Frédéric Joliot Institute for Life Sciences - On the same theme https://joliot.cea.fr/drf/joliot/en/Pages/news/Science/2018/New-function-discovered-protein-Rad52-serious-therapeutic-target-breast-cancer.aspx Website of the Frédéric-Joliot Institute of Life Sciences which includes 4 departments: I2BC, DMTS, NeuroSpin and Service hospitalier Frédéric Joliot (SHFJ). The teams are mainly located at the CEA Paris-Saclay center and at the Orsay hospital. en-US https://www.cea.frhttps://www-cea-fr.admsite.extra.cea.fr/Style%20Library/Themes/drf/instituts/images/logo-cea-joliot.png Frédéric Joliot Institute for Life Sciences - On the same theme https://joliot.cea.fr/drf/joliot/en Rapid genome replication during early vertebrate development: role of the Rif1 protein https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Rapid-genome-replication-role-of-Rif1-protein.aspx I2BC researchers show that the Rif1 protein restrains the replication program and the recruitment of replication initiation factors during early embryonic divisions in X laevis. A step towards elucidating the molecular mechanisms involved in diseases resulting from Rif1 mutations in humans Molecular mechanisms ; DNA SBIGEM Scientific result ; Article Thu, 21 Dec 2023 11:00:00 GMT Phytic acid: a small molecule that helps repair DNA breaks https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/phytic-acid-DNA-repair.aspx In an article published in the journal Nucleic Acids Research, scientists from the I2BC, lPBS and the Institute for Structural and Chemical Biology (University of Leicester, UK) demonstrate how phytic acid, a product of cellular metabolism, stabilises the assembly of a complex enabling the repair of DNA breaks in humans. DNA ; Structural biology Researchers SB2SM Scientific result ; Article Mon, 04 Dec 2023 11:00:00 GMT Multiplier les chimères pour mieux comprendre les interactions inhibiteur-cible protéique https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Multiplier-chimeres-mieux-comprendre-interactions-inhibiteur-cible-proteique.aspx En substituant des segments d’hélice alpha​ par des segments d’oligo-urées dans un peptide inhibiteur d’ASF1, lui conférant ainsi une résistance accrue aux protéases, des chercheurs de l’I2BC en collaboration avec l’IECB explorent les modes de liaison de ces chimères peptide-urée à leur cible. Molecular mechanisms ; Structural biology Researchers SB2SM Scientific result ; Article Tue, 12 Sep 2023 10:00:00 GMT A new role for the Mediator of transcription in chromatin organization at gene promoter regions https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/New-role-Mediator-transcription-chromatin-organization.aspx A team from I2BC has shown that the Mediator of transcription from the yeast S.cerevisiae physically interacts with the chromatin remodeling complex, and that by co-localizing with this complex on DNA promoter regions, it contributes to chromatin organization favorable to transcription initiation. Health & life sciences ; DNA ; Molecular mechanisms SBIGEM Scientific result Mon, 24 Jul 2023 10:00:00 GMT Agir sur les protéines pour limiter la dispersion des microplastiques dans l’eau ? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/proteines-dispersion-microplastiques-dans-eau.aspx Des chercheurs de l’I2BC ont contribué à une étude menée par l’Iramis qui dévoile le rôle des protéines dans la dispersion des microplastiques dans l’eau. Leurs résultats permettent d’imaginer de nouvelles stratégies low tech pour débarrasser l’eau de cette pollution. Impacts on living (organisms) ; Molecular mechanisms ; Remediation Researchers SB2SM Scientific result surfactant;polypropylène;polyéthylène; Wed, 12 Jul 2023 10:00:00 GMT Hypertension: an animal toxin active on angiotensin II receptors https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/HTA-toxine-animale-recepteur-angiotensine-II.aspx SIMoS researchers have identified and characterised an animal toxin (A-CTX-Mila) as a ligand for angiotensin II receptors, which are involved in one of the signalling pathways targeted by antihypertensive drugs. A tool of choice for studying the cellular mechanisms controlled by these receptors. Molecular mechanisms ; Diseases Researchers SIMOPRO Scientific result Fri, 16 Jun 2023 10:00:00 GMT DNA repair machinery more flexible thanks to PAXX? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Reparation-ADN-PAXX.aspx An international collaboration led by researchers from I2BC/CEA-Joliot and IPBS (Toulouse) has solved the atomic structure of molecular assemblies involved in the repair of DNA double-strand breaks. The diversity of assemblies involving the PAXX protein identified in this study highlights the great flexibility of the repair machinery, which could reflect its ability to adapt to biological conditions. The results were published in Science Advances. Structural biology ; Molecular mechanisms Researchers SB2SM Scientific result cryoEM;radiocristallographie; Tue, 06 Jun 2023 10:00:00 GMT Numerical simulation provides information on the restriction of BAF protein dynamics by phosphorylation https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/BAF-numerical-simulation-phosphorylation.aspx Using molecular dynamics simulation and NMR studies, I2BC researchers detail the restriction mechanisms of BAF protein dynamics due to its phosphorylation. Molecular mechanisms ; Structural biology ; Simulation & modelling Researchers SB2SM Scientific result Mon, 16 Jan 2023 11:00:00 GMT A mathematical model applicable to nuclear processes at the genome scale, and at very high spatial resolution https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Mathematical-model-repair-genome.aspx The protocols applied for in vivo mapping of nuclear processes, at the genome scale and at very high spatial resolution, do not allow for high temporal resolution. A team from the I2BC has therefore demonstrated that such an understanding could be wrong by using a mathematical model. This model can be applied to any process that can be modeled by a transition between two states. DNA ; Cellular mechanisms Researchers IBITECS Scientific result XR-seq;réparation de l’ADN;NER; Tue, 13 Dec 2022 11:00:00 GMT The Mediator of transcription at the heart of gene expression regulation and DNA repair https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Mediator-transcription-gene-expression-regulation-DNA-repair.aspx An I2BC team has analyzed, at the genome scale of the yeast S.cerevisiae, the functional interactions between the Mediator of gene transcription and DNA repair proteins, reinforcing the idea that these two fundamental cellular processes are closely linked. Molecular mechanisms ; Cellular mechanisms ; DNA SBIGEM Scientific result Mon, 26 Sep 2022 10:00:00 GMT Towards understanding the mechanisms responsible for intrahepatic cholestasis: biochemical and structural study of the human ATPase ATP8B1 https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Intrahepatic-cholestasis-biochemistry-structure-ATP8B1.aspx A collaborative study involving an I2BC team unveils the mechanism of autoinhibition of the human flippase ATP8B1, as well as its regulation by lipids and phosphorylation. The study provides a better understanding of the impact of flippase mutations responsible for intrahepatic cholestasis on its enzymatic activity. Molecular mechanisms ; Structural biology Researchers SB2SM Scientific result ATP;hydrolyse;protéine membranaire;modifications post-traductionnelles;expression hétérologue;membranes;cryo-EM; Thu, 09 Jun 2022 10:00:00 GMT In silico modelling unveils mechanisms of coordination between pairing and crossovers during meiosis https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Modeling-pairing-crossover-meiosis.aspx In a study conducted by a team from the Institut Curie, researchers from the CEA-Joliot (B3S/I2BC department) have modeled in silico protein-protein interactions and thus contributed to establish at the molecular level the mechanisms that coordinate the pairing and recombination of homologous chromosomes during meiosis. Simulation & modelling ; Structural biology ; Molecular mechanisms Researchers SB2SM Article ; Scientific result recombinaison homologue;AlphaFold;crossing-over;InterEvDock3; Thu, 13 Jan 2022 11:00:00 GMT Senescence and chromatin: new biomarkers? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/senescence_biomarkers_chromatin.aspx Researchers from the DMTS and I2BC depatments of the Joliot Institute's " identify three potential new biomarkers of senescent cells containing persistent DNA damage. Molecular mechanisms Researchers SBIGEM Scientific result Wed, 17 Nov 2021 11:00:00 GMT Plants - Dissipating excess absorbed light energy as heat to protect themselves: light on molecular mechanisms https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Plants-dissipation-exces-energy.aspx In a study published in JBC, a team from I2BC/CEA-Joliot, in collaboration with the Beijing Botanical Institute (China), describes for the first time an intermediate state of the light-harvesting antenna of higher plants that provides a better understanding of the changes that take place at the molecular level during the activation of a plant's photoprotection mechanism. Photosynthesis ; Molecular mechanisms Researchers SB2SM Scientific result Raman analyzer; Mon, 05 Jul 2021 10:00:00 GMT A small RNA regulates photoprotection in cyanobacteria https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Small-RNA-regulates-photoprotection-cyanobacteria.aspx A team of the I2BC (LMB/SB2SM), in collaboration with the Institute of Biology (Freiburg University), discovered a posttranscriptional regulatory mechanism linking the expression of the cyanobacterial Orange Carotenoid Protein, related to photoprotection, directly and in an inverse fashion, to the synthesis of the light collector complexes (phycobilisomes), via a 3’ end-derived small RNA. Photosynthesis ; Microalgae ; Molecular mechanisms Scientific result Wed, 23 Jun 2021 10:00:00 GMT Accelerating mutation accumulation studies with microfluidics https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/accumulation-mutations-microfluidique.aspx Teams from CEA-Iramis and CEA-Joliot (team "Genome transcriptional regulation /I2BC) have joined forces to develop and validate an innovative microfluidic-based system that automatizes cell culture over many generations. It enables with considerable time savings large-scale experiments to be carried out, which are essential for understanding the cellular mechanisms involved in DNA mutation events. DNA ; Cellular mechanisms Researchers Iramis Scientific result Fri, 11 Jun 2021 10:00:00 GMT Phosphorylation of BAF alters its dynamics and interaction with DNA but not its contacts with the nuclear envelope https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/phosphorylation-BAF-interaction.aspx ​A study by researchers from I2BC department shows in vitro the effect of mitotic phosphorylation of the BAF protein on its structure and its interactions with DNA and lamina and unveils consequences on genome organization and on mechanisms responsible for progeroid syndromes. Molecular mechanisms ; DNA ; Structural biology Researchers SB2SM Scientific result NMR;radiocristallography; Mon, 29 Mar 2021 10:00:00 GMT Anti-cancer therapeutic strategy: a chimera to inhibit ASF1 https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Foldamer-inhibitor-ASF1.aspx I2BC researchers, in collaboration with the European Institute of Chemistry and Biology (University of Bordeaux, CNRS), have developed a chimeric peptide/foldamer molecule that is resistant to proteolysis and inhibits ASF1, a potential target for anticancer treatment. The resolution of the structure of this chimera in interaction with its target, the first of its kind, reveals an unsuspected plasticity of the urea-based backbone that hugs the surface of ASF1. Structural biology ; Molecular mechanisms ; Epigenetics ; Cancer Researchers SB2SM Scientific result NMR;radiocristallography; Fri, 19 Mar 2021 11:00:00 GMT Regulation of the Ca2+ ATPase by sarcolipin: a long-range effect https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Sarcolipin.aspx By combining molecular dynamics and in vitro experiments, researchers at the LPSM (I2BC) have revealed the mode of action of sarcolipin in regulating the activity of SERCA1a, responsible for muscle relaxation. Molecular mechanisms ; Fundamental Research Researchers Saclay Scientific result Fri, 05 Mar 2021 11:00:00 GMT Key role of SERCA protein residue E340 in the inter-domain communication necessary for calcium transport https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/E340-SERCA-communication.aspx A study led by Oxford University researchers and involving researchers from the Institut Joliot (I2BC) and the University of Århus reveals the crucial role of the E340 residue in the inter-domain communication of the calcium transporter SERCA. Molecular mechanisms Researchers SB2SM Scientific result fluorescence;mutagenesis;tryptophan; Fri, 15 Jan 2021 11:00:00 GMT Depression and gut microbiota: the endocannabinoid system makes the connection https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Depression-gut-microbiota.aspx A study led by the Institut Pasteur and involving CEA-Joliot has shown, in a mouse model, that a modification of the intestinal microbiota caused by chronic stress is accompanied by modifications of the metabolome which induce a defect in the signaling pathway for endogenous cannabinoids in the hippocampus, which may explain the mood disorders observed. Metabolomics ; Molecular mechanisms Researchers SPI Scientific result Microbiology;neural circuits; Tue, 15 Dec 2020 11:00:00 GMT Mambaquaretin: therapeutic and diagnostic interest? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Mambaquaretin-theranostic.aspx In pursuing their work on mambaquaretin, SIMoS researchers conducted a collaborative study confirming the therapeutic potential of the toxin and paving the way for its use as a diagnostic tool. Diagnosis and innovative treatment ; Molecular mechanisms ; Cellular mechanisms SIMOPRO Scientific result PET Scan;PK/PD; Tue, 10 Nov 2020 11:00:00 GMT Viral deubiquitylation: toning things down brings better control? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/DUB-virale-ubiquitin.aspx A study led by a team from the Institut Joliot (I2BC/B3S) reveals an unusual mode of interaction between a viral deubiquitinase and a ubiquitin, which appears to be optimized to finely control virus replication. Molecular mechanisms SB2SM Scientific result crystal structure;deubiquitinilation;viral protease; Tue, 08 Sep 2020 10:00:00 GMT Dynamic association of PTOX with thylakoids https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Dynamics-PTOX-thylakoides.aspx A collaboration led by I2BC researchers presents, in the Journal of Experimental Botany, a body of evidence for a dynamic association of the PTOX protein with thylakoid membranes, dependent on proton motive force. Bioenergy ; Molecular mechanisms SB2SM Scientific result photosystem;ATP; Sat, 02 May 2020 10:00:00 GMT BRCA2 and breast cancer: a new mechanism revealed? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/BRCA2-breast-cancer.aspx ​In a study conducted by a team from the Institut Curie, I2BC researchers have used their NMR know-how to study the phosphorylation of BRCA2 and have thus contributed to revealing a mechanism potentially at the origin of chromosomal aberrations observed in breast BRCA2-mutated tumors. Molecular mechanisms ; Cancer SB2SM Scientific result homologous recombination;Rad51;kinase; Mon, 27 Apr 2020 10:00:00 GMT A mobile laboratory to study the genetic material of extinct…or emerging species https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Mobile-laboratory-study-genetic-material-extinct-species.aspx A collaboration between researchers from I2BC@Saclay, the french Muséum National d'Histoire Naturelle and owners of prehistoric sites shows the possibility of using a mobile laboratory to quickly identify DNA of archaeological specimens. Evolution ; DNA Scientific result Wed, 08 Apr 2020 10:00:00 GMT From bacteria to Humans: characterization of a new player in tolerance to thermal and oxidative stress https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Characterization-new-player-tolerance-thermal-oxidative-stress.aspx Researchers from SB2SM (I2BC@Saclay) have shown for the first time in vivo in the model cyanobacterium Synechocystis that a cellular detoxification enzyme, the membrane glutathione-S-transferase (GST), maintained in part by evolution, plays a major role in resistance to thermal and oxidative stress, making this cellular model a valuable tool for the study of GSTs conserved from bacteria to plants, down to Humans. Photosynthesis ; Stress response Scientific result Tue, 18 Feb 2020 11:00:00 GMT Formation of nanometric scrolls driven by electrostatic interactions between cationic peptides and anionic lipids https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Lanreotide-nanoscrolls.aspx By studying the self-assembly of a hormone-derived peptide in the presence of lipid membranes, a team of the SB2SM (Joliot Institute / I2BC) in collaboration with the University of Rennes 1 and Ipsen biopharmaceutical group, shows how the interactions electrostatic type modify the structures of the assemblies formed by each of these molecules alone in solution. Molecular mechanisms ; Cell and molecular imaging SB2SM Scientific result Mon, 23 Sep 2019 10:00:00 GMT Glucocorticoids: a better evaluation of their effects in specific cancers? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Glucocorticoids-better-evaluation-effect-cancers.aspx Senescence specialists (SBIGEM), in collaboration with the SCBM and the CNRGH (Jacob Institute), show that glucocorticoids can delay or even short-circuit it and disrupt its function as a tumor suppressor. Cellular mechanisms ; Molecular mechanisms ; Cancer Fontenay-aux-Roses Scientific result MEK/ERK;oncogenesis;Senescence; Mon, 09 Sep 2019 10:00:00 GMT Friedreich’s ataxia: a reliable in vitro model sheds light on physiological role of frataxin https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Friedreich-Ataxia-reliable-in-vitro-model-function-frataxin.aspx By improving the in vitro reconstitution of the iron-sulfur clusters biosynthesis machinery, a team from SBIGEM (CEA-Joliot / I2BC), with its French, German and Spanish collaborators, clarifies the function of frataxin, a protein involved in Friedreich’s ataxia. Molecular mechanisms SBIGEM Scientific result Frataxin;Mössbauer;circular dichroism; Fri, 06 Sep 2019 10:00:00 GMT How the transcriptional machinery recruits a DNA repair protein? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Transcription-and-DNA-repair.aspx Recent work by SBIGeM (I2BC@Saclay) highlights how two essential components of DNA transcription into RNA coordinate to recruit the Rad2/XPG DNA repair protein, thus linking these two fundamental cellular processes. Molecular mechanisms ; DNA Scientific result Thu, 22 Aug 2019 10:00:00 GMT Lipid transmembrane transport: very first structures are revealed! https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Drs2-Cdc50-CryoEM-Structure-Nature.aspx Researchers from I2BC@Saclay, the University of Aarhus and the Max Planck Institute of Biophysics in Frankfurt reveals the first cryo-EM high-resolution structures of one of the P4-ATPases. Study has been published in Nature. It give a better insight towards the understanding of the transport mechanisms of membrane lipids. A lipid pathway through the protein membrane domain is suggested. Structural biology ; Molecular mechanisms Saclay Press release ; Scientific result lipid asymetry;P4-ATPase;membrane lipid translocation; Thu, 27 Jun 2019 10:00:00 GMT New function discovered for the protein Rad52, a serious therapeutic target in breast cancer https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/New-function-discovered-protein-Rad52-serious-therapeutic-target-breast-cancer.aspx Rad52 has garnered great attention lately as a promising target in the battle against certain types of breast cancer. A team from IRCM, in partnership with researchers from the Frédéric-Joliot and Gustave Roussy Institutes, has shed new light on this protein. Stress response ; Molecular mechanisms Jacob Scientific result Rad51 filament;budding yeast;Srs2; Fri, 12 Oct 2018 10:00:00 GMT DNA repair: in-depth look at the initial stages https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/DNA-repair-zoom-first-steps.aspx A research team from the SB2SM (I2BC@Saclay), in collaboration with the CNRS, SOLEIL , Universities of Paris-Sud, Aix-Marseille and Paul Sabatier - Toulouse III and Gustave Roussy, has resolved structures of two complexes involved in radiation-induced DNA damages. These results were published in Nature Structural & Molecular Biology on October, the 5th. DNA ; Structural biology ; Molecular mechanisms SB2SM Press release Mon, 08 Oct 2018 10:00:00 GMT What is the relationship between variants of the BRCA1 gene and susceptibility to cancer? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/relationship-variants-BRCA1-cancer.aspx Research Teams from the Curie Institute, the Gustave Roussy Institute, as well as the biophysics teams from the Institute of Chemistry of Natural Substances and SB2SM (I2BC@Saclay) met to systematically identify structural defects and BRCA1 proteins encoded by variants of the BRCA1 gene, a gene predisposing to breast and ovarian cancer. Their results make it possible to propose a classification of these variants (neutral versus causal). Cancer ; Structural biology ; DNA Scientific result Fri, 28 Sep 2018 10:00:00 GMT An advance in the understanding of exchanges between DNA molecules during recombination https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/advance-exchanges-recombination.aspx Collaborative work between the SBIGeM (I2BC@Saclay) and the Marseille Cancer Research Center, published in Molecular Cell, illuminates the mechanistic basis and genetic control of homologous recombination, a mechanism for repairing DNA breaks responsible for chromosome exchange during meiosis. However, canonical models do not explain the complexity of meiotic recombination profiles and this study, which reconstructs reaction intermediates, constitutes a major advance in the understanding of this mechanism. DNA ; Genomics News Tue, 15 May 2018 10:00:00 GMT Epigenetics: how to reach inaccessible genes? https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2016/Epigenetics_how_reach_inaccessible_genes.aspx ​Biologists have brought to light the operation of "chromatin remodellers", key enzymes in cells. They have discovered how the genetic material, condensed in the nucleus of the cell, needs to be remodelled so that the cell machinery can access the genes. This work, initiated by IBITECS/SBIGeM, coordinated by researchers from a CEA/CNRS/Université Paris-Sud laboratory, under an international collaborative project with Pennsylvania State University (USA) and Guangzhou University (China), was published in Nature on 4 February 2016.​​ Epigenetics News Wed, 12 Apr 2017 13:23:30 GMT Mediator independently orchestrates multiple steps of preinitiation complex assembly in vivo https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2016/Mediator_transcriptional_regulation.aspx ​A genomic study of the role of the Mediator of transcriptional regulation, carried out by a SBIGeM team, shows that this multiprotein complex coordinate the multiple stages of the setting up of the transcriptional machinery in vivo.​​ DNA News Wed, 12 Apr 2017 13:23:19 GMT A new vision of the in vivo function of the transcription mediator https://www.cea.fr/drf/joliot/en/Pages/news/Science/2017/A_new_vision_of_the_in_vivo_function_of_the_transcription_mediator.aspx An in vivo, in vitro and in silico study of the Mediator of Transcriptional Regulation has shown how the function of this multiprotein complex is coordinated with another essential component of the transcription machinery, the TFIIB factor, and the architecture of the promoter. This study, led by SBIGeM, was conducted in collaboration with several other Research Teams (CNRS, CEA, INRA). DNA ; Health & life sciences Scientific result Tue, 31 Jan 2017 11:00:00 GMT Hug1 is an intrinsically disordered protein that inhibits ribonucleotide reductase activity by directly binding Rnr2 subunit. https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2015/Hug1_and_RNR.aspx ​A study, coordinated by a SBIGeM team in collaboration with a SB2SM team, allowed to describe the role of the Hug1 protein in regulating the activity of the ribonucleotide reductase complex (RNR). The level of active RNR is controlled during cell cycle and in response to DNA damages. DNA ; Stress response ; Cell division News Mon, 04 May 2015 10:00:00 GMT How does a mobile DNA sequence find its target? https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2015/How-does-mobile-DNA-sequence-find-target.aspx Certain mobile DNA sequences shape genomes and are maintained over the course of generations. How is this explained? The interaction between two proteins, which is essential for their integration into a specific area of the yeast genome, has been identified. This finding has interesting implications for gene therapy. DNA ; Gene and cell therapy Saclay Scientific result Fri, 01 May 2015 10:00:00 GMT