Frédéric Joliot Institute for Life Sciences - Sur le même thème https://joliot.cea.fr/drf/joliot/en/Pages/news/Science/2017/pet_brain_damage_alcohol.aspx Website of the Frédéric-Joliot Institute of Life Sciences which includes 4 departments: I2BC, DMTS, NeuroSpin and Service hospitalier Frédéric Joliot (SHFJ). The teams are mainly located at the CEA Paris-Saclay center and at the Orsay hospital. en-US https://www.cea.frhttps://www-cea-fr.admsite.extra.cea.fr/Style%20Library/Themes/drf/instituts/images/logo-cea-joliot.png Frédéric Joliot Institute for Life Sciences - Sur le même thème https://joliot.cea.fr/drf/joliot/en Towards a neurodevelopmental model for the prediction of psychotic transition https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Neurodevelopmental-model-prediction-psychotic-transition.aspx A NeuroSpin team has built a predictive model for the onset of psychosis using a combination of supervised learning analyses and a model of neuroanatomical age, based on neuroimaging data from healthy subjects and those at risk of psychotic transition. MRI ; Diseases ; Artificial intelligence ; Brain Neurospin Scientific result Thu, 21 Mar 2024 11:00:00 GMT What do cognitive neurosciences have to say about our perception of time? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Cognitive-neurosciences-perception-of-time.aspx A team from NeuroSpin has recently published 3 papers that address the question of how we perceive time from a cognitive neuroscience perspective, using real-life temporal experiments, laboratory experiments and MEG brainwave measurements indicative of the passage of time, and that shed light on how the brain constructs our experience of lived time. Brain ; Cognition Neurospin Scientific result Tue, 27 Feb 2024 11:00:00 GMT First complete atlas of chimpanzee brain connectivity https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/First-complete-atlas-chimpanzee-brain-connectivity.aspx NeuroSpin researchers map chimpanzee brain structural connectivity for the first time using diffusion MRI data. New image processing enabled them to create two atlases of deep and superficial white matter connectivity. A step towards a better understanding of the evolution of the hominid brain. Brain ; MRI ; Computing Neurospin Scientific result préclinique; Mon, 12 Feb 2024 11:00:00 GMT Where and how is the representation of quantities generated in the brain? Study using ultra-high field functional MRI https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Quantities-representation-brain-fMRI-UHF.aspx In a study published in Nature Communications, researchers from UNICOG and BAOBAB use high-field functional MRI to reveal the brain areas where the representations of quantities generated by a mental arithmetic operation are encoded. Cognition Researchers Neurospin Scientific result Wed, 31 Jan 2024 11:00:00 GMT Dyslexie : certains des dispositifs vendus pour faciliter la lecture ne sont pas efficaces https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Dyslexie-dispositifs-vendus-inefficaces.aspx Les dispositifs tels que les lampes et les lunettes stroboscopiques censés faciliter la lecture des personnes dyslexiques n’auarient en fait aucun impact. C’est ce que révèle une étude menée par une équipe d’UNICOG (NeuroSpin) et publiée dans la revue Proceedings Royal Society. Cognition Scientific result ; Article Sun, 28 Jan 2024 11:00:00 GMT 38 millions d’euros sécurisés pour EBRAINS https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2024/38-millions-euros-EBRAINS.aspx Brain Europe ; Infrastructures ; Article Human Brain Project;HBP; Thu, 11 Jan 2024 11:00:00 GMT Neural representation of uncertainty: towards a consensus? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Neural-representation-uncertainty-consensus.aspx In a review article published in Nature Neuroscience, researchers, including Florent Meyniel from UNICOG (NeuroSpin), show that the two dominant approaches to the neural representation of uncertainty are complementary and would benefit from being used synergistically. Cognition Scientific result ; Article Fri, 17 Nov 2023 11:00:00 GMT Characterization of low-frequency neuronal oscillations in human magnetoencephalography https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Low-frequency-neuronal-oscillations-MEG.aspx NeuroSpin researchers show that spontaneous neuronal oscillations in the 'delta' frequency band (0.5-3 Hz), the wave of unconscious states, can be observed in awake human volunteers using MEG. A step towards characterizing underlying physiological signals? Brain ; Cognition Neurospin Scientific result ; Article Wed, 18 Oct 2023 10:00:00 GMT Impact of metabolic variations on PET imaging of neuroinflammation in humans https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Impact-metabolism-PET-imaging-neuroinflammation.aspx Researchers at BioMaps evaluated the effect of several factors on the distribution of [18F]DPA-714 in 201 subjects who participated in SHFJ PET imaging protocols to better understand the role of neuroinflammation in various neurological diseases. They conclude that measures of individual metabolism are important in image interpretation. Positron Emission Tomography ; Medical imaging ; Pharmacology SHFJ Scientific result Thu, 12 Oct 2023 10:00:00 GMT Understanding the relationship between cerebellar structure and social abilities in young subjects with autism-related symptoms https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Relationship-cerebellar-structure-social-abilities-young-autistic.aspx A collaborative study by NeuroSpin researchers, using anatomical MRI data and a dimensional approach in 850 subjects from the Healthy Brain Network cohort, shows how the social skills of these children and adolescents are linked to the structure of their cerebellum Brain ; Cognition ; MRI Neurospin Scientific result Tue, 12 Sep 2023 10:00:00 GMT Rentrée « en mode kick-off » pour l’équipe MIND https://www.cea.fr/drf/joliot/en/Pages/news/Events/2023/Kick-off-meeting-MIND.aspx ​​​Le 07 septembre, l'équipe MIND organisait son kick-off meeting, symbolisant la volonté commune de sestutell es, CEA et Inria, de consolider et de créer des synergies en intelligence artificielle et machine learning pour les neurosciences. MRI ; Artificial intelligence ; Brain Researchers ; Institutions Neurospin Inauguration ; Colloquium deep learning;Deep Neural Network;réseaux de neurones; Mon, 11 Sep 2023 10:00:00 GMT kick-off meeting for the MIND team https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2023/Kick-off-meeting-MIND.aspx On 07 September, the young MIND team organised its kick-off meeting, symbolising the shared desire of its two supervisory administrations, the CEA and Inria, to consolidate and create synergies in artificial intelligence and machine learning for neuroscience. MRI ; Artificial intelligence ; Brain Researchers ; Institutions Neurospin Inauguration ; Colloquium deep learning;Deep Neural Network; Mon, 11 Sep 2023 10:00:00 GMT PET imaging monitoring of an antibody targeting endothelin receptors expressed by glioblastoma tumors https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/PET-imaging-antibody-endothelin-receptors-glioblastoma-tumors.aspx Researchers at BioMaps (SHFJ) and SPI (DMTS) have studied the pharmacokinetics of a novel immuno-radioligand targeting the endothelin A receptor (ETA), overexpressed in many cancers, particularly glioblastoma. The immunoPET imaging approach used in this study in a preclinical model confirms the theranostic potential of this antibody. Positron Emission Tomography ; Cancer ; Medical imaging Neurospin Scientific result Thu, 07 Sep 2023 10:00:00 GMT L’IA pour l’IRM à haut champ : les multiples pistes développées par l’équipe MIND pour ne plus choisir entre temps et qualité de l’image https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/IA-IRM-haut-champ-multiples-pistes-equipe-MIND.aspx Brain ; MRI ; Artificial intelligence Researchers Neurospin Scientific result ; Patent Wed, 30 Aug 2023 10:00:00 GMT Longitudinal monitoring of tauopathy in PET imaging to better understand the various modalities of clinical evolution of Alzheimer's disease https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Longitudinal-monitoring-tauopathy-PET-imaging.aspx A joint team from GHU Paris and BioMaps (SHFJ) conducted a 2-year longitudinal study of 27 people with Alzheimer's disease, tracking the progression of tau pathology measured by PET imaging, of cortical atrophy using MRI, and their links with cognitive decline. Alzheimer's disease ; Medical imaging ; MRI ; Positron Emission Tomography SHFJ Scientific result ; Article Wed, 02 Aug 2023 10:00:00 GMT Comment le cerveau intègre-t-il efficacement les informations visuelles et auditives de la parole ? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Parole-integrations-informations-visuelles-et-auditives.aspx Une étude dirigée par une équipe d’UNICOG montre que le cerveau humain optimise l’intégration des informations auditives et visuelles de la parole à différentes échelles anatomiques et fonctionnelles, grâce à un ensemble de réseaux neuronaux hiérarchiquement imbriqués et synchronisés. Brain ; Cognition Scientific result Tue, 25 Jul 2023 10:00:00 GMT The "rabbit motif" in 18F-DOPA PET imaging for a simplified diagnostic evaluation of parkinsonian syndromes https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/rabbit-motif-PET-imaging-diagnostic-evaluation-parkinsonian-syndromes.aspx BioMaps researchers compared the diagnostic performance of the rabbit visual pattern observed in 18F-DOPA PET imaging with the standard procedure approved by the international nuclear imaging societies for the diagnosis of parkinsonian syndromes in PET/MRI and obtained encouraging results, which may validate the clinical utility of such a model Positron Emission Tomography ; Medical imaging ; Parkinson's disease ; Brain SHFJ Scientific result Tue, 23 May 2023 10:00:00 GMT Characterization of the neural representation of confidence during probabilistic learning https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Neural-representation-confidence-probabilistic-learning.aspx Using a dynamic probability learning task and high-field (7T) fMRI, a NeuroSpin team identifies regions in parietal and frontal cortex involved in the neural representation of prediction confidence during human learning Brain ; Cognition Neurospin Scientific result Wed, 10 May 2023 10:00:00 GMT Mise en exploitation de l’IRM 11.7 T Iseult : revue de détails https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Mise-en-exploitation-IRM-11-7-T-Iseult.aspx La mise en exploitation de l’IRM 11.7 T Iseult en 2021 a couronné près de 20 ans de recherche et développement du CEA. Dans un article publié dans le journal Magnetic Resonance Materials in Physics, Biology and Medecine, Nicolas Boulant et Lionel Quettier, chefs du projet Iseult pour les instituts Joliot et Irfu du CEA, passent en revue les détails de cette mise en service. MRI ; Brain Article Fri, 28 Apr 2023 10:00:00 GMT Radiomarquage du crizotinib au fluor-18 : un nouvel outil pour suivre par TEP la biodistribution de ce médicament https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Radiomarquage-crizotinib-fluor-18-nouvel-outil-TEP.aspx Des chercheurs du SHFJ ont mis au point la radiosynthèse au fluor-18 du crizotinib, un médicament qui ne pénètre pas dans le cerveau. Ce nouvel outil pour l’imagerie TEP permettra d’explorer de futures stratégies visant à faire passer la barrière hémato-encéphalique à ce médicament pour traiter certaines métastases cérébrales. Positron Emission Tomography ; Cancer ; Diagnosis and innovative treatment Researchers SHFJ Scientific result ; Article Thu, 27 Apr 2023 10:00:00 GMT Genetic variations in evolutionarily acquired DNA regulatory regions affect the morphology of certain sulci in the human cerebral cortex https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Genetic-variations-regulatory-regions-morphology-brain-sulci.aspx Using UK Biobank imaging-genetics data, a collaborative study led by NeuroSpin found that variation in genomic regions, known as enhancers, could affect the morphology of cortical sulci and be associated with the evolution of locomotion in primates and bipedalism in our hominin ancestors. MRI ; Genomics ; Brain Neurospin Scientific result Mon, 27 Feb 2023 11:00:00 GMT Platinum nanoparticles to improve radiotherapy ? PET imaging provides answers https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Nanoparticles-to-improve-radiotherapy.aspx Researchers from the SHFJ laboratory at ISMO have demonstrated the value of platinum nanoparticles as potential radiosensitizing agents for radiation therapy. Diagnosis and innovative treatment ; Positron Emission Tomography Researchers SHFJ Scientific result Radiotherapy;biodistribution;platinum nanoparticles; Tue, 21 Feb 2023 11:00:00 GMT Development of a new radiolabeling strategy in immunoPET for precision imaging https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/New-radiolabeling-strategy-immunoTEP.aspx Researchers from the BioMaps laboratory (SHFJ) and the Molecular Engineering for Health Service (SIMoS, DMTS) developed an enzymatic approach for radiofluorination of an anti-PD-L1 Fab and compared its in vivo properties to the same Fab stochastically labeled by two conventional methods. Diagnosis and innovative treatment ; Positron Emission Tomography Researchers SHFJ Scientific result PD-L1;radiomarquage;lipoate-protéine ligase;radiofluoration; Tue, 21 Feb 2023 11:00:00 GMT Glioblastoma: Does focused ultrasound increase the therapeutic efficacy of cetuximab? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Glioblastoma-FUS-cetuximab.aspx Researchers from the SHFJ, in collaboration with NeuroSpin, show that the use of focused ultrasound does not increase the therapeutic effects of cetuximab on glioblastoma although the opening of the blood-brain barrier is transiently effective. Positron Emission Tomography ; Diagnosis and innovative treatment Researchers Neurospin Scientific result Wed, 15 Feb 2023 11:00:00 GMT Anatomical atypia in autistic people ? Fine morphological analyses contradict the results of the last decade https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Anatomical-atypia-cerebellum-autistic-people.aspx By studying the morphology of the cerebellar gray matter, an international consortium coordinated by NeuroSpin researchers concludes that there are no anatomical atypia in the cerebellum of people with autism. Diseases ; Brain ; Medical imaging Researchers Saclay Scientific result IRM 3T;TDAH; Mon, 06 Feb 2023 11:00:00 GMT ERC Starting Grant for Timo van Kerkoerle at NeuroSpin! https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2022/ERC-Starting-Grant-Timo-van-Kerkoerle-NeuroSpin.aspx Timo van Kerkoerle, researcher at NeuroSpin, is one of the 408 winners of the prestigious ERC Starting Grant 2022 call of the European Research Council. Another European success for the Institute. Cognition Neurospin Success ; Europe Tue, 22 Nov 2022 11:00:00 GMT First results of the "Confined time" study released in Blursday, a resource to understand our perception of time during lockdown https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Blursday-resource-to-understand-our-time-perception-during-lockdown.aspx The participative study on our time perception during the confinement, led by Virginie van Wassenhove (NeuroSpin), provides the first open database, Blursday, which analyzes the nature of the alterations in our relationship to time during physical and social distancing, as we experienced during the Covid-19 pandemic. Brain ; Cognition Neurospin Scientific result Mon, 19 Sep 2022 10:00:00 GMT Specificity of reading and face recognition cerebral circuits during reading acquisition https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Specificity-of-reading-and-face-recognition-cerebral-circuits.aspx By measuring fMRI responses to written words, faces, houses and checkerboards in three groups of children, pre-readers and beginning readers aged 6 and advanced readers aged 9, a team from UNICOG (NeuroSpin) shows that reading acquisition recycles and specializes a pre-existing but plastic visual circuit connected to language areas. Brain ; MRI ; Learning Neurospin Scientific result Mon, 12 Sep 2022 10:00:00 GMT Predicting all cognitive activities from images of the functionning brain, it's possible https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Predicting-cognitives-activities-fMRI-maps.aspx A NeuroSpin team succeeded in decoding a large set of human mental processes by training neural networks to predict cognitive labels from a cognitive atlas and by leveraging the data set of NeuroVault, a web-based database for collecting and sharing statistical maps of the human brain. Brain ; Cognition ; MRI ; Artificial intelligence Neurospin Scientific result Thu, 30 Jun 2022 10:00:00 GMT A novel fluorine-18 thiol carrier for labeling biomolecules used in PET imaging https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/fluorine-18-thiol-labeking-biomolecules-TEP.aspx Radiochemists from the BioMaps unit (SHFJ) have developed and automated the synthesis of an 18F-fluoropyridine containing a thiol function (-SH), allowing its conjugation to model biomolecules within 45 minutes. A step towards rapid radiolabeling of complex biological molecules for PET imaging. Radioactivity ; Chemistry ; Positron Emission Tomography SHFJ Scientific result Tue, 28 Jun 2022 10:00:00 GMT First atlas of anatomical brain connectivities in quail! https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/First-atlas-anatomical-brain-connectivities-quail.aspx The expertise of NeuroSpin in diffusion MRI has allowed to establish the first atlas of the anatomical connectivities of the Japanese quail brain at a resolution of 150 m in three dimensions. MRI ; Brain Researchers Neurospin Scientific result ; Article Tue, 31 May 2022 10:00:00 GMT What if the shape of the early brain sulci could predict certain pathologies? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Shape-early-brain-sulcus-predict-pathologies.aspx Neurospin researchers conducted a longitudinal brain imaging study in very premature infants to analyze the variability of the shape of the central sulcus early in its development and its functional implications. Brain ; MRI Researchers Neurospin Scientific result brain fold;gyrification;prematurity;hemispheric asymmetry; Fri, 20 May 2022 10:00:00 GMT Multisensory integration may be a matter of temporal coincidences https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Integration-multisensory-temporal-coincidences.aspx A team at NeuroSpin, in collaboration with the University of Ulm (Germany), published a study in Nature Communications that suggests the existence of multisensory correlation detectors in the human brain. Brain ; Cognition Researchers Neurospin Scientific result Wed, 18 May 2022 10:00:00 GMT Object detection facilitates segmentation of rare brain tumors in MR imaging https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Segmentation-rare-brain-tumors.aspx A study led by NeuroSpin researchers proposes an optimized delineation of rare brain tumors, based on a combined approach of object detection and deep learning segmentation in tumor images, a key step in the characterization of cancers. Brain ; Medical imaging ; MRI Neurospin Scientific result ; Article Thu, 05 May 2022 10:00:00 GMT New radioligands for anti-PD-1/PD-L1 immunoPET https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Radioligands-immunoPET-PD-1-PD-L1.aspx Researchers from the SHFJ and the DMTS have developed optimized radioligands for immunoPET imaging. The objective is to better predict the effectiveness of anti-PD1/anti-PDL1 immunotherapy used to fight certain cancers. Positron Emission Tomography ; Cancer Researchers SIMOPRO Scientific result programmed cell death-ligand 1; Tue, 12 Apr 2022 10:00:00 GMT Hybrid PET/MRI imaging, a unique examination to improve the detection of epileptogenic lesions https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/PET-MRI-imaging-epilepsy-detection.aspx A team from BioMaps (SHFJ), in collaboration with several hospital groups, shows that hybrid PET/MRI imaging significantly improves the detection of epileptogenic foci and, consequently, the outcome of surgical treatment of epilepsy. Medical imaging ; Positron Emission Tomography ; MRI SHFJ Scientific result Tue, 05 Apr 2022 10:00:00 GMT Alzheimer's: PET imaging of tau protein predicts cognitive decline and progression of brain atrophy https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Alzheimer-Tau-PET-imaging.aspx A joint team from GHU Paris and SHFJ shows the predictive value of PET imaging data of the Tau protein in the progression of Alzheimer's disease. Alzheimer's disease ; Positron Emission Tomography Researchers SHFJ Scientific result ; Press release radiotracer; Sun, 03 Apr 2022 10:00:00 GMT The New York Times is interested in the studies on the sensitivity to geometry conducted at NeuroSpin https://www.cea.fr/drf/joliot/en/Pages/news/Press/2022/The-New-York-Times-geometrie-NeuroSpin.aspx In an article in the New York Times, Stanislas Dehaene (NeuroSpin director) and Mathias Sablé-Meyer (PhD student) discuss recent results obtained in collaboration with the Collège de France, the CNRS and the University of Paris 8 that show that humans have a universal capacity to understand abstract geometric concepts. Cognition ; Artificial intelligence Researchers ; general public Neurospin réseaux neuronaux;modélisation;psychologie exoérimentale;réseaux convolutionnels;cognition comparée; Thu, 31 Mar 2022 10:00:00 GMT Deep brain stimulation of the thalamus restores signatures of consciousness https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/thalamus-DBS-signatures-conscience.aspx Using fMRI and EEG, NeuroSpin and ICM researchers show that deep brain stimulation of the central part of the thalamus restores the richness of brain activity specific to consciousness, which is "switched off" in an anesthetized non-human primate. This work paves the way for clinical studies in patients with consciousness disorders. Cognition ; MRI Researchers Neurospin Scientific result Sat, 26 Mar 2022 11:00:00 GMT 7T Sodium MRI confirms early metabolic damage in Alzheimer's disease https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/7T-sodium-MRI-Alzheimer.aspx ​7T Sodium MRI may well prove increasingly useful in the study of physiological processes in inflammatory and neurodegenerative diseases and brain tumors. An example is a study on Alzheimer's disease, led by a NeuroSpin team. Brain ; Alzheimer's disease Researchers SHFJ Scientific result Mon, 07 Mar 2022 11:00:00 GMT Brain aging: European funding to evaluate an early biomarker https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2022/QSM4SENIOR.aspx The QSM4SENIOR project, led by NeuroSpin and the company VENTIO, aims at developing an original early biomarker of aging by using data from the SENIOR study of NeuroSpin. QSM4SENIOR has just been funded by the EOSC-Life. Brain ; MRI Researchers ; Institutions Neurospin Europe ; Industrial partnerships Wed, 02 Mar 2022 11:00:00 GMT AI: predicting simply and efficiently like the brain https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/IA-predict-like-brain-gated-recurrence.aspx Two researchers of UNICOG/NeuroSpin show that a gated recurrence model of neural networks would allow to make efficient and simple predictions, like our brain, in different environments. In addition to being biologically plausible, this model would be generalizable. Brain ; Artificial intelligence ; Cognition Researchers Neurospin Scientific result sciences cognitives;Bayes; Thu, 17 Feb 2022 11:00:00 GMT The genetic architecture of language functional connectivity revealed https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Genetic-architecture-language-functional-connectivity.aspx Using data from the UK Biobank, the world's largest general population imaging-genetics cohort, a collaboration led by a team at BAOBAB (NeuroSpin) has identified genes involved in the genetic architecture of language functional connectivity. These genes could be a priority for studying natural language. Brain ; MRI ; Cognition ; Genomics Neurospin Scientific result Mon, 14 Feb 2022 11:00:00 GMT Brain development and mental health in adolescents and young adults https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Brain-development-mental-health.aspx A NeuroSpin team has exploited data on mental health and brain developmental disorders of subjects in the Healthy Brain Network cohort. It established a link between certain symptoms, precursors of possible mood disorders, and structural changes in the developing brain in more than 650 young people. Brain ; Diseases Neurospin Scientific result Tue, 25 Jan 2022 11:00:00 GMT Minimal computational models accounting for emergence of a specific region underlying orthographic coding https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/CNN-accounting-for-emergence-of-specific-region-underlying-orthographic-coding.aspx ​Researchers from NeuroSpin designed, trained and tested biologically plausible artificial deep neural networks to identify pictures and written words. They show that these may suffice to account for emergence during reading acquisition of the visual word form area, a specific region underlying orthographic coding. Cognition ; Artificial intelligence Researchers Neurospin Scientific result Tue, 30 Nov 2021 11:00:00 GMT Multiparametric PET-MRI imaging: toward a biological characterization of tumors at the supervoxel level https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/PET-MRI-imaging-tumors-supervoxel-level.aspx A collaborative study led by BioMaps researchers (SHFJ) demonstrates that fully integrated quantitative multiparametric analysis of non-small cell lung cancer in hybrid 18F-FDG PET/MRI 3T imaging is clinically feasible and could enable biological characterization of tumors at the supervoxel scale. Medical imaging ; Positron Emission Tomography ; MRI ; Cancer Scientific result Wed, 10 Nov 2021 11:00:00 GMT PET imaging of tau and amyloid deposits improves the diagnosis of progressive amnesia https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Amyloid-tau-imaging-diagnosis-progressive-amnesia.aspx Researchers from BioMaps (SHFJ) and the Service de Neurologie de la Mémoire et du Langage (Hôpital Ste-Anne) show, through amyloid and tau molecular imaging in patients followed for 2 years, that the diagnosis of progressive amnesia in the elderly is not necessarily Alzheimer's disease and may be caused by other mechanisms clearly distinguishable from it. Positron Emission Tomography ; Medical imaging ; Alzheimer's disease Scientific result Thu, 04 Nov 2021 11:00:00 GMT The most powerful MRI scanner in the world delivers its first images! https://www.cea.fr/drf/joliot/en/Pages/news/Press/premieres-images-irm-iseult-2021.aspx September 2021, the 11.7 Tesla MRI of the Iseult project, the most powerful in the world for human imaging, has just unveiled its first images. Health & life sciences ; Brain ; Physics Journalists ; general public ; Researchers ; Partners Neurospin News ; Press release ; Découvertes et avancées Brain;MRI;neuroanatomy;Iseult;supra; Thu, 07 Oct 2021 05:00:00 GMT A combinatorial neural code for speech is present in the infant https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Combinatorial-neural-code-speech-infant.aspx Researchers at UNICOG (NeuroSpin) show, using a high-resolution electroencephalographic system, that speech, an extremely complex and variable acoustic signal, is perceived by infants as a sequence of stable and invariant segments through an encoding based on distinctive and orthogonal phonetic features, such as manner and place of articulation, which are secondarily combined into phonemes, such as ″b″ or ″m″. Brain ; Cognition Scientific result Tue, 14 Sep 2021 10:00:00 GMT Automatic recognition of brain "lines" https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Automatic-recognition-brain-lines.aspx Researchers at NeuroSpin (CEA-Joliot) propose to automate the classification and recognition of folding patterns on the surface of the cortex that may be related to the occurrence of psychiatric diseases or cognitive disorders using artificial intelligence algorithms. A path towards deciphering the "lines" of the brain. Brain ; Artificial intelligence Scientific result Mon, 23 Aug 2021 10:00:00 GMT Diffusion MRI characterizes radiation-induced neurological impairments https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/diffusion-MRI-characterizes-radiation-induced-neurological-impairments.aspx A team comprising iRCM (CEA-Jacob) and NeuroSpin (CEA-Joliot) researchers analyzed the consequences of irradiation on brain development and neurogenesis in a preclinical model. That work, published in Radiation Research, lays a path for the use of diffusion imaging for the early detection of neurological abnormalities resulting from different types of stress. Brain ; Impacts on living (organisms) ; MRI ; Biomarkers ; Radiobiology Researchers ; Journalists ; general public DRF Scientific result ; Highlight ionizing radiations;Brain;neurodevelopmental disorder;neurogenesis;MRI;structural MRI;diffusion MRI; Thu, 24 Jun 2021 10:00:00 GMT Characteristics of the initial symptoms of Alzheimer's disease in young patients https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Initial-symptoms-Alzheimer-disease-in-young.aspx Researchers from BioMaps (SHFJ) and the Department of Memory and Language Neurology (Ste Anne's Hospital) studied the early clinical signs of Alzheimer's disease (AD) reported by young patients (< 62 years old) compared to those reported in classic AD of the elderly (> 65 years old). They show that these signs are misleading and often appear in the professional context. Alzheimer's disease ; Diagnosis ; Brain Scientific result Thu, 10 Jun 2021 10:00:00 GMT PET imaging reveals the neuropharmacology of buprenorphine https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/PETimaging-neuropharmacology-buprenorphine.aspx Researchers at BioMaps (SHFJ) have succeeded in determining the interaction dynamics of buprenorphine, an opioid drug with a particularly complex pharmacology, with its brain receptors in vivo. To do so, they developed an original PET imaging approach based on the use of the radiolabeled molecule (11C-buprenorphine). Brain ; Positron Emission Tomography ; Pharmacology Scientific result Wed, 05 May 2021 10:00:00 GMT Humans Share an Exceptional Sense of Geometry https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Humains-geometrie.aspx Research from CEA, Collège de France, CNRS and Université Paris 8 shows that humans share a universal ability to understand abstract geometric concepts. This human ability does not depend on age, culture or education, but does not exist in the non-human primates tested. PNAS has just published their results. Cognition Researchers Neurospin Scientific result réseaux neuronaux;modélisation;cognition comparée;psychologie expérimentale; Fri, 23 Apr 2021 10:00:00 GMT Brain sulci imaging and genetics: the UK Biobank cohort has spoken. https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Brain-sulci-imaging-and-genetics.aspx Researchers from NeuroSpin and CNRGH (Jacob Institute) have studied, on a genome-wide scale, the potential associations of haplotypes (set of variants located side by side on a chromosome) with the opening value of imaged brain sulci, indicator of brain aging, from the UK Biobank neuroimaging-genetics cohort. MRI ; Genomics ; Brain Scientific result Mon, 19 Apr 2021 10:00:00 GMT Aloïse Mabondzo receives exceptional funding from NIH ! https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2021/A-Mabondzo-funding-from-NIH.aspx Aloïse Mabondzo, research director, head of the Neurovascular Pharmacology Group of the SPI (DMTS), co-founder and scientific director (CSO) of CERES BRAIN THERAPEUTICS, has just obtained funding of nearly one million US dollars from the prestigious National Institute of Health for his project « Neuroprotective Strategy: Novel Purine Derivatives for Neonatal Hypoxia-ischemia ». Brain ; Diseases News ; Article Mon, 29 Mar 2021 10:00:00 GMT Metabolomics for the clinician and the development of a neuroprotective strategy in acute stroke https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Metabolomics-clinician-neuroprotective-strategy-stroke.aspx The TIRO team (SHFJ), in collaboration with the neurovascular clinicians of the Nice and Marseille University Hospitals, carried out analyses of the metabolome of cerebral clots at the origin of the occlusion of a cerebral artery responsible for a cerebral vascular accident (stroke). A pilot study that improved the understanding of the complex relationship between blood glucose levels and patients' functional prognosis. Metabolomics ; Brain ; Diseases Scientific result Thu, 04 Feb 2021 11:00:00 GMT Towards a transcranial echography https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2021/Towards-transcranial-echography.aspx Jean-Luc Gennisson (BioMaps/SHFJ) coordinated, in partnership with the CEA-List (Sylvain Chatillon), the EchoBrain project (ATTRACT/H2020) aimed at adapting the digital tools developed by the List (CIVA platform) to significantly increase the quality of brain echography images, simple alternative compared to the methods (MRI, X-ray scanner) currently used for the diagnosis of strokes. Brain ; Medical imaging ; Simulation & modelling News ; Article Tue, 19 Jan 2021 11:00:00 GMT Launch of AROMA, a european project to exploit the full potential of NeuroSpin's future 11.7 T scanner. https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2021/Launch-of-AROMA.aspx AROMA, a FET-Open H2020 project, aims to develop the methodology necessary for the optimal operation of the future 11.7 T MRI being installed at NeuroSpin. This 5-year project, coordinated by Nicolas Boulant (NeuroSpin), with an overall budget of 3.6 million euros, involving six partners from five countries representing academia and industry, started on January 1, 2021. Methodologies for life sciences ; Brain ; MRI News Wed, 06 Jan 2021 11:00:00 GMT An atypical cerebral organization for language https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Atypical-cerebral-organization-for-language.aspx Researchers from the Neurofunctional Imaging Group (GIN, NeuroSpin, Bordeaux) studied by functional MRI, the organization of the brain network of sentence processing in individuals "atypical" for language, i.e. with a major role of the right hemisphere. Brain ; MRI Scientific result Wed, 09 Dec 2020 11:00:00 GMT CEA carries for France the EBRAINS infrastructure inscription on the ESFRI roadmap https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2020/CEA-carries-EBRAINS-inscription-for-ESFRI.aspx EBRAINS (European Brain ReseArch INfrastructureS) is a european research infrastructure designed by the scientific community which, based on a set of state-of-the-art digital platforms, aims to answer the analysis and processing needs of large brain data sets. CEA carries for France EBRAINS inscription on the European Strategy Forum on Research Infrastructures roadmap, which was submitted in early September 2020. Brain ; Simulation & modelling News ; Article ; Europe Wed, 09 Dec 2020 11:00:00 GMT BRICON, a project of the Human Brain Project for NeuroSpin (UNICOG) https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2020/BRICON-project-Human-Brain-Project-NeuroSpin.aspx Theofanis Panagiotaropoulos (NeuroSpin) obtains funding from the Human Brain Project for BRICON (Brain Inspired Consciousness), a project of HBP's neuroscience activities. Brain ; Cognition News ; Article Thu, 29 Oct 2020 11:00:00 GMT Analysis of multitask functional MRI data for the establishment of a neurocognitive atlas of the human brain https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Analysis-multitask-functional-MRI-data-IBC.aspx In this study, NeuroSpin researchers leveraged the Individual Brain Charting (IBC) dataset, acquired by high-resolution functional MRI during the performance of behavioural tasks, to investigate the feasibility of individual mapping of the cognitive components underlying the tasks. They thus individualized six regions of interest in the language network and established their cognitive profile. MRI ; Cognition Scientific result Thu, 08 Oct 2020 10:00:00 GMT Permeabilizing the blood-brain barrier to deliver therapeutic antibodies into the brain? ImmunoPET imaging provides answers https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/ImmunoPET-BBB-Ab.aspx Researchers from SHFJ, NeuroSpin and DMTS have demonstrated, by immunoPET imaging, the impact of transient BBB permeabilization on brain exposure to an anti-EGFR antibody. Promising prospects for targeted immunotherapy of glioblastoma. Cancer ; Medical imaging ; Positron Emission Tomography SIMOPRO Scientific result radiomarquage;zirconium;IRM; Tue, 06 Oct 2020 10:00:00 GMT Functional neuroanatomy of number processing at high-resolution https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Functional-neuroanatomy-number-processing.aspx NeuroSpin researchers used ultra-high field (7 Tesla) functional magnetic resonance imaging (fMRI) to better localize the processing and manipulation of numbers in the human brain. The results, which enrich our understanding of the functional organization of the intra-parietal sulcus, the cerebral center of digitization, are published in NeuroImage. Brain ; MRI ; Cognition ; Mathematics Scientific result Wed, 23 Sep 2020 10:00:00 GMT Towards a new generation of antennas for ultra-high field imaging of the brain https://www.cea.fr/drf/joliot/en/Pages/news/Press/mri-antenna-brain.aspx The European Commission once more places its trust on Multiwave company and its partners, Aix-Marseille Université , CEA and Université Catholique de Louvain to revolutionize ultra-high field magnetic resonance imaging of the brain. Health & life sciences ; Brain ; Methodologies for life sciences ; Medical imaging ; MRI Journalists ; Institutions ; Companies Neurospin News ; Focus NeuroSpin;DRF;Europe;MRI;Brain;project;Joliot;antenna;imagery; Tue, 22 Sep 2020 08:06:13 GMT Predicting brain age using a computer model https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Predicting-brain-age-computer-model.aspx Researchers from the PARIETAL team (Inria/CEA) at NeuroSpin and the University of Zurich have developed a computer model capable of accurately determining brain age. This model could be used to combine different types of brain function tests to predict, for example, cognitive decline or depression. Computing ; Brain Neurospin Scientific result algorithm; Mon, 14 Sep 2020 10:00:00 GMT Mapping of normal brain aging: unprecedented results from the SENIOR cohort https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/SENIOR-cohort-cerebral-aging.aspx The SENIOR study, conducted by several NeuroSpin teams, consists in monitoring, since March 2012, a cohort of 100 subjects aged 50 to 70 years by annual MRI imaging over a period of 10 years, to establish a normal aging brain imaging biomarkers mapping. This publication in Alzheimer's Research & Therapy describes the baseline experimental protocol and presents first promising results. Neurodegenerative diseases ; Brain ; MRI ; Positron Emission Tomography Scientific result Tue, 04 Aug 2020 10:00:00 GMT Diffusion MRI to monitor astrocyte activity? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/diffusionMRI-astrocyte-activity.aspx In two articles published in PLoS ONE, researchers at NeuroSpin show that diffusion MRI can monitor astrocyte activity in the brain in a non-invasive way, allowing a better understanding of its involvement in the glymphatic system and in functional MRI. MRI ; Brain Neurospin Scientific result BOLD MRI;functional MRI;aquaporins;diffusion MRI; Thu, 11 Jun 2020 10:00:00 GMT Deep learning in MRI: A standard for comparing the performance of artificial neural networks https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Deep-learning-MRI-Standard-networks-comparison.aspx Using public MRI data sets from the knee and brain, researchers from NeuroSpin and Cosmostat (CEA-Irfu) have written a consistent benchmark of several deep neural networks used for image reconstruction with significantly reduced acquisition time. Artificial intelligence ; MRI ; Brain Neurospin Scientific result Deep Neural Network;fastMRI;3D reconstruction;compressed-sensing MRI; Thu, 04 Jun 2020 10:00:00 GMT Do social and physical distancing change the way we relate to time?…. https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2020/Confined-time-study.aspx In order to answer this question, a vast study of experimental psychology and chronobiology, directed by Virginie Van Wassenhove (NeuroSpin) was launched in collaboration with Inserm and the University of Paris-Saclay. Brain News ; Article Thu, 30 Apr 2020 10:00:00 GMT Innovative approach to radiolabel peptides with fluorine-18 for PET imaging https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Innovative-approach-radiolabel-peptides-fluorine-18-PET-imaging.aspx Radiochemists from the BioMaps unit (SHFJ) have developed and automated a new fluor-18 radiolabelling method for peptides used to characterize specific pathological molecular signatures and thus target treatments. Peptides were conjugated to a specific tag, then radiolabeled in a single step under mild conditions, making this approach an innovative solution for PET imaging of peptides labeled with fluorine-18. Chemistry ; Positron Emission Tomography ; Cancer Scientific result Mon, 17 Feb 2020 11:00:00 GMT An atlas of the rat brain to better understand the human brain https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Atlas-rat-brain-SIGMA.aspx A team from NeuroSpin, in collaboration with researchers from the Sainte-Anne Hospital and from the University of Minho, has developed, using magnetic resonance imaging, a unique set of resources for the analysis and visualization of preclinical data in the rat brain. Brain ; Computing Researchers Neurospin Scientific result functional MRI;high field MRI; Mon, 27 Jan 2020 11:00:00 GMT Pypreclin: a new tool for fMRI preprocessing to facilitate interpretation https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Pypreclin.aspx NeuroSpin researchers have developed a software for preprocessing non-human primate brain raw images obtained by functional magnetic resonance imaging. The aim is to help harmonize methods, improve procedures, facilitate comparison and interpretation of the acquired images and to minimize the number of animals to be used in research. Brain ; Computing Scientific result functional MRI;MR imaging;Neuroimaging; Tue, 21 Jan 2020 11:00:00 GMT NeuroSpin and ENIGMA identify a potential biomarker of bipolar disorder https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/NeuroSpin-ENIGMA-potential-biomarker-bipolar-disorder.aspx NeuroSpin's psychiatric researchers and the Inserm U955 unit (CHU Mondor) coordinated, in collaboration with the ENIGMA consortium (an international group of researchers sharing brain imaging data), the first mega-analysis of diffusion MRI data including 3033 subjects with or without bipolar disorders. They identified extensive abnormalities in the cerebral white matter microstructure in sick people. Abnormalities that could represent a robust biomarker of bipolar disorder. Brain ; MRI ; Diseases Scientific result Tue, 10 Sep 2019 10:00:00 GMT See a tumor in PET imaging by « click-chemistry » in vivo https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/See-tumor-PET-imaging-click-chemistry-in-vivo.aspx A new PET imaging method by antibody pretargeting was developed at SHFJ, in collaboration with teams of SCBM and SPI. It consists in reacting in vivo a molecule labeled with 18Fluor with an antibody previously fixed on a tumor and this, in an extremely fast and selective manner, thanks to a « click-chemistry » reaction. The very good results obtained allow to consider the use of pre-targeted antibodies in nuclear medicine. Positron Emission Tomography ; Chemistry Scientific result Tue, 03 Sep 2019 10:00:00 GMT How our brain counts "at a glance" ? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/How-our-brain-counts-at-a-glance.aspx NeuroSpin researchers used ultra-high-field functional magnetic resonance imaging (7T) to understand how our brains process visual informations in the perception of numbers. Results, published in the journal eLife, show a direct perception of numbers in healthy adults. Brain Scientific result Thu, 29 Aug 2019 10:00:00 GMT 11.7 teslas: The World-Record Magnetic Field Generated by a Human MRI Magnet https://www.cea.fr/drf/joliot/en/Pages/news/Press/Iseult-MRI-Magnet-Record.aspx The Iseult project magnet being installed at Neurospin (CEA Paris-Saclay) reached a nominal magnetic field of 11.7 teslas (T) on July 18, 2019. This is a world record for a whole-body magnetic resonance imager (MRI) magnet, the culmination of years of R&D, at the forefront of innovation in the field of superconducting magnets. Fundamental Research ; Health & life sciences ; Brain ; Neurodegenerative diseases ; Diseases ; Tools & research instruments Journalists ; general public ; Institutions ; Companies ; Partners ; Researchers Neurospin Press release ; News ; En direct ; Focus Joliot;NeuroSpin;RFU;GE HealthCare;IRM;Iseult;magnet;Brain;MRI; Thu, 18 Jul 2019 11:49:45 GMT A new biomarker to predict tumor progression from whole body PET images. https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/New-prediction-biomarker-tumor-progression-PET-images.aspx The SHFJ/IMIV laboratory (Inserm 1023/CNRS/CEA/UP-Sud), in collaboration with hospital-university teams, has shown that, in patients with advanced-stage large cell lymphoma (B type), automatic quantitative measurements of tumor dissemination detected by whole-body PET imaging have a predictive value of progression-free survival (tumor stabilization) and overall survival. Medical imaging ; Positron Emission Tomography ; Cancer Scientific result Tue, 16 Jul 2019 10:00:00 GMT Put your activity-silent non-conscious working memory to work and it ceases to be both silent and non-conscious https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Activity-silent-non-conscious-working-memory-at-work.aspx A NeuroSpin team showed that the mere short-term storage of information may proceed without consciousness or persistent neural activity, but that manipulating information in working memory requires both. This study, thereby reconciling a hotly debated topic in the field of neuroscience, was published in PNAS. Cognition Researchers Saclay Scientific result working memory;consciousness;MEG; Fri, 12 Jul 2019 10:00:00 GMT Neuroscience serving archaeologists : unprecedented deciphering prehistoric graphic expressions. https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Neuroscience-serving-archaeologists.aspx A unique interdisciplinary collaboration between archaeologists and researchers of NeuroSpin (GIN, Bordeaux University/CEA/CNRS) offers for the first time analysis elements of the symbolism of prehistoric traces found on ancient Paleolithic engravings. These abstract patterns are analyzed by the same brain areas than those that recognize objects and also activate a well-known left hemisphere area involved in the treatment of written language. MRI ; Brain Scientific result Wed, 03 Jul 2019 10:00:00 GMT Iseult project: the MRI magnet has just reached a magnetic field of 9.51T https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2019/Iseult-Project-MRI-magnet-9,51T.aspx The magnet of the future MRI at 11.7 teslas of the Iseult project at NeuroSpin (CEA Paris-Saclay) reached a magnetic field of 9.51 teslas during tests carried out on Wednesday 22 May. This new level is a record since the magnet has become on this occasion the most powerful MRI magnet in the world for imaging in humans with a stored energy of 221 MJ. This successful outcome is the result of the work of the Iseult project’s team from the CEA. MRI ; Cryogenics ; Tools & research instruments ; Brain ; Physics ; Technologies Researchers ; general public ; Journalists Joliot Scientific result Fri, 24 May 2019 10:00:00 GMT MRI and AI to develop a virtual brain biopsy tool https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/MRI-and-AI-to-develop-virtual-brain-biopsy-tool.aspx ​Imaging the brain of a patient at the microscopic scale is as of yet not possible but might turn into a reality thanks to a new tool for creating virtual biopsies. This algorithm has been developed by a team of NeuroSpin (CEA-Joliot) in collaboration with the Institute of NeuroScience and Medicine of Juelich as part of the European Human Brain Project. A first study demontrsating the potentiel of the algorithm ot simulate white matter samples has been published in NeuroImage. Brain ; MRI ; Bioinformatic Neurospin Scientific result IA;algorithme;intelligence artificielle;IRM de diffusion;Human Brain Project;HBP; Wed, 03 Apr 2019 10:00:00 GMT A sensory response imaged on a microscopic and mesoscopic scale. https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Sensory-response-imaged-microscopic-mesoscopic.aspx Researchers from Inserm, in collaboration with a team from NeuroSpin, have developed a preparation to observe sequentially the neuronal activity and vascular responses of the same mouse with bi-photonic microscopy, ultrasound imaging and BOLD-fMRI, in response to an olfactory stimulus. This approach made it possible to quantitatively compare the responses to odors observed both at the microscopic and mesoscopic scales. Results, published in Nat. Comm, show that the three techniques similarly measure the concentration of an odor. MRI ; Brain Scientific result Mon, 25 Mar 2019 11:00:00 GMT Towards a better detection of glioblastoma infiltration https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Towards-better-detection-glioblastoma-infiltration.aspx Glioblastoma is a very aggressive cancer of the central nervous system, mainly because of its ability to infiltrate the surrounding areas. A collaboration led by a team of SHFJ and involving NeuroSpin demonstrates the interest of two imaging techniques for the early detection of tumor infiltration. Cancer ; Medical imaging ; Positron Emission Tomography Scientific result PET imaging;glioblastoma; Tue, 26 Feb 2019 11:00:00 GMT Functional MRI: a powerful tool for assessing states of consciousness https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/functional-MRI-powerful-tool-for-assessing-states-of-consciousness.aspx An international collaboration led by a team from the ICM (Brain and Spine Institute) shows that it is possible to assess states of consciousness through an imaging process developed at NeuroSpin. This new tool could help to better diagnose alterations of consciousness. The results were published in Science Advances. Brain Neurospin Scientific result consciousness;functional MRI; Tue, 19 Feb 2019 11:00:00 GMT A study of structure-function relationships of the cerebral cortex thanks to new neuroimaging markers https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Structure-function-relationships-cerebral-cortex-neuroimaging-markers.aspx By using in vivo MRI, researchers at NeuroSpin (GIN-Bordeaux) have been able to evaluate the myelination of nerve fibers in the auditory cortex, area of the brain involved in the processing of language sounds. They observed an asymmetry of myelination in favor of the left hemisphere, in particular according to language performances. They show the usefulness of neuroimaging markers in the study of structure-function relationships at the cerebral cortex level. Brain ; MRI Scientific result Wed, 30 Jan 2019 11:00:00 GMT "Mini-brains" for research on Alzheimer's disease https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/mini-brains-research-Alzheimer-disease.aspx A partnership between the François Jacob Institute of Biology/CEA, The Frédéric Joliot Institute for Life Sciences/CEA and CellTechs (a Sup'Biotech lab) has led to a new approach for modeling Alzheimer's disease in vitro. Health & life sciences ; Brain ; Alzheimer's disease MIRcen Scientific result Brain;Alzheimer; Mon, 14 Jan 2019 11:00:00 GMT Evolution of Alzheimer's disease : a dual role of the neuroimmune reaction https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Alzheimer-disease-role-neuroimmune-reaction.aspx A collaboration involving the Sainte-Anne Hospital, the SHFJ, the Saint-Antoine research center and the ICM identified, through a PET brain imaging study in patients with Alzheimer's disease, two distinct kinetic profiles of the cerebral neuroimmune response, that impact the disease progression differently. Researchers propose an original model of neuroinflammation, likely to open new therapeutic avenues. Brain ; Alzheimer's disease ; Positron Emission Tomography Scientific result Thu, 10 Jan 2019 11:00:00 GMT Physicists and pharmacologists join forces to better understand the biology of the blood-brain barrier. https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/Physicist-pharmacologists-to-better-understand-BBB.aspx Thanks to complementary imaging techniques, researchers from the SHFJ and NeuroSpin have shown that the physical blood-brain barrier (BBB) disruption is not necessarly enough to deliver some drugs into the brain, especially when there are recognized and supported by efflux transporters. Medical imaging ; MRI ; Positron Emission Tomography ; Cellular mechanisms SHFJ News Thu, 20 Dec 2018 11:00:00 GMT Artificial intelligence allows identification of a neuroanatomical signature of schizophrenia https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Artificial-intelligence-identification-neuroanatomical-signature-schizophrenia.aspx An international collaboration of researchers in psychiatry, led by a team from NeuroSpin, has shown that machine learning algorithms identify a neuroanatomical signature of schizophrenia that is reproducible in the various image acquisition centers and for the different stages of the disease evolution. These results offer prospects for the early detection and management of people at risk of psychotic transition. Brain ; Medical imaging ; MRI Scientific result Wed, 12 Dec 2018 11:00:00 GMT Autism spectrum disorders : a new brain imaging study appears to challenge the dominant theoretical model. https://www.cea.fr/drf/joliot/en/Pages/news/Press/AUTISM-SPECTRUM-DISORDERS-a-new-brain-imaging-study-appears-to-challenge-the-dominant-theoretical-model.aspx Brain ; Diseases ; Medical imaging Press release ; Scientific result Wed, 14 Nov 2018 11:00:00 GMT Understanding autism: novel brain imaging study challenges the dominant explanation https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/autism-novel-brain-imaging-study-challenges-dominant-explanation.aspx As part of the InFoR-Autism scientific program involving NeuroSpin, a new neuroimaging study has revealed a correlation between decreased local anatomical connectivity and social cognitive deficits in people with autism spectrum disorders (ASD). Published in the renowned journal Brain, the results challenge the dominant theoretical model explaining ASD and could pave the way for the exploration of new therapeutic approaches. Cognition ; MRI ; Diseases Neurospin Scientific result IRM de diffusion;autisme; Tue, 13 Nov 2018 11:00:00 GMT Open science, ethics and cerebral imaging of non human primates https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/Open-science-ethics-NHP-cerebral-imaging.aspx The goal of the PRIME-DE data exchange is to make primate brain imaging datasets acquired in laboratories available to the entire scientific community. PRIME-DE was created by an international consortium of 22 teams including one from NeuroSpin, all working with macaques. The PRIME-DE initiative, presented in an article published in Neuron should enhance the statistical relevance of acquired data and limit the number of animals used in research. MRI ; Brain Neurospin Press release MRI;database;3R; Thu, 18 Oct 2018 10:00:00 GMT Cerebral lymphoma: a new indication for [18F]Fludarabine? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/TEP-18FFludarabine-lymphome-cerebral.aspx A SHFJ research team (LDM-TEP, GIP Cyceron, Caen) has previously developed and produced a radiopharmaceutical, the [18F]-Fludarabine, to detect lymphomas using PET scan. The team has recently conducted a preclinical study that shows the molecule can help in diagnosis of cerebral lymphoma by differentiate it from glioblastoma, the main brain tumor. A clinical study should be launched before the end of the year. Brain ; Medical imaging ; Cancer ; Diagnosis Joliot Scientific result FDG;lymphoma;glioblastoma; Mon, 08 Oct 2018 10:00:00 GMT A reliable and accessible algorithm based on EEG to diagnose states of consciousness https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/EEG-algorithm-diagnosis-states-consciousness.aspx An international collaboration, led by the Institut du Cerveau et de la Moelle épinière – ICM (Brain & Spine Institute) and involving researchers from NeuroSpin, offers a new electroencephalogram (EEG) tool that helps the diagnosis of disorders of consciousness. Unlike other tools developed so far and dedicated to a few expert centers, “DoC-Forest” would be accessible to most of the hospitals worldwide. Brain ; Medical imaging ; Artificial intelligence ; Diagnosis Neurospin Scientific result EEG;biomarker;disorders of consciousness;machine learning; Fri, 05 Oct 2018 10:00:00 GMT A novel role of the blood-brain barrier in the cerebral elimination of drugs https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/novel-role-blood-brain-barrier.aspx SHFJ Researchers (IMIV), in collaboration with Vienna University, studied the brain transport of a drug, called metoclopramide. Radiolabelling of carbon-11 metoclopramide and PET imaging showed that a transporter of the blood-brain barrier, P-glycoprotein, blocked not only the entry of the drug into the brain but also facilitated the elimination to the blood. This result demonstrates for the first time in vivo and non-invasively a detoxification system able to eliminate certain compounds of the brain. Brain Scientific result Thu, 20 Sep 2018 10:00:00 GMT The discovery of a universal cerebral signature of anesthesia https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/cerebral-signature-anesthesia.aspx By studying the cerebral dynamics of monkeys under general anesthesia using functional MRI (fMRI) and electroencephalography (EEG), NeuroSpin researchers, in collaboration with several hospital-university Teams, have identified a universal brain signature of the induced loss of consciousness by general anesthesia. This signature corresponds to a "stiffening" of the information flow within the brain. Brain ; MRI Scientific result Tue, 31 Jul 2018 10:00:00 GMT Individual Brain Charting: a high-resolution brain mapping of cognitive functions https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/Individual-Brain-Charting.aspx Funded by the Human Brain Project, Individual Brain Charting is a collaborative project involving NeuroSpin that involves acquiring a set of high-resolution functional MRI maps of the human brain while performing behavioral tasks. The data, in open access, will be used to develop a macroscopic functional atlas including a cognitive mapping. This is the first version of the IBC project dataset. Brain ; MRI Scientific result Mon, 16 Jul 2018 10:00:00 GMT LIFEx increasingly popular for characterizing tumor heterogeneity in medical imaging https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/LIFEx-popular.aspx ​IMIV unit (SHFJ), in collaboration with the Gustave Roussy Institute, has developed the free software platform LIFEx that allows to characterize the tumor heterogeneity from any type of medical images: PET, MRI, scanner, ultrasound. With nearly 900 members, this platform has an international success because it facilitates the realization of radiomic studies, conducted in the context of personalized medicine. Positron Emission Tomography ; MRI ; Medical imaging Scientific result Thu, 05 Jul 2018 10:00:00 GMT