https://joliot.cea.fr/drf/joliot/en/Pages/news/Science/2020/C14-anti-inflammatory-drugs.aspx Website of the Frédéric-Joliot Institute of Life Sciences which includes 4 departments: I2BC, DMTS, NeuroSpin and Service hospitalier Frédéric Joliot (SHFJ). The teams are mainly located at the CEA Paris-Saclay center and at the Orsay hospital. en-US https://www.cea.fr/Style%20Library/Themes/drf/instituts/images/logo-cea-joliot-2023.png https://joliot.cea.fr/drf/joliot/en https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/CO2-reduction-catalytic-cycle-porphyrin.aspx Using a range of spectroscopic techniques, researchers at I2BC in collaboration with ICMMO have elucidated the catalytic cycle of a bio-inspired iron porphyrin catalyst, which could form the basis of economically viable solutions for the conversion and recovery of CO2. Green Chemistry ; Bio-inspired catalysis Researchers SB2SM Scientific result ; Article Thu, 13 Jun 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Photocatalytic-CO2-reduction-for-radiolabeled-drug-synthesis.aspx Researchers from SCBM (DMTS) and SB2SM (I2BC) describe a novel and optimized approach to the total photoreduction of 13C-labelled CO2 to carbon monoxide (CO), and the immediate reuse of the latter for the synthesis of high value-added compounds. A step towards a radiochemistry of carbon isotopes potentially useful in human health. Bio-inspired catalysis ; Chemistry ; Green Chemistry ; Carbon cycle SHFJ Scientific result Wed, 22 Nov 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/O2-photoactivation-bio-inspired-hydrocarbon-catalysis.aspx The oxidative functionalization of alkenes, hydrocarbons widely used in the chemical industry, remains a challenge. A team from I2BC used an Oxygen Atom Transfer reaction to an alkene and succeeded in capturing the intermediate species of a bio-inspired photocatalyst produced during the reaction. Bio-inspired catalysis ; Green Chemistry SB2SM Scientific result Wed, 22 Feb 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Functioning-FAP-photoenzyme-deciphered.aspx An international consortium of scientists, including an I2BC team, has just deciphered the functioning of FAP (Fatty Acid Photodecarboxylase), a key photoenzyme for the production of biofuels and other high value added molecules. This work, published in Science, was the object of a CEA press release. Green Chemistry ; Microalgae ; Biofuel Scientific result Mon, 12 Apr 2021 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/CO2-valorization-ChemSusChem.aspx By studying the structure-reactivity relationships of bio-inspired catalysts for CO2 reduction, researchers from I2BC (SB2SM) and ICMMO have shown that the effects of through-space electrostatic interactions surpass the through-bonds electronic effects. A further step towards obtaining a durable catalyst to reduce the atmospheric accumulation of CO2, responsible for global warming. Green Chemistry ; Bio-inspired catalysis ; Carbon cycle Scientific result Wed, 24 Mar 2021 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/C14-anti-inflammatory-drugs.aspx Researchers from the SCBM in collaboration with teams from IRAMIS, AstraZeneca and the Karolinska Institutet have developed a second marking method based on the dynamic exchange of carbon dioxide, this time without catalysis, by "simple" thermal heating. Ideal for organic molecules of therapeutic interest, the method is described in tAngewandte Chemie. Green Chemistry SCBM Scientific result isotopic exchange;radiolabeling; Mon, 04 May 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/valorisation-carbon-dioxide.aspx ​In studies published in ChemPhotoChem, I2BC@Saclay, SCBM and ICMMO researchers have developed a gentle method for photo-CO2 reduction by molecular catalysts, followed by a carbonylation reaction that immediately reuse the CO produced. This device can be used for the introduction of radioactive carbon atoms into molecules of therapeutic interest. Green Chemistry ; Photosynthesis Scientific result Thu, 06 Sep 2018 10:00:00 GMT