dyslexia-devices.aspx Devices such as lights and strobe glasses that are supposed to make reading easier for dyslexic people actually have no impact. These are the findings of a study conducted by a team from UNICOG (NeuroSpin) and published in the journal Proceedings Royal Society. Cognition Scientific result ; Article Sun, 28 Jan 2024 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/elasticity-biomarker-biological-tissue-diagnostics.aspx SHFJ researchers have validated the use of a new biomarker, the nonlinear shear modulus, to measure the elasticity of biological tissues, by comparing results obtained using echography with those obtained using MRI imaging and digital simulation. This biomarker is of particular interest for the diagnosis of certain breast cancers. Medical imaging ; MRI ; Diagnosis SHFJ Scientific result Wed, 24 Jan 2024 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2024/38-millions-euros-EBRAINS.aspx Brain Europe ; Infrastructures ; Article Human Brain Project;HBP; Thu, 11 Jan 2024 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Multiplex-proteotyping-for-identification-microbial-isolates.aspx Researchers at SPI are proposing an innovative multiplexing method for rapid identification of several microbial isolates in a single mass spectrometry analysis. This approach opens up prospects for the large-scale identification of microorganisms resulting from culturomics programs. High-throughput screening ; Methodologies for life sciences ; Proteomics ; Bacteria SPI Scientific result Fri, 24 Nov 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Neural-representation-uncertainty-consensus.aspx In a review article published in Nature Neuroscience, researchers, including Florent Meyniel from UNICOG (NeuroSpin), show that the two dominant approaches to the neural representation of uncertainty are complementary and would benefit from being used synergistically. Cognition Scientific result ; Article Fri, 17 Nov 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Low-frequency-neuronal-oscillations-MEG.aspx NeuroSpin researchers show that spontaneous neuronal oscillations in the 'delta' frequency band (0.5-3 Hz), the wave of unconscious states, can be observed in awake human volunteers using MEG. A step towards characterizing underlying physiological signals? Brain ; Cognition Neurospin Scientific result ; Article Wed, 18 Oct 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/IRM-effets-transitoires-UHF-systeme-vestibulaire.aspx Des chercheurs de NeuroSpin, en collaboration avec NeuroPSI montrent que l’effet des ultra hauts champs magnétiques sur l’appareil vestibulaire de souris est transitoire. MRI Researchers Neurospin Scientific result ; Article cochlée; Fri, 06 Oct 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Relationship-cerebellar-structure-social-abilities-young-autistic.aspx A collaborative study by NeuroSpin researchers, using anatomical MRI data and a dimensional approach in 850 subjects from the Healthy Brain Network cohort, shows how the social skills of these children and adolescents are linked to the structure of their cerebellum Brain ; Cognition ; MRI Neurospin Scientific result Tue, 12 Sep 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Events/2023/Kick-off-meeting-MIND.aspx ​​​Le 07 septembre, l'équipe MIND organisait son kick-off meeting, symbolisant la volonté commune de sestutell es, CEA et Inria, de consolider et de créer des synergies en intelligence artificielle et machine learning pour les neurosciences. MRI ; Artificial intelligence ; Brain Researchers ; Institutions Neurospin Inauguration ; Colloquium deep learning;Deep Neural Network;réseaux de neurones; Mon, 11 Sep 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2023/Kick-off-meeting-MIND.aspx On 07 September, the young MIND team organised its kick-off meeting, symbolising the shared desire of its two supervisory administrations, the CEA and Inria, to consolidate and create synergies in artificial intelligence and machine learning for neuroscience. MRI ; Artificial intelligence ; Brain Researchers ; Institutions Neurospin Inauguration ; Colloquium deep learning;Deep Neural Network; Mon, 11 Sep 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/IA-IRM-haut-champ-multiples-pistes-equipe-MIND.aspx Brain ; MRI ; Artificial intelligence Researchers Neurospin Scientific result ; Patent Wed, 30 Aug 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Longitudinal-monitoring-tauopathy-PET-imaging.aspx A joint team from GHU Paris and BioMaps (SHFJ) conducted a 2-year longitudinal study of 27 people with Alzheimer's disease, tracking the progression of tau pathology measured by PET imaging, of cortical atrophy using MRI, and their links with cognitive decline. Alzheimer's disease ; Medical imaging ; MRI ; Positron Emission Tomography SHFJ Scientific result ; Article Wed, 02 Aug 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Parole-integrations-informations-visuelles-et-auditives.aspx Une étude dirigée par une équipe d’UNICOG montre que le cerveau humain optimise l’intégration des informations auditives et visuelles de la parole à différentes échelles anatomiques et fonctionnelles, grâce à un ensemble de réseaux neuronaux hiérarchiquement imbriqués et synchronisés. Brain ; Cognition Scientific result Tue, 25 Jul 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Proteins-involved-pathogenesis-creatine-transporter-deficiency.aspx Researchers at SPI (DMTS) have identified by mass spectrometry and bioinformatics analysis several biomarkers linked to the creatine transporter deficiency disorder (CTD) using two original models : mice with the clinical characteristics of CTD subjects and brain organoids derived from CTD patient cells. Mass spectrometry ; Genetic diseases ; Biomarkers ; Proteomics SPI Scientific result Thu, 22 Jun 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/rabbit-motif-PET-imaging-diagnostic-evaluation-parkinsonian-syndromes.aspx BioMaps researchers compared the diagnostic performance of the rabbit visual pattern observed in 18F-DOPA PET imaging with the standard procedure approved by the international nuclear imaging societies for the diagnosis of parkinsonian syndromes in PET/MRI and obtained encouraging results, which may validate the clinical utility of such a model Positron Emission Tomography ; Medical imaging ; Parkinson's disease ; Brain SHFJ Scientific result Tue, 23 May 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Neural-representation-confidence-probabilistic-learning.aspx Using a dynamic probability learning task and high-field (7T) fMRI, a NeuroSpin team identifies regions in parietal and frontal cortex involved in the neural representation of prediction confidence during human learning Brain ; Cognition Neurospin Scientific result Wed, 10 May 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Mise-en-exploitation-IRM-11-7-T-Iseult.aspx La mise en exploitation de l’IRM 11.7 T Iseult en 2021 a couronné près de 20 ans de recherche et développement du CEA. Dans un article publié dans le journal Magnetic Resonance Materials in Physics, Biology and Medecine, Nicolas Boulant et Lionel Quettier, chefs du projet Iseult pour les instituts Joliot et Irfu du CEA, passent en revue les détails de cette mise en service. MRI ; Brain Article Fri, 28 Apr 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Structuring-neuroanatomical-criteria-fetal-alcohol-spectrum-disorder.aspx By analyzing brain imaging data, researchers from InDEV (NeuroSpin / UMR NeuroDiderot) have identified recurrent abnormalities in subjects with fetal alcohol syndrome, the combination of which could have a particularly interesting diagnostic value for non-syndromic forms of fetal alcohol spectrum disorders. MRI ; Diagnosis and innovative treatment Researchers Scientific result Mon, 13 Mar 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Genetic-variations-regulatory-regions-morphology-brain-sulci.aspx Using UK Biobank imaging-genetics data, a collaborative study led by NeuroSpin found that variation in genomic regions, known as enhancers, could affect the morphology of cortical sulci and be associated with the evolution of locomotion in primates and bipedalism in our hominin ancestors. MRI ; Genomics ; Brain Neurospin Scientific result Mon, 27 Feb 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Cone-marine-toxin-melanocortin-receptor-antagonist.aspx A SIMoS team discovered a toxin in the venom of a marine cone that it engineers into a high affinity antagonistic peptide for the melanocortin receptor, a major regulator of energy homeostasis. A step towards the development of innovative treatments for certain eating disorders Pharmacology ; High-throughput screening ; Proteomics ; Transcriptomics SIMOPRO Scientific result Thu, 09 Feb 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Virus-hepatite-E-AlphaFold.aspx I2BC researchers unveil an atomic model of the hepatitis E virus replication polyprotein obtained with the AlphaFold artificial intelligence program. The model provides a better understanding of how this RNA virus multiplies its genome in infected cells. Structural biology ; Simulation ＆ modelling ; Artificial intelligence Researchers SB2SM Scientific result AlphaFold2;RNA virus;in vitro translation; Wed, 08 Feb 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Anatomical-atypia-cerebellum-autistic-people.aspx By studying the morphology of the cerebellar gray matter, an international consortium coordinated by NeuroSpin researchers concludes that there are no anatomical atypia in the cerebellum of people with autism. Diseases ; Brain ; Medical imaging Researchers Saclay Scientific result IRM 3T;TDAH; Mon, 06 Feb 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/BAF-numerical-simulation-phosphorylation.aspx Using molecular dynamics simulation and NMR studies, I2BC researchers detail the restriction mechanisms of BAF protein dynamics due to its phosphorylation. Molecular mechanisms ; Structural biology ; Simulation ＆ modelling Researchers SB2SM Scientific result Mon, 16 Jan 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2022/ERC-Starting-Grant-Timo-van-Kerkoerle-NeuroSpin.aspx Timo van Kerkoerle, researcher at NeuroSpin, is one of the 408 winners of the prestigious ERC Starting Grant 2022 call of the European Research Council. Another European success for the Institute. Cognition Neurospin Success ; Europe Tue, 22 Nov 2022 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/SNR-high-field-MRI.aspx ​A collaboration led by a METRIC team (BAOBAB/NeuroSpin) has undertaken to measure the signal-to-noise ratio (SNR) in MRI at the centre of a spherical phantom at different magnetic field strengths (B0). Their data confirm the theories that SNR increases with approximately the square of B0. MRI Researchers Neurospin Scientific result ; Article Thu, 17 Nov 2022 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/CEST-linescan-Etudier-des-metabolites-peu-concentres-dans-cerveau.aspx NeuroSpin researchers, in collaboration with Iramis and the Università Statale di Milano, have developed a CEST magnetic resonance spectroscopy sequence that allows them to detect and confirm the presence of three dipeptides in the brain and skeletal muscle of adult rats and thus to consider future studies of their physiological role. MRI ; Cell and molecular imaging Researchers Neurospin Scientific result Tue, 15 Nov 2022 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Blursday-resource-to-understand-our-time-perception-during-lockdown.aspx The participative study on our time perception during the confinement, led by Virginie van Wassenhove (NeuroSpin), provides the first open database, Blursday, which analyzes the nature of the alterations in our relationship to time during physical and social distancing, as we experienced during the Covid-19 pandemic. Brain ; Cognition Neurospin Scientific result Mon, 19 Sep 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Specificity-of-reading-and-face-recognition-cerebral-circuits.aspx By measuring fMRI responses to written words, faces, houses and checkerboards in three groups of children, pre-readers and beginning readers aged 6 and advanced readers aged 9, a team from UNICOG (NeuroSpin) shows that reading acquisition recycles and specializes a pre-existing but plastic visual circuit connected to language areas. Brain ; MRI ; Learning Neurospin Scientific result Mon, 12 Sep 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Predicting-cognitives-activities-fMRI-maps.aspx A NeuroSpin team succeeded in decoding a large set of human mental processes by training neural networks to predict cognitive labels from a cognitive atlas and by leveraging the data set of NeuroVault, a web-based database for collecting and sharing statistical maps of the human brain. Brain ; Cognition ; MRI ; Artificial intelligence Neurospin Scientific result Thu, 30 Jun 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Pads-dielectriques-IRM-tres-haut-champ.aspx To address the problem of ultre high field MRI signal loss in certain regions of the human body, a collaboration involving the CEA-Joliot, the CEA-Iramis, the Fresnel Institute and Multiwave Imaging has led to the development of a new generation of simple and inexpensive silicon carbide-based pads. The new composition makes the pads invisible to MRI and prolongs their performance when compared to existing solutions. MRI Researchers ; Partners Iramis Scientific result ; Article specific absorption rate;radiofrequency passive shimming;shims; Tue, 07 Jun 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/First-atlas-anatomical-brain-connectivities-quail.aspx The expertise of NeuroSpin in diffusion MRI has allowed to establish the first atlas of the anatomical connectivities of the Japanese quail brain at a resolution of 150 m in three dimensions. MRI ; Brain Researchers Neurospin Scientific result ; Article Tue, 31 May 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Shape-early-brain-sulcus-predict-pathologies.aspx Neurospin researchers conducted a longitudinal brain imaging study in very premature infants to analyze the variability of the shape of the central sulcus early in its development and its functional implications. Brain ; MRI Researchers Neurospin Scientific result brain fold;gyrification;prematurity;hemispheric asymmetry; Fri, 20 May 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Integration-multisensory-temporal-coincidences.aspx A team at NeuroSpin, in collaboration with the University of Ulm (Germany), published a study in Nature Communications that suggests the existence of multisensory correlation detectors in the human brain. Brain ; Cognition Researchers Neurospin Scientific result Wed, 18 May 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Link-intestinal-microbiota-Covid-19.aspx A team from SPI used mass spectrometry to analyze the degree of alteration of the intestinal microbiota of Covid-19 patients and to look for signatures of intestinal infection by the SARS-CoV-2 virus. The level of the observed gut dysbiosis would be an indicator of the stage and extent of the infection. Mass spectrometry ; Proteomics ; Biomarkers ; Infectious diseases SPI Scientific result ; Article Thu, 12 May 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Segmentation-rare-brain-tumors.aspx A study led by NeuroSpin researchers proposes an optimized delineation of rare brain tumors, based on a combined approach of object detection and deep learning segmentation in tumor images, a key step in the characterization of cancers. Brain ; Medical imaging ; MRI Neurospin Scientific result ; Article Thu, 05 May 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/MRI-3D-sparkling.aspx NeuroSpin researchers propose a new version of their compressed MRI acquisition algorithm, SPARKLING, extended to 3D imaging. Their method reduces acquisition time by a factor of 20 for T2*-weighted scans without compromising image quality. Simulation ＆ modelling ; MRI Researchers Neurospin Scientific result ; Europe Thu, 28 Apr 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/PET-MRI-imaging-epilepsy-detection.aspx A team from BioMaps (SHFJ), in collaboration with several hospital groups, shows that hybrid PET/MRI imaging significantly improves the detection of epileptogenic foci and, consequently, the outcome of surgical treatment of epilepsy. Medical imaging ; Positron Emission Tomography ; MRI SHFJ Scientific result Tue, 05 Apr 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/ProMetIS-open-database-multi-omics-phenotyping.aspx A consortium of researchers, led by SPI/DMTS, presents ProMetIS, a pilot study for the deep phenotyping of murine models by combining proteomic and metabolomic approaches. A significant advance for the functional characterization of genes and the development of bioinformatics integration approaches. Mass spectrometry ; Large-scale biology ; Bioinformatic SPI Scientific result Mon, 04 Apr 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Press/2022/The-New-York-Times-geometrie-NeuroSpin.aspx In an article in the New York Times, Stanislas Dehaene (NeuroSpin director) and Mathias Sablé-Meyer (PhD student) discuss recent results obtained in collaboration with the Collège de France, the CNRS and the University of Paris 8 that show that humans have a universal capacity to understand abstract geometric concepts. Cognition ; Artificial intelligence Researchers ; general public Neurospin réseaux neuronaux;modélisation;psychologie exoérimentale;réseaux convolutionnels;cognition comparée; Thu, 31 Mar 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/thalamus-DBS-signatures-conscience.aspx Using fMRI and EEG, NeuroSpin and ICM researchers show that deep brain stimulation of the central part of the thalamus restores the richness of brain activity specific to consciousness, which is "switched off" in an anesthetized non-human primate. This work paves the way for clinical studies in patients with consciousness disorders. Cognition ; MRI Researchers Neurospin Scientific result Sat, 26 Mar 2022 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/7T-sodium-MRI-Alzheimer.aspx ​7T Sodium MRI may well prove increasingly useful in the study of physiological processes in inflammatory and neurodegenerative diseases and brain tumors. An example is a study on Alzheimer's disease, led by a NeuroSpin team. Brain ; Alzheimer's disease Researchers SHFJ Scientific result Mon, 07 Mar 2022 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2022/QSM4SENIOR.aspx The QSM4SENIOR project, led by NeuroSpin and the company VENTIO, aims at developing an original early biomarker of aging by using data from the SENIOR study of NeuroSpin. QSM4SENIOR has just been funded by the EOSC-Life. Brain ; MRI Researchers ; Institutions Neurospin Europe ; Industrial partnerships Wed, 02 Mar 2022 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/IA-predict-like-brain-gated-recurrence.aspx Two researchers of UNICOG/NeuroSpin show that a gated recurrence model of neural networks would allow to make efficient and simple predictions, like our brain, in different environments. In addition to being biologically plausible, this model would be generalizable. Brain ; Artificial intelligence ; Cognition Researchers Neurospin Scientific result sciences cognitives;Bayes; Thu, 17 Feb 2022 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Genetic-architecture-language-functional-connectivity.aspx Using data from the UK Biobank, the world's largest general population imaging-genetics cohort, a collaboration led by a team at BAOBAB (NeuroSpin) has identified genes involved in the genetic architecture of language functional connectivity. These genes could be a priority for studying natural language. Brain ; MRI ; Cognition ; Genomics Neurospin Scientific result Mon, 14 Feb 2022 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/tSNR-optimization-functional-MRI.aspx A NeuroSpin team (BAOBAB) has tested a signal denoising method dedicated to very high field (7T) functional MRI. It is based on the weighted combination of images from each reception channel of the radio frequency coil, a combination that optimizes the stability of the signal over time. MRI ; Physics Neurospin Scientific result ; Article Thu, 27 Jan 2022 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Brain-development-mental-health.aspx A NeuroSpin team has exploited data on mental health and brain developmental disorders of subjects in the Healthy Brain Network cohort. It established a link between certain symptoms, precursors of possible mood disorders, and structural changes in the developing brain in more than 650 young people. Brain ; Diseases Neurospin Scientific result Tue, 25 Jan 2022 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Modeling-pairing-crossover-meiosis.aspx In a study conducted by a team from the Institut Curie, researchers from the CEA-Joliot (B3S/I2BC department) have modeled in silico protein-protein interactions and thus contributed to establish at the molecular level the mechanisms that coordinate the pairing and recombination of homologous chromosomes during meiosis. Simulation ＆ modelling ; Structural biology ; Molecular mechanisms Researchers SB2SM Article ; Scientific result recombinaison homologue;AlphaFold;crossing-over;InterEvDock3; Thu, 13 Jan 2022 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Diagnosis-MS-congenital-disorders-glycosylation.aspx A collaboration initiated in 2017 between AP-HP (Bichat Hospital), Paris-Saclay University (Inserm 1193) and the Laboratoire d’Études du Métabolisme des Médicaments (LEMM/SPI/DMTS), leading to 4 publications in 2021, is advancing knowledge on the origin of certain congenital disorders of glycosylation, through the identification of specific biochemical biomarkers. Mass spectrometry ; Biomarkers ; Genetic diseases SPI Scientific result Tue, 04 Jan 2022 11:00:00 GMT