Frédéric Joliot Institute for Life Sciences - Sur le même thème https://joliot.cea.fr/drf/joliot/en/Pages/news/Science/2018/retro-2-is-widening.aspx Website of the Frédéric-Joliot Institute of Life Sciences which includes 4 departments: I2BC, DMTS, NeuroSpin and Service hospitalier Frédéric Joliot (SHFJ). The teams are mainly located at the CEA Paris-Saclay center and at the Orsay hospital. en-US https://www.cea.frhttps://www-cea-fr.admsite.extra.cea.fr/Style%20Library/Themes/drf/instituts/images/logo-cea-joliot.png Frédéric Joliot Institute for Life Sciences - Sur le même thème https://joliot.cea.fr/drf/joliot/en Detection of monkeypox: Mass spectrometry proves once again its effectiveness https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Detection-monkeypox-massspectrometry.aspx A Li2D team has released the peptidomic profile of the virus that causes monkeypox, which they established using tandem mass spectrometry. These data should help to better understand the evolution of the epidemic and allow the creation of targeted tests to potentially detect the threat more quickly and prevent a new epidemic. Diagnosis ; Infectious diseases Researchers SPI Scientific result Mon, 28 Nov 2022 11:00:00 GMT Molecular engineering of antibodies to accommodate antigenic drift of SARS-CoV-1 and 2 https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Engineering-antibodies-accommodate-antigenic-drift-SARS-CoV-1-2.aspx Researchers from SIMoS and SPI (DMTS) demonstrate that molecular engineering of llama antibodies, capable of neutralizing SARS-CoV-1, allows to obtain optimized antibodies with very high affinities for SARS-CoV-2 and its variants, the culprits of the Covid-19 epidemic. Biotechnology ; Virus SPI Scientific result Thu, 22 Sep 2022 10:00:00 GMT A possible link between changes in gut microbiota and fecal SARS-CoV-2 load ? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Link-intestinal-microbiota-Covid-19.aspx A team from SPI used mass spectrometry to analyze the degree of alteration of the intestinal microbiota of Covid-19 patients and to look for signatures of intestinal infection by the SARS-CoV-2 virus. The level of the observed gut dysbiosis would be an indicator of the stage and extent of the infection. Mass spectrometry ; Proteomics ; Biomarkers ; Infectious diseases SPI Scientific result ; Article Thu, 12 May 2022 10:00:00 GMT First functional characterization of ATP2, an essential Plasmodium flippase and potential antimalarial target https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Functional-characterization-PcATP2-essential-Plasmodium-flippase.aspx I2BC researchers, in collaboration with the Autonomous University of Barcelona, have provided the first studies of the function and structural organization of a flippase encoded by a parasite responsible for malaria, a first step towards understanding the essential physiological function of this transporter and its potential use as an antimalarial target. Structural biology ; Infectious diseases Scientific result Wed, 17 Mar 2021 11:00:00 GMT Première étape vers un test quantitatif par spectrométrie de masse pour le diagnostic spécifique de la COVID-19 ? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Vers-test-quantitatif-MS-diagnostic-specifique-COVID-19.aspx Le LEMM, en collaboration avec le LI2D et l’AP-HP, développe un test de diagnostic spécifique de la Covid-19 par spectrométrie de masse qui permettrait aussi la quantification de la charge virale du patient. Objectif à terme : adapter la méthode pour la rendre plus sensible et compatible avec les équipements d’analyse des hôpitaux. Diagnosis ; Mass spectrometry ; Virus Researchers SPI Scientific result SARS-CoV-2; Tue, 09 Mar 2021 11:00:00 GMT SARS-CoV-2 detection: mass spectrometry shows its potential for rapidity. https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/SARS-CoV-2-detection-mass-spectrometry-rapidity.aspx A team from SPI in Marcoule detected by mass spectrometry, in 3 minutes and without specific reagents, signature peptides of the SARS-CoV-2 virus in clinical samples (nasopharyngeal swabs). It thus provides a proof of concept of the use of this method as a possible alternative to PCR, currently the reference method. Mass spectrometry ; Virus ; Biodetection ; Diagnosis Scientific result Thu, 06 Aug 2020 10:00:00 GMT Proteomic analysis of SARS-CoV-2 infected cells https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Proteomic-analysis-SARS-CoV-2-infected-cells.aspx In order to optimize the amplification of quality inactivated virus, for the manufacture of a vaccine, a team from SPI (CEA Marcoule) used mass spectrometry to analyze the dynamics of the proteome of SARS-CoV-2 infected cells, at two multiplicities of infection. With more than 3,220 identified host proteins, researchers are also starting to decipher the processes and cellular networks impacted by this virus. Virus ; Mass spectrometry ; Proteomics News Mon, 06 Jul 2020 10:00:00 GMT Mapping of Ebola T-cell response: towards a new vaccine ? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Mapping-Ebola-T-cell-response.aspx SIMoS researchers, in collaboration with Genopole, Excellgene, Vaxeal holding SA (Switzerland), used a large-scale approach to map and characterize the response of CD4 T-cells from healthy donors, against two proteins from the Ebola-Zaire virus. They observed a strong response to the viral nucleoprotein (NP) and suggest that components of NP may be included in the design of new Ebola vaccines. Virus ; Vaccine Scientific result Wed, 24 Jun 2020 10:00:00 GMT Tracking down SARS-CoV-2 signature peptides is launched ! https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Proteomics-SARS-CoV-2-signature-peptides.aspx SPI researchers (Marcoule) used proteomics to identify signature peptides of the SARS-CoV-2 virus expressed in vitro. A "short list" of 14 identified and characterized peptides allows to consider developments in targeted mass spectrometry, making this direct and rapid large-scale approach, implantable in hospitals, a potential tool of choice in the detection of the virus responsible for Covid-19. Proteomics ; Virus Scientific result Fri, 05 Jun 2020 10:00:00 GMT How the identification of attenuated forms of the SARS-CoV-2 virus could help to control the current epidemic ? https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2020/Identification-attenuated-covid-virus-variants.aspx An opinion article, published in Environmental Microbiology, and written by an international consortium initiated by three researchers of Joliot Institute, proposes an original way of research on Covid-19 through the identification by sequencing of attenuated variants of the SARS-CoV-2 virus in populations at risk with little or no symptoms. Virus ; Genomics ; Vaccine Tue, 12 May 2020 10:00:00 GMT Characterization of a predictive survival biomarker in the event of septic shock https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Characterization-predictive-survival-biomarker-septic-shock.aspx Two recent studies conducted by SPI researchers, in collaboration with Inserm and AP/HP teams, reveal the value of measuring plasma levels of calgranulins as biomarkers for the prediction of mortality risk of patients with septic shock, admitted in intensive care unit. Biomarkers ; Mass spectrometry ; Infectious diseases Scientific result Tue, 24 Mar 2020 11:00:00 GMT The way is now open for the development of a broad-spectrum drug candidate for several pathogenic viruses, bacteria and toxins https://www.cea.fr/drf/joliot/en/Pages/news/Press/The-way-is-now-open-for-the-development-of-a-broad-spectrum-drug-candidate-for-several-pathogenic-viruses,-bacteria-and-tox.aspx Health & life sciences ; Toxicology ; Virus News ; Press release Fri, 21 Feb 2020 11:00:00 GMT The Retro-2 antiviral spectrum is widening https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/retro-2-is-widening.aspx ​Two Research Teams from SIMOPRO and SCBM, in collaboration with Texas Biomedical Research Institute and Jilin University, showed that anti-ricin compounds Retro-2, discovered at CEA during researches against bioterrorism, inhibit two families of viruses important for public health (Ebola and Marburg filovirus and enterovirus EV71). These results broaden the antiviral spectrum of Retro-2 type compounds. Virus ; Infectious diseases Scientific result Fri, 16 Mar 2018 11:00:00 GMT ZIKAlliance Kickoff https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2017/ZIKAlliance_Kickoff.aspx ​​CEA Frédéric Joliot Institute is part of ZIKAlliance, a project of the European Union focused on studying infection by the Zika virus and preparing for possible epidemics. Health & life sciences ; Virus News Thu, 16 Feb 2017 11:00:00 GMT The team of Laurent Bellanger receives the trophy of societal resilience. https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2015/societal_resilience_trophy_2015.aspx ​​On September 17, the jury for Societal Resilience Trophies of the French High Committee for Civil Defence (HCFDC) awarded to the team of Laurent Bellanger (CEA-IBITECS) the price of technological innovation​​​ for the development of the diagnostic test for Ebola virus disease, named Ebola eZYSCREEN®​​.​ CBRN-E threats ; Virus ; Biodetection News Thu, 17 Sep 2015 10:00:00 GMT