Frédéric Joliot Institute for Life Sciences - Sur le même thème https://joliot.cea.fr/drf/joliot/en/Pages/news/Science/2019/New-nanovectors-anticancer-therapies.aspx Website of the Frédéric-Joliot Institute of Life Sciences which includes 4 departments: I2BC, DMTS, NeuroSpin and Service hospitalier Frédéric Joliot (SHFJ). The teams are mainly located at the CEA Paris-Saclay center and at the Orsay hospital. en-US https://www.cea.frhttps://www-cea-fr.admsite.extra.cea.fr/Style%20Library/Themes/drf/instituts/images/logo-cea-joliot.png Frédéric Joliot Institute for Life Sciences - Sur le même thème https://joliot.cea.fr/drf/joliot/en Nanometric micelles for targeted delivery of a prodrug against atherosclerosis https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Nanomicelles-targeted-delivery-prodrug-atherosclerosis.aspx Teams from SCBM and SIMoS (DMTS) have developed nano-micelles for the vectorization of an active principle which regulates cholesterol metabolism towards atherosclerotic lesions. Nanomedicine ; Diseases SIMOPRO Scientific result ; Article preclinic;animal models; Thu, 14 Mar 2024 11:00:00 GMT Photocatalytic carbon dioxide reduction for radiolabeled drug synthesis https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Photocatalytic-CO2-reduction-for-radiolabeled-drug-synthesis.aspx Researchers from SCBM (DMTS) and SB2SM (I2BC) describe a novel and optimized approach to the total photoreduction of 13C-labelled CO2 to carbon monoxide (CO), and the immediate reuse of the latter for the synthesis of high value-added compounds. A step towards a radiochemistry of carbon isotopes potentially useful in human health. Bio-inspired catalysis ; Chemistry ; Green Chemistry ; Carbon cycle SHFJ Scientific result Wed, 22 Nov 2023 11:00:00 GMT Click-Chemistry: optimized drug delivery from nanomicelles into tumor cells https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Click-Chemistry-optimized-drug-delivery-nanomicelles.aspx Researchers at SCBM have used a click-and-release chemistry approach to mass-release an anti-cancer drug into cells from cleavable nanomicelles, thanks to a bioorthogonal activation process. A step towards the development of new nanomedicines Chemistry ; Biotechnology SCBM Scientific result Fri, 10 Nov 2023 11:00:00 GMT Chimie : passer par le radical anion du CO2 pour le radiomarquage de médicament est possible https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Radical-anion-CO2-radiomarquage.aspx Des chercheurs de l'institut montrent qu’une stratégie fondée sur la formation du radical anion CO2●- marqué au carbone 14 ou carbone 11 s’avère payante pour radiomarquer en conditions douces des médicaments. Chemistry ; Diagnosis and innovative treatment Researchers SHFJ Scientific result ; Article préclinique; Tue, 24 Oct 2023 10:00:00 GMT Un composé radiosensible pour combiner radiothérapie et chimiothérapie ? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Composé-radiosensible-combiner-radiotherapie-et-chimiotherapie.aspx Des chercheurs du SCBM et de l’Iramis publient une étude preuve-de-concept d’un composé radiosensible qui pourrait servir à « libérer » in vivo des médicaments anti-tumoraux, et ainsi de combiner les effets d’une radiothérapie et d’une chimiothérapie. Chemistry ; Radiotherapy Researchers SCBM Scientific result ; Article Tue, 05 Sep 2023 10:00:00 GMT After ISOTOPICS, ISOBIOTICS, the renewal of isotope labeling to strengthen european therapeutic innovation https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2023/ISOBIOTICS-renewal-isotope-labeling-biodrugs.aspx The SCBM was awarded funding from the Horizon Europe program for the ISOBIOTICS project, coordinated by Christophe Dugave. This project will enable the theoretical and practical training of 11 PhD students, including two at SCBM and one at SHFJ, on the development of innovative methods for the isotopic labeling of biodrugs Chemistry SCBM News ; Article ; Europe ; European & international partnerships Wed, 09 Aug 2023 10:00:00 GMT Click chemistry: new "electrophilic" iminosydnones https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/click-electrophilic-iminosydnones.aspx Researchers at the Joliot Institute have developed two new families of iminosydnones that allow the bio-orthogonal release of electrophilic species. These molecules constitute "building blocks" of click-and-release chemistry, useful for reactions with nucleophilic compounds contained in cells. Chemistry Researchers SCBM Scientific result Thu, 02 Feb 2023 11:00:00 GMT A novel fluorine-18 thiol carrier for labeling biomolecules used in PET imaging https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/fluorine-18-thiol-labeking-biomolecules-TEP.aspx Radiochemists from the BioMaps unit (SHFJ) have developed and automated the synthesis of an 18F-fluoropyridine containing a thiol function (-SH), allowing its conjugation to model biomolecules within 45 minutes. A step towards rapid radiolabeling of complex biological molecules for PET imaging. Radioactivity ; Chemistry ; Positron Emission Tomography SHFJ Scientific result Tue, 28 Jun 2022 10:00:00 GMT New perspectives for CO2 photoreduction by iron porphyrins https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Photoreduction-of-CO2-by-iron-porphyrins.aspx ​Researchers from ICMMO* and ISMO**, in collaboration with a team from I2BC, show that the urea-decorated iron porphyrin catalysts they developed previously for the electro-catalysis of CO2, can be successfully employed in a photo-catalytic approach. Chemistry ; Bio-inspired catalysis ; Photosynthesis SB2SM Scientific result Thu, 16 Jun 2022 10:00:00 GMT Facilitating access to deuterated and tritiated molecules: towards more diversity! https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Deuterated-tritiated-molecules-more-dversity.aspx Researchers from the SCBM describe a hydrogen isotope labeling process that is easy to implement and whose starting point is a "simple" mixture, in a solvent, of the product to be labeled with a pre-catalyst. Explanations of this process which finds applications in many fields including drug development or medical imaging. Chemistry ; Diagnosis and innovative treatment ; Medical imaging Researchers SCBM Scientific result marquage isotopique;biomolécule;activation C-H;ADME-DMPK; Wed, 06 Apr 2022 10:00:00 GMT Société Chimique de France: two prizes for two researchers from the Institute https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2021/SCF-2-prizé-2-researchers-SCBM.aspx The members of the Organic Chemistry Division (DCO) of the French Chemical Society met on Monday 10 May to award the DCO 2021 prizes. Sophie Feuillastre and Davide Audisio, both researchers at the SCBM (CEA-Joliot Department of Medicines and Technology for Health) are among the lucky winners. Chemistry Researchers SCBM Article radiolabeling; Thu, 27 May 2021 10:00:00 GMT Carbon labeling by isotopic exchange of nitriles https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Nitrile-carbon-isotope-labeling.aspx Researchers at the CEA-Joliot Institute (Carbon-14 labeling Laboratory), in collaboration with teams from AstraZeneca, Sanofi and Nimbe (CEA-Iramis), have developed a labeling method, based on nitrile exchange using nickel catalysis. This method is currently under study at Sanofi for the labeling of a drug candidate. Chemistry Scientific result ; Europe Fri, 30 Apr 2021 10:00:00 GMT A micellar probe for fluorine magnetic resonance tumor imaging https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Micellar-probe-fluorine-MRI-tumor.aspx A SCBM (DMTS) team, in collaboration with researchers at NeuroSpin and I2BC, is describing micellar nanometric vectors targeting tumors that have been imaged by fluorine magnetic resonance imaging (MRI). The observed 19F signal made it possible to precisely delimit the volume of the tumor zone in a mouse model and to quantify the probe accumulated in the target tissue. Chemistry ; Nanomedicine ; Cancer ; MRI Scientific result Thu, 04 Mar 2021 11:00:00 GMT Carbon labeling with light https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Carbon-labeling_light.aspx Researchers from the LMC (DMTS), in collaboration with a team from AstraZeneca, have developed a labeling method, based on the exchange of carbon dioxide, simply using visible blue light and a photocatalyst. Chemistry ; Biomarkers ; Diagnosis and innovative treatment Researchers SCBM Scientific result ; Europe radiolabeling; Wed, 24 Feb 2021 11:00:00 GMT Chemical synthesis and characterization of a non-radioactive chiral probe for studying enzymatic reaction mechanisms https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/chiral-probe-study-transferases.aspx Chemists of CEA-Joliot have synthesized the two enantiomers of a molecule containing a deuterated chiral ethyl group and characterized their chiral properties using advanced spectroscopic tools. These two compounds will be useful for probing the reaction mechanism of enzymes, as alkyl transferases. Chemistry Researchers SCBM Scientific result isotopic labeling; Tue, 24 Nov 2020 11:00:00 GMT Seeing tomorrow's OLED display technology emerge https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Seeing-tomorrow-OLED-display-technology-emerge.aspx A team from SCBM, in collaboration with IRAMIS, LETI, ENS Paris-Saclay, the Universities of Rennes and San José (USA), has developed new electroluminescent molecules with properties that improve the energy consumption and light production of organic light-emitting diodes (OLEDs). This is the first study correlating the structure and properties of this type of materials, with a promising future in display technologies. Chemistry ; Technologies Scientific result Thu, 22 Oct 2020 10:00:00 GMT A new molecule to fight against intracellular pathogens https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Retro1-new-molecule-against-intracellular-pathogens.aspx The SCBM and SIMoS collaborated to optimize the activity of Retro-1, a benzodiazepine compound, inhibitor of Shiga toxins and ricin, derived from high-throughput biological screening. They succeeded in obtaining an analog 70 times more protective against the cytotoxicity of Shiga toxins, Retro-1.1. Chemistry ; High-throughput screening ; CBRN-E threats Scientific result Mon, 14 Sep 2020 10:00:00 GMT Development of a general strategy for the isotopic labelling of carbamates by incorporation of CO2 https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/carbamates-CO2-isotope-labeling.aspx In a study published in Chemical Communications, the Joliot Institute Carbon labeling laboratory (LMC), in collaboration with the SHFJ, provides proof of concept of a "click" strategy for carbon isotope marking of pharmaceutical molecules containing carbamates. Chemistry ; Diagnosis and innovative treatment SCBM Scientific result ; Europe Thu, 10 Sep 2020 10:00:00 GMT Hydrogen isotopes in the race for new drugs https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Hydrogen-isotopes-race-new-drugs.aspx ​The Grégory Pieters' team (LMT/SCBM) publishes, in the prestigious Angewandte Chemie, two major advances in the field of carbon-hydrogen bonds activation involving the two isotopes of hydrogen, deuterium and tritium, facilitating in particular access to labeled analogues of complex molecules, a prerequisite for the development of new drugs. Chemistry Scientific result Tue, 01 Sep 2020 10:00:00 GMT Chemistry: releasing two fluorophores into living cells by "click and release". https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Click-and-release-liberation-2-fluorophores-dans-cellule.aspx Researchers from the LMC have developed a new series of iminosydnones that can split in two and release two fluorophores. They are providing a proof of concept that this "click and release" reaction can be triggered in living cells. Chemistry SCBM Scientific result Diels-Alder;cycloaddition;BCN;pyrazole; Mon, 29 Jun 2020 10:00:00 GMT Clickable bambusurils to access promising multivalent architectures. https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Clickable-bambusurils.aspx A team from SCBM, in collaboration with researchers from I2BC, SHFJ and IRAMIS, has synthesized new neutral macrocycles called bambusurils (BUs). These BUs can be functionalized by “click chemistry” to obtain multivalent architectures decorated with 8 to 12 ligands of interest, an alternate topology which gives them remarkable supramolecular properties. Chemistry Scientific result Mon, 04 May 2020 10:00:00 GMT Launch of FLIX, a European project for the isotopic labeling of molecules with high added values https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2020/Launch-of-FLIX.aspx In June 2019, the SCBM obtained a European FET-Open funding for the FLIX project (FLow chemistry for Isotopic eXchange), a radically innovative concept of isotopic labeling of molecules with high added values. This 4-year project, coordinated by CEA/SCBM, with an overall budget of 3.5 million euros started on January 1, 2020 and consists of seven European academic or industrial partners in five countries. Chemistry News ; Europe ; Article Wed, 19 Feb 2020 11:00:00 GMT Innovative approach to radiolabel peptides with fluorine-18 for PET imaging https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Innovative-approach-radiolabel-peptides-fluorine-18-PET-imaging.aspx Radiochemists from the BioMaps unit (SHFJ) have developed and automated a new fluor-18 radiolabelling method for peptides used to characterize specific pathological molecular signatures and thus target treatments. Peptides were conjugated to a specific tag, then radiolabeled in a single step under mild conditions, making this approach an innovative solution for PET imaging of peptides labeled with fluorine-18. Chemistry ; Positron Emission Tomography ; Cancer Scientific result Mon, 17 Feb 2020 11:00:00 GMT Davide Audisio (SCBM), winner of a « 2019 Consolidator Grant » from the European Research Council https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2019/Davide-Audisio-winner-Consolidator-Grant-ERC.aspx The European Research Council (ERC) announced, on December 10, 2019, the winners of the 2019 ERC "Consolidator Grants". Three CEA researchers are rewarded for the excellence of their work in astrophysics, particle physics and chemistry. In Joliot, chemistry is honored with the award of the research grant to Davide Audisio, SCBM, for his expertise in labeling molecules of interest with 14Carbone. Chemistry News ; Europe Tue, 10 Dec 2019 11:00:00 GMT Light to release the tension of cycles https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Light-release-tension-of-cycles.aspx A team from SCBM, in collaboration with Mauritian modelers, has shown that carboxylic acids can be easily converted into small rings with four carbon atoms, the cyclobutanes, using blue LEDs and an iridium catalyst. Cyclobutanes are increasingly used in the design of new drugs and the method described here will help to significantly expand the chemical space explored in "drug discovery". Chemistry Scientific result Tue, 03 Dec 2019 11:00:00 GMT See a tumor in PET imaging by « click-chemistry » in vivo https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/See-tumor-PET-imaging-click-chemistry-in-vivo.aspx A new PET imaging method by antibody pretargeting was developed at SHFJ, in collaboration with teams of SCBM and SPI. It consists in reacting in vivo a molecule labeled with 18Fluor with an antibody previously fixed on a tumor and this, in an extremely fast and selective manner, thanks to a « click-chemistry » reaction. The very good results obtained allow to consider the use of pre-targeted antibodies in nuclear medicine. Positron Emission Tomography ; Chemistry Scientific result Tue, 03 Sep 2019 10:00:00 GMT A new generation of nanovectors for anticancer therapies. https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/New-nanovectors-anticancer-therapies.aspx As part of a collaboration with MIRCen (Jacob Institute), researchers of SCBM have developed functional micellar vectors that can effectively target tumors and whose therapeutic activity is intrinsically carried by the constitutive unit of the micelle. This combination leads to better drug load and avoids premature drug release. Chemistry ; Nanosciences ; Nanomedicine Scientific result Wed, 12 Jun 2019 10:00:00 GMT IBiSA labeling of the Saclay plateau screening platforms (C@PS) https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2019/IBiSA-screening-saclay-plateau.aspx ​The union of the Saclay Plateau screening platforms under a single banner C @ PS (Criblage sur le Plateau de Saclay) has just obtained the IBiSA label. Jean-Christophe Cintrat (Joliot / SCBM) is in charge of the overall infrastructure. Chemistry ; High-throughput screening News Tue, 26 Mar 2019 11:00:00 GMT « Click and Release » chemistry for the targeted delivery of drugs in vivo https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Click-Release-chemistry-targeted-delivery-drug-invivo.aspx A team from the SCBM, in collaboration with the SPI, the IC2MP and the University Hospital of Poitiers, has developed a bioorthogonal chemistry strategy that allows, in vivo, the controlled release of active ingredients contained in micelles-targeting cancerous tumors. These results pave the way for new strategies for targeted drug delivery. Chemistry ; Cancer ; Nanomedicine Scientific result Fri, 15 Mar 2019 11:00:00 GMT Incorporating in a single step hydrogene isotopes into nucleic acid derivatives https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Single-step-incorporation-hydrogen-isotopes-in-nucleobases.aspx Facilitating the deuterium and tritium labeling of molecules containing nucleic bases such as many compounds of pharmacological interest? This is what researchers from SCBM in partnership with teams from SPI and Toulouse managed to achieve. Chemistry SPI Scientific result tritium;deuterium;ruthenium;nucleic base;isotopic labeling; Thu, 28 Feb 2019 11:00:00 GMT Helicenes: the familly gets bigger https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Helicenes-familly-gets-bigger.aspx Helicenes are synthetic molecules with attractive properties for physicists expert in materials but also for biologists. A collaboration led by chemists from the SCBM (CEA-Joliot) and involving the NIMBE (CEA-Iramis) allowed the synthesis of a particular class of helicenes. Chemistry SCBM Scientific result helicenes;regioselectivity; Tue, 22 Jan 2019 11:00:00 GMT CO2 and copper to radiolabel pharmaceutical compounds https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/CO2-copper-carbon-label-pharmaceutical-compounds.aspx Researchers from the SCBM and the IRAMIS (CEA/CNRS) have develop a 14C labeling method for therapeutic molecules based on dynamic Misspelled Wordcarbone dioxide exchange. This one step method generates far less radioactive waste. By facilitating some preclinical and clinical steps, it should eventually help to speed up the marketing applications of some new drug discoveries. Chemistry SCBM News échange isotopique;carbone 14;CO2; Fri, 11 Jan 2019 11:00:00 GMT A new method for ultra-rapid isotope labeling of drugs https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/ultra-rapid-isotope-labeling.aspx ​A SCBM Research Team, in collaboration with SHFJ, SIMOPRO and Karolinska Institute, has discovered a method inspired by the "click" chemistry which, from radioactive carbon dioxide, can synthesize in just five minutes radiolabeled molecules containing a cyclic urea moiety. This method has been used for the ultra-rapid isotope labeling of drugs, without modification of their structure and with an unequaled efficiency. Chemistry Scientific result Tue, 19 Jun 2018 10:00:00 GMT Importance of chemical modifications of proteins for their interactions with nanoparticles https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/modifications-proteins-nanoparticules.aspx ​Two Research Teams from I2BC@Saclay and SPI (LI2D, Marcoule), in collaboration with IRAMIS, highlight the very strong affinity of silica nanoparticles for proteins with RGG motifs (family of binding proteins). RNA), especially when these are methylated. These results are important for the development of safe by design approaches. Chemistry Scientific result Thu, 24 May 2018 10:00:00 GMT Metabolomic analysis facilitated by very high resolution mass spectrometry https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/metabolomic-analysis-facilitated-by-mass-spectrometry.aspx In a study published in Analytical Chemistry, the Mass Spectrometry Research Team of the Laboratory Drug Metabolism Research Laboratory (SPI) demonstrated the interest of Orbitrap Fusion, a state-of-the-art mass spectrometer for the identification of relevant metabolites based on their masses and isotopes measured with high accuracy. Chemistry ; Metabolomics ; Mass spectrometry Scientific result Wed, 25 Apr 2018 10:00:00 GMT Functionalized micellar nanovectors for targeted tumor therapy https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/functionalized-micellar-nanovectors.aspx ​As part of a collaboration with MIRCen (Institute of Biology François Jacob) and SBIGeM, SCBM researchers have developed functional micellar nanovectors capable of targeting a population of cancer cells. Chemistry ; Cancer Scientific result Thu, 12 Apr 2018 10:00:00 GMT A rapid isotopic labeling method for complex molecules containing a sulfur atom https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/isotopic-labeling-complex-molecules.aspx ​Researchers from SCBM, in collaboration with Paris-Sud University and INSA Toulouse, developed the first general method for tritium and deuterium labeling of complex molecules with thioether-type motifs (including sulfur atom). This method allows rapid access to tritiated or deuterated molecules used in the pharmaceutical industry for in vivo monitoring or the biological assay of substances of interest. Chemistry Scientific result Thu, 22 Mar 2018 11:00:00 GMT To link and to release selectively molecules in biological media https://www.cea.fr/drf/joliot/en/Pages/news/Science/2017/link_and_release_selectively_molecules_in_biological_media.aspx A Research Team of the SCBM (Frédéric Joliot Institute), in collaboration with the SIMOPRO (Frédéric Joliot Institute), Strasbourg University and the start-up Syndivia, has just discovered a new chemical reaction allowing both to bind and to cleave molecules in biological media ("click and release" reaction). Chemistry ; Health & life sciences Scientific result Tue, 24 Oct 2017 10:00:00 GMT The protein interactome of nanoparticles and its role in their cellular impact https://www.cea.fr/drf/joliot/en/Pages/news/Science/2017/Protein_interactome_of_nanoparticles_and_its_role_in_cellular_impact.aspx Two Research Teams led by Odette Prat of the Institute of Biosciences and Biotechnologies (BIAM) and Jean Armengaud of the Frédéric Joliot Institute (LI2D, Marcoule) have joined forces thanks to an ANR funding to deepen knowledge of the importance of the nature of protein crowns on the cellular impact of nanoparticles. The results from their three recent publications reveal a new concept: "the protein interactome applied to the corona of nanoparticles". Health & life sciences ; Proteomics ; Nanosciences Scientific result Fri, 20 Oct 2017 10:00:00 GMT Micellar nanovectors for tumor imaging. https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2015/Micellar_nanovectors_tumor_imaging.aspx In the context of a collaboration with the I²BM institute, researchers from SCBM have designed micellar vectors for targeting and visual delineation of tumors. Nanomedicine ; Cancer News Tue, 15 Dec 2015 11:00:00 GMT Bio-magnet for targeted medical imaging https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/I2BM_anglais/News/Scientific_news/Articles/2015/Bio-magnet-for-targeted-medical-imaging.aspx The CEA-IBEB has partnered with the CEA-I2BM to develop original MRI contrast agents. Nano-magnets produced by bacteria may reveal targets at the molecular level. Biotechnology ; Cell and molecular imaging ; MRI ; Diagnosis ; Nanomedicine LBC Scientific result Fri, 20 Feb 2015 11:00:00 GMT Performing chemistry within the cell https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2014/Performing-chemistry-within-the-cell.aspx Researchers from the CEA-IBITECS in collaboration with a team from the University of Strasbourg (UDS) have developed new reagents known as “chelating azides”, which can rapidly and selectively couple to any compound equipped with an alkyne group. The reaction can take place in any environment, including within a cell. Chemistry ; Methodologies for life sciences Saclay Scientific result Tue, 06 May 2014 10:00:00 GMT Quantum dot: a promising new imaging agent https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2013/Quantum-dot-a-promising-new-imaging-agent.aspx The drawback to current optical imaging markers is their short life. Researchers are now developing fluorescent nanocrystals (quantum dots) to supplant these markers. A team from the CEA-iBiTec-S, in collaboration with the CEA-I2BM and ESPCI, has developed a new surface chemistry for these particularly effective nanoparticles. Cell and molecular imaging ; Nanomedicine ; Chemistry Fontenay-aux-Roses Scientific result Fri, 22 Mar 2013 11:00:00 GMT